c953-04/00 tile rat - us epa...jun 27, 1995 · +ve 91ear 300 pci : pjlll date gest'n male...

'

Li\C953-04/00

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY lN TilE RAT

INDIVDXIAL ANlMAL ll<\TA SUPPLEMENT

APPENDIX20A

REPRDOO::TIVE PERFOilMAN:E - Fl GENERATION - F2A LITI'ERS

300 Jllll1

ID1ALE NlMlER

PAIRlNG 11'\TE

+VE <MEAR 11'\TE

E'CI 11'\TE GEST'N MALE YOUNG Kf LITIERED PERIOD NlMlER my ONE

(rnl'Sl ALIVE DEAD

YOUNG YOUNG ALIVE ALIVE my 5 my 11

YOUNG ALIVE my 16

YOUNG ALIVE my 22

YOUNGALIVEmy 29

l2l 21/12/92 25/12/92 4 16/01/93 22 97 14 1 14 14 14 14 14 l22 21/12/92 23/12/92 2 14/01/93 22 98 10 0 10 10 10 10 10 l23 21/12/92

lS/01/93 29/12/92 17/01/93

8 2

99104

124 21/12/92 10/01/93

22/12/92 12/01/93

1 2 03/02/93 22

100 102 13 0 13 13 13 13 13

l25 21/12/92 03/01/93 13 25/01/93 22 101 9 0 8 8 8 8 a 126 21/12/92 22/12/92 1 13/01/93 22 102 13 0 11 10 10 10 10 127 21/12/92

10{01/93 22/12/92 13)01/93

1 3 04/02/93 22

103106 12 0 12 12 12 12 12

128 21/12{92 23/12/92 2 14{01{93 22 104 12 1 12 12 12 12 12

129 21/12/92 10/01/93

22/12/92 11/01/93

1 1 02/02/93 22

105 117 9 2 7 7 7 7

130 21/12/92 23/12/92 2 14/01/93 22 106 9 2 6 6 6 6 6

131 21/12/92 25{12/92 4 16{01{93 22 107 13 0 13 13 13 13 13

132 21/12{92 23{12/92 2 14/01/93 22 10a 13 0 13 13 13 13 13

133 21/12/92 22{12{92 1 13{01{93 22 109 5 1

134 21/12/92 23/12/92 2 14/01{93 22 110 8 0 8 8 8 8 a

135 21{12/92 24{12{92 3 lS/01{93 22 111 13 0 12 11 11 11 11

136 21/12/92 25/12/92 4 16/01/93 22 112 4 2 4 4 4 4 4

"-l ...... ' '"'C .......,. 0

...... ""'

..... ..... 0'1 N

·-· ',> ··-~ ., \

;2:::--'~ 'l,.. _.)

·;c...1

i.,: '

::::.~>' ·;; l..-\ . '

)' ~~ I·

Ll\C953-04/00

PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANIMAL D.'ITA SUPPLEMENT

APPENDIX 20A

REPRODUCTIVE PERFORMANCE - Fl GENERATION - F2A LITTERS

FEMALE NlMBER

P.AIRJN; DATE

+VE 91EAR DATE

300

PCI

PJlll

DATE GEST'N MALE YOUNG M LITl'ERED PERIOD NlMBER DAY ONE

(DAYS) ALIVE DE'.!ID

YOUNG YOUNG ALIVE ALIVE DAY 5 DAY 11

YOUNG ALIVE DAY 16

YOUNG ALIVE DAY 22

YOUNG ALIVE DAY 29

137

138

139

21/12/92

21/12/92

21/12/9215/01/93

25/12/92

24/12/92

25/12/92

4

3

4

16/01/93 22 ill 8 4

15/01/93 22 114 8 0

115 120

8 8

6 6

8

6

8

6

8

6

140

141

21/12/9210/01/93

21/12/92

22/12/9212/01/93

22/12/92

1 2

1

03/02/93 22 116 109

117

13 0 13 13 13 13 13

142

143

144

21/12/92

21/12/92

21/12/92

25/12/92

22/12/92

22/12/92

4

1

1

16/01/93

13/01/93

13/01/93

22

22

22

118

119

120

7

8

12

0

3

0

7

5

7

7

5

7

7

5

7

7

5

7

7

5

7

n -< r........, ........, 0 <0 .....

..... ..... 0'\ w

,~, .

LAC953-04/00

PERCHLOIIDETilYLENE: MULTIGENERATION INHALIITION STUDY IN THE RAT

INDIVIIXW.. ANlli\L DATA SUPPLEMENT

APPENDIX 20A

REPRDDOCTIVE PERFOBMAl'n: - F1. GENERATION - F2A LITTERS

1000 pp:n

FEMALE PAJ:IUN:; +VE S-1EAR PCI DATE GEST'N MALE YOUNG AT YOUNG YOUNG YOUNG YOUNG YOUNGNU1BER DATE DATE LITI'ERED PERIOD NU1BER DAY ONE ALIVE ALIVE ALIVE ALIVE ALIVE(DAYSl ALIVE DEAD DAY 5 DAY ll DAY 16 DAY 22 DAY 29

169 2l/l2/92 24/lZ/92 3 15/01/93 22 145 l2 0 ll 10 10 10 10170 2l/l2/92 22/lZ/92 1 13/01/93 22 146 6 2 6 6 6 6 6 171 2l/l2/92 23/lZ/92 2 14/01/93 22 147 15 0 5 5 5 5 5172 Zl/12/92 27/lZ/92 6 14815/01/93 17/01/93 2 08/02/93 22 159 8 1 7 7 7 7 7173 2l/l2/92 22/lZ/92 1 14/01/93 23 149 4 1174 2l/l2/92 22/lZ/92 1 13/01/93 22 150 13 0 8 8 8 8 8 175 2l/l2/92 22/lZ/92 1 13/01/93 22 151 9 0 3176 2l/l2/92 24/lZ/92 3 14/01/93 2l 152 ll 1 8 8 8 8 8177 2l/l2/92 22/lZ/92 1 14/01/93 23 153 1 5

178 2l/l2/92 15415/01/93 149

179 2l/l2/92 25/lZ/92 4 155

180 2l/l2/92 22/lZ/92 1 13/01/93 22 156 8 3

181 2l/l2/92 25/lZ/92 4 16/01/93 22 157 13 0 l2 l2 l2 l2 l2 182 2l/l2/92 23/lZ/92 2 14/01/93 22 158 5 3

183 2l/l2/92 22/lZ/92 1 159

184 2l/l2/92 22/lZ/92 1 14/01/93 23 160

185 2l/l2/92 25/lZ/92 4 16/01/93 22 161 9 0 7 7 7 7 7

n --!

.c:: "0 ....... ..,.0 \0......

............ "'..,.

LAC953-04/00

PERCHLORDETHYLENE: 11IJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlMAL DATA SUPPLEMENT

APPENDIX20A

REPRO!XJCTIVE PERFORMANCE - fl GENERATION - F2A LITTERS

1000 JllDl

FEMALE NtMlER

PAIRING DATE

+VE SMEAR DATE

PCI DATE GEST'N MALE YOUNG KfLITTERED PERIOD NtMlER DAY ONE

(DAYS) ALIVE DEAD

YOUNG YOm; ALIVE ALIVE DAY 5 DAY 11

YOUNG ALIVE DAY 16

YOUNG ALIVE DAY 22

YOUNGALIVEDAY 29

186 21/12/92 23/12/92 2 14/01/93 22 162 12 0 11 11 11 11 11 187 22/12/92 24/12/92 2 16/01/93 23 166 8 3 1 1 1 1 1 188 21/12/92 29/12/92 8 164

189 21/12/92 24/12/92 3 15/01/93 22 165 8 4 6 6 6 6 6 190 21/12/92 22/12/92 1 14/01/93 23 166 2 1

191 21/12/92 25/12/92 4 16/01/93 22 167 11 2 10 10 10 10 10192 21/12/92 25/12/92 4 16/01/93 22 168 10 0 10 10 10 10 10

,.., -i r-....... ""C ....... ... 0

.... ""

...... ...... 0'1 (J"1

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANIMAL DATA SUPPLEMENT

APPENDIX 208

REPRODUCTIVE PERFORMANCE - F1 GENERATION - F2B LITTER

Key:

PCI = pre-coital interval GEST'N = gestation

Females 141, 183, 184 were dead prior to this litter.

CTL/P/4097 - 1166

LAC953-04/00

PERCHLOROET!!YLENE: MULTIGENERATION INHAI.l\TION STUDY IN THE RAT

INDlVIlJUAL ANlMIIL JliiTA SUPPLEMENT

APPENDIX 20B

REPROJXX:TIVE PERFORMANCE - Fl GENERATION - F2B LITTERS

0 ppn

FEMALE NtMBER

PAIRING DATE

+VE SMEAR DATE

PCI DATE GEST'N l1'ILE YOUNG Kf YOUNG LITTERED PERIOD NtMBER JlA.Y ONE ALIVE

(Jl..A.YS) ALIVE DEAD JlA.Y 5

25 28/03/93 21/04/93

29/03/93 22/04/93

1 1

4 3

26 28/03/93 31/03/93 3 22/04/93 22 1 15 0 15

27 28/03/93 30/03/93 2 22/04/93 23 2 7 0 7

28 28/03/93 29/03/93 1 20/04/93 22 3 12 0 12

29 28/03/93 21/04/93

29/03/93 30/04/93

1 9 22/05/93 22

6 9 9 0

30 28/03/93 31/03/93 3 22/04/93 22 5 4 3 4

31 28/03/93 31/03/93 3 22/04/93 22 8 6 0 6

32 28/03/93 29/03/93 1 20/04/93 22 7 10 0 10

33 28/03/93 21)04/93 26/04/93 5

12 7

34 28/03/93 29/03/93 1 20/04/93 22 9 15 2 15

35 28/03/93 29/03/93 1 20/04/93 22 10 13 0 13

36 28/03/93 21/04/93

29/03/93 24/04/93

1 3 16/05/93 22

11 16 16 0 16

37 28/03/93 31/03/93 3 22/04/93 22 14 5 0 5

38 28/03/93 29/03/93 1 20/04/93 22 15 13 0 13

39 28/03/93 29/03/93 1 20/04/93 22 16 8 0 8

40 28/03/93 31/03/93 3 22/04/93 22 13 11 0 11

(""') -; ....... "'0 ......., 0 \0....,

..... .....

...., C"l

l

LI\C953-04/ 00

PERCHLORDET!IYLENE: MULTIGENERAITON INHALATION STUDY IN THE RAT


APPENDJJ( 20B

REPRDOOCTIVE PERFOBMANCE - Fl. GENERATION - F2B LITI'ERS 0 Jllll1

FEMALE PAIRJN:; +VE SMEAR PCI nm; GEST'N W<LE YOUNG M YOUNGNCM8ER nm; nm; LITrERED PERIOD NCM8ER DAY ONE ALIVE(DAYS) ALIVE DEAD DAY 5

41 28/03/93 30/03/93 2 22/04/93 23 18 3 7 42 28/03/93 29/03/93 1 20/04/93 22 l7 7 0 7 43 28/03/93 29/03/93 1 20/04/93 22 20 11 0 11

44 28/03/93 31/03/93 3 22/04/93 22 19 11 0 11

45 28/03/93 25/04/93 22 13 0 13

46 28/03/93 2121/04/93 24/04/93 3 16/05/93 22 15 7 0 5 47 28/03/93 29/03/93 1 24

21/04/93 26/04/93 5 18/05/93 22 20 14 1 1448 28/03/93 30/03/93 2 21/04/93 22 23 10 0 9

("") -;r -.. -c-.. ... 01.0 ......

,_.,_.01 co

L!IC953-04/00


INDIVIIXIAL ANlMAL DATA SUPPLEMENT

1\PPENDIX 20B

REPROIXX::TIVE PERl'DRMANCE - Fl GENERATION - F2B LITI'ERS

300 ppn

FEMIILE NtMlER

PAIR.IN; IlliTE

+VE SMEAR IlliTE

PCI IlliTE GEST'N MilLE YOUNG KJ:LI'I'l'ERED PERIOD NtMlER DAY ONE

YOUNGALIVE

(DAYS) ALIVE DEAD DAY 5

121 28/03/93 30/03/93 2 ll/04/93 22 100 12 1 12

122 28/03/93 ll/04/93

29/03/93 26/04/93

1 5

9799

123 28/03/93 31/03/93 3 22/04/93 22 98 0 3

124 28/03/93 29/03/93 1 20/04/93 22 99 11 0 10

125 28/03/93 30/03/93 2 ll/04/93 22 102 7 0 7

126 28/03/93 29/03/93 1 20/04/93 22 101 8 1 6

127 28/03/93 31/03/93 3 22/04/93 22 104 7 0 7

128 28/03/93 31/03/93 3 22/04/93 22 103 13 0 12

129 28/03/93 31/03/93 3 22/04/93 22 106 5 0 5

130 28/03/93 31/03/93 3 22/04/93 22 105 5 1 5

131 28/03/93 ll/04/93 01/05/93 10

108 100

132 28/03/93 31/03/93 3 22/04/93 22 107 12 0 12

133 28/03/93 29/03/93 1 ll/04/93 23 112 5 0 4

134 28/03/93 29/03/93 1 20/04/93 22 109 8 0 8

135 28/03/93 31/03/93 3 22/04/93 22 110 7 0 7

136 28/03/93 29/03/93 1 20/04/93 22 lll 5 1 5

137 28/03/93 29/03/93 1 20/04/93 22 114 2 0

("") -l r ........, ........, 0

...... '""

...... ...... 0">

'""

LAC953-04/ 00

PERCHLOBDETHYLENE: MDLTIGENERATION INHAlATION STUDY lll TilE RAT


APPENDIX 20B

REPRDDOCTIVE PERFORMANCE - Fl. GENERATION - F2B LI:!TERS

300 ppn

FEMALE PAIRING +VE SMEAR PCI DATE GEST'N MALE YOUNG AT YOUNGNU1llER DATE DATE LITTERED PERIOD NU1llER DAY ONE ALIVE(DAYS) ALIVE DEAD DAY 5

1.38 28/03/93 30/03/93 2 1l.321/04/93 22/04/93 1 14/05/93 22 112 8 0 8 1.39 28/03/93 30/03/93 2 21/04/93 22 116 9 0 9 140 28/03/93 30/03/93 2 21/04/93 22 ill 14 0 14142 28/03/93 31/03/93 3 22/04/93 22 117 8 0 8143 28/03/93 29/03/93 1 21/04/93 23 120 5 l 5144 28/03/93 29/03/93 1 20/04/93 22 119 9 2 5

(""')

,--; ......"'C ...... .,.0

......'"" I

,_.,_.......0

LAC953-04/00

PEBCHLORDE'lliYLENE: MULTIGENER81'ION INHALATION STUDY IN THE RAT

INDIVIlX!AL 1lNll1M.. DATA SUPPLEMENT

.APPENDIX 20B

REPRDJ:OCTIVE PERFORMANCE - F1 GENER81'ION - F2B LITIERS

1000 pjll1

Fl!MALE Nll1BER

PAIRIN:; D.A.TE

+VE S1EliR Il!il'E

PCI Il!il'E GEST'N 11'\.LE YOm::; AT LITI'ERED PERIOD Nll1BER DAY ONE

YOUNGALIVE

(DAYS) ALIVE DEAD DAY 5

169 28/03/93 31/03/93 3 22/04/93 22 146 12 0 ll

170 28/03/93 31/03/93 3 22/04/93 22 145 2 0 1

171 28/03/93 31/03/93 3 22/04/93 22 148 7 1 5

172 28/03/93 21/04/93

31/03/93 25/04/93

34 17/05/93 22

147 146 9 2 0

173 28/03/93 21/04/93 22/04/93 1

150 145

174 28/03/93 22/04/93 149 2 2 2

175 28/03/93 29/03/93 1 20/04/93 22 152 6 7 4

176 28/03/93 25/04/93 151 8 0 7

177 28/03/93 29/03/93 1 20/04/93 22 154 8 0 8

178 28/03/93 21/04/93

29/03/93 1 155 148

179 28/03/93 29/03/93 1 20/04/93 22 156 ll 0 2

180 28/03/93 21/04/93 22/04/93 1 14/05/93 22

153 154 8 0 2

181 28/03/93 21/04/93 24/04/93 3 16/05/93 22

158 156 14 0 14

182 28/03/93 30/03/93 2 22/04/93 23 157 1 8

185 28/03/93 31/03/93 3 23/04/93 23 162 1 5

.,.., -; r-..._ -o ..._ .<> 0

...... ""

...... ...... ...... ......

LAC953-04/00

PERCHLORDETHYLENE: M!JLTIGENERATION IN!:IALATION STUDY IN THE RAT

INDIVJIIUAL i\NJMAL DATA SUPPLEMENT

APPENDIX 20B

REPROrocTIVE PERFD~ - fl GENERATION - F2B LITTERS

1000 ppn

FEMALE Nl.MBER

P.AIRJN:; DATE

+VE SMEAR PCI DATE

DATE GEST'N MALE YOm> .AX LITI'ERED PERIOD Nl.MBER DAY ONE

(DAYS) .1\LIVE DEAD

YOm;.1\LIVE DAY 5

186 28/03/93 30/03/93 2 21/04/93 22 161 10 0 9

187 28/03/93 30/03/93 2 21/04/93 22 164 8 1 8

188 28/03/93 21/04/93

29/03/93 28/04/93

1 7 21/05/93 23

159 161 2 1 0

189 28/03/93 31/03/93 3 22/04/93 22 166 9 0 9

190 28/03/93 29/03/93 1 20/04/93 22 165 4 2 4

191 28/03/93 21/01,/93 22/04/93 1 14/05/93 22

168 162 1 0 0

192 28/03/93 21/04/93

29/03/93 25/04/93

1 4 18/05/93 23

167 166 3 3 1

-1 " r--... "0 --... -!'> 0 1.0....,

.... .... ...... N

~---



APPENDIX 20C

REPRODUCTIVE PERFORMANCE - F1 GENERATION - F2C LITTER

Key:

PCI = pre-coital intervalGEST'N = gestation

CTL/P/4097 - 1173

LAC953-04/00

PERCH!..OROEI!IYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVmJAL ANIMIIL DATA SUPPLEMENT

APPENDIX 20C

REPRDJ:X:CriVE PERFORMANCE - F1. GENERATION - FZC LITI'ERS

0 ppn

FEMALE NU1BER

PAIRING IlliTE

+VE SMEAR IlliTE

PCI D.'\.TE GEST'N MilLE YOUNG KJ: LITIERED PERIOD NU1BER DAY ONE

YOUNGALIVE

{DAYS) ALIVE DEAD DAY 5

201 ll/04/93 14/04/93 3 06/05/93 22 1 13 0 12

202 ll/04/93 13/04/93 2 06/05/93 23 2 3 0 2

203 ll/04/93 29/04/93

13/04/93 02!05/93

2 3 24/05/93 22

310 12 0 12

204 ll/04/93 04/05/93 4 10 0 9

205 ll/04/93 13/04/93 2 06/05/93 23 5 3 0 3

206 ll/04/93 13/04/93 2 05/05/93 22 6 13 0 13

207 ll/04/93 14/04/93 3 06/05/93 22 7 12 0 ll

208 ll/04/93 13/04/93 2 05/05/93 22 8 15 0 15

209 ll/04/93 04/05/93 9 1 0 0

210 ll/04/93 12/04/93 1 04/05/93 22 10 7 1 7

2ll ll/04/93 04/05/93 ll 1 0 0

212 ll/04/93 12/04/93 1 04/05/93 22 12 14 1 13

213 ll/04/93 12/04/93 1 05/05/93 23 13 2 0 0

214 ll/04/93 14/04/93 3 06/05/93 22 14 14 0 14

215 ll/04/93 12/04/93 1 04/05/93 22 15 13 0 13

216 ll/04/93 15/04/93 4 07/05/93 22 16 10 0 10

217 ll/04/93 29/04/93 01/05/93 2 23/05/93 22

17 12 14 0 13

" ...... .-. '"0 -. -"' 0 <0 .....

.....

..... --"'

LAC953-04/00

PERCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDI\IIIXIAL ANIMAL DATA SUPPLEMENT

APPENDIX 20C

REPRO~ PERFORM!INCE - F1 GENERATION - F2C LITTERS

0 ppn

FEMALE PAIRIN:; +VE SMEAR PCI DATE GEST'N f1.\LE YOUN:; X! YOUN:;NlMBER DATE DATE LI'ITERED PERIOD NlMBER DAY ONE liLIVE

(IlAYS) liLIVE DEAD DAY 5

218 11/04/93 15/04/93 4 07/05/93 22 18 13 0 11 219 11/04/93 13/04/93 2 05/05/93 22 19 16 0 15 220 11/04/93 13/04/93 2 05/05/93 22 20 14 0 13

221 11/04/93 14/04/93 3 06/05/93 22 21 4 0 4

222 11/04/93 2229/04/93 13

223 11/04/93 12/04/93 1 04/05/93 22 23 3 0 3

224 11/04/93 12/04/93 1 04/05/93 22 24 11 0 3

("") -ir...... -o ......... 0 \0......

..................tJ1

~

LAC953-04/00

PERCHLORDETHYLENE: MULTIGENERATION IN!!ALA1'ION STUDY IN THE R!l:r

INDIVIIXlAL Alill1AL DATA SUPPLEMENT

APPENDIX zoe REPRDJJI:K:TIVE PERFORMANCE - FJ. GENERATION - F2C LI'ITERS

1000 PJ:Ill

FEMALE PAIRING +VE EMEAR PCI M.TE GEST'N MALE YOUNG X! YOUNG NU1BER M.TE M.TE LITI'ERED PERIOD NU1BER !lilY ONE

(DAYS) /ILIVE DEAD IILIVE !lilY 5

225 11/04/93 13/04/93 2 05/05/93 22 145 15 1 14

226 11/04/93 14/04/93 3 06/05/93 22 146 12 0 11

227 11/04/93 13/04/93 2 05/05/93 22 147 12 1 11

228 11/04/93 13/04/93 2 05/05/93 22 148 12 0 11

229 11/04/93 29/04/93

14/04/93 01/05/93

3 2 23/05/93 22

149145 13 0 13

230 11/04/93 12/04/93 1 150

231 11/04/93 15/04/93 4 07/05/93 22 151 12 2 11

232 11/04/93 13/04/93 2 05/05/93 22 152 5 0 4

233 11/04/93 29/04/93 01/05/93 2

153 146

234 11/04/93 30/04/93 03/05/93 3 25/05/93 22

154 150 9 0 9

235 11/04/93 155

236 11/04/93 13/04/93 2 05/05/93 22 156 16 0 16

237 11/04/93 13/04/93 2 05/05/93 22 157 9 0 7

238 11/04/93 14/04/93 3 06/05/93 22 158 8 0 8

239 11/04/93 29/04/93

159 147

240 11/04/93 13/04/93 2 05/05/93 22 160 13 0 12

("") -i r-....... "0 ....... .., 0 ....., ""

...... ...... ....., 0\

Lt\C953-04/00

PERCHLORDETHYLENE: MULTIGENERATION INI!AIATION STUDY IN THE RAT

INDIVIIllTAL ANIMAL DATA SUPPLEMENT

APPENDIX20C

REPROW::TIVE PERFORMAN:::E - Fl GENERATION - F2C LITIERS

1000 ppn

FE1ALE P.AIRIN:; +VE EMEAR PCI DATE GEST'N MALE YOUNG K£ YOUNGNU1BER DATE DATE LITI'ERED PERIOD NU1BER DAY ONE 1\LIVE(MYS) ALIVE DEAD DAY 5

241 ll/04/93 04/05/93 161 2 0 0 242 ll/04/93 15/04/93 4 07/05/93 22 162 l3 1 10 243 12/04/93 14/04/93 2 06/05/93 22 150 ll 0 10244 ll/04/93 164

30/04/93 152

245 ll/04/93 15/04/93 4 16529/04/93 02/05/93 3 25/05/93 23 148 10 0 9

246 ll/04/93 06/05/93 166 l2 1 l2

247 ll/04/93 15/04/93 4 07/05/93 22 167 ll 2 ll248 ll/04/93 13/04/93 2 05/05/93 22 168 6 0 6

r, ......r...._ -o ...._ 0.j:>

....,\0

..............,

......

,-, --,

PERCHLOROETIIYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 21A

CLINICAL OBSERVATIONS (LITTERS PER SYMPTOM) - F2A PUPS

The incidence is presented as the number of pups affected per litter.

Key:

E = extreme X = present L = left R = right B = bil atera1 M= male F = female

The findings do not include the observations during exposure.

CTL/P/4097 - 1178

LAC955-02/02

PERCHLOROETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANJMi\L ll>\TA SUPPLEMENT

APPENDIX 2lA

GROUP 00: 3

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2A PUPS

BODY SYSTEM:

MJTHER NJ, SEVERITY OF LITI'ER CODE

llEliTH

DAY 1

CLINICAL OBSERVATION: FOUND DFAD

DAY DAY DAY DAY DAY DAY DAY 2 3 4 5 6 11 16

(CANNIBIILISEDl

DAY DAY 22 29

1.33 X 2

C'"'l_, r -... -o ......._,. 0 ....,"'

....,-"'

LAC955-02/02

PERCHLORDETHYLENE: MOLTIGENERATION INHALATION STUDY IN TilE RAT

INDIVIDUAL ANlMAL DATA SUPPLJM:NT

APPENDIX 21A

CLINICAL OBSERVATIONS (LITI'ERS PER S'il1Pm1) - F2A PUPS

GROUP ID: 4

BODY SYSIDJ: DEATH CLINICAL OBSERVATION: FOUND DEAD (C'.ANNIBALISED) MJl'HER m. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITI'ER CODE l 2 3 4 5 6 ll 16 22 29

182 X l

"-i.......,,

.......!»0\0....,

,_.,_.co0

-~

LAC955-02/02

PERCHLOROETHYLENE: MULTIGENERA:ITON lNHALATION STUDY IN TilE RAT

INDIVIIX!AL ANJMI\L ll'\TA SUPPLEMENT

APPENDIX 2lA

CLINICAL OBSERVATIONS (LITI'ERS PER SY.Ml"'tMl - F2A PUPS

GROUP 00: l

BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DEIID

M)THER 00. OF LITI'ER

SEVERITY CODE

Jl.\Y l

Jl.\Y 2

Jl.\Y 3

Jl.\Y 4

Jl.\Y 5

Jl.\Y 6

Jl.\Y ll

Jl.\Y 16

Jl.\Y 22

Jl.\Y 29

28 X l

32 X l

('").... r-"'0-~ 0 <.0.....,

.... .... co....

37

39

X

X

2

2

44 X l

47 X l

. -·" ------------··

LAC955-02/ 02

PERCHLOBDETilYLENE: M!JLTIGENERATION JNHAUTION STUDY IN THE RAT

INDIVIIX.lAL ANlMAL DATA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVATIONS CLITI'ERS PER SYMPTCM) - F2A PUPS

GROUP N:l: 2

BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DE8D MJTHER N:J, OF LITI'ER

SEVERITY CODE

DAY 1

DAY 2

DAY 3

DAY 4

DAY 5

DAY 6

DAY 11

DAY 16

DAY 22

DAY 29

74 X 2

75 X 1

n...;

' ...... '"0 ......... 0 <.0 ......

,_. ,_. co N

95 X 3

IAC955-02/02

PERCHLORDE'I'HYLENE: MULTIGENERATION IN!IliLATION STUDY IN THE RAT

INDIVIDUAL .ANIMAL llAXA SUPPLEMENT

liPPENDIX 2JA

GROUP ID: 3

CLINICAL OBSERV.ATIONS (LITTERS PER SYMPTCM) - F2A PUPS

BODY SYSTEM: DEA1'H CLINICAL OBSERV.ATION: FOUND DEi\D

MJTHER ID. OF LITTER

SEVERITY CODE

JlliY 1

JlliY 2

JlliY 3

JlliY 4

Il'\Y 5

D!\Y 6

JlliY ll

JlliY 16

JlliY 22

JlliY 29

121 X 1

128 X 1

('") ..... r........., ........., 0 <0 ......

.... .... 0> w

129

130

133

136

137

X

X

X

X

X

2

1

2

3

2

2

143 X 3

LAC955-02/02


INDlVIIJUAL ANIMAL DATA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVATIONS (LI'ITERS PER SYMPTCM) - F2A PUPS GRllUP NO: 4

BODY SYSTEM: DEATII CLINICAL OBSERVATION: FOUND DF.!ID MYI'liER NO. SEVERITY' DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITTER CODE 1 2 3 4 5 6 11 16 22 29

169 X 1

170 X 2

171 X 2

172 X 1

173 X 1

176 X 1

177 X 2 2

180 X 3

181 X 1

182 X 3 1

187 X 3

189 X 3 1

190 X 1

191 X 2 1

("') -ir-....... "0.........,. 0\0.._,

,...,...Q:l ..,.

LAC955-02/02


INDIVI!XJAL ANIMAL ll'lTA SUPPLlliENT

APPENDIX 2lA

CLINICAL OBSERVATIONS (LITTERS PER SYMP'ro1) - F2A PUPS

GROUP NO: 4

BODY SYSTEM: DEATH CLINICAL OBSERVATION: KILLED INVESTIGATION

MJT!IER NO. OF LITTER

SEVERITY CODE

DAY 1

DAY 2

DAY 3

DAY 4

DAY 5

DAY 6

DAY 11

DAY 16

D.A.Y 22

DAY 29

175 X 2

187 X 2

("") ......-... "0-.....,. 0

"" ......

..... ..... co U'1

LAC955-02/02

PERCHLORDEI'HYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVllXIAL ANlMAL DATA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVATIONS CLITIERS PER SYMP'JXM) - F2A PUPS GROUP NO: l

BODY SYSTEM: DEATH CLINICAL OBSERVATION: KILLED IN EliTREMIS MJTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITIER CODE l 2 3 4 5 6 ll 16 22 29

39 X 2

45 X l

('")-;

.......,r

......~lO......

