c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · xiii. a noli steady state kinetic evaluation of the...

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Page 1: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

~u )) jl rI~Hmiddot-~l )j~ JtT In r-- JllAs 1) )iW 4oIu 0)I1Jl

~)r -oAU )~~ ~I ~c5~gt~ ~)) Jjl EJ jlhic=jr )1 U)J

tlr oUu-- yJjJ u b ~I ~ 4)Jo ~jlr JIIrlioU ~ vt 0 Ir tl~ j1lAs

c5-y~I~ ~u c5)b ~1 Jjl Ir ~ ~)ru-- J)jJ ~ 1~1 ~ 4lJo JFS

o ~~ 4ilj)j~ jj rvJ c51jl ~ r~ TT jlb-~ (phenylbutazone) )jtJ~

bullgt c5t1lt i~ bl J)jJ 0)1gt1 j 1r j) v ~~ c5~gt ~1 ~~ c5~gt J)jJ ju

- ~ bullir )1 4oIu ))~ 0)11)) )1lAsBUN Jo-J t ~x tJsJl

1-1 )~xlii-- c5-YU=_1 ~~ c5)b Ia olb ~1~1 lLe ) j1JA~

u~ )~j~ )j rvJ Ijl ~ r~ middot1 )1b- ~ (Isoflupredone acetate)

ir bU c5~gt J)jJ ~ c5)b c5~1 ~ ~u )14oIL )) )1lAs ~ )jtJ ~ J)jJ 1)) 4)))1 I~I)~ eli

middot0 J-I-S Jljil T MCHC Jljil IT J Jljil (0 JA c5tJrlS

-~ IS( ~w ISv ~ ISW -J5ISl ~ 1)IjlJljil

)1lAs ~ I)~xlikyJjJI)) (pltIO)1 ~b)b~ IS((V )gt I5rlTl - bull oljil W )i Jljil ~ JA c5tJrlS )1LU 4oIu ))

jlIST t ~x JjiXTO~ Jo-Jbull IST1l ~ ISjAJ( )iis1

-~ Jljil X~~w Jlji1t to ~ Jljil XTOA-J5 bull IS ((1 )gt )1

(pltoloO)1 ~b)b~ ISj~

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~lI~ ~ ltS lA4i Jl ltS~J-Ir-i-

l)JA Jl 0~ XJol~ jJr GuiJli ltSlAC--~

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J jol

v

J

J

tSlJ~Ab tSLjJJ tSl~~ ~lL

T 0) jI JP J$ ~l tSljJJ ~ ~L)

