CANCER IMMUNOTHERAPY

Cancer Immunotherapy• Immunotherapy is also sometimes called biologic

therapy or biotherapy. It is treatment that uses certain parts of the immune system to fight diseases such as cancer

• Stimulating your own immune system• Giving you immune system components

• Cancer immunotherapy is the use of the immune system to reject cancer. The main premise is stimulating the patient's immune system to attack the malignant tumor cells that are responsible for the disease.

CANCER IMMUNOTHERAY

• In late 1800s Dr William Coley first noted that getting an infection after surgery seemed to help some cancer patients. he began treating cancer patients by infecting them with certain kinds of bacteria, which came to be known as Coley toxins.

Types of immunotherapy• Monoclonal antibodiesa) Naked mAbs b) Conjugated mAbs i. Radiolabelledii. Chemolabelediii. immunotoxin• Cancer vaccines• Non-specific immune

therapiesa) Cytokinesb) interleukin

DIFFERENT MONOCLONAL ANTIBODIES METHODS

Alemtuzumab + CD 52 against melanoma

Before After

Cancer immunotherapy:Monoclonal antibodies[2]

Antibody Brand name

mab type Type Target Approved treatment(s)

Alemtuzum ab Campath Naked mAB humanized CD52 Chronic lymphocytic leukemia

denileukin diftitox (Ontak®) Chemolabeled

mABhumanized CD25 colorectal cancer

Brentuximab vedotin Adcetris

Chemolabeled

mABchimeric CD30ss Hodgkin lymphoma,Anaplastic large-

cell lymphoma

Ibritumomab tiuxetan Zevalin

Radiolabel led

mABmurine CD20 non-Hodgkin lymphoma(with

yttrium-90 or indium-111

Antibiotic based drugs

CANCER VACCINES

• Tumor cell vaccines• Antigen vaccines• Dendritic cell vaccines• DNA vaccines• Vector-based vaccines

VACATION STRATEGIES

LATEST RESEARCH

• Newer Monoclonal Antibodies• In June 2008, it was announced that United States doctors from the

Clinical Research Division led by Cassian Yee at Fred Hutchinson Cancer Research Centerin Seattle have for the first time successfully treated a skin cancer patient by using immune cells cloned from his own immune system which were then re-injected into him.

• Topical immunotherapy• Imiquimod immune enhancement cream

• Natural product• Agaricus subrufescens

LATEST RESEARCH

CANCER IMMUNOTHERAPY A NEW HOPE