..........co"'

l.AC955-02/02

PERCI:Il..ORDETHYLENE: MIJLTIGENERATION IN!lALATION STUDY IN THE RAT

INDIVIDUAL AN.IMAL Jl.\TA SUPPLEMENT

APPENDIX 2lA


GROUP 00: 2

BODY SYSTEM: llEA1'H CLINICAL OBSERVATION: KilLED IN EXTREMI:S

MJTHER 00. OF LITI'ER

SEVERITY CODE

DAY l

D.A.Y 2

DAY 3

D.A.Y 4

DAY 5

D.A.Y 6

DAY ll

DAY 16

DAY 22

DAY 29

83 X l

("") -1.... .......,...... ""' 0 0.0 ......

..... ...... o:> ......

I.

LAC955-02/02

PERC!lLORDETHYLENE: MIJLTIGENERATION INHAL/\TION STUDY IN THE RAT

INDIVI!JUAL .ANIMAL DATA SUPPLEMENT

APPENDIX 2lA

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2A PUPS GROUP NO: 3

BODY SYSTEM: DEATH CLINICAL OBSERVATION: KilLED IN EXTREMIS MJTBER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITTER CODE 1 2 3 0 4 ~ 6 11 16 22 29

130 X 2

133 X 1

137 X 1

144 X 2

("')

I'"' ...... ..,-i

.......,.0<0....,

..........cccc

I.<\C955-02/02


INDIVIIXJAL ANIMAL DATA SUPPLEMENT

APPENDIX 2lA

GROUP NJ: 4

CLINICAL OBSERVATIONS (LITTERS PER SYMPTCMl - F2A PUPS

BODY SYSTEM:

MJTHER NJ. SEVERITY OF LITIER OODE

171 X

DEATH

JlA.Y 1

JlA.Y 2

JlA.Y 3

2

JlA.Y 4

JlA.Y 5

CLINICAL OBSERVATION:

JlA.Y JlA.Y 6 11

KILLED IN EXTREMIS

JlA.Y JlA.Y 16 22

JlA.Y 29

173 X 2

'"'-l r...... -o ......... 0

"' .....,

.... .... co "'

175

176

177

182

189

X

X

X

X

X

3

1

1

1

2

2

190 X 2

LAC955-02/02

PERCHLOROETHYLENE: MLlLTIGENERATION INHilllmON STUDY IN THE RAT

INDIVIlXlt\1 1INlMIIL DATA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVATIONS (LITTERS PER SYMPTCM) - F2A PUPS GROUP NO: 1

BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSING,PBEstM:D DEAD M:JTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITI'ER CODE 1 2 3 4 5 6 11 16 22 29

32 X 2 34 X 1

36 X 137 X 4

39 X 4

40 X 5

41 X 1 43 X 1

45 X 4

("") .... r....... '"0....... 0""' 1.0 ......

--1.0 0

LAC955-02/02

PERCHLOROETHYLENE: MULTIGENERATION JN!lAL.<\TION STUDY IN TilE RA:r

INDIVIDUIIL AN1MAL IWrA SUPPLEMENT

APPENDIX 21A


GROUP ID: 2

BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSJN:;.PRESU1ED DEAD

M:lTHER ID. OF LITTER

SEVERITY OODE

J:l.IU' 1

D.'\Y 2

D.'\Y 3

J:l.IU' 4

J:l.IU' 5

DAY 6

J:l.IU' ll

J:l.IU' 16

J:l.IU' 22

J:l.IU' 29

73 X 1

77 X 2

('"') -i r ....... -o ........., 0

"" .....,

--"" .....

81 X 2

87 X 2

88 X 1 2

89 X 1

91 X 3

93 X 1 1

95 X 6

96 X 1

LAC955-02/02

PERCHLOROET!:!YLENE: MDLTIGENERATION INHALIITION STUDY 1N THE RAT INDIVIDUAL .i\NIM8L DATA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVATIONS (LITTERS PER SYMP'I'Q1) - F2A PUPS GROUP NO: 3

BODY SYSTEM: DEAl'H CLINICAL OBSERVATION: MISSING,PRESLMED DEADMlTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY OF LIITER DAY CODE DAY DAY1 2 3 4 5 6 11 16 22 29

125 X 1 126 X 2 1 129 X 2130 X 2135 X 1 1138 X 2 143 X 3 144 X 3

(") .... ,... ....... "0....... ..,. 0....., ""

.......... ""N

'~

LIIC955-02/02

PERCHLORDETHYLENE: !1llLTIGENERATION INHALIITION STUDY IN THE RAT

INDIVIDUAL AlmlAL DATA SUPPLEMENT

APPENDIX 2lA

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCMl - F2A PUPS

GROUP 00: 4

BODY SYSTEM: llEATil CLINICAL OBSERVATION: MISS:rn:;, PRESlliED DEAD

MJTHER 00. OF LIITER

SEVERITY OODE

DAY 1

DAY 2

DAY 3

DAY 4

Dl\l' 5

Di\.Y 6

DAY 11

DAY 16

DAY 22

]l.;.Y 29

169 X 1 1

171 X 6

(") -l........., ...... ""' 0

'""....,

...... ...... '"" w

172 X 1

173

174

X

X

2

5

175 X 3 1

176 X 1

180 X 8

182 X 1 1

185 X 2

186 X 1

187 X 6

189 X 1

LAC955-02/02

PERCHLOROETHYLENE: MIJLTIGE:NERATION INHAlATION STUDY IN THE RAT

INDIVIIXTAL .ANIMAL !lATA SUPPLEMENT

.APPENDIX 21A

CLINICAL OBSERVATIONS (LITTERS PER SYMPTCM) - F2A PUPS GROUP NO: 3

BODY SYSTEM: EQUILIBRitM AND GAIT CLINICAL OBSERVATION: REW::ED HINDLIMB l'tiOCTION MlTHER NO. SEVERITY DKi DKi DKi DKi DKi DKi DKi DKi DKi DKiOF LITI'ER CODE 1 2 3 4 5 6 11 16 22 29

130 E 1

("')...........''"0.......1:>0

-1.0.....,

..... 1.0.1:>

~'

LAC955-02/02

PERCHLOROEI'!IYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANJ:M<\L DATA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVATIONS (LITTERS PER SYMP'l'CM) - F2A PUPS

GROUP NO: 2

BODY SYSTEM: EYES GENERAL CLINICAL OBSERVATION: CHRCMJll'ICRYORRHE'A

MJTilER NO. OF LITTER

SEVERITY CODE

DAY 1

DAY 2

DAY 3

DAY 4

DAY 5

no,y 6

DAY ll

DAY 16

DAY 22

DAY 29

91 L 1 1

n

........., ' -f

....... 0 ""' .....

.....

'""

..... 0"1 '""

,_

LAC955-02/02

PERCill.OROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlMIIL lliiTA SUPPLEMENT

APPENDIX 21A


BODY SYSTEM: EYES GENERAL CLINICAL OBSERVATION: CHRJ:Mlll>\CiilRRHFAMlTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY OF LITI'ER DAY CODE DAY DAY1 2 3 4 5 6 11 16 22 29

126 L 1 1

132 B 1 1 1

n-ir-..."'0-... 0""'lO......

..........lOC'l

~

("") -i, ....... ....... ""'..,. 0

..... ""

--..... ""

····- ·------ ----~--

LIIC955-0Z/OZ

PERCHLOBDETHYLENE: MULTIGENERATION IN!lALATION STUDY IN THE RAT

INDIVIIJUAL ANlMAL DATA SUPPLEMENT

APPENDIX Z1A

CLINICAL OBSERVATIONS (LIT!'ERS PER SYMPTCM) - F2A PUPS

GROUP NO: 4

BODY SYSTEM: EYES GENERAL CLINICAL OBSERVATION: CER!M)J:l.\CRYORRHE'A

M:lTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITI'ER OODE 1 z 3 4 5 6 11 16 zz 29

171 R 1 1

172 R 1

191 L 1


INDIVIOOAL ANIMAL DIITA SUPPLEMENT

APPENDIX 2JA

CLINICAL OBSERYATIONS (LITTERS PER SYMI?TCM) - F2A PUPS GROUP NJ: 1

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: COLD MlT!lER NJ. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LI'ITER CODE 1 2 3 4 5 6 11 16 22 29

28 X 1

32 X 1

37 X 2

39 X 11

40 X 1

43 X 1

45 X 7

46 X 4

"-1..........-c.........0.....,"'

.........."'CXl

LAC955-02/02

~.

l.AC955-02/02

PERCHLOROETHYLENE: MDLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIOOAL ANlMI\L DATA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVI\TIONS (LITI'ERS PER SYMPTCMl - F2A PUPS

GROUP 00: 2

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: COLD

MlTHER 00. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITI'ER CODE 1 2 3 4 5 6 11 16 22 29 73 X 2

76 X 2

77 X 2

81 X 1

88 X 1

91 X 13

94 X 2

95 X 11

(") -l,... ...... -o ...... ... 0 \0 ....,

..... ..... \0 \0

l'ERall..ORDETHYLENE: MllLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANJMAL OOA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVATIONS CLITI'ERS PER SYMP'l'a1) - F2A PUPS GROUP NO: 3

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: COLD M:lTHER NO. SEVERITY TWI DAY DAY DAY DAY DAY DAY TWI DAY DAY OF LITI'ER CODE 1 2 3 4 5 6 11 16 22 29

126 X 1

130 X 2

131 X 1

133 X 1

143 X 8

144 X 12

LAC955-02/02

("") ....,......r .,...... -!'>0<.0 .....

N..... 00

~-',

LliC955-02/02

PERCHLOilDET!IYLENE: MULTIGENERATION lNHALIITION STUDY IN THE RAT

INDIVIDUAL ANIMAL J:li\11\ SUPPLEMENT

APPENDIX 2lA

CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'ICM) - F2A PUPS

GROUP 00: 4

BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: OOLD

MlTHER 00. SEVERITY DAY D."-¥ DAY DAY DAY DAY DAY DAY DAY DAY OF LITI'ER OODE 1 2 3 4 5 6 11 16 22 29 169 X 1

171 X 4

173 X 4

176 X 1

180 X 2

182 X 1

186 X 2

189 X 7

191 X 1

("") -i

....... '

....... '"" ..,. 0 <D

"

...... N 0 .....

LAC955-02/02

PERCHLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANlMAL DATA SUPPLEMEN'l'

APPENDIX 2JA

CLINICAL OBSERVATIONS (LITl'ERS PER SYMPTCM) - F2A PUPS GROUP NO: 2

BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: HIND LlMB J:li>MAGEDMJTHER NO. SEVERITY IlAY IlAY DAY IlAY IlAY IlAY IlAY IlAY DAY OF LITI'ER DAYOODE l 2 3 4 5 6 ll 16 22 29

93 L l

.........

., 0

("")............

...,"'

N..... 0N

.~

LAC955-02/02

PERCHLORDETHYLENE: MULTIGENERATION IN!l'Al.AITON STUDY IN THE RAT

INDIVIlXJAL AN:lMAL DATA SUPPLEMENT

APPENDIX 2lA

CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'ICM) - F2A PUPS

GROUP 00: 3

BODY sYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: IIDID LlMB DliMAGED

MlT!lER 00. SEVERITY ll'IY ll'IY D.'\Y ll'IY ll'IY ll'IY ll'IY ll'IY ll'IY ll'IY OF LITI'ER OODE 1 2 3 4 5 6 11 16 22 29

133 L 1

('") ..... r '"0 -...--0 <0....,

...... N 0 w

~ --- -- ---- --~----------·

LAC955-02/02

PERCHLOROErllYLENE: MULTIGENERATION INIWATION STUDY IN THE RAT

INDIVIDUAL .ANIMAL IliiTA SUPPLEMENT

APPENDIX 21A


BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: HIND LIMB llliMAGED1-DTilER NO. SEVERITY D.'U' Dtcr Dtcr Dtcr Dtcr D.'<Y OF LITI'ER Dtcr Dtcr CODE Dtcr 1 Dtcr2 3 4 5 5 11 16 22 29

170 R 1

185 B 2

('"').....r......"0.........,.0....,'""

.......,.0N

LAC955-02/02

PERCHLOBDETI!YLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANIMAL IlATA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVATIONS (LITI'ERS PER SYMP1U1) - F2A PUPS

GROUP NO: 1

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: HIND LlMB 5\o!JLLEN

MJTHER NO. OF LITTER

SEVERITY CODE

DAY 1

DAY 2

Il.'>Y 3

DAY 4

DAY 5

DAY 6

DAY 11

DAY 16

DAY 22

DAY 29

28 L 1

47 B 1

("')

........,' -;

...... ""'0

..... ""

..... N 0 U"1

PERCHLOROETHYLENE: M!JLTIGENERATION INHALATION STUDY IN THE RAT

INDIVJIIUAL ANlMAL DATA SUPPLEMENT

.APPENDIX 21A

CLINICAL OBSERVATIONS (LI'ITERS PER SYMPTCM) - F2A PUPS GROUP NO: 1

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: MJRIBUND MlTHER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAYOF LITI'ER DAY CODE 1 2 3 4 5 6 11 16 22 29

37 X 1

. L

LAC955-02/02

r,-!r ......-c.........0

......

N.....

"'0

""

LAC955-02/02

PEllCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDJAL ANIMAL DllTA SUPPLEMENT

APPENDIX 2JA


GROUP NO: 2

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: PALE

MJTHER NO. OF LITI'ER

SEVERITY OODE

JltiY 1

JltiY 2

JltiY 3

JltiY 4

Di\Y 5

Di\Y 6

JltiY 11

JltiY 16

Di\Y 22

JltiY 29

91 X 2

-i " r-.... -....'"" 0"" ...... ""

,_. N 0 ......

LAC955-02/02

PERCHLOROE'l.'l!YLENE: MULTIGENERATION INHALATION STUDY lN THE RAT

INDIVI!XTAL ANlMi\L DATA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVATIONS (LITIERS PER SYMPTCM) - F2A PUPS GROUP NO: 4

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: PALE M)'!'HER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITTER DAYOODE 1 2 3 4 5 6 11 16 22 29

173 X 2

n-ir.._-o......."""0<D....,

......N0C»

.~. \ \

18C955-02/02

PERCHLOROEI'l!YLENE: MULTIGENERATION INHALAl'ION STUDY IN THE RAT

INDIVIDl.lAL ANlMIIL DATA SUPPLEMENT

APPENDIX 2lA


GROUP NO: 1

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: ~

J1)THER NO. OF LITI'ER

SEVERITY CODE

DAY 1

DAY 2

DAY 3

DAY 4

DAY 5

DAY 6

DAY ll

DAY 16

DAY 22

DAY 29

26 X 1

37 X 1

47 X 2 (") -l.-.....,-... "" 0

"" ......

-N 0

""

PERCHLORDEI'IlYLENE: MIJLTIGENERATION 1NEALATION STUDY IN THE RAT

INOIVIIXli\L ANlMi\L DATA SUPPLEMENT

APPENDlX 21A

CLINICAL OBSERVATIONS (LI'l'rERS PER sYMP'ltM) - F2A PUPS GROUP NO: 2

BODY SYSTEM: GENERiiL CONDITION CLINICAL OBSERVATION: OMI\LL MlTBER NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LI'ITER CODE 1 2 3 4 5 6 ll 16 22 29

76 X 1

86 X 1 1 1 1 90 X 1 1 1 1 1

- -~ -. -- ·- _J.

LAC955-02/02

("')

...._-ir "'0...._...0<.0......

....N

0....

LAC955-02/02

PERCHLO!lOET!lYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXIAL ANlMAL l:l!\TA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVATIONS (LITIERS PER SYMPTCM) - F2A PUPS

GROUP NO: 3

BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: SMALL

M)THER NO. OF LITI'ER

SEVERITY OODE

DAY 1

DAY 2

DAY 3

DAY 4

lltU' 5

DAY 6

DAY 11

DAY 16

DAY 22

DAY 29

124 X 3 1 1 1 1

134 X 1

"-i r....... -o .........,. 0 \0 ......

.... N ..... ....

135

137

140

X

X

X

1

1

1

1

1

1

1

1

1

1

1

'"

LAC955-02/02

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY JN THE R<\T

INDIVIDllAL 1INlMAL lliiTA SUPPLEMENT

APPENDlX 2lA

CLJNICAL OBSERVATIONS (LI'ITERS PER SYMPTCM) - F2A PUPS GROUP ID: 4

BODY SYSTEM: GENERAL CONDITION CLJNICAL OBSERVATION: EM/ILL MlTHER ID. SEVERITY DR! DR! DR! DAY DR! DR! DR! DR! DR! DR!OF LI'ITER CODE 1 2 3 4 5 6 11 16 22 29

170 X 1 1 1 1 174 X 1 7

175 X 3

176 X 1

181 X 1 1182 X 1

187 X 1 1

n -!r-......."0....... .., 0 ...., "" '

.....N.....N

""

LAC955-0Z/OZ

PERCHLORDETHYLENE: MllLTIGENERliT.ION INHALATION STUDY lN THE RAT

INDIVIJX!AL ANIMAL D.-'ITA SUPPLEMENT

APPENDJX Z1A

CLINICAL OBSERVATIONS (LITTERS PER SYMI?TCMl - FZA PUPS

GROUP 00: l

BODY SYSm!: GENERAL CONDITION CLINICAL OBSERVATION: TAIL DAMAGED

MJTHER 00. OF LITTER

SEVERITY CODE

DAY l

DAY z

DAY 3

DAY 4

DAY 5

DAY 6

DAY ll

DAY 16

DAY zz

DAY 29

41 X 1

("") -l r ....... "0 ....... 0 """ u::>-..

...... N ...... w

PERCHLOROE'I'HYLENE: MULTIGENERATION INHALATION STIIDY IN THE RAT

INDIVI!XlAL ANIMAL DATA SUPPLEMENT

.APPENDIX 21A

CLINIC&. OBSERV.ATIONS (LITTERS PER SYMPTCM) - F2A PUPS

GROUP 00: 1

BODY SYSTEM: GENERAL OONDITION CLINIC&. OBSERV.ATION: SEE FREE TEXT MlTHER 00. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITI'ER OODE 1 2 3 4 5 6 11 16 22 29

44 X 1

-··--·-·---~·----- ---·--- ----

I..A£955-02/02

('")

......r-i

.,......""'0

"""

N..........""'

~,

LAC955-02/02

PERCHLORDETHYLENE: MIJLTIGENERATION lliHA!.ATION STUDY IN THE RAT

INDIVIWAL ANlMAL IliiTA SUPPLE!1ENT

APPENDIX 2lA


GROUP 00: 2

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SEE FREE TEXT

illTHER 00. SEVERITY Il<\Y Il<\Y Il<\Y Il<\Y Il<\Y DAY Il<\Y Il<\Y Il<\Y Il<\Y OF LITTER CODE 1 2 3 4 5 6 11 16 22 29

74 X 1

92 X 1

(""')

-I r--o -.., 0

""" ......

,_. N,_. U1

LAC955-02/02

PERCHLORDETHYLENE: MULTIGENERATION INHAJ:.ATION STUDY lN THE RAT

lNOIVIIX.IAL liNlMAL DATA SUPPLEMENT

APPENDIX 2lA

CLINICAL OBSERVATIONS (LITI'ERS PER SYMI'TCM) - F2A PUPS GROUP NO: 3

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SEE FREE 1EXT M)THER. NO. SEVERITY DAY DAY DAY DAY DAY DAY DAY DAY DAY OF LITl'ER DAYCODE 1 2 3 4 5 6 11 16 22 29

127 X 1

130 X 1

144 X 1("") ....-...,r-....,.0.....,""

.....N.....en

Ll\C955-02/02


INDIVIIXIAL 1INJMAL DATA SUPPLEMENT

APPENDIX 2lA

CLINICAL OBSERVATIONS (LIITERS PER SYMPTCM) - F2A PUPS

GROUP NO: 1

BODY SYSTEM: CLlN OBS RELATING TO HEAD CLINICAL OBSERVATION: HEAD SIDLLEN

MlTilER NO. OF LITIER

SEVERITY CODE

DAY 1

llliY 2

llliY 3

llliY 4

llliY 5

llliY 6

llliY 11

llliY 16

llliY 22

llliY 29

26 X 1

('") ....; ;...... ...... ""' "" 0 <.0 ......

..... N ..... ......

LAC955-02/02

PEBCHLORDE'l'l!YLENE: MDLTIGENER/\TION INHAl.ATION STUDY IN 'l1lE RAT

INDIVIOOAL ANlMAL DATA SUPPLEMENT

APPENDIX 21A

CLINICAL OBSERVATIONS (LI1TERS PER SYMPTCM) - F2A PUPS

COMMENT PAGE

CCM1ENTS: MJTllER NO. DAY NO. CCM1ENT

26 16 M 19.0g KlLLED SICK - AFTER CLIN-OB (10:00AM)

26 22 1 PUP TERMlNA1'ED DAY 16.

26 29 1 PUP TERMlNA1'ED DAY 16.

28 5 ONE PUP SEZED WRONG DAY 1 SHOULD BE MALE NOT Fl!MALE.

29 11 ONE Fl!MALE WRONGLY SEZED, SHOULD BE 5 MALES, 8 Fl!MALES. DAY 11.

36 5 ONE PUP EXTRA DAY 5 (Fl!MALE) •

37 1 MALE 6. Og COLD AND MJRIBUND DIEO AFTER CLINICAL OBSERVATION.

39 1 2 PUPS (KlLLED SICK) MJRIBUND.

40 22 DAY 21 ONE PUP FOUND WITH lli\l1AGE TO HEAD.

41 5 One extra pup found day 5 ,

44 1 MALE 6 • 6 BRUISING ON CHIN

44 5 One extra pup found day 5. (Fatale).

45 1 F 5.5g (KlLLED SICK) - WJUND TO LEFT SIDE OF HEAD.

74 1 M 6.0g accidently dropped, appears OK. F 5.9g bruised head.

74 5 One male pup sexed wrongly day 1. Should be 8 males, 3 fatales.

78 5 ONE Fl!MALE PUP SEXED WRONG DAY 1 SHOULD BE MALE.

78 11 ONE PUP SEZED WRONG DAY 5 SHOULD BE 5 MALES 6 Fl!MALES.

90 5 ONE PUP SEXED WRONG DAY 1. EXTRA Fl!MALE INSTEAD OF MALE DAY 5.

-; (")

.......r., ....... "" 0 <0......

....N ..... ():)

~

LAC955-02/02

PERCHLOROETHYLENE: MULTIGENERATION lNHt\IATION STUDY IN THE RAT


APPENDIX 2lA

CLINIQ\L OBSERVATIONS (LITTERS PER SYMI?TCMl - F2A PUPS

COMMENT PAGE

CCM1ENTS: MJTHER NJ. DAY NJ. CCM1ENT

92 1 F s.og snout bruised.

126 5 ONE PUP SEXED WRONG DAY 1 FE1ALE SHOULD BE MilLE.

127 1 MilLE PUP 5.6g LEFT HIND LIMB MAI.:ROTATED.

132 11 DAY 11 ONE PUP SEXED w"RONG DAY 1 & 5 SHOULD BE 13M, SF.

137 1 M 5. Sg KILLED SICK - TAIL MISSING AND RIGHT HIND RXJT CANNIBALISED

144 1 SKIN TORN UNDER LEFT FOBELIMB.

144 3 BOTH PUPS HAVE YELLOW COLOUBATION OF SKIN.

169 5 EXTRA MilLE FOUND DAY 5, PUP LOST DAY 2 TO BE DELETED.

171 5 ONE PUP SEXED WRONG DAY SHOULD BE MilLE NOT FE1ALE.

177 2 1 extra female found day 2.

187 4 ONE FEMIILE FOUND DAY 4.

n -i ,.-.., -""'0 \0 .......

.... N .... \0



APPENDIX 21B

CLINICAL OBSERVATIONS (LITTERS PER SYMPTOM) - F2B PUPS


Key:

X = present

CTL/P/4097 - 1220

I..AC955-02/02

PERCHLOROETHYLENE: MIJLTIGENERATION INHAI.ATION STUDY IN THE RAT

INDIVIJJUAL ANlMAL DATA SUPPLEMENT

.APPENDIX 2lB

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2B PUPS

GROUP NO: 1

BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DEAD (CANNilll\LISEDl

MYI'BER NO. OF LITI'ER

SEVERITY CODE

Jl.\Y 1

Jl.\Y 2

Jl.\Y 3

Jl.\Y 4

Jl.\Y 5

34 X 1

41 X 1

('") -i r-"0 .........,. 0

'""....,

,_. N N,_.

---------. ----------------- -------- L.

L.'\C955-02/02

PERCHLOROETHYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT

INDIVIDUAL .1\NIMi\L DATA SUPPLEMENT

APPENDIX 21B

CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'ro1) - F2B PUPS GROUP NO: 3

BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DEAD (C\NNIBALISED)MlTHER NO. SEVERITY DAY DAY DAY DAY DAYOF LITI'ER CODE 1 2 3 4 5

143 X 1

"-!r......'"0...... 0""......""

....NNN

-.

I.M:955-02/02

PERCHLORDETHYLENE: MllLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANIMAL DATA SUPPLEMENT

APPENDIX 21B

CLINICAL OBSERVATIONS (Ll'ITERS PER SYMPTCM) - F2B PUPS

GROUP N:J: 4

BODY SYSTEM: llEA'IH CLINICAL OBSERVATION: FOUND DEAD (CANNIBALISED)

M)TilER N:J. OF LITI'ER

SEVERITY OODE

DAY 1

D.>\Y 2

DAY 3

DAY 4

DAY 5

174 X 2

179 X 2

182 X 2

185 X 1

192 X 2 1

('") -i r...._ ..,...._..,. 0 <0 ......

.... N N w

LAC955-02/02

PERCHLORDETI!Yl.ENE: MDLTIGENERATION INHAl..ATION STUDY lN THE RAT

INDIVIDUAL AN1MAL DATA SUPPLEMENT

APPENDIX 21l3

CLlNICAL OBSERVATIONS (LITI'ERS PER S'iMPTCM) - F2B PUPS GROUP NO: 1

BODY SYSTEM: DEATH CLlNICAL OBSERVATION: FOUND DEAD MlTHER NO. SEVERITY DAY DAY DAY DAY DAYOF LITTER CODE 1 2 3 4 5

29 X 1

30 X 2

34 X 1

41 X 6

47 X 1

"-i..-.......-c....... "" 0\0.....

,_. NN

""

LAC955-02/02


INDIVIIJlli\L ANJMAL DATA SUPPLEMENT

APPENDIX 21B

CLINICAL OBSERVATIONS (LITTERS PER SYMPTCM) - F2B PUPS

GROUP 00: 3

BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DEAD

M:lTHER 00. OF LITTER

SEVERITY CODE

DAY 1

DAY 2

DAY 3

DAY 4

DAY 5

121 X 1

130 X 1

136 X 1

144 X 2

('") -1........ "'0 ........,. 0

"'....,

..... N N U1

'

I.M:955-02/02

PERCHJ..ORDE'l'HYLENE: M!JLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIIJUAL .ANIMAL Th\TA SUPPLEMENT

APPENDIX 21B

CLINICAL OBSERVATIONS CLITI'ERS PER SYMP'KM) - F2B PUPS GROUP N:J: 4

BODY SYSTEM: D&\TH CLINICAL OBSERVATION: FOUND IID\DMJTHER N:J, SEVERITY DAY Di\Y DAY DAY DAYOF LITI'ER CODE 1 2 3 4 5

170 X 1 171 X 1

172 X 2

175 X 4 2

179 X 3

182 X 6 1

185 X 4

188 X 1

190 X 2

192 X 1

".......r-i

.,....... 0 ""' """

...... NN

"'

LAC955-02/02

PERCHLOROETilYLENE: MULTIGENERATION INHliiATION STUDY IN THE RAT

INDIVIOOAL 1INJMIIL DA:rA SUPPLEMENT

APPENDIX 21B

CLINICAL OBSERVATIONS (LITIERS PER SYMP'I'CM) - F2B PUPS

GROUP NO: 3

BODY SYSTEM: DEATH CLINICAL OBSERVATION: KILLED l'OR HtMIINE REASONS

MJTilER NO. OF LITTER

SEVERITY CODE

DAY 1

DAY 2

DAY 3

DAY 4

DAY 5

123 X 3

(""") -i r ........, ........, 0 ....., "'

...... N N.....,

LAC955•02/02

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY lN THE RAT

INDIVIDJAL 1lNlli\L Jl.\TA SUPPLEMENT

APPENDIX 2lB


GROUP NO: l

BODY SYSTEM: llFATll CLINICAL OBSERVATION: 1C!LLED lN EliTREMIS M:l'I'HER NO. SEVERITY DAY DAY DAY DAY DAYOF LITI'ER CODE l 2 3 4 5

30 X l

n,...-i

......."'C........,.0\0....,

CX>-"'"'

--

LAC955-02/02

PERCHLOROEI'HYLENE: MULTIGENERATION INIIAUI1'ION STUDY IN THE Rl\1'


APPENDIX 21B

CLINIC8L OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2B PUPS

GRlJUP NO: 3

BODY SYSTEM: DEATH CLINIC8L OBSERVATION: Kil.J1lD IN EXrREMIS

MlTliER NO. SEVERITY DAY DAY DAY DAY DAY OF LITI'ER CODE 1 2 3 4 5

126 X 1

("")_, , -o --..,. 0

...... ""

...... N N

""

LAC955-02/02

PERCBLOROETHYLENE: MULTIGENERATION lNHAIATION STUDY IN THE RAT

INDIVIDUAL .I\NIMI\1 DATA SUPPLEMENT

APPENDIX 2lB

CLINICAL OBSERVATIONS (LIITERS PER SYMPTCM) - F2B PUPS

GROUP NO: 4

BODY SYSTEM: DEATH CLINICAL OBSERVATION: KILLED IN EliTREMIS MJTHER NO. OF LIITER

SEVERITY OODE

DAY 1

DAY 2

DAY 3

DAY 4

DAY 5

175 X 3

187 X 1

("') -l r...... -o ........, 0 1.0....,

..... N w 0

UIC955-02/02

PERCHLORDETIIYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXIAL ANIMAL JlliTA SUPPLEMENT

APPENDIX 21B

CLINICAL OBSERVATIONS (LITI'ERS PER sYMPTCM) - F2B PUPS

GROUP ID: 1

BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSm:;. PREStMED DEAD M:lTHER m. SEVERITY D.>\Y DAY DAY DAY DAYOF LITTER CODE 1 2 3 4 5

41 X 3

46 X 2

48 X 1".......--..-o--....,.

-0<0....,

Nw-

L!IC955-02/02

PERCHLOROETHYLENE: MULTIGENERATION IN!lAI.ATION STUDY JN THE RAT

JNDIVIlli18L ANJMliL DATA SUPPLEMENT

APPENDIX 21B

CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'l'Cl1) - F2B PUPS

GROUP ID: 3

BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSING,PRES!.MED DEAD MJTl:!ER NO. SEVERITY DAY DAY DAY DAY DAYOF LITI'ER CODE l 2 3 4 5

124 X l

126 X 2

128 X l

133 X l

137 X 2

144 X 4

.......r n-1

.,....... ... 0lO.....,

....NwN

~-----

LAC955-02/02

PEru::!!LOROE'IHYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT


APPENDIX 2lB


GROUP N:l: 4

BODY SYSTEM: IJEA1'H CLINICAL OBSERVATION: MISSING,PRESLMED DEi\D

MJTHER N:l. OF LITI'ER

SEVERITY CODE

DAY 1

DAY 2

Il<\.Y 3

DAY 4

DAY5

169 X 1

171 X 2

172 X 9

176 X 1

179 X 4

180 X 6

185 X 1

186 X 1

188 X 2

191 X 1

192 X 1

" ..... r -. ., .........,. 0 \0 ....,

..... N w w

LAC955-02/02

PERCHLOROETHYLENE: MOLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDUAL IINll1AL ll8TA SUPPLEMENT

.APPENDIX 2lB

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCM) - F2B PUPS GROUP 00: l

BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: 0010 MlT!lER NO. SEVERITY I>\¥ I>\¥ I>\¥ I>\¥ I>\¥OF LITI'ER OODE l 2. 3 4 5

35 X l

38 X l

('")

.._-lr

.._.,...0lO....,

N..... w...