JJ~t ~lA-1

rn = rnl- rn2

010 rnxlOO tJ1JIJ Iw=gtJ~ = 2JoO- rn

jJJ r ~ J~ ~~ ViJ 0 ~~ = rnl

~bull LmiddotIJ

lYJ jI Ji) uU jJJ J~ 01~~~l- = rn2

(JJb

~ ~

J 0JjIJ yJa lYJ jl bulllA1 ~~ ~

J~ ~L) ~J 01~~ ~ u1 0J~liJy1

)bull JJu- I bulllo ~~ r J JW JJ1ushy

~IS~jluIISUr-IJ~ ~~ --J~ - JJ~

J~ ~l1 cJJIJ(uJiI J cJJjliJ ~JJ~ jl ~~

~IjlJ Ji b1 ~I1tJtJliljtl sl~~~

+IA(NS) +OV(NS) j- IStJrlLW

+1(10middotmiddotmiddotmiddot +IVbullbull Jci IStJrlW

+1t +I(NS) 1It +I(NS) - o(NS) vw +middottmiddotmiddotmiddotmiddot -I(NS) MeHC

_o(NS) -fA(NS) MCH

-I(NS) -VA(NS) MCV

(IV(NS) +W ~I

+If(NS) -nfbullbull

WO(NS) -Iff amp1

-IOv(NS) -Wymiddotmiddot ~~I

J~~ ~~ tSlr- ~J~ rl~J JJJJ

~lAIJi ~L tSJ~ tSl4lJ J~ J ci$ ~rA

LtS tSJJI~ EDTA

~ cr ~~ tSlIJ~ tSrS jIu1 ~

jl ~J- J-I ~ ~ 0Y-~~ A 01r- ~ J~

J~~ ~~ tSlr- ~J~ rbJ JJ

jti-rL ~L) tSl4lJJ~ JlotS ci$~rA

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tSJJI~ )J J ~Lw t~ ~ ~J~

~$tS

jl ~ 4L1i~ tSjJlJ u~L

Yj tSlJ~ hW LtS i~1 tSrS0Yshy

J ~ts ~~~ 01J-t ~ J ~

o~lA-1 ~ (MCV MCH MCHC) J~tSl~u1

Jt ~)obull ~~ ~ J Ii-~ tSl~JJ jl

gtL ~ ~jAb ~o 0 0 tSjJlA ~Jfill

tSlJ~ ~ ~JW j$ uJ- 0l11

J ~y- ~- ~ jI ~ Iw=gtJ~ uJ-~ ~

j$ UJ- 4J ~ tSr-IJ

~)J)S~JJ ~ ir JJr-lStSrSmiddotjIli1

JJ- ~JJ ~ ir- i V ~Jn tS~middotjlli1

~j JJjJ5 ~JJ ~ ir ~ tSrSmiddotjlli1

~y ~ltS ~JJ ~ ir BUN tSrSjlli1

4 ISP rJi 41-J~ (r r-t J ~ 1Sr$middotjlJ1

ri-i 1Sr$jlJ1 J blS rL F1M2S1 JAo ~

(~)J ~JjltJ jJl) J 5JcJJJ JJJ ~ (r

u~UI tSJLI JJ- J ~~ J~~

~ J dgt~ ~~ ~JU ~JJ jl bull lA ~

bullbullbullbull bullbullbull bullbull

J

( )

-y

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+tolluU

-11

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+

e NS

J shy~I ~ I ~ b yl I)v~ IJfIJj J

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yJJJei- J1Slt-~

~lS ~J (-TV

IS~ (rt)

u lw ltlt_I~~J

-- ISI IS)r

~ hY ulj~1(W) ~ (ttL yAjj

s~(WA)

(n)

(pltO05)

b

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(n)

(V)

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J

J

J J J

J

J

Y)

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)

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(YI)

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vt=-6yeni JJ~~ JJI

~)rJ1 ltbh~ J

(t) f~

~I

J

J

V) ub~ J (Wanner)

~ SJ ti

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~~~o~~ Wtl s ~~ ci~ ~S

( Wo) ~r=-~

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~ uJlb Wtl JiIJ J ~) )I)~ ~S

~ J ) uJgtVt t(SJJgt fil

I~ uly~ ul 151Jgt ~6- J6- Jl

I 15J15tJ I5tJLI5J) Jgt UJjbYo

~p ( 15t4JfiJl

JJ-IS )iU

J rt (pltOOl) 1 ci~ ~Ijl I5Jb~

( ~A) vJ$

yJ YA 15t~1 uJe-I~1 ~Ij

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h Jb jl JJ ~ uy 15t-~ u=t9) jl

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Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~

(YO)

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4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~

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u~(AT) uL~

J~ ~ ---Jlr-shy

umiddotv 0

AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)

J) ~

J

JJJ5

J J~I ~ts

OJJJ-iI U ~IS J)

1$ jl

1_- - )I~ + J 17 8J

(YV) ~ o~) rb J

The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 2: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

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J jol

v

J

J

tSlJ~Ab tSLjJJ tSl~~ ~lL

T 0) jI JP J$ ~l tSljJJ ~ ~L)

