caffeine and migraines

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CAFFEINE AND MIGRAINES Solution and cause of all problems

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what has consumed my life and thoughts for the past week or so.

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Page 1: Caffeine and migraines

CAFFEINE AND MIGRAINESSolution and cause of all problems

Page 2: Caffeine and migraines

MIGRAINE: A HEADACHE ON SPEED

Four phases: prodrome, aura, pain, postdrome

Not all migraine sufferers go through all phases

True origins are un-clear; theories abound

Image: http://observantbystander.files.wordpress.com/2007/07/aura.jpg

Page 3: Caffeine and migraines

MIGRAINES: A REAL PAIN

No tests or biomarkers, diagnosis is done by observation and exclusion

Symptoms vary widely per each patient Guidelines are set by the International

Headache Society (2)

Seven subtypes exist and patients can go from one to the other (2)

Due to this, very difficult to research

Image: http://www.zazzle.com/vintage_ad_photo_card_headache_man-137322563792988907

Page 4: Caffeine and migraines

MIGRAINES: A REAL PAIN (CONT.) Affects 36 million Americans (3)

More common in women than men (2)

Higher prevalence in low-income and low-education groups (4)

Often co-morbid with psychiatric disorders, epilepsy, stroke, lupus among others (2)

Page 5: Caffeine and migraines

COMMON MIGRAINE TRIGGERS Hormonal changes Stress Sensory stimuli Changes In Weather Lack of sleep Food (5)

Everything

Image: http://www.blogcdn.com/www.asylum.com/media/2009/06/headache_vintage_getty_72353812.jpg

Page 6: Caffeine and migraines

A LITTLE MORE ABOUT FOOD TRIGGERS… Tyramine a. Causes release of adrenaline, increases blood pressure

b. Found in ripened cheeses, some sausages, and beers

Chocolate a. Extremely common trigger

b. Contains an amine found in cheese and red wine

Citrus Fruits Alcohol And…caffeine! (2)

Image:http://farm4.static.flickr.com/3012/2972084682_36a191baa3.jpg

Page 7: Caffeine and migraines

TRIMETHYLXANTHINE, CODE NAME: CAFFEINE

C8H10N4O2,

Nitrogen-based alkaloid Odorless, bitter white

crystals Water soluble Extracted from plants Consumed via pills,

coffee, tea, chocolate, and soda (6)

Image: http://itech.dickinson.edu/chemistry/?p=304

Page 8: Caffeine and migraines

Source: Center For Science In The Public Interest

Page 9: Caffeine and migraines

THIS IS YOUR BRAIN ON CAFFEINE

CNS stimulant Passes the blood-brain

barrier Nearly 100% bio-available Half-life of 3 to 7.5 hours in

healthy adults, longer in pregnant women and infants

Can act as an analgesic Can lead to physical

dependence in 30% of people(7)

Image: http://en.wikipedia.org/wiki/File:Caffeinated_spiderwebs.jpg

Page 10: Caffeine and migraines

ADACHI, ET AL (2003) 1264 Daisen residents over the age of 20

surveyed Separated into 4 types of headaches 2.3% one-year prevalence in men, 9.1% in

women, overall 6.0% Migraineurs consumed significantly far more

fatty foods, coffee, and tea than nonheadache subjects

Migraineurs did not report food triggers

Page 11: Caffeine and migraines

GADOTH AND HERING-HANIT (2003)

36 Children

a. 1.5 Liters of Cola drinks a day: 192.88 mg/caffeine daily, 1414.5 mg/week

Followed up 2, 4, 6, 12 and 24 weeks

Gradual withdrawal led to complete cessation of headache for 33 subjects after two weeks and through out the follow up period

Source: http://momgrind.com/wp-content/uploads/2008/05/coca-cola-ad.jpg

Page 12: Caffeine and migraines

EDELSTEIN AND MAUSKOP (2008) Review of literature on Pubmed from 1966 to

February 2008 Concluded caffeine was effective as a

treatment of headache when used infrequently

Found high doses of caffeine consumption associated with headache due to withdrawal

Recommended headache patients consume less than 200mg of caffeine a day

Page 13: Caffeine and migraines

CONCLUSIONS Heavy use of caffeine can

cause migraine headaches due to withdrawal

One theory: migraine headaches are largely just caffeine withdrawal headaches

Caffeine’s effect as an analgesic is important to remember, so not all caffeine can be eliminated

Research is on-goingSource: http://web2.slc.qc.ca/jmc/w04/caffeine/caffeine%20junkie.jpg