immunoterapy of cancer

James P. Allison

Timeline

1980x – James P. Allison started to work on T-Cells1992 – collaboration with David Raulet about CD28 molecule( http://www.rcsb.org/pdb/protein/P10747 )1990x (beg) Tak Mak group proved that CTLA-4 is inhibitor in invitro studies in Allison's lab ( http://www.rcsb.org/pdb/explore.do?structureId=1DQT )1994 Dana tested on mice and then repeated1997 Cell piblication 2007 successful clinical trials with anti CTLA-4 (ipilimumab) >25%cured2010x CTLA-4 and PD-1 trials, >50% cured

Cancer surpresses immune systems

CTL-4 immunoterapy of cancer

CTL-4 immunoterapy of cancer

Thank you for your attention!