JJ~t ~lA-1

rn = rnl- rn2

010 rnxlOO tJ1JIJ Iw=gtJ~ = 2JoO- rn

jJJ r ~ J~ ~~ ViJ 0 ~~ = rnl

~bull LmiddotIJ

lYJ jI Ji) uU jJJ J~ 01~~~l- = rn2

(JJb

~ ~

J 0JjIJ yJa lYJ jl bulllA1 ~~ ~

J~ ~L) ~J 01~~ ~ u1 0J~liJy1

)bull JJu- I bulllo ~~ r J JW JJ1ushy

~IS~jluIISUr-IJ~ ~~ --J~ - JJ~

J~ ~l1 cJJIJ(uJiI J cJJjliJ ~JJ~ jl ~~

~IjlJ Ji b1 ~I1tJtJliljtl sl~~~

+IA(NS) +OV(NS) j- IStJrlLW

+1(10middotmiddotmiddotmiddot +IVbullbull Jci IStJrlW

+1t +I(NS) 1It +I(NS) - o(NS) vw +middottmiddotmiddotmiddotmiddot -I(NS) MeHC

_o(NS) -fA(NS) MCH

-I(NS) -VA(NS) MCV

(IV(NS) +W ~I

+If(NS) -nfbullbull

WO(NS) -Iff amp1

-IOv(NS) -Wymiddotmiddot ~~I

J~~ ~~ tSlr- ~J~ rl~J JJJJ

~lAIJi ~L tSJ~ tSl4lJ J~ J ci$ ~rA

LtS tSJJI~ EDTA

~ cr ~~ tSlIJ~ tSrS jIu1 ~

jl ~J- J-I ~ ~ 0Y-~~ A 01r- ~ J~

J~~ ~~ tSlr- ~J~ rbJ JJ

jti-rL ~L) tSl4lJJ~ JlotS ci$~rA

JJr-lS BUN tSrSjIu1 J ir tSjLlu-~

tSJJI~ )J J ~Lw t~ ~ ~J~

~$tS

jl ~ 4L1i~ tSjJlJ u~L

Yj tSlJ~ hW LtS i~1 tSrS0Yshy

J ~ts ~~~ 01J-t ~ J ~

o~lA-1 ~ (MCV MCH MCHC) J~tSl~u1

Jt ~)obull ~~ ~ J Ii-~ tSl~JJ jl

gtL ~ ~jAb ~o 0 0 tSjJlA ~Jfill

tSlJ~ ~ ~JW j$ uJ- 0l11

J ~y- ~- ~ jI ~ Iw=gtJ~ uJ-~ ~

j$ UJ- 4J ~ tSr-IJ

~)J)S~JJ ~ ir JJr-lStSrSmiddotjIli1

JJ- ~JJ ~ ir- i V ~Jn tS~middotjlli1

~j JJjJ5 ~JJ ~ ir ~ tSrSmiddotjlli1

~y ~ltS ~JJ ~ ir BUN tSrSjlli1

4 ISP rJi 41-J~ (r r-t J ~ 1Sr$middotjlJ1

ri-i 1Sr$jlJ1 J blS rL F1M2S1 JAo ~

(~)J ~JjltJ jJl) J 5JcJJJ JJJ ~ (r

u~UI tSJLI JJ- J ~~ J~~

~ J dgt~ ~~ ~JU ~JJ jl bull lA ~

bullbullbullbull bullbullbull bullbull

J

( )

-y

_HU

+tolluU

-11

_Vrn

_u -VI +fn

+

e NS

J shy~I ~ I ~ b yl I)v~ IJfIJj J

1 L--Jmiddot_~_~ ~JJ J J~ I1 t~ tul y~ bull- bull

YljtIJ ~

yJJJei- J1Slt-~

~lS ~J (-TV

IS~ (rt)

u lw ltlt_I~~J

-- ISI IS)r

~ hY ulj~1(W) ~ (ttL yAjj

s~(WA)

(n)

(pltO05)

b

)1 jl ACTH ( )

ISJJ

J

(n)

(V)

J

J

J

J J J

J

J

Y)

J

)

J --- shy

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v~)tiT J~ ~ cP~

(YI)

~IJI JJ Dtl

vt=-6yeni JJ~~ JJI

~)rJ1 ltbh~ J

(t) f~

~I

J

J

V) ub~ J (Wanner)

~ SJ ti

J I5J~ J (0)