,~

LAC955-02/02

PERCHLORDETHYLENE: MULTIGENERATION lNHAI.ATION STUDY IN THE RAT

INDIVIDUAL liN1MAL DATA SUPPLEMENT

APPENDIX 2lB

CLINICAL OBSE!WATIONS (LITTERS PER SYMP'ICM) - F2B PUPS

GROUP NO: 3

BODY SYSTEM: GENERAL OONDITION CLINICAL OBSERVATION: OOLD

MJTHER SEVERITY DAY DAY DAY DAY DAY OF LITI'ER OODE 1 2 3 4 5

137 X 2

m.

n -< r..... "'0 .......,. 0 .....,"'

-N w U1

-- -- ! -

LAC955-02/02

PERCHLOROE'l1lYLENE: MULTIGENERATION INHIIJ.ATION STUDY IN THE RAT

INDlVI!JUi\L ANIMAL DATA SllPP.LEMENT

APPENDIX 21B

CLINICAL OBSERVATIONS (LITTERS PER SYI1I'TCM) - F2B PUPS GROUP NO: 4

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: COLD MJTHER NO. SEVERITY DAY DAY DAY DAY DAYOF LITI'ER CODE 1 2 3 4 5

169 X 1

171 X 1

177 X 1

179 X 4

185 X 1

188 X 2

190 X 4

(""")

......r-!

"0...... 0"""1.0 ......

'....w""0'>

I.

J..J\C955-02/02

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY lli THE RAT

INDIVIIJUAL AN1WIL DATA SUPPLEMENT

APPENDIX 21B

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCMl - F2B PUPS

GROUP NJ: 1

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: PALE

M:lTHER NJ. OF LITIER

SEVERI1Y OODE

DAY 1

DAY 2

DAY 3

DAY 4

DAY 5

39 X 1

n -f....... "'0 ...... 0 """ ...., "'

..... N w....,

-------------------------~~---- -- ·--· "L

LAC955-02/02


INDIVIDUAL 1INM\L DATA SUPPLEMENT

APPENDIX 2lB

CLINICAL OBSERVATIONS (LI'ITERS PER SYMPTCM) - F2B PUPS

GROUP I'D: l

BODY SYSTEM: GllNERAL CONDmON CLINICAL OBSERVATION: i:MALL M)T!lER I'D. OF LITI'ER

SEVERITY CODE

DAY l

DAY 2

DAY 3

DAY 4

D.'<Y5

39 X l l

47 X l

n -;

........, r

....... .... 0 1.0 ......

..... N w ():)

-~,

LAC955-02/02

illTHER NO. OF LITTER

SEVERITY CODE

DAY 1

DAY 2

DAY 3

DAY 4

DAY 5

128 X 1

140 X 1 1

(") ............ '"0 ........,. 0

""' "

..... N w ""'


INDIVI!XlAL iiNIMIIL DATA SUPPLEMENT

APPENDIX 21B

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPitMl - F2B PUPS

GROUP NO: 3

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SMAI.J..

I"

LAC955-02/02


INDIVlDUAL ANM\1 DATA SUPPLEMENT

APPENDIX 21B

CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'J'(M) - F2B PUPS

GROUP NO: 4

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: OMALL MlTHER NO. SEVERITY DAY DAY DAY DAY DAYOF LITI'ER CODE 1 2 3 4 5

169 X 1

171 X 1

180 X 2

190 X 2

192 X 1

n -ir-...... "'0...... ""'0 <0....,

N..... ""'0

"~ ~---

l..AC955-02/02

PERCHLORDE:l'HYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INOIVIlXIAL ANlM.'\L DATA SUPPLEMENT

APPENDIX 2lB

CLINICAL OBSERVATIONS (LI'ITERS PER SYMPTCM) - F2B PUPS

GROUP l'Kl: 3

BODY sYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SEE FREE TEXT

MJTHER l'Kl. SEVERITY DAY DAY DAY DAY DAY OF LITTER CODE 1 2 3 4 5

142 X 1

(""')_, r ....... '"t:l ....... 0""' ..... '""

...... N

...... ""'

--

LAC955-02/02

PERCHLORDETilYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT


APPENDIX 21B

CLJNICAL OBSERVATIONS (LIITERS PER SYMPTCM) - F2B PUPS

COMMENT PAGE

CCM1ENTS: MlTHER NO. DAY NO. CCM1ENT

41 1 3 LIVE PUPS IXl NOT APPEAR TO HAVE BEEN FED.

123 1 PUPS KILLED DUE TO DAM KILLED DIFFICULT PARTURITION

142 1 FE1ALE 4. 8g BRUISING TO BACK OF HEAD.

175 1 THREE PUPS KILLED SICK AlL MlRIBUND.

182 1 LIVE PUP !XlES NOT APPEAR TO HAVE BEEN FED.

187 1 FE1ALE PUP 4.6g MlRIBUND.

189 5 1 m!ALE SEXED WRONGLY AT DAY 1.

190 1 LIVE PUPS APPEAR NOT TO HAVE BEEN FED.

"-! ...... ' "0 ......... 0 ...,"'

.... N... N

-~



APPENDIX 21C

CLINICAL OBSERVATIONS (LITTERS PER SYMPTOM) - F2C PUPS


Key:

X = present F = female

CTL/P/4097 - 1243

LI\C955-02/02


INDIVIllUAL AN1MAL DATA SUPPLEMENT

APPENDIX 21C

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCMl - F2C PUPS

GROUP NO: 1

BODY SYSTEM: DEATH CLINICAL OBSERVATION: FOUND DEAD


SEVERITY CODE

DAY 1

DAY 5

210 X 1

212 X 1

n ..... r ........, ......... 0 \0....,

..... 1'0......

-·--·-··-·---

LAC955-02/02

MJTilER N:). OF LITI'ER

SEVERITY CODE

DAY 1

DAY 5

225 X 1

227 X 1

231 X 2

242 X 1

246 X 1

247 X 2

n --l r-........, ........,. 0 <.0 ....,

...... N.,. <.TI

PERCHLOROEl'HYLENE: MULTIGENERATION INHALATION STUDY lli THE RAT

INDIVIIXJAL ilNJMI\L DATA SUPPLEMENT

APPENDIX 21C

CLINICAL OBSERVATIONS (LI'ITERS PER SYMPTCM) - F2C PUPS

GROUP N:l: 4

BODY SYSTEM: DFATH CLINICAL OBSERVATION: RJUND DEAD

LAC955-02/02

PERCHLORDEI'HYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIXIAL ANIMAL DATA SUPPLEMENT

APPENDIX 21C

CLINICAL OBSERVATIONS (LITI'ERS PER SYMPTCMl - F2C PUPS

GROUP NO: 1

BODY SYSTEM: llEAXll CLINICAL OBSERVATION: MISSIN:;,PRESlMED DEAD

Ml'l'HER NO. OF LITI'ER

SEVERITY CODE

DAY 1

DAY 5

201 X 1

202 X 1

204 X 1

207 X 1

209 X 1

2ll X 1

212 X 1

2l3 X 2

217 X 1

218 X 2

219 X 1

220 X 1

224 X 8

('")

-<, .

"""

......, ...... 0

"' .....,

.... N

0"1 """

_L.

LAC955-02/02

PEru::Hl..ORDErHYLENE: MULTIGENERATION 1NHALATION STUDY IN THE RAT

INDIVIDJAL ANJMi\1 DATA SUPPLEMENT

APPENDIX 21C

CLINICAL OBSERVATIONS (LITI'ERS PER SYMP'ICM) - F2C PUPS GROUP NO: 4

BODY SYSTEM: DEATH CLINICAL OBSERVATION: MISSING,PREStl1ED DEAD MJTHER NO. SEVERITY DAY DAYOF LITI'ER CODE 1 5

225 X 1

226 X 1

227 X 1

228 X 1

231 X 1

232 X 1

237 X 2

240 X 1

241 X 2

242 X 3

243 X 1

245 X 1

('"')

-....-fr "'C-.... ..,. 0

......

N

"'

-..,......,

LAC955-0Z/OZ

PEI<CHLOROET!!YLENE: MULTIGENERATION 1NHAI.JITION STUDY IN 'IHE RAT

INDIVIDUAL AN1M!IL Jl.\TA SUPPLEMENT

APPENDIX ZlC

CLINICAL OBSERVATIONS (Ll'ITERS PER SYMP'ID1l - F2C PUPS

GROUP NO: 1

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: COLD

MlTHER NO. OF LITI'ER

SEVERI'lY CODE

D.'IY 1

DAY 5

Zll X 1

Zl5 X 1

ZZ4 X 2 n -i, .._ -o.._ ., 0 '-0.....,

N --<> ():)

-- - .l

LAC955-02/02

PERCHLORDETHYLENE: MULTIGENERATION :rnHALATION STUDY lN THE RA:r

lNDIVIDJAL ANIMAL IliiTA SlJPPLEl1ENT

APPENDIX 21C

CLINICAL OBSERVATIONS (LITTERS PER SYMPTCM) - F2C PUPS

GROUP N:l: 4

BODY SYSTEM: GENERAL CONDITION CLJNICAL OBSERVATION: COLD MYl'HER N:). SEVERITY DAY DAYOF LI'ITER CODE 1 5

228 X 1

245 X 1

.,.-in

.......

........,.0

.....""

......,.""""

!JIC955-0Z/OZ

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUDY W THE RAT

INDIVIIJIJAL ANn1AL DATA SUPPLEMENT

APPENDIX 21C

CLINICAL OBSERVATIONS (LITTERS PER SYMI?TCM) - F2C PUPS

GROUP NO: 1

BODY SYSTEM: GENERAL CONDITION CLWICAL OBSERVATION: SWil.J..


SEVERITY CODE

DAY 1

DAY 5

203 X 1

206 X 1

208 X 1

214 X 2

217 X 2

218 X 2 1

219 X 4

220 X 1

(")

-i

........., r

....... .,. 0

...... ""

..... N c.n 0

I..AC955-02/02

PEBCHLOROETHYLENE: MDLTIGENERATION 1Nl!/\LATION STUDY IN THE RAT

INDIVI!JUAL ANlli\1 DATA SUPPLEMENT

APPENDIX 21C

CLINICAL OBSERVATIONS (LIITERS PER SYMPTCM) - F2C PUPS GROUP NO: 4

BODY SYSTEM: GENERAL CONDITION CLINICAL OBSERVATION: SMALL MJTHER NO. SEVERITY DAY DAYOF LITTER CODE 1 5

228 X 2

231 X 4

236 X 1

237 X 1 3

238 X 1 1

240 X 1

242 X 1

246 X 1

("") ....,r-... -o-... 0""'1.0 ......

..... l1'lN

.....

LAC955-02/02

PERC!lLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVI!X.TAL ANIMAL DATA SUPPLEMENT

APPENDIX 21C

CLINICAL OBSERVATIONS (LITTERS PER SYMPTCMl - F2C PUPS

COMMENT PAGE

CCM1ENTS: M:>THER NO. UIIY NO. CCM1ENT

207 5 1 FEM\LE PUP SEXED \oiRDNGLY UIIY 1 NOW 8 M!ll..ES NOT 7.

219 1 F 4. 5G DISCOLOURED NOSE. (REDl

n ..... r ........., ........., 0 1.0

"

...... N (J1

N



APPENDIX 22A

BODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTUM - F2A PUPS


Females 33, 80, 139, 178, 179, 183, 184, 188 did not litter.

Female 123 was killed due to difficult parturition.

Litter from female 129 day 11 was not weighed in error.

Key:

CNT = count (number of pups) WT = weight M = male F = female

CTL/P/4097 - 1253



APPENDIX 22A

BODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTUM .. F2A PUPS


Females 33, 80, 139, 178, 179, 183, 184, 188 did not litter.

Female 123 was killed due to difficult parturition.

Litter from female 129 day 11 was not weighed in error.

Key:

CNT = count (number of pups) WT = weight M = male F = female

CTL/ PI 4097 - 125.3

l.IIC950-03/06

PERCHLOROETIIYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIOOAL ANn1IIL DA'l:A SUPPLEMENT

APPENDIX 22A

DAM NlMlER

PUP SEK 0 PJlll

EODYWEIGHTS (g) BY

INDIVIDUAL

LITTER TO DAY 29 rosT PARTt

WEIGHTS

M - F2A PUPS

DAY 00: 1 MALES MEAN wr.

FEMALES CNT. MEAN CNT.

wr.

25 M F

6.2 6.0

6.3 6.2

6.4 6.4

6.6 6.6 6.8 7.4 6.4 6.9

6.61 7 6.38 5

26 M F

6.2 6.1

6.4 6.3

6.6 6.4 6.5 6.5

6.40 3 6.36 5

27 M F

6.1 5.4

6.9 5.7

7.1 5.8

7.5 7.5 6.1 6.7 6.8 7.1

7.02 5 6.23 7

28 M F

5.1 4.7

5.1 5.3

5.5 5.5

5.5 5.6

5.8 6.0

5.8 5.9 6.3 5.63 8 5.42 5

29 M F

5.6 5.0

5.9 5.3

6.0 5.3

6.6 5.7 5.7 5.8 5.8 5.9 6.1

6.03 4 5.62 9

30 M F

5.4 5.2

5.6 5.3

5.7 5.5

6.0 6.2

6.2 6.3

6.4 6.5 6.7 6.06 8 5.70 5

31 M F

5.1 4.8

5.4 4.9

5.9 5.3

6.1 5.7

6.1 6.3

6.5 6.6 5.96 7 5.40 5

32 M F

5.4 6.3

5.9 6.7

6.1 6.5 5.98 4 6.50 2

34 M F

5.4 5.0

5.6 5.2

5.8 5.5

6.1 5.7

6.5 5.7

6.5 5.9

6.5 5.9 6.2

6.06 7 5.64 8

35 M F

4.9 5.2

5.0 5.2

5.2 5.3

5.4 5.4

5.5 5.5

6.5 5.5 6.0 6.3

5.42 6 5.55 8

36 M F

5.7 5.2

6.1 5.6

6.1 5.8

6.2 5.9

6.8 6.0

7.0 6.0

6.32 6 5.75 6

"--i r-... -o-.....,. 0 \0....,

..... N c.n..,.

I

!.8C950-03/06

PERalLOROETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIWAL ANlMAL DATA SUPPLEMENT

APPENDIX 22A

BODYWEIGHTS (g) BY LITTER TO Il!\Y 29 POST PART!.M - F2A PUPS MALES FEMALESll8M PUP INDIVIDUAL WEIGHTS Il!\Y 00: 1 MEAN CNT. MEAN CNT.NtMlER SEX 0 ppn wr. wr.

37 M 6.0 6.1 6.4 6.4 6.6 6.30 5F 5.5 5.50 1 38 M 6.4 6.4 6.5 6.9 6.55 4F 6.0 6.1 6.6 6.23 3 39 M 5.5 5.7 5.9 6.0 6.1 6.1 5.88 6 F 5.0 5.4 5.6 5.8 6.4 5.64 540 M 4.9 4.9 4.9 5.0 5.0 5.0 5.1 5.2 5.3 5.7 5.8 5.16 11F 4.2 4.5 4.8 5.1 5.6 4.84 5 41 M 5.0 5.2 5.2 5.4 5.5 5.5 5.6 5.8 6.1 6.3 5.56 10F 4.7 4.7 4.8 5.1 5.6 4.98 5 42 M 5.5 5.6 5.7 5.7 5.8 5.9 5.70 6F 5.2 5.4 5.30 243 M 5.3 5.3 5.5 5.6 5.7 6.2 5.60 6

F 4.2 4.9 5.3 5.5 5.5 5.6 5.7 5.8 5.31 8 44 M 6.0 6.0 6.2 6.2 6.6 6.20 5

F 5.1 5.2 5.6 5.7 5.9 6.1 6.2 5.69 7 45 M 5.5 5.9 6.4 6.6 6.6 6.7 6.8 6.36 7

F 5.0 5.6 5.7 5.8 6.1 6.3 6.4 5.84 7 46 M 6.0 6.0 6.0 6.2 6.2 6.5 6.15 6

F 5.3 5.5 5.5 5.6 5.7 5.8 5.57 6 47 M 5.2 5.3 5.4 5.8 5.9 5.9 6.0 5.64 7

F 4.3 4.3 4.9 5.2 5.3 5.8 4.97 6

("'"') -<r-...... -c ...... 0 \0""' .....

......N t.11 t.11

~, ~,

LAC950-03/06

PERCffi..OROETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVI!JUAL ANIMAL DATA SUPPLEMENT

APPENDIX 22A

Jl.\M NU1BER

PUP SEX 0 Pfill

BODYWEIG!ITS (g) BY LITTER TO DAY 29 POST PARTIM - F2A PUPS

INDIVIDUAL WEIGHTS DAY NJ: 1 MALES MEAN wr.

m1IILES CNT. MEAN CNT.

wr.

48 M F

6. 7 5.4

7.z 5.9 6.3 6.8

6.95 2 6.10 4

"-I ' ...... '"'0 ...... ""' 0

"".._,

-N CJ'l en

GROUP SlM1ARY MEAN

S.D.

COUNT

6. 07 140

0.47 0

23

5.67 124

0.46 0

23

---

-.L.

LAC9S0-03/06

PERCHLOROETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIlUAL ANIMAL DATA st1PPLEMENT

APPENDIX 22A

BODYWEIG!ITS (g) BY LITTER TO DAY 29 POST PART!M - F2A PUPS MALES lm1ALESDAM PUP INDIVIDUAL WEIGHTS DAY NO: s MEAN CNT. MEAN CNT.Ntl1BER SEX 0 ppn wr. wr.

2S M 8.8 8.8 9.3 9.5 9.5 9.6 9.7 9.31 7F 9.0 9.1 9.3 9.4 9.8 9.32 5 26 M 8.6 8.6 8.7 8.63 3F 8.1 8.4 8.5 8.9 9.1 8.60 5 27 M 8.8 9.2 9.7 10.4 10.5 9.72 5 F 7.7 7.7 8.2 8.8 9.1 9.8 10.2 8.79 728 M 8.0 8.2 8.2 8.3 9.1 9.2 9.2 9.2 9.3 8.74 9F 7.9 8.3 8.5 8.6 8.33 429 M 9.6 10.2 10.3 10.6 10.18 4

F 8.4 8.6 8.6 9.4 9.5 9.6 10.1 10.2 10.7 9.46 9 30 M 8.7 8.9 9.4 9.5 9.5 9.7 9.7 9.8 9.40 8

F 7.6 8.6 9.1 9.3 9.6 8.84 531 M 8.1 8.8 9.0 9.2 9.3 9.3 9.4 ~ 9.01

F 7.3 7.7 8.3 8.7 9.2 ' 8.24 5 32 M 7.0 8.3 7.65 2

F 7.5 8.7 8.10 2 34 M 8.0 8.5 8.5 8.8 8.8 8.9 9.7 8.74 7

F 7.2 7.3 7.8 8.1 8.2 9.2 9.3 8.16 7 35 M 7.5 7.5 8.4 8.8 9.6 10.6 8.73 6

F 7.9 8.0 8.3 8.4 8.5 9.0 9.1 9.7 8.61 8

36 M 7.0 7.6 7.7 7.8 8.1 8.8 7.83 6F 7.6 7.6 7.8 7.8 8.0 8.0 8.3 7.87 7

(") -1r-....... "C ....... 0~

"'.....

.....N U'l.....

--~

LAC950-03/06

PERCBLOROE'l'IIYLENE: MULTIGENERATION INHALATION STUDY ill THE RAT

INDI\TliJU8L ANIMAL DATA SUPPLEMENT

APPENDIX 22A

J:IIIM NU1BER

PUP SEX 0 ppn

BODYVlEIGHTS (g) BY LITI'ER 'IO Jli\Y 29 POST Pl\R'TIM - F2A PUPS

INDIVIDUAL WEIGHTS Jli\Y 00: 5 MALES MEAN wr.

liliMALES CNT. MEAN CNT.

wr.

37 M 7.0 7.00 1

38 M F

8.8 9.5

9.4 9.9

10.0 10.3

10.2 9.60 4 9.90 3

39 M F

9.6 7.9

10.5 9.3

10.7 9.9 10.8

10.27 3 9.48 4

n -i r........, .........,. 0

"" .....,

..... N (,11 co

40

41

42

M F

M F

M F

6.4 6.9

8.0 6.4

10.5 10.5

6.5 7.8

8.0 7.5

10.9 13.2

7.1

8.1 7.5

10.9

7.1

8.3 7.8

11.3

7.2

8.5 7.8

13.2

7.3

8.6 8.1

13.7

7.3

8.9

7.3

9.1

7.4

9.3 9.5

7.07

8.63

11.75

9

10

6

7.35

7.52

11.85

2

6

2

43

44

M F

M F

8.3 8.2

8.4 7.6

8.8 8.5

8.5 7.6

9.1 8.9

8.5 7.8

9.2 9.3

8.7 8.3

10.1 9.8

8.8 8.5

10.4 9.9

8.8

10.1

8.8

9.32

8.58

6

5

9.24

8.20

7

7

45 M F

7.5 6.6

8.2 6.7

8.2 6.8

9.1 6.8 7.3 7.6

8.25 4 6.97 6

46 M F

7.3 6.4

8.2 7.8

8.5 8.1

8.6 8.3

9.0 8.4

9.7 8.4

8.55 6 7.90 6

47 M F

8.9 7.1

8.9 7.8

9.1 8.3

9.2 8.8

9.6 8.9

9.7 9.7

10.3 9.39 7 8.43 6

48 M F

13.0 11.1

13.1 11.1 12.2 12.8

13.05 2 11.80 4

LAC950-03/06

PERCHLOROE'l'HYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 22A

IW1 NtMlER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LITI'ER TO JlA.Y 29 POST PARTtM - F2A PUPS

INDIVIDUAL WEIGHTS JlA.Y NO: 5 MALES MEAN wr.


wr.

n -!,.... ........, ...... ""' 0 lO ......

.... N

""lO

-

GROUP SUMARY MEAN

S.D.

COUNT

9.10 127

1.36 0

23

8.77 117

1.23 0

22

LAC950-03/06

PERCHLOROE'l'l!YLENE: MULTIGENERATION INHAlATION S'IUDY IN THE RAT

INDIVI!JtlAL ANlM!IL Jl.\TA SUPPLEMENT

APPENDIX 22A

DAM NtMllER

PUP SEX 0 ppn

BOJJYWEIG!ITS (g) BY LITI'ER 'IO ll'IY 29 POST PARTIM - F2A PUPS

INDIVIDUAL WEIGHTS ll'IY NO: 11 MALES MFAN wr.

FE1ALES CNT. MFAN CNT.

wr.

25 M F

17.2 18.1

17.9 18.2

18.7 18.5

18.8 18.9

19.1 18.9

19.2 19.7 18.66 7 18.52 5

26 M F

15.7 16.9

17.4 18.5

18.2 18.8 19.1 19.5

17.10 3 18.56 5

(""') --! r..... '"tl..... """ 0

"'....,

,_. N 0'\ 0

27

28

29

M F

M F

M F

16.5 15.9

16.1 17.5

18.5 16.2

18.6 15.9

17.2 18.1

18.8 17.1

18.9 17.3

17.6 18.9

19.0 17.9

19.2 17.5

18.0 19.0

19.1 18.5

20.5 17.9

19.0

20.1 18.9

18.8

19.3

19.2

19.3

19.3

19.6

19.6

20.6

20.3

18.74

18.49

19.10

5

9

5

17.51

18.38

18.50

7

4

8

30 M F

16.5 16.4

16.8 16.6

17.1 17.0

17.2 17.6

18.1 17.7

18.4 18.5 18.5 17.64 8 17.06 5

31 M F

16.1 15.2

16.8 16.2

17.8 17.4

18.3 17.6

18.6 18.7

18.6 18.8 17.86 7 17.02 5

32 M F

18.9 20.4

20.7 22.4

19.80 2 21.40 2

34 M F

15.0 13.8

15.3 14.0

16.5 14.6

16.5 14.9

16.6 15.9

16.7 16.2

17.0 16.8

16.23 7 15.17 7

35 M F

13.8 15.5

13.8 15.7

16.5 15.9

17.9 16.0

18.2 16.1

19.2 16.1 16.7 17.5

16.57 6 16.19 8

36 M F

15.5 16.5

15.8 16.8

16.7 17.1

17.5 17.1

18.1 17.7

18.5 18.3

17.02 6 17.25 6

.I

LAC950-03/06

PERC!:!LOROETHYLENE: MIJLTIGENERATION lNHALATION STUDY IN THE RAT


APPENDIX 22A

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIN - F2A PUPS DAM

N1:MlER PUP SEX 0 ppn

INDIVIDUAL WEIGHTS DAY 00: 11 MI\LES MEAN wr.

ID!!\LES CNT. MEAN CNT.

wr.

37 M 11.6 11.60 1 38 M

F 20.8 20.8

21.4 21.7

21.7 22.8

23.5 21.85 4 21.77 3

39 M F

20.9 18.9

22.0 20.8

23.0 21.5 25.0

21.97 3 21.55 4

<"') .....,...-.. '"0-....,. 0 \!:)....,

N 0'\--

40 M F

13.6 15.7

13.7 16.1

14.7 14.8 15.1 15.5 15.6 15.8 16.4 15.02 9 15.90 2

41

42

M F

M F

15.2 14.0

20.9 20.9

15.9 16.9

21.2 22.3

15.8 17.1

21.7

17.1 17.2

21.8

18.2 17.4

22.5

18.2

23.4

18.5 19.0 19.2 20.4 17.85

21.92

10

5

16.52

21.60

5

2 43 M

F 15.9 15.5

17.7 15.7

18.1 17.0

18.3 17.7

18.9 17.7

19.7 17.9 18.2

18.27 6 17.39 7

44 M F

15.7 15.7

17.7 17.2

17.9 17.4

18.4 17.7

18.9 17.8 18.5 18.7

17.92 5 17.71 7

45 M F

15.1 14.5

15.7 14.7

17.5 14.9

18.3 15.0 17.5 17.7

15.55 4 15.90 5

45 M F

15.5 13.5

15.3 16.5

15.7 15.5

17.5 15.7

17.9 17.5

18.7 17.5

17.12 6 15.37 5

47 M F

17.5 15.9

17.8 15.2

18.3 17.7

18.8 17.8

19.0 18.3

19.1 18.7

19.1 18.51 7 17.43 5

48 M F

26.6 21.7

27.o 23.9 24.7 26.1

26.80 2 24.10 4

LIIC9S0-03/06

PEBCHLOROEI'l!YLENE: !1LJLTIGENERATION INHALATION STUDY IN THE RAT

INDI.VIIXIAL .ANlMAL DATA SUPPLEMENT

APPENDIX 22A

BOIJYWEIGHTS (g) BY LITTER TO DAY 29 POST PAR:TIM - F2A PUPS

DAM NU1BER

PUP SEX 0 P!IIl

INDIVIDUAL WEIGHTS DAY NO: ll MALES MEAN wr.


wr.

GROUP stM1iiRY MEAN 18.38 128 18.26 ll4

S.D. 2.90 0 2.35 0

COUNT 23 22

n -1,......... -c ........,. 0

""....,

..... N

""N

------

···- ... -----~- .. !

LAC950-03/06

PERO:!LORDE'l'HYLENE: M!JLTIGENERATION INHA!.ATION STUDY IN THE RAT

INDIVIDUAL ANIMAL !lATA SUPPLEMENT

.APPENDIX 22A

DAM Nil18ER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LITTER '!'0 DAY 29 POST P.ART!M - F2A PUPS

INDIVIDUAL WEIGHTS DAY NO: 16 MALES MEAN wr.

FE1ALES 00. MEAN 00.

wr.

