bs452 immunology ( 면역학 )
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TRANSCRIPT
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Seung-Hyo Lee, PhD
Biomedical Research Center, Room 3106
Cellular Immunology Laboratory
GSMSE, KAIST
Contact Information: [email protected], 4235
BS452 Immunology (면역학)
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Course Overview• Basic concepts of immunology
• Elements of immune system (tissue, cell, molecule)
• Innate and adaptive immunity
• Antigen (Ag) recognition by immune cells
• Development of B and T cells
• B and T cell mediated immune responses
• Application of immune reaction• Immune responses against infection
• Failure of body’s defense
• Over-reaction of immunity
• Transplantation
• Tumor immunology
• Manipulation of immune response
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Course Material Available
http://cil.kaist.ac.kr
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Evaluation
• Mid-term examination: 30%
• Final examination: 30%
• Quiz and Report: 30%
• Participation: 10%
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Seung-Hyo Lee, PhD
Biomedical Research Center Room 3106, Phone: 4235
E-mail: [email protected]
Cellular Immunology Laboratory
GSMSE, KAIST
Elements of the Immune System
and Their Roles in Defense
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Figure 1-1Effects of Vaccination
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1. Infectious organisms (pathogens)
2. Cells and tissues of immune system
3. Innate and adaptive immunity
Overview
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1. Bacteria
2. Viruses
Infectious Organisms
3. Fungi
4. Parasites
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Figure 1-2Four Classes of Pathogen
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Figure 1-3 part 1 of 4Pathogens (1)
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Figure 1-3 part 3 of 4Pathogens (2)
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1. Epithelial barriers
2. Immune cells
3. Circulating/cellular pattern recognition molecules
Components of Immune System
4. Protein
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1. Physical barriers (mechanical, chemical, biological)
2. Phagocytes and inflammation
3. NK cells
Components of Innate Immunity
4. Circulating pattern recognition molecules
5. Cytokines
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Figure 1-4
Physical Barriers
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Figure 1-4Physical Barriers
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Bad Effect of Antibiotic Treatment
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Figure 1-5Effector Mechanism of
Immune System
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Figure 1-6Inflammation by Innate Immune
System at the Site of Infection
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Figure 1-7Characteristics of
Innate and Adaptive Immunity
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Figure 1-8
Selection of Lymphocytes
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Benefits of Having Both Immunities
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Figure 1-10
Sites of Hematopoiesis
durring Development
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Figure 1-11
Hematopoiesis
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Figure 1-12Abundance of Leukocytes
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Figure 1-9 part 1 of 6Immune Related
Hematopoietic Cells (1)
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Figure 1-9 part 3 of 6Immune Related
Hematopoietic Cells (2)
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Figure 1-9 part 5 of 6Immune Related
Hematopoietic Cells (3)
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Figure 1-13Function of Neutrophil
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Figure 1-14Function of Macrophage
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Summary
• Various pathogens
• Components of immunity
• Hematopoiesis
• Cells of immune system
• Characteristics of innate and adaptive immunity
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1. Primary lymphoid organs: Bone marrow and thymus
2. Secondary lymphoid organs: Lymph node, spleen, and mucosal immune system
Anatomy of Lymphoid Tissues
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1. T Lymphocytes: alpha/beta T cells (CD8 and CD4)
gamma/delta T cells
2. B Lymphocytes
Cells of Adaptive Immunity
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Figure 1-15
Major Lymphoid Organs
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Lymphocyte Recirculation
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Figure 1-16
Lymphatic System
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Overview of Immune Responses
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Figure 1-17Structure of Lymph Node
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Figure 1-18
Activation of Immune Responses
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Figure 1-18Circulation of Immune Cells
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Figure 1-19
Structure of Spleen
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Figure 1-20
GALT
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Figure 1-30
Features of Adaptive Immunity
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Figure 1-31
Successful Vaccination
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Summary
• Anatomy of lymphoid tissues
–Primary lymphoid organs
–Secondary lymphoid organs
• Cells of adaptive immunity
–Lymphocytes
–APCs
• Features of adaptive immunity