tS)~ Jb~ ~ JJi J

~~~o~~ Wtl s ~~ ci~ ~S

( Wo) ~r=-~

~~S (~A) uL~ J

( ~A ) u6~ J -115t(S)Jgt 4

u=t9J ~ jllJ ~~S ~ ~1 JJ

Wtl JJ 4 ~hil Wtl J 1 OIJ (A J YO) ))1 uJgtlu

~ uJlb Wtl JiIJ J ~) )I)~ ~S

~ J ) uJgtVt t(SJJgt fil

I~ uly~ ul 151Jgt ~6- J6- Jl

I 15J15tJ I5tJLI5J) Jgt UJjbYo

~p ( 15t4JfiJl

JJ-IS )iU

J rt (pltOOl) 1 ci~ ~Ijl I5Jb~

( ~A) vJ$

yJ YA 15t~1 uJe-I~1 ~Ij

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~LS (JS uly~ Wt J

15t~j r pi Lt-~ LJ

h Jb jl JJ ~ uy 15t-~ u=t9) jl

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151Jgt rPJt ltgt JJ) 4~~l~ t~bfiJl

Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~

(YO)

(AY) uL~ J (Bronder)

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4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~

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u~(AT) uL~

J~ ~ ---Jlr-shy

umiddotv 0

AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)

J) ~

J

JJJ5

J J~I ~ts

OJJJ-iI U ~IS J)

1$ jl

1_- - )I~ + J 17 8J

(YV) ~ o~) rb J

The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 3: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

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jJJ r ~ J~ ~~ ViJ 0 ~~ = rnl

~bull LmiddotIJ

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(JJb

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(IV(NS) +W ~I

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+

e NS

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u lw ltlt_I~~J

-- ISI IS)r

~ hY ulj~1(W) ~ (ttL yAjj

s~(WA)

(n)

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1$ jl

1_- - )I~ + J 17 8J

(YV) ~ o~) rb J

The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 4: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

bullbullbullbull bullbullbull bullbull

J

( )

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_HU

+tolluU

-11

_Vrn

_u -VI +fn

+

e NS

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1 L--Jmiddot_~_~ ~JJ J J~ I1 t~ tul y~ bull- bull

YljtIJ ~

yJJJei- J1Slt-~

~lS ~J (-TV

IS~ (rt)

u lw ltlt_I~~J

-- ISI IS)r

~ hY ulj~1(W) ~ (ttL yAjj

s~(WA)

(n)

(pltO05)

b

)1 jl ACTH ( )

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(n)

(V)

J

J

J

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Y)

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)

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(YI)

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J

V) ub~ J (Wanner)

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( Wo) ~r=-~

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JJJ5

J J~I ~ts

OJJJ-iI U ~IS J)

1$ jl

1_- - )I~ + J 17 8J

(YV) ~ o~) rb J

The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 5: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

J shy~I ~ I ~ b yl I)v~ IJfIJj J

1 L--Jmiddot_~_~ ~JJ J J~ I1 t~ tul y~ bull- bull

YljtIJ ~

yJJJei- J1Slt-~

~lS ~J (-TV

IS~ (rt)

u lw ltlt_I~~J

-- ISI IS)r

~ hY ulj~1(W) ~ (ttL yAjj

s~(WA)

(n)

(pltO05)

b

)1 jl ACTH ( )

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J

(n)

(V)

J

J

J

J J J

J

J

Y)

J

)

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v~)tiT J~ ~ cP~

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J

V) ub~ J (Wanner)

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( Wo) ~r=-~

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~ uJlb Wtl JiIJ J ~) )I)~ ~S

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I 15J15tJ I5tJLI5J) Jgt UJjbYo

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JJ-IS )iU

J rt (pltOOl) 1 ci~ ~Ijl I5Jb~

( ~A) vJ$

yJ YA 15t~1 uJe-I~1 ~Ij

(A) la~ ~S

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15t~j r pi Lt-~ LJ

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jI ~Ici~ ~S 15)~ J1~ uYJJ~ uji

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Jl jJJ ulo ~ ~ jJJ Jl ui uJJ rP ~

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JJj-3 J~- ~) U~I JJ~ L

4 UJJby ~ (Y) ~Iu tY-Jrp UJjbYo ~

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u~(AT) uL~

J~ ~ ---Jlr-shy

umiddotv 0

AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)

J) ~

J

JJJ5

J J~I ~ts

OJJJ-iI U ~IS J)

1$ jl

1_- - )I~ + J 17 8J

(YV) ~ o~) rb J

The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 6: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

ISJJ

J

(n)

(V)

J

J

J

J J J

J

J

Y)

J

)

J --- shy

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v~)tiT J~ ~ cP~

(YI)

~IJI JJ Dtl

vt=-6yeni JJ~~ JJI

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(t) f~

~I

J

J

V) ub~ J (Wanner)

~ SJ ti

J I5J~ J (0)

tS)~ Jb~ ~ JJi J

~~~o~~ Wtl s ~~ ci~ ~S

( Wo) ~r=-~

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1$ jl

1_- - )I~ + J 17 8J

(YV) ~ o~) rb J

The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 7: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

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The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 8: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

J --- shy

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J

V) ub~ J (Wanner)

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J) ~

J

JJJ5

J J~I ~ts

OJJJ-iI U ~IS J)

1$ jl

1_- - )I~ + J 17 8J

(YV) ~ o~) rb J

The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 9: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

~I

J

J

V) ub~ J (Wanner)

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J I5J~ J (0)

