By Jamie Richardson& Derek DeFazio

Function Rough Endoplasmic Reticulum- Network of

channels that are created by membranes located in the cytoplasm

Found in the cytoplasm of eukaryotic cells

The Rough ER synthesizes

proteins for export to the outside

of the cell and enzymes to be

incorporated into cellular

organelles

Structure The rough ER gets its name from its surfaceappearance, whichis pebbly due to thepresence ofribosome's

The ER is composed of aphospholipid bi-layer embedded with proteins

Location

Pseudoachondroplastic Dwarfism

A rough-surfaced Endoplasmic Reticulum storage disease

Patients with pseudoachondroplastic dwarfism had indications of a specific ultrastructural defect—a storage in the rough-surfaced endoplasmic reticulum of inclusions with alternately electron-dense and electron-lucent layers

This disease is a rare inherited disorder consisting of skeletal malformations resulting in short legs and mild to moderate short stature.

THE ENDWork citedCooper, Reginald, and Jerry Maynard. "Pseudoachondroplastic Dwarfism."

JB&JS The Journal of Bone and Joint Surgery, 1973. Web. 25 Mar 2010. <http://www.ejbjs.org/cgi/content/abstract/55/3/475>.

"Pseudoachondroplastic Dysplasia." CIGNA. National Organization for Rare Disorders, Inc., 22 Apr 2008. Web. 25 Mar 2010. <http://www.cigna.com/healthinfo/nord1120.html>.

"rough endoplasmic reticulum ." The Free Dictionary. Elsevier, Inc, 2007. Web. 25 Mar 2010. <http://medical-dictionary.thefreedictionary.com/rough+endoplasmic+reticulum

Raven, Peter. Biology. 8th ed. Boston: McGraw-Hill company, inc, 2008. 70. Print.