(') -i r ...... "C ........,. 0 1.0 .....,

..... N

"' w

25

26

27

28

29

30

31

32

34

M F

M F

M F

M F

M F

M F

M F

M F

M F

26.6 26.6

19.0 27.0

25.0 24.3

24.6 26.2

25.0 25.6

23.2 22.5

24.7 23.3

33.0 33.4

21.8 20.5

26.9 26.6

27.4 29.1

27.2 24.5

24.8 26.2

27.9 26.0

23.8 22.6

25.9 24.1

33.4 36.4

22.4 20.8

27.6 27.5

29.2 29.2

27.5 25.6

26.2 26.7

28.6 27.1

23.8 23.4

26.7 26.4

23.1 20.8

28.1 27.8

29.5

28.0 26.2

26.5 27.2

28.6 27.4

24.1 23.4

26.8 26.6

23.4 21.6

29.0 28.3

29.7

29.5 26.8

26.6

29.2 27.9

24.7 25.0

26.9 26.9

23.4 23.0

29.2

27.0

26.7

28.2

25.8

27.4

23.6 23.4

29.4

28.2

27.3

28.3

26.2

27.5

24.1 24.6

27.6

29.9

26.6

27.9

28.11

25.20

27.44

26.47

27.86

24.78

26.56

33.20

23.11

7

3

5

9

5

8

7

2

7

27.36

28.90

26.09

26.58

27.55

23.38

25.46

34.90

22.10

5

5

7

4

8

5

5

2

7

35 M F

20.5 21.9

21.9 22.1

24.4 22.4

25.0 23.6

25.7 23.8

28.2 23.8 24.3 24.6

24.28 6 23.31 8

36 M F

24.6 25.9

25.3 25.9

26.0 26.6

26.8 26.8

27.3 27.2

28.9 27.8

26.48 6 26.70 6

LAC950-03/06

PERC!!LOROEI'HYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIJJUliL ANIMAL DATA SUPPLEMENT

APPENDIX 22A

DAM NtMBER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PliRTIM - F2A PUPS

INDIVIDUAL WEIGHTS DAY 00: 16 MIILES MEAN wr.

FE111LES CNT. MEAN CNT.

wr.

37 M 17.9 17.90 1

38 M F

32.4 31.5

32.8 31.9

32.9 33.0

34.3 33.10 4 32.13 3

39 M F

34.5 31.3

36.0 34.5

36.1 35.1 37.8

35.53 3 34.68 4

n -i

' ....... -o .........,. 0 \0....,

.... N ~..,.

40

41

42

M F

M F

M F

23.2 25.9

22.2 19.9

29.4 29.3

23.7 26.2

23.4 24.6

29.7 29.6

24.8

23.9 24.9

30.3

24.9

24.2 24.9

30.5

25.1

25.6 25.8

31.6

25.4

26.5

31.8

26.1

26.7

26.6

27.2

26.8

27.7 27.7

25.18

25.51

30.55

9

10

6

26.05

24.02

29.45

2

5

2

43

44

M F

M F

25.5 23.1

25.9 25.9

26.1 25.3

27.9 26.3

26.3 25.8

28.0 26.4

26.8 27.2

28.3 27.1

27.4 27.2

29.7 27.5

27.6 27.3

27.6

28.3

27.7

26.62

27.96

6

5

26.31

26.93

7

7

45 M F

24.3 22.0

24.9 23.2

26.6 23.3

27.8 24.3 24.9 27.0

25.90 4 24.12 6

46 M F

24.5 22.2

25.3 25.6

25.5 25.7

26.3 25.8

27.2 26.0

28.4 26.6

26.20 6 25.32 6

47 M F

26.2 24.0

26.5 25.0

26.9 25.2

27.2 26.3

27.9 26.4

28.5 27.5

28.7 27.41 7 25.73 6

48 M F

39.5 34.1

39.8 36.1 36.2 38.5

39.65 2 36.23 4

LAC950-03/ 06

PEOC.llLOROErHYI.JlNE: MilLTIGENERATION !NHALATION STUDY IN THE RAT

INDIVliJUAL .ANIMAL DATA SUPPLEMENT

.1\PPENDIX 22A

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS MIILES DAM FEMALESPUP INDIVIDUAL WEIGHTS DAY ID: 16 MEAN CNT. MEAN CNT.NtMBER SEX 0 ppn wr. wr.

GROUP SlM1ARY MEAN 27. 61 128 27.42 114

S.D. 4.46 0 3.88 0

COUNT 2322

('"") -l

.......

.........,"" r

0....,'""

N.....

"'U'1

LI\C950-03/06

PERCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIJUAL ANlMI\L ~ SUPPLEMENT

APPENDIX 22A

IW1 Nt:MBER

PUP SEX 0 Jllll1

BO!JYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTU1 - P2A PUPS

INDIVIDUAL WEIGHTS DAY NO: 22 11!\LES MEAN wr.


wr.

25 M F

39.2 40.8

43.3 40.9

43.4 41.4

43.9 42.8

44.0 42.9

44.0 45.0 43.26 7 41.76 5

26 M F

45.5 43.3

46.0 44.9 45.4 45.8 47.4

45.75 2 45.36 5

"-i,..-., -""' 0

"'....,

..... N

"' "'

27

28

29

M F

M F

M F

37.6 35.8

32.7 34.9

44.2 40.3

37.8 36.3

34.7 35.1

44.4 41.6

38.1 36.9

35.9 36.5

45.1 41.7

40.7 38.3

35.9 37.2

45.1 42.2

44.2 39.3

36.6

43.7

41.0

36.6

44.3

41.3

36.8

45.0

38.3

45.8

39.1

47.1

39.68

36.29

44.70

5

9

4

38.41

35.93

43.52

7

4

9

30 M F

37.3 37.1

38.4 37.3

38.8 37.6

39.9 39.5

40.3 40.3

41.9 42.4 43.1 40.26 8 38.36 5

31 M F

40.6 37.6

42.1 38.2

43.4 41.4

45.5 42.9

45.8 44.0

46.1 46.2 44.24 7 40.82 5

32 M F

49.2 48.9

50.5 53.9

49.85 2 51.40 2

34 M F

31.2 27.5

31.7 27.9

31.8 29.7

32.3 31.7

32.5 32.8

33.6 33.8

34.6 34.0

32.53 7 31.06 7

35 M F

32.3 34.8

33.9 35.6

37.6 36.3

37.6 36.7

38.9 36.7

41.7 37.8 37.9 38.2

37.00 6 36.75 8

36 M F

36.9 40.0

39.1 40.4

39.7 40.8

42.1 41.1

42.5 41.2

44.9 41.7

40.87 6 40.87 6

"-1.......,r..........0....,""

.....Ncr.....,

LAC950-03/06

PERCHLOROEI'HYLENE: 11ULTIGENERATION INHALATION STUDY IN THE RAT

INOIVIDtli\L IINJMAL DATA stlPPLEMJ!NT

APPENDIX 22A

BOIJYWEIGHTS (g) BY LITrER '10 DAY 29 POST PARTIM - F2A PUPS MALES FEMALESDAM PUP INDIVIDUAL WEIGHTS DAY NO: 22 MEAN CNT. MEAN CNT.NlMlER SEX 0 P!lll wr. wr.

37 M 29.8 29.80 1 38 M 47.9 48.0 48.6 49.9 48.60 4F 46.7 47.5 49.7 47.97 3 39 M 53.6 54.1 54.3 54.00 3F 47.4 49.0 52.1 57.2 51.43 4 40 M 33.9 34.3 36.0 36.5 37.8 38.3 38.4 38.7 40.6 37.17 9F 27.6 39.5 33.55 2 41 M 30.4 30.5 31.5 32.9 33.9 37.4 37.5 38.3 38.4 38.8 34.96 10F 27.1 30.7 31.5 33.9 36.4 31.92 5 42 M 44.3 45.2 45.5 46.9 47.9 50.6 46.73 6F 44.0 45.3 44.65 2 43 M 39.2 40.6 40.7 42.1 42.5 43.2 41.38 6F 37.3 37.6 40.4 40.5 41.2 42.0 43.1 40.30 7 44 M 40.6 42.0 42.3 43.4 43.5 42.36 5F 39.8 40.2 40.5 40.7 40.9 43.8 44.8 41.53 7 45 M 37.9 38.5 41.8 42.8 40.25 4F 35.0 35.2 36.4 37.0 37.2 40.5 36.88 6 46 M 36.0 37.6 37.9 38.5 39.8 40.8 38.43 6

F 32.3 37.5 38.0 38.3 38.9 39.8 37.47 6 47 M 38.8 39.3 40.3 40.4 41.0 41.6 44.1 40.79 7

F 35.9 36.0 37.9 38.6 39.8 40.0 38.03 6

48 M 60.4 60.7 60.55 2F 52.5 54.5 55.2 57.1 54.83 4

LAC9S0-03! 06

PEBCHLORDETHYLENE: MULTIGENERATION INHALATION STUDY ill THE RAT

OOlVIIJUAL AN1MAL DATA SUPf'I..EMENT

APPENDlX 22A

DAM NCMBER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS

INDIVIDUAL WEIGHTS DAY 00: 22 MALES MEAN wr.

FEMALES CNT. MEAN CNT. wr.

n ...;,.... ....... "'C ....... ""' 0 <0....,

...... N

"'OJ

GROUP StM1IIRY MEAN

S.D.

COUNT

42.15 126

6.87 0

23

41.04 115

6.28 0

22

LAC950-03/06

PERCHLORDETHYLENE: MDLTIGENERATION INHAlATION STUDY lN THE RAT

lNDIVIDUAL ANlMI\L DATA SUPPUMENT

APPENDIX 22A

DAM NtMBER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LI'ITER ro DAY 29 POST P.ARTIM - F2A PUPS

INDIVIDUAL WEIGHTS DAY N:l: 29 MALES MEAN wr.


wr.

r, ~ r ...... "C ........,. 0 \0....,

..... N

"' \0

25

26

27

28

29

M F

M F

M F

M F

M F

71.3 71.4

81.6 75.4

73.1 68.4

73.0 70.7

79.0 73.0

80.7 73.4

82.9 78.1

75.1 68.8

74.9 72.1

80.0 75.2

82.4 74.8

79.2

78.4 71.0

75.1 73.9

81.2 75.3

82.9 76.1

79.5

80.5 72.8

75.7 76.1

83.5 77.3

83.0 76.1

80.4

85.5 73.5

76.6

77.8

83.7

75.4

76.7

78.3

84.5

77.1

78.2

80.0

79.8

81.4

81.3

85.5

81.21

82.25

78.52

76.81

80.93

7

2

5

9

4

74.36

78.52

72.43

73.20

78.20

5

5

7

4

9 30

31

M F

M F

70.9 68.2

76.1 67.0

73.5 68.6

82.7 67.7

74.5 69.1

84.0 74.7

75.2 72.8

85.0 76.4

76.8 73.6

87.6 78.0

77.2

88.9

77.3

89.1

78.4 75.48

84.77

8

7

70.46

72.76

5

5 32 M

F 86.9 81.7

92.7 89.4

89.80 2 85.55 2

34 M F

59.4 54.5

64.9 58.2

65.3 58.4

66.9 62.0

67.3 62.8

68.4 69.1

68.8 69.5

65.86 7 62.07 7

35 M F

67.0 66.5

67.9 66.8

72.0 68.4

73.4 69.5

74.2 70.1

80.8 71.5 71.7 74.6

72.55 6 69.89 8

36 M F

70.2 73.1

73.0 73.1

73.2 74.5

76.3 75.3

77.9 76.5

82.4 76.5

75.50 6 74.83 6

L\C950-03/06

PEru::HLORDETHYLENE: MtlLTIGENERATION INHAlATION STUDY IN TllE RAT

INDIVJJ:UAL AN1W<L lliiTA SUPPLEMENT

APPENDIX 22A

M1 NU1BER

PUP SEX 0 ppn



rn1ALES CNT. MEAN CNT.

wr.

37 M 57.1 57.10 1 38 M

F 84.6 80.9

88.5 86.5

89.8 86.7

95.8 89.68 4 84.70 3

("") ..... r-.... "0-......,. 0

"' .....

..... N ..... 0

39

40

41

42

M F

M F

M F

M F

94.8 82.4

62.9 55.5

62.2 55.5

80.5 80.4

96.3 84.1

66.2 72.5

62.8 59.0

82.0 83.4

97.1 92.1

68.9

64.8 62.1

82.5

97.1

70.3

67.5 66.6

86.0

71.0

70.9 69.1

86.2

71.3

71.7

92.2

73.3

74.3

73.5

74.5

73.7

76.2 77.9

96.07

70.12

70.28

84.90

3

9

10

6

88.93

64.00

62.46

81.90

4

2

5

2 43

44

M F

M F

76.1 71.2

76.7 73.6

80.7 72.8

77.7 74.6

81.0 73.7

79.6 75.6

81.5 77.6

82.1 76.1

82.7 78.0

83.0 76.9

84.2 79.3

77.2

79.6

78.4

81.03

79.82

6

5

76.03

76.06

7

7

45 M F

75.1 64.0

77.9 64.0

85.1 68.2 68.6 68.8 73.6

79.37 3 67.87 6

46 M F

69.1 63.7

72.4 69.9

73.7 70.1

75.4 70.4

78.6 72.2

79.9 72.8

74.85 6 69.85 6

47 M F

73.5 65.0

73.7 67.3

74.9 67.9

76.4 71.1

78.1 72.7

80.2 73.6

83.6 77.20 7 69.60 6

48 M F

101.0 107.o 88.6 90.4 93.0 93.8

104.00 2 91.45 4

l.AC950-03/ 06

PERCELORDETHYLENE: MDLTIGENERATION :INEAI.ATION STUDY IN TilE RAT

INDIVIOOAL AliD1AL DATA SUPPLEMENT

APPENDIX 22A

BODYWEIGHTS (g) BY LITrER TO DAY 29 POST PARTtM - F2A PUPS MALES FEMALESDi\M PUP INDIVIDUAL WEIGHTS DAY NO: 29 MEAN CNT. MEAN CNT.NU1BER SEX 0 ppn wr. wr.

GROUP stM1IIRY MEAN 79.48 125 74.78 ill

S.D. 9.85 0 8.03 0

COUNT 2322

(") -i

......-o' .........0<.0......

.....N...........

LAC950-03/06

PERCHLOROEI'HYLENE: M!JLTIGENERATION INHAlATION STUDY IN THE RAT . INOIVID.TAL ANIMAL DATA SUPPLEMENT

APPENDIX 22A

DAM NCMBER

PUP SEl( 100 ppn


INDIVIDUAL WEIGHTS DAY!>Kl: 1 MALES MEAN wr.


wr.

73 M F

5.5 5.5

5.6 5.6

6.3 6.4

6.3 6.4 6.5 6.6 6.7 6.24 a 5.83 3

74 M F

5.8 5.3

6.0 5.3

6.1 5.7

6.1 5.9

6.1 6.4 6.7 6.17 7 5.55 4

("') -i r..._ -c..._..,. 0.., ......

...... N ...... N

75

76

77

M F

M F

M F

5.8 6.0

6.1 5.5

5.8 4.9

5.9 6.3

6.2 5.6

5.8 5.6

6.0

6.3 5.7

6.6 5.6

6.1

6.4 6.0

6.8 5.7

6.2

6.4

6.9 5.7

6.2

5.8

6.3

5.8

6.4

6.3

6.8

6.5

7.4 6.31

6.28

6.38

10

5

5

6.15

5.70

5.77

2

4

9

78 M F

4.8 4.8

5.1 5.0

5.6 5.2

5.7 5.6

5.8 5.8 5.8

5.40 5 5.37 6

81 M F

5.8 5.2

5.8 5.3

7.2 5.7 5.7 5.8 5.9 6.0 6.3 6,6

6.27 3 5.83 9

82 M F

6.1 5.1

6.2 5.2

6.2 5.8

6.4 6.1

7.1 6.40 5 5.55 4

83 M F

5.6 5.5

5.7 5.6

5.8 5.8

6.2 5.8

6.5 6.6 7.6 6.29 7 5.68 4

84 M F

4.8 5.3

5.7 5.4

5.7 5.7

5.9 5.9

6.1 5.9

6.1 5.9 6.3

5.72 6 5.77 7

85 M F

6.2 5.4

6.3 5.7

6.4 6.1

6.4 6.5

6.6 6.7

6.6 6.7 6.46 7 6.08 5

(")-!r......"C...... 0""'<0....,

.....N....,w

.----,

LAC950-03/06

PERCHLOROETHYLENE: M!JLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDUI\L ANJMAL Jl.\TA SUPPLEMENT

l\PPENDIX 22A

EODYWEIGHTS (g) BY LITIER TO ll<\Y 29 POST PAR.TIM - F2A PUPS MALES FEMALESIW1 PUP INDIVIDUAL WEIGHTS ll<\Y ID: 1 MEAN CNT. MEAN CNT.NU1BER SEX 100 ppn wr. wr.

86 M 5.4 5.5 5.7 5.7 5.9 6.0 6.2 5.77 7F 4.7 5.0 5.3 5.3 5.4 5.5 5.7 5.27 787 M 5.4 5.9 5.9 5.9 6.0 6.1 7.0 6.03 7F 5.7 6.2 6.3 6.9 6.28 488 M 5.5 5.9 6.1 6.2 6.4 6.4 6.08 6F 5.4 5.4 5.4 5.5 5.7 5.8 5.53 6 89 M 5.0 5.1 5.2 5.2 5.5 5.7 5.8 5.9 5.43 8F 4.8 5.0 5.1 5.1 5.3 5.4 5.12 6 90 M 3.9 6.0 6.1 6.1 5.53 4F 5.0 5.2 5.6 5.6 5.8 5.8 5.9 6.0 5.61 8 91 M 5.8 6.0 6.3 6.9 6.25 4F 5.1 5.1 5.3 5.4 5.6 5.7 6.1 6.1 6.5 5.66 9 92 M 5.7 6.3 6.4 6.5 6.7 6.32 5F 5.0 5.6 5.30 2 93 M 5.0 5.6 5.7 5.7 5.8 5.9 6.0 6.7 5.80 8F 4.9 5.2 5.5 5.7 5.7 5.9 6.0 6.3 5.65 8 94 M 5.9 6.0 6.2 6.4 6.5 6.20 5F 6.2 6.2 6.4 6.6 6.35 4 95 M 6.2 6.5 6.6 6.6 6.8 7.1 6.63 6F 6.2 6.2 6.2 6.3 6.4 6.4 6.28 6 96 M 5.3 5.7 5.7 6.0 6.0 6.3 5.83 6

F 5.1 5.1 5.4 5.5 5.9 5.40 5

.~

L!IC9So-o3!06

PERCHLORDETHYLENE: 11ULTIGENERATION IN!W..ATION SWDY IN THE RAT

INDIVIOOAL 11N1MAL DATA SUPPLEMENT

.APPENDIX 22A

DAM NtMBER

PUP SEX 100 ppn

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 PJST PARTIM - F2A PUPS

INDIVIDUAL WEIGHTS DAY NO: 1 M!\LES MEAN WT.

CNT. miALES MEAN CNT. WT.

n ..... '-....,-...., 0

"" .....,

,_. N ........,

GROUP StM1ARY MEAN

S.D.

COUNT

6. 08 134

0.35 0

22

5.71122

0.34 0

22

"-ir......"0......""00.0......

.....N......tJ1

-~

LAC950-03/06

PERCHUlRDETHYLENE: MULTIGENERATION !NHAJ...ImON STUDY IN THE JlAT

INDlVIlltiAL ANlMAL Jl.\TA SUPPLEMENT

.APPENDIX 22A

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS MALES FEMALESDl!M PUP INDIVIDUAL WEIGHTS DAY ID: 5 MEAN CNT. MEAN CNT.NU1BER SEX 100 Jl!l1l wr. wr.

73 M 8.3 8.4 8.4 8.8 8.9 9.0 9.2 8.71 7F 7.9 8.3 8.7 8.30 374 M 8.3 8.7 8.8 9.2 9.4 9.4 9.6 9.7 9.14 8F 7.8 8.2 8.9 8.30 375 M 8.9 10.1 10.2 10.4 10.5 n.o ll.1 ll.1 ll.3 ll.4 10.60 10 F 10.4 10.7 10.55 2 76 M 9.3 9.3 10.1 9.57 3F 6.4 7.8 8.7 8.8 7.93 4 77 M 9.0 9.0 10.2 10.4 10.9 9.90 5F 8.0 8.6 8.6 8.8 9.0 9.0 9.2 8.74 7 78 M 7.3 7.6 8.0 8.0 8.3 8.5 7.95 6F 7.3 7.4 7.9 8.1 8.4 7.82 5 81 M 7.9 8.1 8.00 2F 6.3 7.0 7.0 7.1 7.3 7.6 8.2 8.2 7.34 8 82 M 8.8 9.4 9.8 10.2 10.2 9.68 5F 8.0 8.2 8.6 9.9 8.68 4 83 M 8.4 8.8 9.0 9.0 9.1 9.4 9.9 9.09 7F 8.0 8.2 8.2 9.1 8.38 4 84 M 6.7 8.2 8.5 8.6 8.7 8.9 8.27 6

F 7.7 7.9 8.3 8.3 8.5 9.3 9.3 8.47 7 85 M 9.5 9.6 9.7 9.7 9.8 10.0 10.1 9.77 7

F 8.0 9.1 9.2 9.4 9.9 9.12 5

-~

LAC950-03/06


INDIVIDUAL 1INlMAL DATA SUPPLEMENT

APPENDIX 22A

Il'IM Nl.MBER

PUP SEX 100 pp:n

BODYWEIGHTS (g) BY LITI'ER TO JlA.Y 29 POST PARTlM - F2A PUPS

INDIVIDUAL WEIGHTS JlA.Y NJ: 5 MALES MEAN wr.

l'EM\LES CNT. MEAN CNT.

wr.

86 M F

6.8 5.5

7.9 6.3

8.2 6.8

8.4 7.4

8.5 7.5

9.0 7.5

9.1 8.3

8.27 7 7.04 7

87 M F

8.8 9.4

9.1 9.9

9.2 10.5

9.5 9.6 10.2 9.40 6 9.93 3

("") --l r....... -o .........,. 0 <.0.....,

...... N....., ""

88

89

90

M F

M F

M F

7.3 6.7

8.5 7.6

9.9 4.9

7.4 6.9

8.6 8.3

10.1 7.8

8.0 7.1

8.9 8.4

10.2 8.4

8.3 7.3

9.0 8.5

8.6

8.3 7.6

9.1 9.0

8.8

7.8

9.2 9.1

9.2

9.7

9.3 9.7 9.7

7.86

9.00

10.07

5

7

3

7.23

8.48

8.49

6

6

9

91

92

M F

M F

9.0 8.1

10.4 7.1

9.4 8.4

10.8 10.1

9.4 8.8

11.6

9.9 8.9

12.2

9.3

12.2

9.5 9.43

11.44

4

5

8.83

8.60

6

2

93 M F

6.6 6.2

7.1 6.9

7.2 7.2

7.7 7.7

7.8 7.9

8.1 8.0

8.3 8.3

8.7 7.69 8 7.46 7

94 M F

8.3 9.0

8.6 9.0

9.1 9.3

9.3 9.5

9.4 8.94 5 9.20 4

95 M F

9.1 7.6

9.2 7.6

9.6 9.6 9.38 4 7.60 2

96 M F

9.0 8.5

9.2 9.7

9.5 9.9

9.6 10.1

9.6 10.1 9.50 6 9.55 4

UC950-03/06


INDIVIIXJAL liN1MAL MTA SUPPLEMENT

APPENDIX 22A

DAM NtMBER

PUP SEX 100 ppn




wr.

('") ..............., ...... """ 0

""....,

..... N....,....,

~

GROUP SlM1ARY MEAN

S.D.

COUNT

9.17 126

0.93 0

22

8.46 108

0.88 0

22

LIIC950-03/ 06

PEIJCHLOROETHYLENE: MIJLTIGENERATION IN!lAI.IITION STUDY IN THE RAT

INDIVIIXJAL ANIMIIL ll1\TA SUPPLEMENT

APPENDIX 22A

BODYWEIGHTS (g) BY LIT!'ER TO Jlli.Y 29 BJST PARTIM - F2A POPS MALES m1ALES

IW1 pUp INDIVIDUAL WEIGHTS Jlli.Y 00: 11 MEAN CNT. MEAN CNT. NtMBER SEX 100 ppn wr. wr.

73 M 16.7 17.8 17.9 18.3 18.3 18.9 19.3 18.17 7 F 16.4 16.8 18.5 17.23 3

74 M 16.9 16.9 17.3 17.5 17.5 17.7 18.1 18.2 17.51 8 F 16.4 16.5 16.8 16.57 3

75 M 18.8 20.1 20.2 20.4 20.4 20.6 20.8 21.1 21.2 21.3 20.49 10

" -i........ -o .........,. 0 <0 .....

-N ..... CXJ

F 19.3 21.2 20.25 2

76 M 19.5 19.6 19.7 19.60 3 F 14.6 17.0 18.0 18.5 17.03 4

77 M F

18.8 17.3

18.9 17.8

19.9 18.1

20.7 18.4

20.7 18.4 18.7 19.1

19.80 5 18.26 7

78 M 16.5 17.6 17.7 17.8 18.4 17.60 5 F 16.6 17.3 17.4 17.5 18.0 18.3 17.52 6

81 M F

15.4 12.2

17.3 14.5 14.8 14.9 15.1 16.6 17.0 17.7

16.35 2 15.35 8

82 M 17.0 17.6 20.0 20.0 20.5 19.02 5 F 15.9 16.8 16.9 19.8 17.35 4

83 M F

18.5 17.6

18.5 17.8

18.5 18.5

19.0 18.9

19.1 19.6 19.7 18.99 7 18.20 4

84 M F

13.5 14.6

14.9 15.0

15.0 15.5

15.2 15.6

16.1 16.4

16.4 16.5 16.8

15.18 6 15.77 7

85 M F

17.3 17.0

18.1 17.4

18.8 17.6

18.9 17.9

18.9 19.2

19.6 19.6 18.74 7 17.82 5

("')-<......""C.........r

0lO.....

N..........lO

/-',

~ --------. . - .

LAC950-03/06

PERC!lLORDETHYLENE: MIJLTIGENERATION !NHALATION STUDY IN THE RAT

INDIVJU!AL ANIMAL MTA SUPPLEMENT

APPENDIX 22A

BODYWEIGHTS (g) BY LITIER 'IO DAY 29 POST PAR.TtM - F2A PUPS MALES FEMALESDAM PUP INDIVIDUAL WEIGHTS DAY N:l: 11 MEAN CNT. MEAN NlWIER CNT.SEX 100 ppn wr. wr.

86 M 14.1 16.3 16.4 16.7 16.7 17.2 18.5 16.56 7F 10.8 13.1 13.2 14.8 14.9 15.9 16.3 14.14 787 M 19.4 20.1 21.3 21.5 22.3 24.9 21.58 6F 22.1 22.3 22.7 22.37 388 M 17.2 18.2 18.8 19.1 18.33 4F 15.2 16.2 16.8 17.1 18.0 16.66 589 M 17.4 17.9 18.4 18.7 18.7 18.9 19.5 18.50 7F 16.4 17.7 17.8 18.4 19.3 19.5 18.18 6 90 M 19.1 19.3 20.2 19.53 3F 9.7 16.5 17.5 17.9 18.1 18.5 18.5 18.8 19.1 17.18 9 91 M 19.2 20.2 21.4 22.1 20.73 4F 18.1 19.1 19.5 19.8 20.6 20.7 19.63 6 92 M 19.8 21.9 22.2 23.0 24.6 22.30 5F 15.3 19.6 17.45 2 93 M 14.4 15.4 15.8 16.4 16.8 17.3 17.4 17.8 16.41 8F 11.4 14.4 16.2 16.4 16.8 17.3 15.42 6 94 M 18.2 18.3 19.0 19.4 20.3 19.04 5F 18.6 18.7 19.0 19.9 19.05 4 95 M 20.7 21.3 21.5 21.6 21.28 4F 15.7 17.3 16.50 2 96 M 18.4 18.9 19.2 19.4 20.4 21.0 19.55 6F 17.9 18.8 19.7 20.6 19.25 4

LAC950-03/06

l'ERC!lLOllllE'l1!YLENE:: MULTIGENERATION INHALATION STUDY IN TEE RAT

INDIVIOOAL ANlMAL DATA stlPPLEl1ENT

APPENDIX 22.11

EODYVIEIGHTS (g) BY LITI'ER TO DliY Z9 POST PARTIM - F2A PUPS

DAM NU1BER

PUP SEX 100 ppn

INDIVIDUAL WEIGHTS DliY NO: 11 MALES MEAN wr.

FEMIILES CNT. MEAN CNT.

wr.

GllllUP SlM1ARY MEAN 18.88 124 17.60 107

S.D. 1.81 0 1.81 0

COUNT ZZ zz

(""') -i r ........, .........,. 0 <0 ......

..... N co 0

UIC950-03/06


INDlVIIXJAL ANIMAL DATA SUPPLEMENT

APPENDIX 22A

DAM NlMBER

PUP SEX 100 ppn

BODYWEIGHTS (g) BY LI'l'l'ER ro DAY 29 POST PARTIM - F2A PUPS

INDIVIDUAL WEIGHTS DAY 00: 16 MALES 1:1&\N wr.

FEMALES CNT. 1:1&\N CNT.

wr.

"--!,....... -o .........,. 0 <0 .....,

..... N 0> .....

~

73

74

75

76

77

78

81

82

M F

M F

M F

M F

M F

M F

M F

M F

26.4 25.2

24.8 23.6

27.7 28.3

29.8 24.3

26.7 25.4

23.1 24.1

21.4 19.5

26.6 24.8

27.1 26.9

24.9 24.1

29.3 30.5

30.5 26.6

27.8 25.7

24.6 24.8

23.4 19.8

26.9 25.7

27.5 27.1

25.3 24.9

29.9

31.8 27.7

28.3 26.8

26.1 25.1

20.4

29.4 25.9

27.6

25.6

30.1

28.3

28.4 26.8

27.0 25.6

20.8

29.7 29.2

27.8

25.8

30.1

29.0 26.8

27.0 25.6

21.5

29.9

27.9

25.9

30.1

26.9

26.1

22.9

28.8

26.0

30.3

27.0

23.4

26.5

30.3

23.7

30.8 31.5

27.59

25.60

30.01

30.70

28.04

25.56

22.40

28.50

7

8

10

3

5

5

2

5

26.40

24.20

29.40

26.73

26.49

25.22

21.50

26.40

3

3

2

4

7

6

8

4

83 M F

29.5 27.8

30.1 28.3

30.3 28.4

30.4 29.5

30.5 30.9 30.9 30.37 7 28.50 4

84 M F

20.7 22.1

21.6 22.1

21.8 22.1

22.7 22.4

23.0 23.2

24.5 23.6 23.8

22.38 6 22.76 7

85 M F

25.3 24.5

26.7 25.8

27.5 26.0

27.8 26.5

28.0 27.2

28.3 28.6 27.46 7 26.00 5

LAC950-03/06

PERCHLOROE:l'HYLENE: MlLTIGENERli:I.'ION INI!ALATION STUDY IN THE RAT

INDIVIllUAL ANIMAL DATA SUPPLEMENT

APPENDIX 22A

Jl.'M NU1BER

PUP SEX 100 PJl11


INDIVIDUAL WEIGHTS DAY 00: 16 M!ILES ME'.AN wr.