tS)~ Jb~ ~ JJi J

~~~o~~ Wtl s ~~ ci~ ~S

( Wo) ~r=-~

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( ~A ) u6~ J -115t(S)Jgt 4

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JJJ5

J J~I ~ts

OJJJ-iI U ~IS J)

1$ jl

1_- - )I~ + J 17 8J

(YV) ~ o~) rb J

The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 10: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

~ SJ ti

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OJJJ-iI U ~IS J)

1$ jl

1_- - )I~ + J 17 8J

(YV) ~ o~) rb J

The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 11: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

umiddotv 0

AUiI ( tJ J olS J ( AT) otJ) ( IAf) J (Morris)

J) ~

J

JJJ5

J J~I ~ts

OJJJ-iI U ~IS J)

1$ jl

1_- - )I~ + J 17 8J

(YV) ~ o~) rb J

The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 12: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

The IOWa Stctte Univensity Press USA

20shy hrnnvl~ responses test In

hormones Am J Vet Res 49 503gt507

21 doses of 9-tJ-flunmrefiinisl3iorle acetate lM on blood 811iUIi~ serum

Sci 43 553

22shy on the eosillolphllic 1e~Yle poJ)ul8l1on of

rat tlleue I Duametbasone J of Pharmacol 189 303gt310

23 shy 1981 InJllleD=e the blood

picture of cattle Tlelranillcl1e UITiIIIhIIl11 51 2785

24 shy DP 1970 A clnicians views on the IlIIe tmd misIlIIe of phEnYll3utIIZOliIe Eq Vet J 4 63gt65

25 shy H r PM 1981

toxicosis in A ~helmlCaI Am J Vet Res 42

M 1983 Tkbullbullbull_11 nubullI1

normal

MD 1974 The effect of

26middot 1986 Textbook of anlcal ChImiddot WE saunders

27 PR and

44 1410-1418

LM 1983

28- Wanner

acetyiaiion In the hone

R 1979 A prellmlrillY

Inl MedCDrIihd Eds T Tobins JW Black tmd WE Woods LalngltonKellltud~

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 13: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

1shy

0

References Athens JW Boggs DR Wanner HR Cartwright GE and Wintrobe MM 1968

XiiI A noli steady state kinetic evaluation of the mechanism of cortisone induced

grllll1uJllicytgtsis J Cln 249

2shy Brlllnder GC Pugh DM ltUld B~er RJ 1982 Veterimuy Applied Pharmacology and Therapeutic

4th ed Greyecat hOUlle London England

3shy EH 1986 Veterinary Cnical PathI 4th ed WB Saunders Compo Philadelphia

4shy LG and Tyler DE 1985 ExperimentallY induced pnenylbutatooe toKicCISis in ponies

Description of the and its prevention with synthetic PGE2 Vet Res 48 1605-1615

5shy IdA~lst()ne D Mueller Heubach E and Caritis SN 1978 Effect of dexamethasone on leukocyte count

in pregnant sheep and fetalllllmbs Amer J Obst Onco 131 677-681

6shy Fauci DIllie DC and JE 1976 Glucocorlicoid of acHon and

clinical conSideration Ann Inter Med 84 309

7 shy Glade M J 1975 Chronic dexamethasone treatment to horse and pony foals Dissertation Abstract

International 41 6-7

8shy Goodman LS and A 1986 The Pharmacological Basis of a ~UIIIll 5th ed Macmillan

PubllShingCelnc New York USA

9shy Cbullbull____ DE 1983 Renal necrClSis in horses JAVMA 182 263-266

10 shy and L 1983 Renal papillary necrClSis in horses after phenylbutazone and water

deprivation Vet PllIthol 20 603-610

11 - Horrobin DF 1971 Essentillll Biochemistry Endocrinology and Nutrition MTP Com pp 86-87

12 shy Jones LM 1988 Veterinlllry Pharmacology and Therapeutics 6th ed The Iowa Stcde University

Press

13 - Kaneko JJ 1980 Clinical Biochemistry of Domestic Animals 3rd ed Academic Press Inc

New York

14 shy BG 1989 Basic and Clinical Pharmacology 4th ed Prentice Hau International (UK)

London

15 shy Creed Gerring EEL Gould PW Humphreys DJ Michell AR lind

Tayler JB 1983 Biochemical and haematologicaleffects of phenylbutazone in horses Vet J 15

158-176

16 shy Lees P and Higgins AJ 1985 Clinical pharmacology and therapeutic uses of non-steroidal

the horse Eq Vet J 17 83-96

17 shy MagnusonS KL E1978 In vitro and vivo effects

ohortioosteroids on blood lymphocytes from Am J Vet Res 39 gt1-wIo

18 shy TJ 1979 The pharmacologic interactions with laboratory test 596 Burnham

Etobiocoke Ontario Canada

19 shy Maxine M B5 1960 Outline of Veterinary Clnica Pathology_ 2nd ed pp 131-132

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords

Page 14: c;.#profdoc.um.ac.ir/articles/a/1038413.pdf · XiiI. A noli steady state kinetic evaluation of the mechanism of cortisone induced grllll1uJl:licyt!>sis

J No 1991

SUlLdlJ on

tn1l1amlrn2lto~ry n1lIIIInrR on 014100 J]lidule

sheep

Sa1rmldii AA

ZtllDlDlalry

In this from Veterirlaru School Animal

HulbllndilUY Unit were from 40 to

age was from 2~4 years old

blood )08tameters

Keywords