by rini agustin. introduction radioctive and how radioactive is produced : atom, radioactivity and...

17
By Rini Agustin

Upload: allyson-mcdonald

Post on 18-Jan-2016

220 views

Category:

Documents


0 download

TRANSCRIPT

Page 1: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

By Rini Agustin

Page 2: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

Introduction Radioctive and How radioactive is

produced : atom, radioactivity and radioactive decay

Radiopharmaceutical preparation Label compound Kit radiopharmacy Quality control of radiopharmaceutical Protection of Radiation Clinical application of radiopharmaceuical in

organ system of body

Radio Pharmacy (2 SKS)

Page 3: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

Saha.B.Gopal,( 2004), Fundamentals of Nuclear Pharmacy, fifth ed, New York.

Anonym ( 1994), Dep Kes RI, Farmakope Indonesia, ed IV

European Association of Nuclear Medicine, The Radiopharmacy : A technology Guide

cGRPP-guidelines, version2 March 2007,EANM Radiopharmacy Committee, Guidelines On Current Good Radiopharmacy Practice (Cgrpp) In The Preparation of Radiopharmaceuticals

Page 4: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

Trefoil first appeared in 1946

Page 5: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

SRA plus syndroma kutanius Chernobyl

An accident in Radiography industry, in Yanango, Lima PERUIr-192 (37 Ci / 1,37 TBq), 20 Feb. 1999

What is on your mind if you hear radioactive ?

Page 6: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

Radioactive/radioisotope is unstable isotope which are distinguishable by radioactive transformation.

Isotope of an atom have the same number of protons (atomic number), but a different number of neutrons.

nucleus:

neutron

protonnucleon

XZ

A A = mass number

= proton + netron

Z = atomic number

Do you know radioactive?

Page 7: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation
Page 8: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

Radioactivity: the process in which an unstable isotope undergoes changes until a stable state is reached and in the transformation emits energy in the form of radiation (alpha particles, beta particles and gamma rays).

Radiation refers to particles or waves coming from the nucleus of the atom (radioisotope or radionuclide) through which the atom attempts to attain a more stable configuration.

Page 9: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

1- Natural radioactivity: Nuclear reactions occur spontaneously (cosmic radiation, water, solar radiation, terrestrial

radionuclides))

Page 10: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation
Page 11: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

Radiation have used in health, Industry, Agriculture, Army, Power supply, Chemistry and nuclear medicineIn Health : RadiopharmaceuticalsIndustry : Cs-137, Co-60, Ir-192 for radiography, Logging dan Gauging (Cs 137 & Co-60).Agronomy : P-32, for fertilizer.Army: Th-237, Cs-137Nuclear medicine : organ Imaging , Gamma Camera, MRI

Radioactive is not always something that we affraid of it, but it is also helpfull to human life

Page 12: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

A radiopharmaceutical (Radiopharmacy) is

a radioactive compound used for the diagnosis and therapeutic treatment of human diseases

( Melichart, saha )

Radiopharmaceuticals

Page 13: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

In Nuclear Medicine - in the form of diagnostics, treatment, reasearch and

clinical trials. Radiopharmacy = Nuclear Pharmacy medicinal products for use in diagnosis and therapy =

radiopharmaceuticals

Page 14: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

Sagital

Page 15: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

Barium swallow – examination of upper GI tract Non-imaging diagnostics

Radioactive Isotope labelling for tracing i.e. More specific tests for thyroid function, renal function

and vitamin adsorption. used in tracer techniques for measuring physiological

parameters (e.g. 51 Cr-EDTA for measuring glomerular filtration rate).

Radiopharmaceuticals for diagnostic imaging

(e.g.99m TC-methylene diphosphonate (MDP) used in bone scanning, Non-osseus uptake Tc-99m MDP : Pulmonary Carcinoma).

Page 16: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

Chromic phosphate P32 for lung, ovarian, uterine, and

prostate cancers

Sodium iodide I 131 for thyroid cancer

Samarium Sm 153 for cancerous bone tissue

Sodium phosphate P 32 for cancerous bone tissue and other

types of cancers

Strontium chloride Sr 89 for cancerous bone tissue

Palliative treatment - refers to the management of symptoms

when the underlying disease is untreatable or terminal.

Radiotherapy may aid in prolonging the life of dying patients.

Page 17: By Rini Agustin.  Introduction  Radioctive and How radioactive is produced : atom, radioactivity and radioactive decay  Radiopharmaceutical preparation

The use of Radioactive in clinical application : in

nuclear medicine and radiopharmacy, medicinal

products used for diagnostic and therapy

It require very specialist radioactive substances, A

specialist discipline, “Specials” licensure, specialist

knowledge and skill