FEMALES CNT. ME'.AN CNT.

wr.

86 M F

21.4 17.2

24.1 19.8

24.5 21.0

24.7 22.2

25.8 22.5

25.9 24.1

26.8 24.4

24.74 7 21.60 7

87 M F

30.3 32.6

31.7 33.6

32.0 33.7

32.8 34.0 36.3 32.85 6 33.30 3

n .....-'""' -..,. 0

""......

.... N co N

88

89

90

M F

M F

M F

28.4 26.9

25.8 24.7

28.2 18.4

30.7 27.1

26.7 26.2

28.4 25.7

31.5 27.9

26.9 26.5

28.6 25.9

32.6 28.6

27.2 26.9

26.4

29.5

27.7 27.8

26.5

27.9 28.2

26.8

28.3

27.0 27.1 27.9

30.80

27.21

28.40

4

7

3

28.00

26.72

25.74

5

6

9

91 M F

29.2 27.1

29.2 27.7

30.0 28.6

31.8 29.0 29.6 30.7

30.05 4 28.78 6

92 M F

29.0 24.5

32.4 29.1

33.4 33.9 35.6 32.86 5 26.80 2

93 M F

22.1 19.8

23.0 22.5

23.3 24.1

23.7 24.4

24.2 24.4

25.2 25.4

25.3 25.6 24.05 8 23.43 6

94 M F

25.7 27.0

26.5 27.6

27.9 28.0

28.3 28.3

29.0 27.48 5 27.73 4

95 M F

31.0 25.7

31.6 28.5

33.0 33.8 32.35 4 27.10 2

96 M F

26.2 25.2

26.2 27.1

27.9 27.7

27.9 28.3

27.9 28.5 27.43 6 27.08 4

LAC950-03/06

PERCHLOROETHYLENE: 11DLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANIMAL Th\TA SUPPLEMENT

APPENDIX 22A

BODYWEIGHTS (g) BY LITIER TO Jl.\.Y 29 POST P.ARTIM - F2A PUPS MALES FEMALESDliM PUP INDIVIDUAL WEIGHTS Jl.\.Y NO: 16 MEAN CNT. MEAN CNT.NU1IlER SEX 100 ppn wr. wr.

GROUP stM1ARY MEAN 28.04 124 26.36 107

S.D. 3.07 0 2.66 0

COUNT 2222

("') -i r .._ "'0..........0lO......

....Ncow

LAC950-03/06

PERCHLORDETHYLENE: MDLTIGENERATION INHALATION STUDY IN TilE RAT

INDIVIDUAL ANIMI\L DATA SUPPLEMENT

APPENDIX 22A

IW1 NlMBER

PUP SEX 100 P!Ill

BODYWEIGHTS (g) BY LITl'ER TO JlliY 29 POST PARTlM- F2A PUPS



wr.

73 M F

38.4 37.5

38.5 38.2

38.9 40.9

39.2 40.5 42.2 43.5 40.17 7 38.87 3

74 M F

40.2 38.3

40.3 40.2

41.6 41.0

42.3 42.5 43.0 44.0 44.2 42.26 8 39.83 3

('") ..... ' ........, ....... ""' 0

""' ......

..... N OJ

""'

75

76

77

M F

M F

M F

40.3 43.6

44.7 35.1

40.5 36.9

44.2 44.1

45.2 39.5

40.9 37.7

44.2

45.7 41.2

41.0 37.7

45.2

42.7

42.8 39.0

45.6

43.2 39.1

45.8

39.1

46.1

39.4

46.2 47.0 49.1 45.37

45.20

41.68

10

3

5

43.85

39.63

38.41

2

4

7

78 M F

38.9 38.7

42.3 39.0

43.4 39.3

43.4 39.5

44.0 40.5 42.4

42.40 5 39.90 6

81 M F

34.0 31.6

35.6 32.9 33.2 33.9 35.7 36.6 37.6 38.3

34.80 2 34.98 8

82 M F

40.1 37.8

41.6 38.9

43.8 39.1

44.7 44.3

45.7 43.18 5 40.03 4

83 M F

44.8 40.5

45.3 44.8

46.2 44.9

47.3 46.5

48.5 49.3 49.8 47.31 7 44.18 4

84 M F

33.6 35.7

35.3 37.3

36.3 37.8

36.9 38.0

37.8 38.7

38.9 40.3 41.6

36.47 6 38.49 7

85 M F

38.2 35.8

39.6 36.8

41.2 39.7

42.3 40.1

42.5 40.6

42.6 43.9 41.47 7 38.60 5

LAC950-03/06

PERCHLOROETHYLENE: MilLTIGENERATION INHALATION STUDY IN THE RAT

lNDIVIOOAL .ANIMAL DATA SUPPLEMENT

APPENDIX 22A

Ili\M NlMBER

PUP SEX 100 ppn

BODYWEIGl:!TS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS

INDIVIDUAL WEIGHTS DAY NO: 22 MALES MFAN wr.

FE1ALES CNT. MFAN CNT.

wr.

86

87

M F

M F

33.4 25.7

44.6 48.5

35.5 28.9

49.5 50.5

35.7 32.4

49.5 51.9

35.8 32.8

49.7

36.0 34.5

52.2

37.4 35.3

54.9

40.6 36.3

36.34

50.07

7

6

32.27

50.30

7

3

("') -i r-"0 -"""0 >.0.....,

...... N co c.n

88

89

90

M F

M F

M F

42.8 40.3

38.3 36.9

43.2 28.1

46.2 41.4

39.7 38.7

44.1 39.0

47.0 42.3

40.4 39.0

45.2 40.2

48.3 43.3

41.2 39,6

40.9

44.9

41.3 41.6

40.9

43.8 42.4

41.2

43.9

41.3 43.1 43.5

46.08

41.23

44.17

4

7

3

42.44

39.70

39.80

5

6

9 91

92

93

M F

M F

M F

43.2 40.1

49.8 39.8

32.5 27.9

43.6 41.7

52.4 47.4

33.6 32.4

43.7 42.2

54.9

35.3 33.9

47.9 42.5

55.0

35.9 36.1

43.5

56.3

36.4 36.1

44.1

36.4 36.9

37.5 37.7

44.60

53.68

35.66

4

5

8

42.35

43.60

33.88

6

2

6

94 M F

39.8 41.3

40.0 43.1

42.5 43.2

42.9 44.4

44.0 41.84 5 43.00 4

95 M F

46.3 41.9

46.5 42.5

49.4 50.1 48.08 4 42.20 2

96 M F

42.2 42.0

43.9 44.4

44.5 45.2

45.7 46.1

46.1 46.2 44.77 6 '44.43 4

L<\C950-03/06

("') --{ r ....... ""0 ....... -"' 0

"'......

,_. N 0>

""

PERCH!.OllDETHYLENE: MULTIGENERATION IN!W.ATION STUDY IN THE RAT

INDIVIIXIAL 11NIMAL DATA SUPPLEMENT

APPENDIX 22A

BODYWEIGHTS (g) BY LITrER TO U\Y 29 POST PARTtM - F2A PUPS

JlAM NlliBER

PUP SEX 100 ppn

INDIVIDUAL WEIGHTS U\Y 00: 22 MALES MEAN wr.


wr.

GROUP SlM1ARY MEAN 43 •04 124 40.49 107

S.D. 4.68 0 3.91 0

OOUNT 22 22

LAC950-03/06

PERCHLORDET!!YLENE: MJLTIGENERATION INHAlATION STUD\:' IN TEE RAT

INDIVIDUAL liNlMAL DA:rA SllPPLEMENT

APPENDIX 22A

DAM Ntl1BER

PUP SEX 100 ppn

BODYWEIGHTS (g) BY LI'l'I'ER TO DAY 29 POST PART!M - F2A PUPS

INDIVIDUAL WEIGHTS DAY NO: 29 MALES ME'.i\N wr.

FEMALES CNT. ME'.i\N CNT.

wr.

73 M F

72.2 73.9

78.4 77.2

78.5 77.3

79.6 80.4 84.2 84.2 79.64 7 76.13 3

74 M F

73.6 73.1

75.5 73.9

78.2 78.2

78.8 80.1 80.4 83.8 84.1 79.31 8 75.07 3

...,

..... r ......., ...... ""' 0

""....,

..... N co....,

"

75

76

77

M F

M F

M F

76.0 76.4

83.3 66.1

76.9 67.4

82.0 78.7

84.4 73.0

77.9 68.8

82.7

85.5 74.7

78.1 70.1

83.5

77.5

80.9 70.2

85.0

81.4 71.7

85.1

71.7

86.7

73.3

86.7 86.8 89.5 84.40

84.40

79.04

10

3

5

77.55

72.83

70.46

2

4

7

78 M F

72.1 68.8

79.0 71.3

80.6 71.8

81.8 72.1

82.7 73.3 74.6

79.24 5 71.98 6

81 M F

65.9 58.2

65.9 58.4 60.0 63.3 66.7 66.8 70.2 70.9

65.90 2 64.31 8

82 M F

77.9 68.8

80.0 72.2

80.5 73.2

85.0 79.8

85.0 81.68 5 73.50 4

83 M F

86.6 80.2

87.0 81.1

90.1 81.7

91.0 82.1

91.9 93.3 95.0 90.70 7 81.28 4

84 M F

65.1 64.5

68.5 68.7

68.6 70.1

70.7 71.1

70.9 71.2

71.8 72.4 73.5

69.27 6 70.21 7

85 M F

71.9 66.9

79.1 67.7

79.1 72.0

79.2 72.2

79.8 73.6

80.8 84.6 79.21 7 70.48 5

LAC950-03/06

PERCHLOROETIIYLENE: MJLTIGENERATION 1NHALATION STUDY Til THE RAT

INDIVIDUAL ANn1AL DATA SUPPLEMENT

.IIPPENDIX 22A

IW1 NU1BER

PUP SEX 100 PJIIl

BOIJYWEIGHTS (g) BY LITI'ER TO !l'.Y 29 POST PARTU1 - F2A PUPS

INDIVIDUAL WEIGHTS !l'.Y ro: 29 MALES MEAN wr.


wr.

86 M F

65.2 52.7

68.9 59.4

69.5 60.8

69.5 62.0

70.2 63.4

73.2 64.6

78.0 68.9

70.64 7 61.69 7

87 M F

81.8 82.3

86.8 84.0

87.3 86.1

87.4 92.7 95.8 88.63 6 84.13 3

n ..... r........, .......,. 0

"" ....,

..... N co co

88

89

90

M F

M F

M F

80.7 74.5

77.0 70.1

79.5 57.0

88.1 76.0

77.8 70.4

80.5 71.0

90.6 78.8

78.2 72.8

84.8 71.5

91.3 80.7

81.4 73.5

71.7

88.3

82.8 77.4

72.2

83.3 78.5

73.6

84.1

74.0 75.4 76.0

87.68

80.66

81.60

4

7

3

79.66

73.78

71.38

5

6

9

91 M F

80.1 72.9

82.1 74.7

84.3 75.0

90.9 79.7 81.9 82.2

84.35 4 77.73 6

92

93

M F

M F

87.4 69.9

67.7 56.4

92.7 81.7

68.0 61.6

97.2

71.4 65.6

98.4 100.9

71.7 72.0 67.1 69.4

72.5 69.7

73.3 77.5

95.32

71.76

5

8

75.80

64.97

2

6

94 M F

75.7 76.8

77.6 78.4

79.9 78.5

80.3 80.7

87.3 80.16 5 78.60 4

95 M F

86.7 78.5

88.9 80.2

90.0 91.9 89.38 4 79.35 2

96 M F

77.4 75.2

80.6 78.9

82.6 80.5

82.7 82.1

83.1 87.3 82.28 6 79.18 4

---~ --. --·-·--·

LAC950-03/06

PERCHLORDETHYLENE: MDLTIGENERATION INHALATION STUDY Dl THE RAT

INDIVIDUAL ANlMAL DATA S1JllPl..ruENT

APPENDIX 22A

BODYWEIGHTS {g) BY LITTER TO D& 29 EOST PliRTIM - F2A PUPS

!lAM NU1llER

PUP SEJ( 100 ppn

INDIVIDUAL WEIGHTS D& NO: 29 MALES MEAN wr.

FE1ALES CNT. MEAN CNT.

wr.

GROUP SlM1ARY MEAN 81.15 124

S.D. 7.18 0 74.09 107

5.68 0 OOUNT 22

22

('") -! r ...... "0 ...... ""' 0 <.0 ......

..... S5 <.0

I.JIC950-03/06

l?ERC!lLORDEl'HYLENE: MULTIGENERATION INHAlATION STUDY IN THE llAT


APPENDIX 22A

JlAl1 NU1BER

PUP SEX 300 ppn

EODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTtM - F2A PUPS



wr.

l2l M F

5.8 5.3

5.9 5.5

6.2 5.7

6.2 5.8

6.3 5.8

6.3 6.0

6.4 6.2

6.16 7 5.76 7

l22 M F

6.4 6.0

6.6 6.1

6.7 6.2

6.7 6.3

7.1 6.5

6.70 5 6.22 5

"-1 r........., .......... 0

""....,

.... N

""0

124

l25

126

M F

M F

M F

5.2 4.2

4.1 5.2

5.2 4.8

6.0 5.6

6.0 5.9

5.3 4.9

6.2 6.1

6.0 6.0

5.4 5.3

6.3 6.1

6.0

5.4 5.3

6.4 6.3

6.2

5.6 5.6

6.5

6.4

6.1 5.9

6.8

6.1

6.9 6.29

5.78

5.59

8

6

7

5.66

5.70

5.30

5

3

6

127

128

M F

M F

5.4 5.4

5.1 4.9

5.4 5.7

5.1 5.7

5.5 5.8

5.4 6.0

5.5 6.1

5.5

5.6

5.7

5.7

5.7

5.7

6.0

5.8

6.4 6.7

5.58

5.73

8

9

5.75

5.53

4

3

129 M F

5.5 5.2

6.2 5.4

6.2 5.9

6.3 5.9

6.4 6.12 5 5.60 4

130 M F

6.0 5.0 5.3 5.4 5.6 5.7 5.7 5.7 6.1

6.00 1 5.56 8

131 M F

5.3 5.6

5.7 5.7

5.8 5.9

5.9 6.1 6.1 6.2 6.2 6.5 6.5 6.03 10 5.73 3

132 M F

5.2 5.2

5.4 5.4

5.8 5.5

5.8 5.6

5.9 5.6

6.1 6.3

6.1 5.76 7 5.60 6

LAC950-03/06

PERCBLOBDETiiYLENE: MlJLTIGENERA:riON INHALATION STUDY IN THE RAT

INDIVIJXTAL llNJMAL DATA SUPPLEMENT

APPENDIX 22A

Jli\M NU1BER

PUP SEX 300 P!Il1

BODYWEIGHTS (g) BY LITTER TO MY 29 POST PARTU1 - F2A PUPS

INDIVIDUAL WEIGHTS MY NO: 1 MALES MEAN wr.

FJ;MALES CNT. MEAN CNT.

wr.

133 M F

4.6 4.9

5.0 4.9

6.3 5.30 3 4.90 2

134 M F

6.3 6.1

6.4 6.1

6.9 6.4

7.0 7.2 6.76 5 6.20 3

....., -I...._.,..._.., 0 \0....,

..... N \0 .....

,-_

135

136

137

138

140

M F

M F

M F

M F

M F

5.6 3.9

5.0 4.7

4.1 5.0

6.3 4.9

5.9 5.8

5.7 4.2

5.0

5.6 5.3

6.3 5.0

6.1 6.0

5.9 4.8

5.9

5.9 5.9

5.6

6.4 6.3

5.9 5.1

6.0

5.9

6.6 6.3

5.2

6.1

6.0

6.6 6.5

5.5

6.6

7.1 6.7

5.5

6.8

5.6 6.2 5.78

5.30

5.54

6.30

6.45

4

3

5

2

6

5.11

4.70

5.40

5.67

6.34

9

1

3

6

7

142 M F

5.9 5.4

6.4 5.9 6.2 6.5 7.0

6.15 2 6.20 5

143 M F

5.2 5.5

5.8 5.7

6.7 5.8 6.1 6.2

5.90 3 5.86 5

144 M F

6.1 5.5

6.3 5.8

6.3 6.0

6.5 6.1

6.5 6.3

6.7 6.4

6.40 6 6.02 6

LAC950-03 I06

PERCHLORDETHYLENE: MDLTIGENERATION JNHALATION STUDY IN THE RAT

INDIVIIXJ8L 1IN.IM!<L DATA SUPPLEMENT

APPENDIX 22A

DAM NtMBER

PUP SEX 300 PJill



Fl'MALES CNT. MEAN CNT.

wr.

GROUP SlM1ARY MEAN

S.D.

COUNT 21

5. 98 ll2

0.41 0 5.66 101

0.42 0

21 (") -i r -""' -.., 0

"" ......

,_. N

""N

LAC950-03/06

PERCHLOROET!lYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDlVIIJUAL ANlMAL DATA SUPPLEMENT

APPENDIX 22A

Il8M NU1BER

PUP SEX 300 ppn

BOIJYWEIG!ITS (g) BY LITIER 'IO Il!\Y 29 POST P.ARTIM - F2A PUPS

INDIVIDUAL WEIGHTS Il!\Y NO: 5 MALES MEAN wr.

FEMALES CNT. MEAN em.

wr.

121 M F

8.1 7.5

8.5 7.7

9.0 7.9

9.3 8.2

9.4 8.3

9.7 8.8

9.9 9.2.

9.13 7 8.2.3 7

12.2. M F

8.8 8.4

8.9 8.6

9.7 8.7

9.7 9.0

9.7 9.6

9.36 5 8.86 5

("")....,,... ....... -o .......

"""0 \0 .....,

..... N \0 w

'~

12.4

12.5

12.6

M F

M F

M F

6.6 7.0

9.3 9.1

6.1 6.2

8.1 8.5

9.7 9.6

6.6 6.7

9.1 10.1

9.7 9.8

6.6 7.5

9.3 10.3

9.8

7.2

9.5 11.2

10.2

7.2

10.5

7.2

10.8

7.7

11.3

7.8

9.40

9.74

7.05

8

5

8

9.42

9.50

6.80

5

3

3

12.7 M F

7.6 7.9

8.7 8.3

8.7 8.6

8.7 8.8

8.7 9.0 9.2. 9.3 8.74 8 8.40 4

12.8 M F

7.6 8.0

8.3 8.2

8.4 8.4

8.5 9.1 9.2 9.5 9.6 10.2 8.93 9 8.20 3

12.9 M F

9.2 8.5

9.3 8.7

9.8 9.3

10.1 9.60 4 8.83 3

130 F 7.7 8.2 8.3 8.3 8.4 9.0 8.32 6

131 M F

7.3 6.5

7.3 7.4

7.4 8.1

7.5 7.6 7.6 7.8 8.1 8.2 8.3 7.71 10 7.33 3

132 M F

8.5 8.0

8.6 8.9

8.6 9.3

8.7 9.6

9.3 9.6

9.6 9.9

10.7 9.14 7 9.22 6

134 M F

7.0 5.1

7.4 6.6

7.7 7.4

7.9 8.1 7.62 5 6.37 3

UC950-03/06

PERCHLORDETHYLENE: MIJLTIGENERATION JNHl\LATION STUDY IN THE RAT

INDIVIIXJAL ANIMAL DATA SUPl'LEl1ENT

APPENDIX 22A

lliiM NlMBER

pUp SEl( 300 P!lll

BODYWEIGHTS (g) BY LITI'ER TO Jl.\Y 29 POST P.i\RTIM - F2A PVPS

INDIVIDUAL WEIGHTS Jl.\Y 00: 5 MALES MEAN wr.


wr.

135 M F

7.4 5.0

7.8 6.0

7.9 6.9

8.1 7.2 7.2 7.4 7.5 7.8

7.80 4 6.88 8

136 M F

6.2 5.4

6.9 7.7 6.93 3 5.40 1

n ...;....... "0 ........,. 0 140

"

..... N 140..,.

137

138

140

M F

M F

M F

5.4 7.8

8.8 6.6

8.7 7.8

9.5 8.7

8.8 7.4

8.8 8.5

9.6 9.7

8.8

9.1 8.5

10.5

9.0

9.1 8.8

11.3

9.3 8.9

10.3 9.0 9.8

9.26

8.80

9.22

5

2

6

8.73

7.95

8.76

3

4

7

142 M F

8.9 7.6

9.1 9.0 9.6 9.8 10.3

9.00 2 9.26 5

143

144

M F

M F

7.1 8.1

6.8 6.2

8.8 8.3

6.8 6.8

8.9

7.6 7.0

7.9

7.95

7.28

2

4

8.43

6.67

3

3

----------------------GROUP SlM1!<RY MEAN

S.D.

OOUNT

8.56 104

0.91 0

19

8.08

1.14

20

85

0

----------------------

("").....r..._ "C..._.l>o0<0....,

N..... <0<.11

~~

LAC950-03/06

PERCHLORDETHYLENE: MIJLTIGENERA:J.'ION INI!ALATION STUDY IN THE RAT

INDIVIOOl\L ANlMAL IlA.TA SUPPLEMENT

APPENDIX 22A

BODYWEIG!ITS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS MALES F.EMALESDAM PUP INDIVIDUAL WEIGHTS DAY 00: 11 MFAN CNT. MFAN CNT.NU1llER SEX 300 ppn wr. wr.

121 M 15.4 15.8 17.2 17.4 17.7 18.4 19.2 17.30 7F 14.1 14.9 15.3 15.4 15.5 17.3 17.4 15.70 7 122 M 18.0 18.1 18.6 18.8 19.4 18.58 5F 16.9 19.1 19.2 19.3 19.7 18.84 5 124 M 11.5 16.0 16.8 17.1 17.2 17.2 17.9 18.0 16.46 8F 14.9 16.4 16.5 16.9 17.7 16.48 5 125 M 18.8 20.7 21.0 21.2 21.6 20.66 5F 20.5 20.7 21.4 20.87 3 126 M 14.9 15.2 15.4 16.3 16.3 17.4 18.1 18.3 16.49 8F 15.5 17.0 16.25 2 127 M 14.4 16.2 16.5 16.6 17.0 17.1 17.2 17.6 16.58 8F 15.3 15.4 16.4 16.7 15.95 4 128 M 15.4 15.9 16.2 16.7 17.1 17.3 17.9 18.5 19.3 17.14 9F 15.9 16.5 16.6 16.33 3 130 F 17.3 18.9 19.4 19.8 19.9 20.0 19.22 6 131 M 13.5 14.1 15.0 15.9 16.2 16.2 16.3 16.5 16.7 17.4 15.78 10F 15.4 16.1 16.4 15.97 3 132 M 16.0 16.2 16.6 16.7 16.8 17.4 18.0 18.0 16.96 8F 15.3 16.5 16.5 16.5 18.1 16.58 5 134 M 15.0 15.3 17.2 17.3 18.2 16.60 5

F 11.1 15.2 16.2 14.17 3

135 M 15.8 16.8 17.6 16.73 3F 10.1 12.8 15.3 15.3 15.4 15.6 16.0 16.5 14.63 8

LAC950-03/06

PERCHLORDETHYLENE: MIJLTIGENERATION IN!WATION STUDY IN THE RAT

INDIVIJXJAL ANIM!\L JliiTA SUPPLEMENT

APPENDIX 22A

IW1 NLMilER

PUP SEX 300 P!lll

BODYWEIGHTS (g) BY LITTER TO J:l.\Y 29 POST PARTIM - F2A PUPS

INDIVIDUAL WEIGHTS J:l.\Y 00: 11 MALES MEAN wr.


wr.

("") -I r-.,-.....,. 0 \0.....,

..... N \0

""

1.36

1.37

1.38

140

142

143

144

M F

M F

M F

M F

M F

M F

M F

1.3.9 15.3

12.9 16.8

19.1 15.4

16.9 14.0

19.0 15.4

15.1 16.5

16.2 14.0

17.1

19.6 17.1

19.2 16.3

17.3 16.6

19.5 19.0

15.9 18.5

17.3 16.2

17.2

20.2 20.3

18.1

18.3 17.2

19.3

19.6

18.1 17.2

20.3

20.0

18.3 18.1

19.4

22.1

22.0

18.4 18.2

20.2

18.4 18.7 19.4

16.07

19.00

19.15

17.93

19.25

15.50

18.43

3

5

2

6

2

2

4

15.30

18.07

17.45

17.46

18.66

18.20

15.80

1

3

4

7

5

3

3

----------------------GROUP SlM1ARY MEAN

S.D.

COUNT

17.48 100

1.42 0

18

16.94

1.70

19

80

0

----------------------

LAC950-03/06

PERC!ILOROE'I'HYLENE: MULTIGENERATION JNHALATI:ON STUDY IN THE RAT

INDIVIIXJAL 1INlMAL DATA SUPPLEMENT

APPENDIX 22A

DAM NU1BER

PUP SEl{ 300 ppn

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTlM - F2A PUPS



wr.

121 M F

23.4 22.8

23.9 23.0

23.9 23.2

24.5 23.4

25.6 24.7

26.3 25.4

27.7 25.5

25.04 7 24.00 7

122 M F

26.5 25.1

26.5 26.9

27.5 27.0

28.0 27.5

28.7 28.1

27.44 5 26.92 5

(") ..... r....... "".......... 0

"" .....,

.... N

"" .....,

124

125

126

M F

M F

M F

17.1 20.3

29.8 30.0

24.0 24.1

22.6 23.0

30.7 30.6

24.3 26.8

22.9 23.1

30.9 30.6

24.3

23.5 23.1

31.0

26.1

23.7 24.1

31.1

27.2

23.8

27.4

24.2

27.6

24.3

28.8

22.76

30.70

26.21

8

5

8

22.72

30.40

25.45

5

3

2

127

128

129

M F

M F

M F

21.7 22.3

24.2 24.2

29.5 27.9

23.9 22.9

24.3 24.2

30.6 28.5

24.1 23.8

24.3 24.4

31.3 32.0

24.2 24.0

24.7

31.9

24.4

24.8

24.6

25.7

24.8

25.7

25.2

26.0 27.5

24.11

25.24

30.83

8

9

4

23.25

24.27

29.47

4

3

3

130 F 27.8 28.7 29.0 30.0 30.0 30.1 29.27 6

131 M F

21.0 20.5

22.6 22.8

22.8 23.5

23.4 23.9 24.1 25.0 25.1 25.4 25.4 23.87 10 22.27 3

132 M F

23.0 22.7

23.4 23.8

23.7 23.9

24.1 24.8

24.1 24.9

24.7 24.9 25.4 24.16 8 24.02 5

134 M F

24.3 18.8

24.6 24.6

26.3 24.8

26.6 28.4 26.04 5 22.73 3

·~

I..<\C950-03/06

PERCHLORDETHYLENE: MDLTIGENERATION INHIILATION STUDY IN THE RAT

INDIVIIXJAL ANlMAL DATA SUPPLEMENT

APPENDIX 22A

ll'IM NlMlER

PUP SEX 300 PJlll

BODYWEIGHTS (g) BY LITrER 1D ll'IY 29 POST PARTIM - F2A PUPS


FEMALES 00. MEAN CNT.

wr.

135 M F

23.4 16.7

23.8 19.9

26.1 21.9 22.4 22.8 22.9 23.3 23.4

24.43 3 21.66 8

136 M F

24.4 27.1

27.7 28.9 27.00 3 27.10 1

n --i r-.. ""0 ...... ""' 0 <.0.....,

..... N <.0 ():)

137

138

140

M F

M F

M F

21.7 26.8

31.2 25.5

25.3 21.4

29.6 27.0

31.3 27.0

26.5 24.4

29.7 29.8

30.3

26.5 25.3

29.9

32.2

27.1 25.7

32.2

27.2 26.5

28.3 27.0 27.5

28.62

31.25

26.82

5

2

6

27.87

28.75

25.40

3

4

7

142 M F

29.5 24.4

29.8 28.9 29.0 29.5 29.8

29.65 2 28.32 5

143

144

M F

M F

22.8 26.8

25.4 23.9

27.1 28.7

26.4 26.5

30.6

28.4 26.7

29.3

24.95

27.38

2

4

28.70

25.70

3

3


S.D.

COUNT

26.66 104

2.56 0

19

25.91

2. 73

20

83

0

----------------------

n-;r.....-o..... 0""'1.0....,

....N1.01.0

LAC950-03/06

PERCBLOBDETHYLENE: MDLTIGENERATION INffALIITION STUDY IN THE RAT

INDIVIIXIAL ANlMAL DATA SUPPLEMENT

APPENDIX 22A

BODYWEIGHTS (g) BY LITTER TO DAY 29 POST PARTIM - F2A PUPS MALES FEMALES1lllM PUP INDIVIDUAL WEIGHTS DAY NO: 22 ME'AN CNT. ME'AN CNT.NU1BER SEX 300 wn wr. wr.

l2l M 34.5 34.8 35.0 35.1 36.0 37.5 40.0 36.13 7F 32.3 33.1 33.3 33.9 34.3 36.5 36.9 34.33 7 122 M 41.0 42.4 42.6 42.7 43.5 42.44 5F 38.2 41.2 42.2 42.6 42.7 41.38 5 124 M 20.9 29.2 30.9 31.0 31.1 31.3 31.8 32.6 29.85 8F 27.4 30.6 31.9 32.7 32.8 31.08 5 125 M 43.6 44.7 46.4 48.4 49.4 46.50 5F 44.8 45.6 45.7 45.37 3 126 M 36.7 36.7 38.0 39.9 40.8 42.6 43.2 43.4 40.16 8

F 36.7 40.2 38.45 2 127 M 33.7 36.8 37.7 38.0 38.5 38.7 39.6 40.7 37.96 8F 35.7 35.9 37.9 38.2 36.93 4 128 M 37.1 37.4 38.6 38.7 39.2 39.2 39.6 40.0 42.8 39.18 9

F 38.2 38.3 38.9 38.47 3 129 M 45.4 47.4 49.3 49.9 48.00 4

F 43.0 43.8 47.7 44.83 3 130 F 40.2 42.3 42.6 43.0 43.4 43.6 42.52 6 131 M 30.3 32.8 33.4 34.1 34.5 35.4 36.8 37.4 38.0 38.9 35.16 10

F 31.2 33.2 35.5 33.30 3 132 M 33.9 35.3 35.3 35.4 35.8 36.6 37.3 39.1 36.09 8

F 32.9 34.5 34.7 35.7 36.3 34.82 5

134 M 34.4 35.4 36.8 38.5 39.8 36.98 5F 27.7 36.6 36.7 33.67 3

-

Lt\C950-03/06

PERCHLOROETHYLENE: MULTIGENERATION INHALATION STUllY IN THE RAT

INDIVIIXJl\L ANIMI\L DATA SUPPLEMENT

l\Pl?ENDD{ 22A

JlAM NU1BER

PUP SEX 300 ppn

BODYWEIGHTS (g) BY LIITER TO J:l.\Y 29 POST PiiRTtM - F2A PUPS

INDIVIDUAL WEIGHTS J:l.\Y ID : 22 MALES MFIIN wr.

FEMALES CNT. MFIIN CNT.

wr.

135 M F

37.3 26.6

37.7 30.7

40.2 34.5 34.7 35.6 36.2 36.5 37.2

38.40 3 34.00 8

136 M F

39.1 42.4

46.2 46.8 44.03 3 42.40 1

(""') -l r-... -o-... "" 0 1.0....,

,_. w 0 0

137

138

140

142

M F

M F

M F

M F

33.9 42.1

44.7 36.3

36.1 29.4

42.2 34.2

46.4 42.7

46.6 38.7

38.1 34.5

43.2 42.2

47.3 48.0

43.4

38.4 35.0

42.7

49.6

44;9

38.7 35.5

44.4

51.0

39.1 37.3

45.5

41.3 38.2 39.0

45.64

45.65

38.62

42.70

5

2

6

2

44.27

40.83

35.56

41.80

3

4

7

5

143

144

M F

M F

36.5 42.0

37.9 36.1

42.4 45.4

40.9 38.9

45.9

42.0 39.5

43.8

39.45

41.15

2

4

44.43

38.17

3

3

----------------------GROUP SlM1ABY MFIIN

S.D.

COUNT

40.22 104

4.57 0

19

38.83

4.46

20

83

0

----------------------

LAC950-03/06

PERCHLOROETHYLENE: M!JLTIGENERATION INHALATION STODY IN THE RAT

INDIVIIXIAL ANlMAL Jl.IITA SUPPLEMENT

APPENDlX 22A

JlAM Nil1BER

PUP SEX 300 ppn

BODYWEIGHTS (g) BY LI'ITER TO DAY 29 POST PARTIM - F2A PUPS

INDIVIDUAL WEIGHTS DAY N:l: 29 1-W..ES MEAN wr.


wr.

121 M F

67.9 61.5

69.0 62.0

69.1 63.4

69.9 64.6

69.9 65.2

73.4 68.6

73.6 69.3

70.40 7 64.94 7

122 M F

79.9 71.0

81.9 76.3

82.0 77.9

82.2 78.3

82.4 78.6

81.68 5 76.42 5

n ..... r--o -..,. 0 <0....,

..... w 0 .....

~

124

125

126

M F

M F

M F

43.3 52.2

81.5 78.8

69.6 68.3

58.3 56.1

81.6 78.8

71.6 72.6

58.8 60.0

88.5 81.8

71.9

62.0 60.8

92.1

72.1

62.3 63.1

92.4

73.5

62.9

74.2

63.5

76.3

64.9

79.0

59.50

87.22

73.53

8

5

8

58.44

79.80

70.45

5

3

2

127

128

M F

M F

70.4 66.7

68.8 66.0

71.7 72.1

70.5 69.6

74.4 72.6

70.8 70.0

75.4 73.1

72.2

75.6

73.0

75.7

74.7

75.7

75.4

77.0

75.8 80.9

74.49

73.57

8

9

71.13

68.53

4

3

129 M F

82.3 76.6

87.4 78.5

88.9 79.8

91.3 87.48 4 78.30 3

130 F 74.2 75.4 76.7 77.8 79.7 81.6 77.57 6

131 M F

63.8 60.3

66.3 62.8

66.5 65.1

67.1 67.1 70.9 71.0 71.2 71.3 72.0 68.72 10 62.73 3

132 M F

68.6 62.2

68.9 66.6

69.7 67.2

70.0 68.0

70.3 69.8

70.7 72.1 79.2 71.19 8 66.76 0

~

134 M F

69.5 57.3

70.1 70.3

73.2 70.3

75.3 80.3 73.68 5 65.97 3

LAC950-03! 06

PERCHLOROETHYLENE: MULTIGENERAl'!ON INHALATION STUDY ru THE RAT

INDI.VmlAL ANIM.'IL DATA SUPPLEMENT

APPENDIX 22A

DIIM NU1BER

PUP SEX 300 ppn

BODYWEIGHTS (g) BY LI'ITER TO DAY 29 POST PiiRTtM • F2A PUPS

INDIVIDUAL WEIGHTS DAY N:l: 29 11<\LES MEAN wr.

Fl:MALES CNT. MEAN CNT.

wr.

135 M F

69.3 51.7

70.9 60.1

78.0 63.9 65.6 66.4 66.8 68.7 69.2

72.73 3 64.05 8

136 M F

72.1 70.1

78.3 78.5 76.30 3 70.10 1

<"> -1 r-.. """-....,. 0 <.0.....,

...... w 0 N

137

138

140

M F

M F

M F

65.3 75.5

79.8 67.5

71.5 54.8

81.8 77.3

84.5 71.5

72.2 63.2

84.9 82.7

78.1

72.5 63.7

87.5

81.6

73.8 66.9

89.1

74.0 71.1

75.1 71.3 71.8

81.72

82.15

73.18

5

2

6

78.50

74.68

66.ll

3

4

7

142 M F

82.7 66.9

84.9 77.8 80.5 81.4 83.6

83.80 2 78.04 5

143

144

M F

M F

73.7 76.5

72.3 65.9

85.2 82.0

74.9 70.0

83.5

78.2 72.5

81.3

79.45

76.68

2

4

80.67

69.47

3

3

----------------------GBDUP stM1II.RY MEAN

S.D.

COUNT

76.18 104

6.88 0

19

71.13

6.50

20

83

0

c-j\:

)'''

.-...

!'., '· :~ ...,, •., >.:,,

----------------------

LAC950-03/06

PERCHLORDETHYLENE: MOLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIIX!AL ANIMAL DATA SUPPI..EMENT

APPENDIX 22A

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS MIILES ffi1ALESDAM PUP INDIVIDUAL WEIGHTS DAY NO: 1 MEliN 00. MEliN 00.Nll1BER SEX 1000 ppn wr. wr.

169 M 4.9 5.3 5.5 5.6 5.7 5.9 5.48 6F 4.5 4.5 4.8 5.0 5.0 5.0 4.80 6 170 M 5.5 5.7 5.8 5.67 3F 4.6 6.1 6.1 5.60 3 171 M 5.4 5.5 5.6 5.7 5.55 4 F 5.0 5.1 5.1 5.2 5.3 5.4 5.6 5.6 5.6 5.8 6.0 5.43 11172 M 5.0 5.3 6.2 6.3 5.70 4F 5.2 5.3 5.6 6.0 5.53 4 173 M 6.1 6.10 1F 5.6 6.7 7.3 6.53 3 174 M 4.8 4.9 5.0 5.4 5.4 5.4 5.7 5.7 5.29 8F 3.6 4.7 4.7 5.0 5.3 4.66 5 175 M 4.9 5.6 5.25 2F 4.6 4.8 5.0 5.0 5.3 5.5 5.9 5.16 7 176 M 4.5 4.6 4.6 4.9 4.65 4F 3.8 4.0 4.3 4.5 4.5 4.7 4.9 4.39 7 177 M 6.2 6.20 1 180 M 5.6 6.1 5.85 2

F 5.3 5.4 5.8 6.0 6.0 6.8 5.88 6 181 M 4.1 4.6 4.7 4.7 4.7 4.8 4.9 5.2 4.71 8

F 4.2 4.6 4.6 4.7 4.7 4.56 5

182 M 3.8 4.8 5.1 5.2 5.6 4.90 5

("') -!r...... "0 ...... ol»

-a0

.....

w -0 w

LAC950-03/06

PERCHLOROEJ.'HYLENE: MULTIGENERATION INHALIITION STUDY IN THE RAT

INDIVIlXlAL ANlMAL J:li\TA SUPPLEMENT

APPENDIX 22A

lli\M NU1BER

PUP SEX 1000 ppn

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 .POST PIIRTlM - F2A PUPS


IDlALES CNT. MEAN CNT. wr.

("") -i r..... -o..... """ 0 10 ......

1-' w 0

"""

185

186

187

189

190

191

192

M F

M F

M F

M F

M F

M F

M F

5.0 4.7

5.3 4.6

4.9 4.8

5.4 4.2

6.6 7.0

4.7 4.1

5.2 5.2

5.2 5.0

5.4 4.7

5.0 5.5

4.7

5.0 5.1

5.6 5.6

5.2 5.6

5.8 5.2

5.0 5.5

4.8

5.5 5.2

5.7 6.2

5.7

5.8 5.3

5.7 5.7

5.2

5.6 5.3

5.9

5.8

5.9 5.6

5.2

5.8 5.5

5.9

5.8

6.3 5.7

5.6

5.5

5.9

5.9

6.2

5.45

5.75

5.15

5.40

6.60

5.32

5.77

6

6

4

1

1

5

7

5.10

5.18

5.38

5.09

7.00

5.12

5.67

3

6

4

7

1

6

3


S.D.

OOUNT

5.52

0.49

19

78

0 5.36

0.67

17

87

0

U.C950-03/06

PERCHLOROETHYLENE: MDLTIGENERATION INllAI.ATION STUDY IN THE RAT

INDIVIIX.1AL AN1MAL DATA 51lPPLEMENT

APPENDIX 22A

DAM NU1BER

PUP SEX 1000 pp:n

BODYWEIGHTS (g) BY LITTER TO 0& 29 POST PARTlM - F2A PUPS

INDIVIDUAL WEIGHTS D&NO: 5 MALES MEAN wr.


wr.

169 M F

6.4 5.8

6.9 6.9

7.0 7.0

7.1 7.0

7.2 7.8 8.8 7.31 7 6.68 4

170 M F

7.9 5.0

8.9 8.8

8.9 9.1

8.57 3 7.63 3

(""') ..... ;..._ "0..._., 0 <0....,

..... w 0 c.n

171

172

174

M F

M F

M F

5.6 5.9

5.5 6.3

5.9 5.6

6.3

6.2 6.5

6.1 6.3

6.7

6.6 6.5

6.3

7.8

6.8

6.5 6.7 7.4

6.60

6.10

6.48

4

3

6

5.90

6.53

5.95

1

4

2

175 M F

4.5 4.1 4.5

4.50 1 4.30 2

176 M F

5.2 4.8

5.6 5.6

5.8 5.8

6.5 6.3

5.78 4 5.63 4

181 M F

6.7 5.0

6.9 6.8

7.4 7.1

7.6 7.2

7.7 7.6

7.7 8.7 7.53 7 6.74 5

185 M F

7.6 7.8

7.9 8.1

8.1 9.1 9.6 8.46 5 7.95 2

186 M F

7.2 6.6

7.8 7.6

7.9 7.6

7.9 7.7

8.0 7.7 8.0

7.76 5 7.53 6

187 F 5.2 5.20 1

189 M F

7.1 5.9 6.5 7.0 7.6 7.7

7.10 1 6.94 5

LAC950-03/06

PEBCH!..OROETHYLENE: MilLTIGENERl\TION lNHAI.ATION STUDY IN THE RAT

INDIVI!XlAL ANIMAL DATA SUPPLEMENT

JlliM NLMBER

PUP SEX 1000 ppn

APPENDIX 22A

BODYWEIG!ITS (g) BY LITTER TO 0!\Y 29 POST PARTIM - F2A PUPS

INDIVIDUAL WEIGHTS 0!\Y NO: 5 MALES MEAN wr.

EEMIILES CNT. MEAN CNT.

wr.

191

192

M F

M F

6.9 6.1

7.9 7.9

7.8 7.3

8.4 8.0

7.8 7.4

8.7 9.0

8.1 7.4

8.7

8.0

8.8

8.0

9.0 9.0

7.65

8.64

4

7

7.37

8.30

6

3

('"") ...... '--o -""" 0 <0.....,

...... w 0 0>

GROUP stM1ARY MEAN

S.D.

OOUNT

7.11

1.21

13

57

0 6.62

1.13

14

48

0

LAC950-03 I06

PERCHLOROETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVI.Dl.lliL ANIMAL 11<\TA SUPPLEMENT

APPENDIX 22A

DAM NU1BER

PUP SEX 1000 ppn



FEM\LES CNT. MEAN CNT.

wr.

169 M F

16.3 15.0

16.3 15.4

16.7 15.9

17.0 16.6

17.1 17.7 16.85 6 15.73 4

170 M F

18.9 9.6

21.0 20.3

21.1 20.3

20.33 3 16.73 3

(") -1,... ...... "tl ...... ""'0 1.0 ......

..... w 0 ......

171

172

174

M F

M F

M F

14.1 15.0

12.3 14.2

14.5 14.5

15.2

14.1 14.5

16.2 15.6

15.8

14.8 14.8

16.3

16.9

14.8

16.5 17.2 18.2

15,50

13.73

16.48

4

3

6

15.00

14.58

15.05

1

4

2

176 M F

11.6 10.8

12.6 13.0

13.7 13.2

15.5 14.7

13.35 4 12.93 4

181 M F

15.1 11.2

15.7 15.2

16.3 16.4

17.0 16.5

17.1 16.6

17.2 18.8 16.74 7 15.18 5

185 M F

17.1 17.2

18.4 17.3

19.0 20.8 21.1 19.28 5 17.25 2

186 M F

15.0 14.0

16.1 15.4

16.5 16.1

16.8 16.3

16.9 16.3 16.4

16.26 5 15.75 6

187 F 14.6 14.60 1

189 M F

18.5 15.4 17.3 17.6 18.4 18.4

18.50 1 17.42 5

191 M F

15.3 13.7

17.5 16.2

17.6 16.3

18.2 17.5 17.9 18.5

17.15 4 16.68 6

LAC950-03/06


INDIVI!JUflL liNlMAL DATA SUPPLEMENT

APPENDIX Z2A

BODYWEIGHTS (g) BY LITI'ER TO Il'IY 29 POST PARTIM - F2A PUPS MAlES FE1ALES

DAM PUP INDIVIDUAL WEIGHTS Il'IY 00: 11 MEliN CNT. MEliN CNT. NlMlER SEX 1000 Jlliil wr. wr.

192 M 17.3 17.6 18.0 18.3 18.9 19.1 19.8 18.43 7 F 16.4 17.3 19.7 17.80 3

----------------------GROUP SlM1ABY MEliN 16.88 55

15.75 46 S.D. 2.08 0

1.39 0 COUNT 12

13

("") -i........ -o .........,. 0 <.0....,

...... w 0 0>

LAC950-03/06

PEBCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDUAL .ANlMAL DATA SUPPLEMENT

APPENDIX 22A

ll'IM Nrl1BER

PUP SEX 1000 ppn

BODYWEIGHTS (g) BY LI'ITER 'IO DPCl 29 POST PiiRT!M - F2A PUPS

INDIVIDUAL WEIGHTS DPCl NO: 16 MALES MF1IN wr.

FEMALES CNT. MF1IN CNT.

wr.

"-I ' ........, ....... "" 0

"" ......

..... w 0

""

169

170

171

172

174

176

181

185

M F

M F

M F

M F

M F

M F

M F

M F

25.4 23.1

30.5 16.9

25.8 27.7

20.7 22.5

24.2 24.3

20.9 19.6

23.8 20.5

28.1 28.0

25.6 25.2

31.6 30.8

28.8

22.0 23.0

25.1 25.5

22.0 22.1

25.0 25.0

29.9 29.1

26.9 25.7

32.6 32.1

29.2

24.3 23.0

26.2

24.1 23.0

25.7 25.5

30.2

27.4 26.0

30.3

23.3

26.2

25.1 24.9

26.0 26.2

32.2

27.4

27.1

27.2 26.3

32.8

28.1

28.2

27.5 29.8

26.80

31.57

28.53

22.33

26.17

23.03

26.43

30.64

6

3

4

3

6

4

7

5

25.00

26.60

27.70

22.95

24.90

22.40

24.70

28.55

4

3

1

4

2

4

5

2 186 M

F 24.4 22.6

25.1 23.4

25.2 23.6

25.4 24.3

25.9 24.6 25.4

25.20 5 23.98 6

187 F 27.8 27.80 1 189 M

F 30.2. 27.2 29.5 29.6 30.1 30.6

30.20 1 29.40 5

191 M F

24.6 23.5

2.7.0 25.7

27.5 26.0

28.2 27.2 27.3 29.3

26.83 4 26.50 6

LAC950-03/06

PERCHLOROET!!YLENE: 11IJLTIGENERATION INilAI.ATION STUDY rn TilE RAT

!NDIVIIJUAL 1INlMAL Jli\TA SUPPLEMENT

APPENDIX 22A

EODYWEIGHTS (g) BY LI'ITER TO DAY 29 POST PARTlM - F2A PUPS MALES EEMALES

JliiM PUP INDIVIDUAL WEIGHTS DAY 00: 16 ME'IIN CNT. ME'IIN CNT. NU1BER SEX 1000 pjl1l wr. wr.

192 M 27.2 27.6 28.0 28.6 28.8 29.2 29.5 28.41 7 F 26.0 27.3 29.6 27.63 3

----------------------GROUP SlM1ARY ME'IIN 27.18 55

26.01 46 S.D. 2.86 0

2.19 0 COUNT 12

13

("") -I !""" ......., ......... 0

""' ......

...... w ...... 0

n-ir

'""----.,.0....,""

w....--

LAC950-03/06

PERCHLORDETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT INDIVI!XTAL ANIMAL DATA SUPPLEMENT

APPENDIX 22A

BODYWEIGHTS (g) BY LITTER !0 DAY 29 POST PARTIM - F2A PUPS MALES !lAM PUP FJ!M!ILESINDIVIDUAL WEIGHTS DAY ID: 22 NtMBER MEAN SEX CNT. MEAN 1000 CNT.PJlll wr. wr.

169 M 42.5 43.0 43.2 44.8 45.1 45.1 43.95 F 6 38.3 38.5 41.0 41.1 39.73 4170 M 48.0 51.3 53.0 50.77 F 328.5 47.5 48.2 41.40 3171 M 40.7 45.1 46.0 48.2 45.00 4 F 43.8 43.80 1172 M 33.8 35.4 39.3 36.17 3 F 35.0 35.1 35.7 36.1 35.48 4174 M 41.1 43.2 43.3 43.9 45.4 48.6 44.25 6F 39.3 41.6 40.45 2176 M 33.3 34.0 37.1 37.2 35.40 4 F 30.9 34.5 35.1 38.7 34.80 4181 M 38.5 39.1 39.7 42.0 43.4 43.7 47.0 41.91 7F 31.7 39.8 40.4 41.1 41.7 38.94 5185 M 43.3 45.3 46.1 49.2 50.4 46.86 5F 43.7 45.3 44.50 2186 M 36.9 39.5 40.5 41.6 42.0 40.10 5F 35.3 36.7 36.8 37.8 38.5 40.3 37.57 6187 F 45.5 45.50 1189 M 49.8 49.80 1F 43.1 46.7 46.9 47.4 47.7 46.36 5 191 M 40.2 43.3 44.1 44.7 43.08 4F 38.1 41.3 42.0 43.0 44.3 44.6 42.22 6


OOIVIOOAL ANlMAL DATA SUPPLEMENT

APPENDIX 22A

BODYWEIGHTS (g) BY LITI'ER TO DAY 29 POST PARTIM - F2A PUPS Jli\M MALES PUP FEMALESINDIVIDUAL WEIGHTS DAY N:>: 22 MFiiN NU1BER CNT. MFiiN SEX 1000 CNT.ppn wr. wr.

192 M 42.5 43.2 43.6 44.6 44.9 45.9 46.9 44.51 7F 40.4 42.2 45.2 42.60 3

-----------------------GROuP stM:1!\RY MFiiN 43.48 55

41.03 46S.D. 4.69 0

3.65 0COUNT 12

13

U\C950-03/06

(")

......r--i

'""0 ......... 01.0......

w-N.....

LAC950-03/06

PERCHLOROETHYLENE: MULTIGENERATION INHAU\TION STUDY IN THE RAT

INDlVIJJUAL l\NlMAL DATA SUPPLEMENT

APPENDIX 22A

BODYWEIGHTS (g) BY LITrER TO DAY 29 POST P.i\RTtM - F2A PUPS MALES FE1ALESruM PUP INDIVIDUAL WEIGHTS DAY NO: 29 MEAN CNT. MEAN CNT.NU1llER SEX 1000 ppn wr. wr.

169 M 73.9 75.0 80.6 81.1 81.8 82.6 79.17 6F 66.6 68.0 69.4 69.8 68.45 4 170 M 87.8 94.2 94.7 92.23 3F 52.0 82.0 85.8 73.27 3 171 M 73.6 77.8 81.5 84.1 79.25 4F 75.8 75.80 1172 M 66.8 69.7 74.7 70.40 3F 61.5 64.4 68.1 68.7 65.68 4 174 M 76.2 77.7 78.0 82.0 83.7 85.6 80.53 6F 71.6 77.7 74.65 2176 M 63.7 65.6 68.0 68.1 66.35 4F 57.5 63.6 64.2 71.1 64.10 4181 M 73.3 74.2 77.4 79.7 81.0 81.7 85.5 78.97 7F 58.5 71.4 74.7 75.0 75.9 71.10 5 185 M 75.8 76.1 81.5 86.0 90.4 81.96 5F 76.3 77.6 76.95 2 186 M 69.0 74.1 75.3 75.6 79.1 74.62 5

F 63.6 66.4 67.2 68.5 68.5 71.0 67.53 6 187 F 79.2 79.20 1 189 M 88.0 88.00 1

F 73.6 75.6 76.2 78.0 81.4 76.96 5

191 M 68.9 76.9 77.2 82.0 76.25 4F 68.1 70.4 72.9 73.0 78.4 79.2 73.67 6

n -i

...... .,

.........' 0 ...., ""

.....w ..... w

~~--

LAC950-03/06

PERCHLOROETHYLENE: 11IJLTIGENERATION INHA!liTION STUDY IN THE RAT

INDIVIIXIAL .ANIMAL DATA SUPPLEMENT

APPENDIX 22A

Dl!M NlMBER

PUP SEX 1000 ppn

BODYWEIGHTS (g) BY LITTER TO !liT 29 POST PARTIM - F2A PUPS

INDIVIDUAL WEIGHTS DAY NO: 29 MIILES MEAN wr.


wr.

192 M F

78.8 73.0

79.9 74.4

82.6 78.8

82.9 83.0 83.7 84.2 82.16 7 75.40 3

----------------------GROUP Sl.M1IIRY MEAN

S.D.

COUNT

79.16

6.99

12

55

0 72.52

4.75

13

46

0

n -! r..._ -o..._.,. 0

"'....,

..... w ......,.



APPENDIX 228

BODYWEIGHTS (g) BY LITTER TO DAY 5 POST PARTUM

- F2B PUPS

Females 25, 33, 122, 131, 173, 178 did not litter.

Pups from female 123 were all dead.


The litter from dam 29 was weighed on day 4 post partum and not on day 5

post oartum.

Key:

CNT = count (number of pups)

WT = weight

M = male

F = female

CTL/P/4097 - 1315

LAC950-03/06

PERCHLORDETHYLENE: MULTIGENERATION INHAUITION STUDY IN THE RAT

INDIVIOOAL ANJMIIL 11'\TA SUPPLEMENT

APPENDIX 22B

JlliM NU1BER

PUP SEX 0 Jlllll

BODYWEIGHTS (g) BY LITI'ER 10 DIIY 5 EIJST PARTIM - F2B PUPS

INDIVIDUAL WEIGHTS DIIY N:l: 1 MALES MEliN wr.

CNT. rn-w.ES MEliN CNT. wr.

26 M F

5.2 4.8

5.4 5.0

5.8 5.1

5.8 5.4

5.8 5.5

6.0 5.6 5.7 5.8 5.9

5.67 6 5.42 9

27 M F

7.3 5.8

7.6 6.4 6.9 6.9 7.0

7.45 2 6.60 5

n --i.--.. -o-....,. 0

"" ......

..... w ..... 01

28

29

30

M F

M F

M F

5.4 5.3

6.4 6.5

6.5 5.9

5.5 6.1

6.8 6.5

6.1

5.9 6.1

7.1

6.2

6.0 6.1

7.2

6.2 6.2

7.3

6.4

7.4

6.5

7.7

5.99

7.13

6.50

7

7

1

5.96

6.50

6.07

5

2

3

31 M F

6.2 6.2

7.2 6.6 6.7 7.5

6.70 2 6.75 4

32 M F

6.2 5.7

6.2 5.9

6.3 6.0

6.4 6.1 6.2 6.4

6.28 4 6.05 6

34 M F

5.3 5.0

5.5 5.1

5.7 5.1

5.8 5.3

5.9 5.4

6.0 5.6

6.1 6.3 6.3

5.76 7 5.51 8

35 M F

5.5 5.4

5.7 5.6

5.9 5.8

6.0 5.8

6.2 5.8

6.7 6.1

6.8 6.11 7 5.75 6

36 M F

5.0 4.9

5.6 5.1

5.7 5.1

5.7 5.2

5.7 5.3

5.9 5.4

6.1 5.5

6.2 5.5

5.74 8 5.25 8

37 M F

7.4 6.6

8.1 7.4 7.4

7.75 2 7.13 3

('")_,........"1::>....... 0""'\0.....,

.....w..........,

.~

.. I

LAC950-03 I06

PERCHLOROETHYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT

INDIVIIXIAL ANlMAL MTA SUPPLEMENT

APPENDIX 22B

BODYWEIGHTS (g) BY LITI'ER ID DAY 5 POST PARTtM - F2B PUPS MALES FEMALESJlAM PUP INDIVIDUAL WEIGHTS DAY NO: 1 MEAN CNT. MEAN CNT.NU1BER SEX 0 ppn wr. wr.

38 M 5.5 5.7 5.7 6.0 6.2 5.82 5F 5.1 5.2 5.3 5.6 5.6 5.7 5.9 6.2 5.58 8 39 M 4.3 6.2 7.5 8.0 6.50 4F 6.6 7.3 7.3 7.8 7.25 4 40 M 5.2 5.4 5.9 5.50 3F 4.6 5.0 5.3 5.3 5.7 5.8 6.2 6.5 5.55 8 41 F 4.7 5.4 5.6 5.23 3 42 M 5.2 6.6 6.6 6.7 6.28 4F 6.1 6.2 6.6 6.30 3 43 M 5.7 5.8 6.1 6.2 6.4 6.7 6.9 6.26 7F 5.4 6.0 6.6 6.9 6.23 4 44 M 6.4 6.5 6.7 7.6 6.80 4F 5.8 6.0 6.2 6.2 6.4 6.5 6.6 6.24 7 45 M 6.1 6.2 6.4 6.5 6.5 6.5 6.5 6.6 7.0 6.48 9F 5.5 5.6 6.0 7.0 6.03 4 46 M 6.5 6.7 7.4 7.5 7.03 4F 4.6 5.6 6.1 5.43 3 47 M 4.7 5.3 5.6 5.8 6.0 6.0 6.2 6.5 5.76 8

F 4.4 4.8 5.0 5.6 5.8 6.1 5.28 6

48 M 6.3 6.5 6.5 6.5 6.8 6.52 5F 5.8 5.9 6.0 6.2 6.6 6.10 5

LAC950-03/06

PERCHLOBOETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVIlXJAL ANIMAL DATA SUPPLEMENT

APPENDIX 22B

IliiM NU1BER

PUP SEX 0 ppn

BODYWEIGHTS (gi BY LITI'ER TO JliiY 5 POST PARTIM - F2B PUPS

INDIVIDUAL WEIGHTS JliiY NO: 1 MALES MEAN wr.

rn1ALES CNT. MEAN CNT.

wr.

("") ..... r-... '"t:l ....... ""0 1.0 .....,

..... w ..... CX>

GBOUP 5lM1ARY MEAN

S.D.

COUNT

6.38 106

0.61 0

21

6.01 114

0.59 0

22

-~ --- ·------------· --- --· ----- .. -- ... ----------------

LAC950-03/06

PERCHLORDETHYLENE: M!JLTIGENERATION INHALATION STUDY lli THE RAT

INDIVIOOAL ANIM>\L DATA SUPPJ..EMEm

APPENDIX 22B

BODYWEIGHTS (g) BY LITI'ER TO DAY 5 POST P.AR.Tl.M- F2B PUPS MALES :fEM.\LES

ll8M PUP INDIVIDUAL WEIGHTS DAY NO: 4 MEAN CNT. MEAN CNT. NtMBER SEX 0 P!lil wr. wr.

29 M 10.0 10.3 10.5 10.9 11.1 11.5 11.6 10.84 7 F 10.8 10.80 1

----------------------GROUP StM1ARY MEAN 10.84 7

10.80 1 S.D. 0.00 0

0.00 0 COUNT 1

1

("")

-1 r........, ....... ol'> 0 \0.....,

..... w ..... \0

'~

l..!IC950-03/06

PERCBLOllOETI!YLENE: MULTIGENEBA:l'ION lN!W..ATION STUDY IN THE RAT

IND!VJIIUAL ANIMAL DATA SUPPLEMENT

1\PPENDIX 22B

D!IM Nl.MBER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LITI'ER TO JliiY 5 POST PARTtM - F2B PUPS

INDIVIDUAL WEIGHTS JliiY 00: 5 MALES MEAN wr.

FE1'.LES CNT. MEAN CNT. wr.

26 M F

6.5 7.0

7.8 7.2

7.9 8.0

8.5 8.0

8.7 8.2

8.7 8.5 8.6 8.6 9.2

8.02 6 8.14 9

27 M F

12.0 9.0

12.1 10.3 10.6 11.0 11.1

12.05 2 10.40 5

n -f,-.,-""' 0 <.0.....,

..... w N 0

28

30

31

M F

M F

M F

8.3 8.7

11.5 10.8

8.7 9.1

9.1 8.9

11.0

10.6 9.3

9.3 9.3

11.6

9.3

9.7 9.3

9.5

9.9 9.4

10.1 10.1 9.50

11.50

9.65

7

1

2

9.12

11.13

9.30

5

3

4

32 M F

9.5 8.9

9.8 8.9

10.6 9.6

10.7 9.6 10.1 10.8

10.15 4 9.65 6

34 M F

8.0 6.6

8.4 7.1

8.5 7.5

8.5 7.7

8.6 8.4

9.3 8.6

9.4 8.7 8.8

8.67 7 7.93 8

35 M F

8.9 8.7

9.4 9.1

9.6 9.1

9.6 9.2

9.7 9.2

10.0 9.4

10.5 9.67 7 9.12 6

36 M F

7.5 7.8

8.3 7.9

8.9 8.0

8.9 8.0

9.0 8.3

9.2 8.4

9.3 8.9

10.0 9.0

8.89 8 8.29 8

37 M F

11.7 11.1

12.6 12.0 12.5

12.15 2 11.87 3

38 M F

8.5 7.8

8.9 8.1

9.0 8.2

9.2 8.3

9.6 8.4 8.9 9.3 9.9

9.04 5 8.61 8

LAC9S0-03/06

PERCHLOROETHYLENE: M!JLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL AN1W1L DATA SUPPLEMENT

APPENDIX 22B

!lAM Nrl1BER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LITTER TO DAY 5 POST PART!M - F2B PUPS

INDIVIDUAL WEIGHTS DAY 00: 5 MALES ME'IIN WT.

FEMALES CNT. ME'IIN CNT.

WT.

39 M F

6.6 10.0

9.5 10.8

ll.6 ll.5

12.2 12.2

9.98 4 ll.l3 4

40 M F

8.2 6.9

8.6 7.4

8.8 8.1 8.3 8.3 8.3 8.5 8.7

8.53 3 8.06 8

n -; r...... -o ...... .;:, 0 <.0.....,

..... w N .....

42

43

44

M F

M F

M F

8.2 10.1

8.1 7.5

8.1 7.2

10.7 10.1

8.7 8.7

8.5 7.3

ll.O 10.5

9.0 9.6

8.6 7.6

ll.4

9.1 10.0

9.6 7.7

9.6

8.2

9.8

8.6

9.9

8.7

10.33

9.17

8.70

4

7

4

10.23

8.95

7.90

3

4

7

45 M F

9.3 9.4

9.6 9.4

9.7 9.4

9.8 10.0

9.9 10.0 10.1 10.2 10.4 9.89 9 9.55 4

46 M F

9.0 8.7

9.5 10.7 10.7 9.98 4 8.70 1

47 M F

7.4 6.0

9.0 7.8

9.3 8.0

9.9 9.2

10.0 9.9

10.1 9.9

10.1 10.3 9.51 8 8.47 6

48 M F

10.6 9.7

10.8 10.1

10.9 10.5

ll.1 10.6

ll.2 10.92 5 10.23 4

!.AC950-03/06

PERCHLOROE'l'HYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INOIVIJXlAL liNlMIIL Jl.\TA SUl'PLEMENT

APPENDIX 22B

Ili'M Ntl1BER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LITTER TO Jl.\Y 5 EQST Pi\RT!M - F2B PUPS

INDIVIDUAL WEIGHTS ll<\Y NO: 5 MALES MEAN wr.


wr.

('") -t r-... '""-.....,. 0 0.0....,

..... w N N

GROUP SlM1IIRY MEAN

S.D.

OOUNT

9.81

1.14

20

99

0 9.34 106

1.17 0

20

~J

LAC950-03/06

PERCH!..OROE'l'HYLENE: MIJLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDUAL ANlMAL DIITA SUPPLEMENT

.APPENDIX 22B

DAM NU1llER

PUP SEX 300 ppn

BODYWEIGHTS (g) BY LITTER TO DAY 5 POST PARTtM - F2B PUPS



wr.

121 M F

5.3 5.6

5.6 5.6

5.7 5.6

5.8 5.6 5.7 5.7 5.7 6.1

5.60 4 5.70 8

124 M F

5.8 4.9

6.0 5.4

6.0 5.6

6.1 5.7

6.1 6.1 6.2 6.04 7 5.40 4

"-i I""..._ "C..._ ""'0 <0 .....

..... w N w

125

126

127

M F

M F

M F

6.1 5.6

5.0 5.1

6.7 5.8

6.6 6.5

5.3 5.2

6.7 6.4

6.7 6.6

5.4 5.6

6.4

6.9

5.4

6.8

5.5

6.8

6.58

5.32

6.70

4

5

2

6.23

5.30

6.44

3

3

5

128 M F

5.1 4.9

6.3 5.6

6.5 5.6

6.7 5.9

6.7 6.1

6.9 6.4 6.4

6.37 6 5.84 7

129 M F

6.1 6.1

6.4 6.2 6.4

6.25 2 6.23 3

130 M F

5.3 6.1

6.1 6.1 6.5 6.00 4 6.10 1

132 M F

6.5 6.2

6.7 6.2

6.7 6.4

7.1 6.5

7.2 6.5 6.6 7.0

6.84 5 6.49 7

133 M F

6.0 4.8

6.4 5.5 6.5

6.20 2 5.60 3

134 M F

5.5 6.7

6.0 6.1 6.2 6.5 6.7 7.4 6.34 7 6.70 1

LAC950-03I06

PERCHLORDETHYLENE: MJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIDUAL ANlMAL rwrA SUPPLEMENT

APPENDD{ 22B

ll'IM Nl.MBER

PUP SEX 300 ppn

EODYWEIGHTS (g) BY LITTER TO Il8Y 5 POST PARTtM - F2B PUPS

INDIVIDUAL WEIGHTS Il8Y ID: 1 MALES MEAN wr.


wr.

135 M F

6.8 5.5

6.9 6.2

7.4 6.6 6.9

7.03 3 6.30 4

136 M 4.6 5.3 5.6 5.8 6.1 5.48 5

137 F 4.4 4.6 4.50 2

("> ..... r..... "" ......., 0

"' ....,

,... w N..,

138

139

140

M F

M F

M F

6.4 5.6

5.4 5.1

5.4 3.9

5.9

5.6 5.3

6.0 5.5

6.1

5.6 5.8

6.1 5.6

6.4

6.8 5.9

6.2 5.8

6.4

6.9

6.3 5.8

6.6

6.6 5.9

6.7

5.9 5.9

6.40

6.06

6.10

1

5

6

6.24

5.53

5.54

7

4

8

142

143

M F

M F

4.8 4.7

6.5 6.4

4.8

7.1 6.5

4.9

6.9

5.1 5.2 5.4 5.7 4.80

6.80

1

2

5.11

6.60

7

3

144 M F

5.9 5.5

6.5 5.6

6.7 5.7 6.0 6.2 6.2

6.37 3 5.87 6

----------------------GROUP st:M1ABY MEAN

S.D.

COUNT

6.17

0.56

19

74

0 5.88

0.57

19

86

0

----------------------

LAC950-03/06

PERC!lLOROEI'!IYLENE 1 MULTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 22B

lliiM NlMlER

PUP SEX .300 wn

BODYWEIGHTS (g) BY LITTER TO DAY 5 POST PARTtM - F2B PUPS

INDIVIDUAL WEIGHTS DAY ID: 5 MALES MEAN wr.

FEMALES CNT. MEAN CNT. wr.

121 M F

8.0 7.8

8.5 8.4

8.6 8.8

9.3 9.0 9.0 9.6 9.7 9.9

8.60 4 9.03 8

124 M F

7.6 7.4

7.7 8.2

7.8 8.6

8.5 8.7 8.7 8.8 8.26 7 8.07 3

n -1 r...... "" ...... -1'> 0

"' .....

..... w,.., c..n

125

126

127

M F

M F

M F

8•.3 7.9

8.4 8.4

9.0 8.2

9.4 9.0

9.0 8.6

9.1 8.7

9.5 9.5

9.5 9.0

8.8

10.6

8.8 9.1

9.45

8.97

9.05

4

.3

2

8.80

8.67

8.72

3

.3

5

128 M F

7.9 8.1

8.8 8.2

8.9 8.3

9.1 8.3

9.2 8.8

9.7 9.0

8.93 6 8.45 6

129 M F

8.1 8.0

8.5 8.8 8.9

8.30 2 8.57 3

130 M F

7.7 9.1

8.3 8.6 9.2 8.45 4 9.10 1

132 M F

8.8 8.6

8.9 8.9

9.0 9.1

10.3 9..3

10.5 9 • .3 9.4 9.7

9.50 5 9.19 7

133 M F

9.6 8.6

9.7 10..3

9.65 2 9.45 2

134 M F

6.5 9.4

7.5 8.3 8.6 9.0 9.1 9.6 8.37 7 9.40 1

LAC950-03/06

PERCBLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVlWAL .ANlMIIL DATA SUPPLEMENT

APPENDIX 22B

JlAM NU1BER

PUP SEX 300 ppn

BODYWEIGHTS (g) BY LITI'ER 1D DAY 5 POST PARTtM - F2B PUPS



wr.

135 M F

9.0 7.6

9.6 8.3

9.7 8.3 9.3

9.43 3 8.38 4

136 M 7.2 7.9 8.3 8.8 9.0 8.24 5

138 M F

8.7 8.4 8.7 8.8 9.0 9.5 9.6 9.6

8.70 1 9.09 7

n --!........ -o .........,. 0

"' ......

-w N 01

139

140

142

M F

M F

M F

9.0 8.8

8.2 4.3

7.7 6.9

9.1 8.9

8.3 7.7

7.5

9.8 9.4

8.9 8.0

7.5

10.9 10.5

9.0 8.2

7.9

11.0

9.0 8.4

8.2

9.1 8.4

8.2

8.5

8.2

9.0

9.96

8.75

7.70

5

6

1

9.40

7.81

7.77

4

8

7

143

144

M F

M F

10.6 10.0

7.1 6.8

10.7 11.1

6.8

11.5

7.0 7.4

10.65

7.10

2

1

10.87

7.00

3

4


S.D.

COUNT

8.85

0.82

19

70

0 8.76

0.84

18

79

0

:i-!'!:? \ OP

L\C9~0-03/06

PERCHLOROE'J'!IYLENE:: MIJLTIGENERATION INHALATION STOIJY' IN THE RAT

INDIVID.IAL ANJMAL DATA SUPPLEMENT

APPENDIX 22B

Il!\M NU1BER

PUP SEX 1000 pp;n

BODYWEIGHTS (g) BY LI'l'l'ER TO DAY 5 POST PARTtM - F2B PUPS

INDIVIDUAL WEIGHTS DAY NO: 1 MALES MEAN WT.

FEMALES CNT. HE:t\N CNT,

wr.

169 H F

5.6 3.5

5.7 4.2 4.7 4.7 5.0 5.0 5.3 5.4 5.4 6.0

5.65 2 4.92 10

170 M F

6.6 6.5

6.60 1 6.50 1

C") -i r ...... -o ......... 0 1.0....,

..... w N....,

171

172

174

175

M F

M F

M

M F

4.8 3.8

5.6 5.2

5.5

5.3 4.8

5.2 4.4

5.7 5.3

5.7

5.4 5.3

4.9

6.0 5.4

5.7 6.3

5.3

5.5

5.4

5.6 6.2

5.00

5.77

5.60

5.47

2

3

2

3

4.76

5.53

5.47

5

6

3

176

177

H F

M F

5.8 5.0

4.7 5.0

6.0 5.2

5.3 5.8

6.3 5.3

5.4 5.8

6.3 5.7

5.4 5.7

6.10

5.30

4

5

5.30

5.53

4

3

179 H F

5.8 5.4

5.8 5.7

5.9 6.0

6.5 6.0 6.0 6.0 6.3

6.00 4 5.91 7

180 M F

5.6 4.4

5.8 5.2

6.0 6.4 6.5 6.6 6.15 6 4.80 2

181 M F

4.3 5.6

5.0 5.6

5.5 5.8

5.7 5.8

5.9 5.8

6.2 5.9

6.2 6.0

5.54 7 5.79 7

182 F 4.5 4.50 1

.•r,r,

PERCELOROETHYLENE: MULTIGENERATION lNHALATION STUDY IN THE RAT

INDIVI!X.TAL ANJMAL DATA SUPPLEMENT

APPENDlX 22B

JltiM N!MlER

PUP SEX 1000 ppn

BODYWEIGHTS (g) BY

INDIVIDUAL

LITI'ER TO lltiY 5 POST ' WEIGHTS

PARTtM - F2B PUPS

lltiY !Kh 1 MALES MEAN wr.

F.EMIILESCNT. MEAN CNT.wr.

185 M 4.4 4.40 1 186 M

F 5.8 5.1

6.3 5.5

6.7 5.6 5.8 5.8 6.0 6.0

6.27 35.69 7

187 M F

5.5 5.1

5.5 5.4

5.7 6.3

5.8 6.8 5.86 55.60 3

188 M F·

4.9 4.1

4.90 14.10 1

189 !1 F

5.7 5.5

6.1 6.0

6.4 6.1 6.1 6.2 6.3

6.07 36.03 6

190 M F

4.9 4.2

5.0 4.8

4.95 24.50 2

191 F 6.2 6.20 1

192 !1 4.1 5.2 5.2 4.83 3

-----------------------GROUP ST.M1!\RY MEAN

S.D.

COUNT

5.58

0.59

18

57

0 5.36

0.67

17

69

0

- --------------· -···· ·-----·····------~--~-----------------.

LAC950-03/06

C"")

-l.-... -..." .... 0

......

,_.

""

w S5

LAC950-03/06

PERCHLORDETHYI.ENE: MULTIGENERATION INHAlATION STUDY JN THE RAT

INDIVIWAL .1\N.lMAL JliiTA SUPPLEMENT

APPENDIX 22B

Dlll1 NU1BER

PUP SEX 1000 ppn

BODYWEIGHTS (g) BY LITI'ER TO D& 5 POST PARTIM - F2B PUPS

INDIVIDUAL WEIGHTS D&NO: 5 MALES MEAN wr.


wr.

169 M F

7.0 5.3

7.3 5.6 5.9 6.2 6.5 6.6 6.7 6.9 7.2

7.15 2 6.32 9

170 F 8.2 8.20 1

171 M F

6.6 5.7 6.7 7.5 7.8

6.60 1 6.93 4--

("")

""",.... ....... "' .........,. 0

"'.......

,__. w N

"'

174

175

176

M

M F

M F

7.5

5.3 5.7

9.4 8.1

7.7

5.6

9.8 9.1

6.4

9.8 10.1

10.1 . _[·· ·~,;..,v-_

.J;.: ''

t'~ J:, j_

ri.LlBS

I

'" ;,., - ,:.;2-.L

...

~.- ::... -·1

c

- t,.).· .__ <!

··.

·<.' '"

7.60

5.77

9.78

2

3

4

5. 70

9.10

l

3

177

179

M F

F

6.5 6.6

6.7

6.8 7.4

6.9

6.9 8.3

7.1 7.4 6.94 5 7.43

6.80

3

2

180 M 5.2 5.7 5.45 2

181 M F

7.3 8.4

7.6 8.7

8.9 8.8

9.1 8.9

9.5 9.2

9.5 9.3

9.6 9.5

8.79 7 8.97 7

186

187

M F

M F

8.4 8.2

8.3 8.5

9.0 8.2

8.3 8.5

9.1 8.4

8.7 9.1

8.4

8.7

8.8

9.3

9 · 4

·8.83

8.66

3

5

8.57

8. 70

. 6

3

189 M F

8.3 8.1

9.0 8.1

9.1 8.5

9.5 8.6 9.0

8.98 4 8.46 5

1AC950-03/06

,-,.

" ,·,

r, • •

;•

fl'? ;)'J

J ·I"'

8"•!

lliiM NU1BER

PUP SEX

..-:_ ·r

1000

,-,-.

ppn

PERCHLOROETHYLENE: MULTIGENERATION lNHAiliTION STUDY IN THE RAT

INOIVI!XlAL ANlMAL DATA SUPPLEMENT

APPENDIX 22B

BODYWEIGHTS (g) BY LITI'ER TO 00' 5 POST PARTlM - F28 PUPS '~ .

INDIVIDUAL WEIGHTS 00' 00: 5 MALES MEAN wr.

F<MALES " OlT. MEAN CNT.

wr.

190

192

M F

M

5.1 4.8

5.8

6.5 6.4

5.80

5.80

2

1

5.60 2

<"> ...... c -o -.., 0 \0.....,

-w w 0

1[, ! ! .., r

:·!

..s

Lf~

..·, {

(j'.'.T''

'"t,'(>:i20-0::? \ 0·:'

j

····;

n: •. ·:.

GROUP S1M1ARY MEAN

S.D.

COUNT

7. 40

1.48

13

41

0 7.56

1.27

12

46

0



APPENDIX 22C

BODYWEIGHTS (g) BY LITTER TO DAY 5 POST PARTUM- F2C PUPS

Key:

CNT = count (number of pups)WT = weight M = male F = female

CTL/P/4097 - 1331

("")-lr......"0.......,.0.....,'""

.....wwN

--- ----- ·- L

LAC950-03 I06

PERCHLOROETHYLENE: MULTIGENERATION INHA!.IITION STUDY IN THE RAT

INDIVIDUAL llNlMAL DIITA SUPPLEMENT

APPENDIX 22C

BODYWEIGHTS (gJ BY LITTER '!0 ll\Y 5 POST PARTIM - F2C PUPS DliM MALES PUP FE1ALESINDIVIDUAL WEIGHTS ll\Y 00: 1 NlMlER ME'iiN CNT. ME'iiN SEX 0 CNT.Jli:I!l wr. wr.

201 M 4.9 5.5 5.5 5.8 6.2 5.58 F 54.6 4.9 5.0 5.1 5.3 5.4 5.6 6.0 5.24 8202 M 6.2 6.3 7.0 6.50 3203 M 5.9 6.1 6.3 6.4 6.6 6.26 F 55.4 5.6 5.6 6.0 6.1 6.1 6.6 5.91 7204 M 5.8 5.9 5.85 2F 5.4 5.4 5.5 5.5 5.5 5.6 5.9 5.9 5.59 8205 M 5.8 5.80 1 F 6.5 7.2 6.85 2206 M 5.0 5.9 6.3 6.4 6.4 6.5 6.5 6.14 7F 5.6 5.6 5.8 5.9 6.0 6.4 5.88 6207 M 5.8 6.0 6.0 6.1 6.1 6.2 6.6 6.11 7F 5.5 5.7 5.7 5.9 6.3 5.82 5208 M 5.8 6.2 6.2 6.4 6.15 4F 4.7 5.1 5.2 5.4 5.6 5.6 5.9 5.9 5.9 6.0 6.1 5.58 11209 F 6.2 6.20 1210 M 5.6 6.3 6.6 7.1 6.40 4F 6.1 6.1 6.4 6.20 3 211 F 6.0 6.00 1 212 M 5.2 5.3 5.3 5.5 5.6 5.9 5.9 5.53 7F 4.6 4.7 5.0 5.0 5.2 5.2 5.5 5.03 7

)..

LAC950-03/06

JlAM PUP NlMBER SEl( 0 ppn


INDIVIDJAL ANlMAL !l.\TA SUPPLEMENT

APPENDIX 22C

BODYWEIGHTS (g) BY LI'ITER TO Di\Y 5 POST PARTU1 - FZC PUPS MALES FEMALES

INDIVIDUAL WEIGHTS Di\Y NO: 1 MEAN CNT. MEAN CNT. wr. wr.

n ..... r......., ........,. 0

"' ......

..... w w w

ill M F

214 M F

215 M F

M216 F

217 M F

218 M F

219 M F

220 M F

221 M F

223 M F

224 M F

7.1 5.9

5.2 4.7

5.8 5.5

5.7 5.1

5.9 5.0

5.8 5.0

4.8 4.1

4.6 4.4

7.6 6.5

7.5 7.1

5.2 5.3

5.3 5.3 5.3 5.3

5.9 6.2 5.6 5.8

5.9 6.4 5.5 5.6

6.0 6.1 5.0 5.1

6.0 6.1 5.1 5.3

4.9 5.0 4.2 4.3

4.7 4.9 4.6 4.7

7.7 6.6

7.4

5.5 5.6 5.3 5.3

7.10 1 5.90 1

5.6 5.7 5.7 5.8 5.9 6.0 6.1 5.66 105.4 5.18 4

6.3 6.05 4 5.8 5.9 5.9 6.1 6.3 6.4 5.92 9

6.7 6.36 57.1 5.7 6.6 5.70 5

6.3 6.7 7.0 6.33 6 5.1 5.2 5.8 5.9 6.1 5.40 8

6.1 6.5 6.6 6.18 6 5.5 5.7 6.3 6.5 5.63 7

5.3 5.4 5.7 5.18 6 4.3 4.5 4.6 4.7 4.8 5.2 5.2 4.59 10

5.0 5.2 5.4 4.97 6 4.9 5.3 5.4 5.5 5.6 5.05 8

7.65 2 6.55 2

7.50 1 7.25 2

5.8 5.8 5.9 5.63 6 5.5 5.6 5.40 5

~ ·--

---···L

LAC950-03/06

PERCHLORPETHYLENE: MULTIGENERAT.ION JNIALATION STUDY IN THE RAT

INDIVIOOAL ANIMAL Jli\TA SUPPLEMENT

APPENDIX 22C

BODYWEIGHTS {g) BY LITTER TO ll'IY 5 POST P.ARTIM - F2C PUPS MALES FEMALESDAM PUP INDIVIDUAL WEIGHTS ll'IY NJ: 1 MFIIN CNT. MFIIN CNT.NU1BER SEX 0 ppn wr. wr.

GROUP SU11>\RY MFIIN 6.14 98 5.77 120

S.D. 0.67 0 0.61 0

COUNT 21 22

(""')

.......-ir..,.........,.01.0.....

......ww..,.

LAC950-03/06

PERCBLOROETHYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT

INDIVJLUAL ANIMAL DATA SUPPLEMENT

APPENDIX 22C

IW1 NtMBER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LITI'ER TO DAY 5 POST PARTtM - F2C PUPS



wr.

201 M F

7.0 7.3

7.7 7.7

8.1 7.8

8.2 8.2

8.7 8.3

8.9 8.9 8.21 7 7.86 5

202 M 7.7 7.9 7.80 2

203 M F

8.9 7.5

9.0 8.3

9.5 8.5

9.7 8.7

9.9 9.1 9.4 9.4

9.40 5 8.70 7

n ..... r .._..,.._.., 0 1.0 .....

.... w w <.n

-

204

205

206

M F

M F

M F

9.0 8.2

8.4 9.9

6.5 7.4

8.2

9.9

7.8 7.6

8.4

7.9 7.8

8.4

8.4 8.0

8.6

8.6 8.3

8.6

8.7 8.7

8.7

8.8

9.1 9.00

8.40

8.10

1

1

7

8.53

9.90

7.97

8

2

6

207

208

M F

M F

8.0 7.0

6.8 6.1

8.1 7.8

7.9 6.1

8.1 7.9

8.0 6.4

8.2

8.1 7.1

8.3

7.5

8.9

7.7

8.9

7.8

9.0

7.8 7.9 8.1 8.3

8.44

7.70

8

4

7.57

7.35

3

11

210 M F

7.9 9.0

10.5 9.0

10.7 10.2

11.5 10.15 4 9.40 3

212 M F

6.6 5.5

6.8 6.0

6.9 6.1

7.3 6.2

7.4 6.6

7.5 7.0 7.2

7.08 6 6.37 ~

' 214 M

F 6.2 5.8

6.5 7.3

6.7 7.3

7.1 7.4

7.2 7.5 7.7 7.8 7.9 8.0 7.26 10 6.95 4

215 M F

8.1 7.1

8.6 7.8

8.8 7.8

9.1 8.0 8.0 8.1 8.4 8.7 9.4

8.65 4 8.14 9

l.AC950-03/06

PE!lCHLORDEl.'HYl.Em: MULTIGENERATION INf!Al.ATION STUDY IN TEE RAT

IND:rv:rru\L ANJMIIL DATA SUPPLEMENT

APPENDIX 22C

DAM NU1BER

PUP SEX 0 ppn

BODYWEIGHTS (g) BY LITI'ER TO Jl.\Y 5 POST PARTIM - F2C PUPS

INDIVIDUAL WEIGHTS Jl.\Y 00: 5 MALES l1EllN wr.

FEMALES CNT. l1EllN CNT.

wr.

n -1 r..._.,..._..,. 0 1.0....,

...... w w "'

216

217

218

219

220

221

223

M F

M F

M F

M F

M F

M F

M F

9.8 9.0

8.4 7.0

7.9 5.6

6.9 5.8

6.4 6.5

9.2 9.0

11.3 10.7

10.1 9.3

8.8 7.2

8.0 7.5

7.2 6.1

6.6 6.9

10.6 10.1

10.8

10.3 9.6

8.8 7.3

8.4 7.6

7.6 6.4

7.0 7.4

10.6 10.1

8.9 7.8

8.4 7.7

7.6 6.5

7.7 7.5

10.8 10.9

9.1 7.9

8.5 7.7

8.0 6.5

7.9 7.6

9.4 8.5

7.8

9.0 6.6

8.0 7.6

8.8

7.2

8.4

7.7 8.1

10.32

8.90

8.24

7.72

7.27

9.90

11.30

5

6

5

6

6

2

1

9.78

7.79

7.32

6.77

7.41

9.55

10.75

5

7

6

9

7

2

2

224 M F

5.6 4.8

6.1 5.85 2 4.80 1

----------------------GROUP SU11'IRY l1EllN

S.D.

COUNT

8.48

1.28

20

92

0 8.05 104

1.42 0

19

----------------------

LAC950-03/06

PERCHLOROEI'HYLENE: MIJLTIGENERATION INHALATION STUDY IN TBE RAT

INDIVIDUAL ANlMAL JltiTA SUPPLEMENT

APPENDIX 22C

lll!M NU1llER

PUP SEX 1000 ppn

BODYWEIGHTS (g) BY LITI'ER TO Dtcr 5 POST PARTIM - F2C PUPS

INDIVIDUAL WEIGHTS Dtcr NO: 1 MALES MEAN wr.

F'EMALES CNT. MEAN CNT.

wr.

225 M F

4.8 4.8

4.9 4.9

4.9 5.1

5.0 5.0 5.1 5.2 5.3 5.3 5.4 5.5 5.7 5.18 12 4.93 3

226 M F

5.7 5.1

5.9 5.8

6.1 5.9

6.1 6.0

6.4 6.1

6.5 6.4

6.12 6 5.88 6

("'") -1 r ...... "0 ...... "" 0

""....,

..... w w....,

~

227

228

229

M F

M F

M F

5.1 5.0

4.8 4.4

4.8 4.8

5.5 5.3

5.5 5.8

5.0 4.8

5.9 5.3

5.9 6.0

5.1 4.9

6.1 5.8

6.0

5.3 4.9

6.3 5.8

6.1

5.5 4.9

6.3 6.1

6.1

5.5 5.3

6.2

5.6

6.3 6.5

5.87

5.93

5.26

6

9

7

5.55

5.40

4.93

6

3

6

231 M F

5.5 5.1

6.4 5.5

7.1 5.5 5.8 5.9 5.9 6.0 6.2 6.4

6.33 3 5.81 9

232 M F

5.5 6.6

5.8 6.3 6.5 6.03 4 6.60 1

234 M F

6.8 6.7

7.0 6.7

7.2 6.8

7.4 7.8 8.2 7.40 6 6.73 3

236 M F

4.3 5.1

5.3 5.2

5.4 5.3

5.4 5.4

5.6 5.4

5.7 5.6

5.8 5.8

6.0 6.1 5.51 9 5.40 7

237 M F

5.8 4.4 5.0 5.2 5.5 5.7 6.0 6.0 6.2

5.80 1 5.50 8

238 M F

5.6 4.4

5.7 5.2

5.9 5.4 5.5 5.9

5.73 3 5.28 5

PERCHLOROETHYLENE: 11ULTIGENERATION INHALATION STI!OY IN THE RAT

INDIVIru\L ANlli\L D.t<rA SUPPLEMENT

.APPENDIX 22C

BODYWEIG!ITS (g) BY LITI'ER TO DAY 5 POST PAR11M - F2C PUPS MIILES DAM FEMM.:ESPUP INDIVIDUAL WEIGHTS ll!IY NO: 1 MEANNU1BER em. MEAN SEX em.1000 ppn wr. wr.

240 M 5.1 5.1 5.3 5.4 5.4 5.4 5.5 5.5 5.6 5.37 9F 4.4 5.2 5.3 5.5 5.10 4241 M 6.3 6.8 6.55 2242 M 5.4 5.5 5.9 6.0 6.5 5.86 5F 4.9 5.5 5.5 5.5 5.5 5.5 5.5 5.9 5.48 8243 M 5.4 5.6 5.6 5.6 6.0 6.2 6.4 6.6 5.93 8F 5.4 5.4 5.8 5.53 3245 M 6.6 6.9 7.8 7.8 7.28 4F 6.8 6.9 7.1 7.2 7.3 7.9 7.20 6246 M 5.6 6.0 6.0 6.1 6.2 6.2 6.3 6.3 6.5 6.13 9F 5.5 5.9 6.1 5.83 3247 M 5.7 5.8 6.2 6.3 7.0 6.20 5F 5.6 6.1 6.2 6.3 6.3 6.6 6.18 6248 M 6.7 6.8 6.8 7.0 7.1 6.88 5F 7.0 7.00 1

-----------------------GROUP SlM1ARY MEAN 6.07 113

5.80 88S.D. 0.61 0

0.69 0COUNT 19

18

-----------------------

.._'"'r..,-;

..__.,.0

.....,""

w....wco

LAC950-03/06

LAC950-03/06

PERCHLOROEI'HYLENE: MULTIGENERATION INHAI.MION STUDY IN THE RAT

INDIVIIJUl\L 1\NJMI\L IlATA SUPPLEMENT

APPENDIX 22C

DAM NU1BER

PUP SEX 1000 ppn

BODYWEIGHTS (g) BY LITTER ro DAY 5 POST P.AR.TtM - F2C PUPS



wr.

225 M F

5.6 6.8

6.3 7.0

6.5 6.6 6.7 6.7 6.8 6.9 6.9 7.1 7.1 8.1 6.78 12 6.90 2

226 M F

8.1 8.1

8.6 8.4

9.0 9.0

9.1 9.8

9.3 10.0

9.9 9.00 6 9.06 5

('") -; r ........, .......,. 0 \0 ......

.... w w \0

--,

227

228

229

M F

M F

M F

8.1 7.3

6.9 8.4

6.8 6.2

8.7 8.0

8.0 8.6

7.3 6.8

9.3 8.1

8.6

7.4 6.9

9.4 9.1

8.9

7.4 7.2

9.5 9.6

9.2

8.0 7.4

9.7

9.4

8.2 7.4

9.6

8.5

10.1 10.3

9.00

9.00

7.66

5

9

7

8.63

8.50

6.98

6

2

6

231 M F

7.7 7.7

8.4 7.8

8.5 8.0 8.1 8.4 8.6 8.6 8.9

8.20 3 8.26 8

232 M F

6.0 7.4

6.8 7.4 6.73 3 7.40 1

234 M F

8.8 8.0

8.9 8.6

9.0 9.0

9.3 9.8 10.2 9.33 6 8.53 3

236 M F

7.1 5.3

7.2 7.1

7.6 7.4

8.1 7.6

8.2 7.9

8.2 8.2

8.3 8.2

8.3 8.4 7.93 9 7.39 7

237 M F

7.0 5.4 5.6 5.8 6.8 7.3 7.3

7.00 1 6.37 6

238 M F

7.2 5.0

7.6 6.8

8.0 7.0 7.2 8.1

7.60 3 6.82 5

PERCHLOJIDE'IHYLENE: MOLTIGENERATION lNHAUITION STUDY IN THE RAT

INDIVIDUAL .ANlMIIL DATA SUPPLEMENT

APPENDIX 22C

BODYWEIGHTS (g) BY LITIER ro ll'IY 5 POST PARTLM - F2C PUPS MALES JlAM FEMALESPUP INDIVIDUAL WEIGHTS ll'IY NO: 5 MEAN CNT. MEAN NtMBER CNT.SEX 1000 ppn wr. wr.

240 M 7.8 7.9 7.9 8.0 8.0 8.2 8.3 8.7 8.8 8.18 9 F 7.9 8.2 8.4 8.17 3242 M 7.9 8.5 8.5 9.2 9.2 8.68 5 F 7.5 8.2 8.3 8.4 8.5 8.20 5243 M 7.1 7.5 7.5 7.6 7.5 8.0 8.8 7.73 7F 7.0 7.1 7.6 7.23 3245 M 9.5 10.1 10.2 9.93 3F 8.9 9.6 10.0 10.4 11.1 11.2 10.20 5246 M 7.0 8.1 8.3 8.5 8.5 8.8 8.8 8.8 9.2 8.44 9F 7.5 7.8 7.9 7.73 3247 M 8.5 9.1 9.1 9.2 10.1 9.20 5F 8.8 9.5 9.9 10.2 10.4 10.5 9.88 6248 M 10.6 10.6 10.9 11.2 11.8 11.02 5F 11.8 11.80 1

-----------------------GROUP SlM1ARY MEAN 8.41 107

8.23 78S.D. 1.12 0

1.37 0COUNT 18

18

-----------------------

n-Ir........,........,0.....,""

.....w..,0

LAC950-03/05



APPENDIX 23

ORGAN WEIGHTS (g) - Fl GENERATION

Organs were only weighed from animals surviving to scheduled termination.

The right kidney from male 161 and left kidney from female 186 were notweighed in error.

Key:

NO = number WT = weight RGHT = right

CTL/P/4097 - 1341

LAC960-05/03

PERCHLORDETHYLENE: MULTIGENERATION 1Nf!ALATION STUDY IN THE RAT


APPENDIX 23

GRJJUP: 01 OOSE LEVEL: 0 ORGAN WEIGHTS ppn

(g) - Fl. GENERATION SEX: MALE

ANIMAL NO.

BODYWEIGHT (g)

TESTIS wr LEFT

TESTIS wr RGHT

KIOOEY wr LEFT

lClLNEY wr RGHT

LIVER WEIGHT

1 552.0 1.735 1.760 1.772 1.693 20.390

2 521.0 1.530 1.542 1.500 1.571 18.137

3 533.0 1.783 1.803 1.823 1.789 19.967

".... r......., ...... ""' 0 u::> .....

..... w ""'N

4 534.0 1.935 1.845 1.928 2.098 20.673

5

6

550.0

556.0

1.669

1.595

1.635

1.611

2.008

1.714

2.024

1.772

21.672

19.375

7 542.0 1.743 1.752 1.810 1.876 16.269

8 600.0 1.920 1.871 2.227 2.196 21.299

9 560.0 1.659 1.689 1.748 1.729 18.360

10 479.0 1.679 1.655 1.566 1.613 16.797

11 535.0 1.954 1.970 1.644 1.626 20.008

12 550.0 1.689 1.660 2.039 2.113 22.120

13 507.0 1.584 1.624 1.481 1.532 17.026

14 529.0 1.754 1.744 1.712 1.826 18.657

l5 573.0 1.865 1.819 2.278 2.437 23.336

16 589.0 1.597 1.610 1.909 2.028 21.796

17 608.0 1.845 1. 781 1.965 1.839 21.051

18 586.0 1.612 1.671 1.805 1.758 22.690

19 600.0 1.570 1.556 1.998 1.893 20.020

LAC960-05/ 03

PERCHLORDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL i\NlMtiL DATA SUPPLEMENT

APPENDlX 23

GROUP: 01 roSE LEVEL: 0 ORGAN WEIGHTS ppn

(g) - F1 GENERATION SEX: MALE

i\NlMtiL NO.

BODYWEIGHT (g)

TESTIS wr LEFr

TESTIS wr RGHT

Kil:NEY wr LEFr

Kil:NEY wr RGHT

LIVER WEIGHT

20 525.0 1.880 1.884 1.559 1.521 18.171

21 535.0 1.652 1.705 1.732 1.709 23.078

22 531.0 1.608 1.596 1.726 1.728 19.894

n -; r..._..,..._ ""0 <.0.....,

..... w "" w

23

24

539.0

545.0

1.679

1.616

1.759

1.600

1.688

1.882

1.723

1.854

19.730

24.442

U\C960-05/03

PERalLOROETHYLENE: MULTIGENERATION lNHAIATION STUDY IN THE RAT


APPENDIX 23

ORGAN WEIGHTS (g) - F1 GENERATION GROUP: 02 DJSE LEVEL: 100 ppn SEX: MALE

ANIMAL BODYWEIGHT TESTIS TESTIS lCillNE:Y lCillNE:Y LIVER 00. (g) wr LEFr wr RGHT wr LEFT wr RGHT WEIGHT

49 675.0 1.491 1.534 2.043 2.117 25.910

50 656.0 1.632 1.652 1.953 2.141 23.838

51 674.0 2.006 2.113 2.197 2.296 25.481

52 613.0 1.739 1.780 1.865 1.923 23.185

53 530.0 1.654 1. 710 1.740 1.816 20.117

54 580.0 1.631 1.594 1.557 1.612 20.725

55 612.0 1.840 1.843 2.042 2.lll 26.477

56 617.0 1.698 1.731 1.680 1.782· 21.437

57 575.0 1.813 1.826 1.724 1.714 21.392

59 548.0 1.603 1.518 1.574 1.741 19.430

60 555.0 1.581 1.500 1.783 1.977 22.053

61 625.0 1.648 1.682 2.056 2.051 22.974

62 571.0 1.748 1.752 1.949 1.947 19.120

63 506.0 1.549 1.600 1.699 1.883 18.332

64 543.0 1.502 1.611 1.519 1.640 18.801

66 568.0 1.533 1.572 1.814 1.896 23.782

67 567.0 1.675 1.690 1.721 1.631 19.449

68 559.0 1.492 1.541 1.766 1.642 22.023

69 624.0 1.559 1.584 2.069 2.078 23.767

("')

-i r-...... "'0 ...... -"' 0

"" ......

.... w -"' -"'

LAC960-05/03


INDl'li!JlW. llNIMAL Il'lTA S\JPPLl;MENT

APPENDIX 23

GROUP: 02 IXlSE LEVEL: 100 ORGAN WEIGHTS ppn

(g) - F1. GENERATION SEX: MALE

llNIMAL NO.

70

71

72

BODYWEIGHT (g)

646.0

547.0

610.0

TESTIS wr LEFr

1.836

1.942

1.627

TESTIS wr RGHT

1.836

1.891

1.574

lGINEY wr LEFl'

2.003

1.513

1.757

lGINEY wr RGHT

2.184

1.527

1.840

LIVER WEIGHT

27.379

19.080

21.129

C'")_, r.._ -o.._ ~ \0 ......

.... w _;,. c.n

UIC960-05/03

PERCHLORDET!IYLENE: !1llLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIWAL .1\NIMi\L DATA SUPPI..EMENT

APPENDIX 23

GROUP: 03 OOSE LEVEL: 300 OBGAN WEIGHTS Jlliil

(g) - Fl GENERATION SEX: MALE

.1\NIMi\L NJ.

BODYWEIGHT (g)

TESTIS wr LEFT

TESTIS wr RGHT

KI:J:mY wr LEFT

KI:J:mY wr RGHT

LIVER WEIGHT

97 553.0 1.497 1.478 1.812 1.909 21.799

98 532.0 1.644 1.781 1.638 1.929 21.081

99 517.0 1.352 1.389 2.752 1.893 18.272

n -1 r--c -""' 0

"" ....,

-w

""' O"l

100 594.0 1.710 1. 731 2.316 2.330 26.834

101 547.0 1.761 1.711 1.883 1.930 16.394

102 594.0 1.737 1.796 2.095 2.283 22.570

103 541.0 1.564 1.588 2.044 1.809 18.828

104 591.0 1.588 1.565 1.581 1.719 21.861

105 620.0 1. 706 1.731 2.019 2.206 12.354

106 584.0 1.664 1.677 2.010 2.036 23.998

107 592.0 1.666 1.677 2.198 2.385 26.739

108 495.0 1.527 1.549 1.671 1.877 17.931

109 540.0 1.582 1.588 1.580 1.675 18.175

110 574.0 1.650 1.628 1.848 1.909 22.367

1ll 574.0 1.617 1.667 1.807 1.831 19.822

ll2 527.0 1.668 1.643 1.805 1.920 19.778

113 557.0 1.668 1.646 1.882 1.972 23.799

114 514.0 1.433 1.454 1.624 1.502 18.982

115 601.0 1.478 1.519 1.985 2.134 24.743

LAC960-05/03

PERCHLOB!lET!IYLENE' 11IJLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 23

GROUPo 03 LOSE LEVEL: 300 ORGAN WEIGHTS ppn

(g) - Fl GENERATION SEX: MALE

'"' -;,........_ '"0...._..,. 0 \0....,

..... w..,.....,

~-

ANIMAL NO.

ll6

ll7

ll8

ll9

120

BODYWEIGHT (g)

616.0

564.0

559.0

615.0

555.0

TESTIS wr LEFr

1.808

1.698

1.419

1.553

1.667

TESTIS wr RGHT

1.820

1.669

1.457

1.491

1.661

KrJ:tlEY wr LEFr

1.956

1.829

l. 794

1.704

2.061

KrJ:tlEY wr RGHT

2.169

l.8l5

1.862

1.740

2.031

LIVER WEIGHT

23.901

20.252

19.598

22.006

23.450

l.IIC960-05/03



APPENDJX 23

GRJJUP: 04 DJSE LEVEL: 1000 ORC.-'IN WEIGHTS P!Ifl

(g) - Fl GENERATION SEX: MilLE

ANlMAL NJ.

BODYWEIGHT (g)

TESTIS wr LEFT

TESTIS wr RGHT

lCliNEY wr LEFT

lCliNEY wr RGHT

LIVER WEIGHT

145 443.0 1.556 1.625 1.801 1.753 17.609

146 503.0 1.297 1.402 1.988 2.047 20.102

147 533.0 1.541 1.536 1.948 1.987 22.683

n_, r....... -o .........,. 0 <.0....,

-w..,. "'

148

149

150

151

152

153

154

155

513.0

598.0

491.0

535.0

474.0

511.0

503.0

486.0

1.447

1.434

1.503

1.381

1.484

1.459

1.395

1.337

1.503

1.454

1.476

1.413

1.494

1.437

1.494

1.377

2.187

2.127

1.613

1.932

1.622

2.235

1.763

1.562

2.110

2.270

1.748

2.115

1.753

2.117

1.888

1.577

22.603

29.776

19.229

24.477

18.365

18.021

20.943

18.718

156 511.0 1.442 1.441 1.766 1.931 21.599

157 495.0 1.315 1.343 1.915 1.825 21.685

158 501.0 1.387 1.421 1.881 1. 795 20.139

159 529.0 1.377 1.335 1.844 1.839 21.252

160 584.0 1.715 1. 736 1.743 1.974 23.277

161 460.0 1.235 1.315 1.522 20.389

162 429.0 1.495 1.504 1.638 1.677 18.053

164 514.0 1.516 1.557 2.152 2.103 27.921

LAC960-05/03

PERCHLOROETHYLENE: l1IJLTIGENERATION IN!!ALATION STUDY IN THE RAT

INDIVIDUAL AN1MAL DATA SUPPLEMENT

APPENDIX 23

GROUP: 04 roSE LEVEL: 1000 OBGAN VlEIGHTS ppn

(g) - Fl GENERATION SEX: MilLE

n ..... ' ........., ....... """ 0., .....,

1-' w

""".,

AN1MAL NO.

165

166

167

168

BODYWEIGHT (g)

457.0

584.0

458.0

435.0

TESTIS wr LEFT

1.326

1.549

1.298

1.296

TESTIS wr RG!rr

1.324

1.587

1.342

1.342

I<IIMY wr LEFT

1.623

2.812

1.733

1.431

I<IIMY wr RG!IT

1.531

2.659

1.770

1.539

LIVER VlEIGHT

17.682

28.113

19.637

17.680

LAC960-05/03


INDIVIDUAL ANlMIIL DATA SUPPLEMENT

APPENDIX 23

ORGAN WEIGHTS (g) - Fl. GENERATION GROUP: 01 OOSE LEVEL: 0 P!lll SEX: rn1ALE

ANlMIIL BODYWEIGHT KIJ:llEY KIJ:llEY LIVER N:l. (g) wr LEFr wr RGHT WEIGHT

25 329.0 0.973 1.076 11.490

26 354.0 1.067 1.166 15.276

27 354.0 1.117 1.172 14.081

28 339.0 1.168 1.235 14.989

29 394.0 1.365 1.446 14.860

30 312.0 1.078 1.017 12.769

31 381.0 l.ill 1.074 14.262

32 359.0 1.053 1.118 13.487

34 356.0 1.178 1.215 15.431

35 331.0 1.118 1.120 13.157

36 411.0 1.192 1.209 15.893

37 367.0 1.102 1.230 15.088

38 364.0 1.100 1.138 14.288

39 388.0 1.287 1.558 15.618

40 322.0 1.104 1.159 14.798

41 344.0 1.207 1.199 13.999

42 314.0 1.045 1.144 12.380

43 346.0 1.073 1.174 11.401

44 384.0 1.243 1.311 16.430

("') -I r ...... ""' ...... ~ 0 ....., ""

...... w U'l 0

L\C960-05/03

PERCHLORDETHYLENE: 11IJLTIGENERATION INHAlATION STUDY IN THE RAT

INDIVIDUAL ANlMAL Jlo\TA SUPPLEMENT

APPENDJJ( 23

ORGAN WEIGHTS (g) - Fl GENERATION GROUP: 01 IXJSE LEVEL: 0 JliDl SEX: FE1ALE

ANlMAL BODYWEIGHT KI:OOEY KI:OOEY LIVER NO. (g) wr LEFT wr RGHT WEIGHT

45 388.0 1.154 1.252 15.009

46 365.0 1.108 1.180 13.255

47 343.0 1.076 1.104 14.770

48 357.0 1.277 1.331 14.124 C"') -i ;...... "'0 ...... .... 0 1.0....,

-w U1-

LAC960-05/03

PERCHLORDETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT

INDIVIOOAL ANn111L DATA SUPPLEMENr

APPENDIX 23

ORC.~ WEIGHTS (g) - F1. GENERATION GROUP: 02 OOSE LEVEL: 100 ppn SEX: EEMAl.E

ANn1IIL BODYWEIGHT KII:NE\' KII:NE\' LIVER NO. (g) wr LEFT wr RGHT WEIGHT

73 319.0 1.040 1.074 11.971

74 324.0 1.140 1.236 12.818

75 329.0 1.006 1.lll 12.870

76 286.0 1.108 1.110 10.392

77 321.0 1.107 1.146 11.035

78 324.0 1.037 1.092 10.985

80 369.0 1.168 1.210 13.345

81 315.0 0.989 1.035 11.555

82 289.0 1.029 1.062 11.442

83 333.0 1.061 1.032 11.299

84 288.0 0.918 1.039 10.134

85 342.0 1.236 1.171 12.665

86 305.0 1.150 1.294 14.280

87 311.0 0.891 1.028 11.811

88 386.0 1.178 1.268 15.585

89 297.0 0.999 1.121 10.966

90 291.0 1.040 0.900 9.891

91 326.0 1.064 1.136 11.409

92 317.0 1.096 1.092 10.555

n ~ r-....... '""' .........,. 0 ...., '""

..... w <.TI N

--

-----------

UC960-0S/03

PERC!lLOROETHYLENE: MDLTIGENERATION INHALATION STUDY IN THE RAT


APPENDIX 23

ORGAN WEIGHTS (g) - F1 GENERATION SEX: F.EMt\LE100 GRIJfJP: 02 roSE LF»EL: Jlllll

KIDNEY LIVER ANlMAL BODYWEIGHT KIDNEY wr RGHT WEIGHT NO. (g) wr LEFT

1.129 10.420 93 307.0 1.069

0.962 9.960 94 321.0 0.985

1.107 10.791 95 318.0 1.017

0.963 8.396 96 269.0 0.938

-;""'r -o----.,.0\0......

.....wU"lw

LAC960-05/03

PERCHLOROETHYLENE: l1ULTIGENERATION INHAIMION STUDY IN THE RAT

INDIVIDUAL IIN1MAL DATA stlPPLEMENT

APPENDJX 23

ORGAN WEIG!ITS (g) - F1. GENERATION GROUP: 03 IXJSE LEVEL: 300 ppn SEX: ID1ALE

IIN1MAL BODYWEIG!IT KII:NEY KII:NEY LIVER 00. (g) wr LEFT wr RGHT WEIG!IT

121 367.0 1.085 1.203 17.219

124 326.0 1.031 1.126 13.891

125 351.0 1.043 1.191 14.353

126 356.0 1.090 1.102 13.578

127 332.0 1.066 1.019 13.791

128 348.0 1.224 1.316 15.310

129 349.0 1.101 1.198 14.698

130 345.0 1.001 1.106 13.909

131 333.0 1.224 1.234 11.711

132 349.0 1.107 1.070 15.001

133 322.0 0.970 0.943 11.219

134 365.0 1.180 1.135 13.527

135 363.0 1.091 1.215 16.074

136 337.0 1.051 1.078 12.699

137 343.0 1.153 1.232 12.697

138 420.0 1.145 1.207 14.414

139 327.0 1.055 1.106 13.664

140 354.0 1.225 1.159 14.463

142 315.0 0.889 0.963 13.533

n ...;,... ...... "'0 ...... 0 ""' ...., '""

w -U"1

""'

LAC960-05/03

PERCHLORDETHYLENE: MlJLTIGENERATION INHALATION STUDY IN THE RAT

INDI\IIIJlJAL AN1WIL Il';TA S1.JPl'L'EMENT

APPENDIX 23

GROUP: 03 OOSE LEVEL: 300 ORGAN WEIGHTS ppn

(g) - F1. GENERATION SEX: FEMALE

AN1WIL NO.

143

144

BOIJYWEIGHT (g)

374.0

354.0

lGJJNEY wr LEFr

0.976

1.249

lGJJNEY wr RGHT

1.097

1.212

LIVER WEIGHT

15.251

15.777

("') -;,...... "'0 ........, 0 1.0....,

..... w c..T1 c..T1

.

I..IIC960-05/03

PERCHLORDET!IYLENE: MDLTIGENERATION IN!l.!ILATION STUDY IN THE RAT

INDIVIJXIAL ANlMIIL DATA SUPPLEMENT

APPENDIX 23

ORGAN WEIGHTS (g) - Fl GENERATION GROUP: 04 OOSE LEVEL: 1000 ppn SEX: FEMALE

ANlMIIL BODYVlEIGHT KII:NEY KII:NEY LIVER NO. (g) wr LEFT wr RGHT WEIGHT

169 309.0 1.068 1.123 13.531

170 334.0 0.695 1.476 14.278

171 390.0 1.246 1.318 15.880

172 373.0 1.220 1.189 13.485

173 300.0 0.961 1.024 11.093

174 350.0 0.939 1.021 14.309

175 321.0 1.044 1.056 14.530

176 304.0 0.968 0.978 12.434

177 332.0 1.084 1.162 14.446

178 336.0 1.468 1.518 14.118

179 309.0 0.934 1.006 11.952

180 330.0 1.102 1.060 12.759

181 396.0 1.033 l.lll 14.322

182 317.0 0.960 1.086 12.237

186 313.0 1.090 14.191

187 320.0 0.967 0.987 13.845

188 363.0 1.218 1.292 14.805

189 329.0 0.948 1.027 14.305

190 378.0 1.092 1.169 15.544

('"") -i r....... -o ....... ""' 0 '-0....,

.... w U'1

"'

LAC960-05/03

PER!::HLORDETHYLENE: M!JLTIGENERATION lNHALATION STUDY lN THE RAT


APPENDIX .23

ORGAN lYEIGHTS (g) - F1. GENERATION GROUP: 04 lXlSE LEVEL: 1000 ppn SEX: FEMALE

ANlMAL BODYWEIGHT JallNEY JallNEY LIVER NO. (g) wr LEFT wr RGHT lYEIGHT

191 347.0 0.999 1.085 12.696

192 292.0 0.990 0.938 10.637

("") ..... r .._ "'0.._.., 0 <0 .....

..... w <J1 .....

L8C960-05/03

PERCHLOROE'l.HYLENE: MIJLTIGENERATION INHA!..ATION STUDY Til THE RAT

INDIVIDIAL liNll1AL DATA SUPPLEMENT

APPENDIX 23

ORGAN WEIGHTS (gJ - fl GENERATION GROUP: 03 IXJSE LEVEL: 300 ppn SEX: MilLE

-------------------------- C 0 MM EN T S -------------------------- liNll1AL NO.

98 CYST ON RIGHT KIDNEY.

99 MASS ON LEFT KIDNEY.

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APPENDIX 24

ORGAN WEIGHTS (g) - F2A PUPS

Organ weights for male 85A and kidney weight for female 140A were missed in error.

Key:

NO. = number TERM = terminal bodyweight KIDB = kidney (both) LIV = liver TESB = testes (both) PUPID = pup identification

CTL/P/4097 - 1359

PERCHLORDEI'HYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT INDIVIlXIAL ANIMAL DATA SUPPLEMENT

APPENDD: 24 ORC.-'IN WEIG!ITS (g) - F2A PUPS

MALES GROUP: 1 IXJSE LEVEL: 0 PR1

PARENT EEMALE N:l. PUPID TEilM KIDB LIV TESB

28 B 74.9 0.856 4.586 0.571 29 A 88.0 0.993 4.752 0.8ll 30 A 79.1 1.045 4.674 0.634 31 A 99.6 1.078 4.960 0.752 37 F 59.0 0.758 3.065 0.470 38 A 98.5 1.165 5.542 0.913 40 F 73.3 0.893 4.360 0.508 41 B 67.5 0.944 3.959 0.519 43 46

B A

80.7 75.4

0.932 0.888

4.060 4.169

0.566 0.609

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PERCI[.()ROETHYLENE: MJ.JLTIGENERATION INHAlATION STUDY IN THE RAT INDlVIIJUAL ANlMAL llAl'A SUPPLEMENT

APPENDIX 24

MALES ORGAN WEIGHTS (g) - F2A PUPS

GROUP: 2 IXlSE LEVEL: 100 PIM

PARENT FEMALE 00. PUPID TERM KIDB LIV TESB

73 74 75 85

B c B A

71.1 83.8 86.8 90.5

0.918 1.111 1.117

4.184 5.147 5.206

0.5460.558 0.782

86 89 91 92 95 96

A B D A J B

73.2 93.5 85.6 112

97.3 92.1

0.833 1.209 1.027 1.222 1.217 1.303

4.189 5.313 4.830 6.189 4.964 5.295

0.5870.7460.689 0.878 0.9990.821

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PERCHI.ORDETHYLENE: MIJLTIGENERATION INHALATION STUDY IN THE RAT OOIVTIX!AL ANJM\1 DATA SUPPLEMENT

APPENDIX 24 ORG!ill WEIGHTS (g) - F2A PUPS

M\LES GROUP: 3 !XJSE LEVEL: 300 PFM

PARENT FE1I\LE NO. PUPID TERM IGDB LIV TESB

121 125 126 128 131 132 134 135 136 144

B B D B A A A c c F

78.1 92.4 74.8 70.5 80.5 70.7 73.2 78.0 86.3 76.6

0.929 1.226 1.019 0.908 0.888 0.942 1.010 0.878 l.ll9 0.981

4.390 4.459 4.248 3.669 4.087 3.949 3.972 4.397 4.562 4.288

0.697 0.727 0.656 0.538 0.7100.516 0.462 0.606 0.587 0.568

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MALES GROUP: 4

PERCHLORDETH

IXJSE LEVEL:

YLENE: MIJLTIGENERAINDIVIOOAL ANIMAL

APPENDIX 24 ORGAN WEIG!ITS

1000 PR1

TION Il!\.TA SUPPLEMENT

tg)

INHAI..A1'ION STUDY IN THE RAT

- F2A PUPS

PARENT FE1ALE 00. PUPID TERM IGDB LIV TESB

169 170 171 174 176 181 185 186 189 191 192

c c J F E B c B G D A

82.6 103

84.1 87.4 68.0 84.4 99.3 69.0 88.0 94.0 88.1

1.072 1.404 0.998 1.126 0.944 1.046 1.175 0.923 1.019 1.090 1.001

4.307 6.208 4.589 4.652 3.375 4.276 5.075 3.732 4.834 4.602 4.714

0.597 0.736 0.523 0.670 0.486 0.670 0.790 0.506 0.631 0.801 0.717 ("")

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PERCHLOROETHYLENE: MULTIGENERATION INHAlATION STUDY IN THE RAT INDIVIllUAL ANlMAL rnTA SUPPLEMENT

APPENDIX 24 ORC.-'lN WEIGHTS (g) - E2A PUPS

FEMALES GROUP: 1 lXlSE LEVEL: 0 PEM

PARENT FEMALE N:l. PUPID TERM KIDB LIV TESB

25 A 82.9 0.893 4.204 26 B 75.4 0.994 4.232 32 E 90.7 1.231 4.934 35 A 66.8 0.794 3.656 36 B 85.2 0.969 4.338 39 I 84.1 1.054 4.564 44 B 77.2 0.946 4.317 45 G 72.5 0.975 4.402 47 B 71.1 0.875 3.704 48 A 89.9 1.261 4.767

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PERCHLOROE'l'l!YLENE: !10LTIGENERATION INHALATION STUDY IN THE RATINDIVIIJUAL ANIMAL DATA SUPPLEMENT

APPENDIX 24ORGAN WEIGHTS (g) - F2A PUPSFEMALES

GROUP: 2 IXlSE LEVEL: 100 PEM PARENT FEMALE NO. PUPID TERM KIDB LIV TESB

77 c 82.4 0.974 4.37578 A 73.5 0.925 4.24781 c 74.3 0.840 3.94982 A 79.8 0.994 4.91283 B 78.5 0.967 4.88684 A 72.4 0.952 4.08089 c 78.6 1.044 4.68890 A 81.2 0.906 4.24593 c 67.1 0.919 3.64794 A 81.8 0.966 4.337r.--!.............""-1'>0....,"'

......

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PERCHLOROEI'HYLENE: MULTIGENERATION INHALATION STUDY IN THE RAT INDIVIDJAL ANIMAL JliiTA SUPPLEMENT

APPENDIX 24

ID1ALES ORGAN WEIGHTS (g) - F2A PUPS

GROUP: 3 IXlSE LEVEL: 300 PEM

PARENT FEMALE 00. PUPID TERM KIDB LIV TESB

121 c 78.4 1.105 4.033 122 A 78.6 1.000 4.493 125 c 78.8 1.076 4.128 129 E 76.6 0.989 3.645 130 G 81.6 1.020 4.693 137 E 85.0 0.981 4.958 138 c 81.6 0.986 4.522 140 A 71.8 . 3.711 142 A 87.8 1.037 4.473 143 G 78.8 0.896 4.252

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PERCH!..OROETHYLENE: !1llLTIGENERATION INHAIATION STUDY lli THE RAT lliDIIIIIXTAL l\NIMAL DATA SUPPLEMENT

APPENDIX 24

l!'EMALES OBGAN WEIGHTS {g) - F2A PUPS

GROUP: 4 OOSE LEVEL: 1000 PEM

ARENT 1!'EMALE NO. PUPID TERM KIDB LIV TESB

169 170 174 176 181 185

K D G F c D

69.8 92.1 80.2 57.5 84.3 86.1

0.945 1.383 1.057 0.800 0.951 0.976

3.635 5.132 4.057 2.737 4.387 4.860

186 c 68.5 0.860 3.309 187 K 88.1 1.010 4.354 189 H 75.6 0.972 4.054 191 E 84.7 1.029 4.640 192 B 85.1 1.072 4.152

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c953-04/00 tile rat - us epa...jun 27, 1995 · +ve 91ear 300 pci : pjlll date gest'n male...

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