Bringing the Lab to the VillageMedical Testing for Resource Limited Settings

Presentation to AHEAD@NU

July 1, 2010

People Living with HIV AIDS by Country Income Classification

N = 32.6M

The Problem of Health Disparity

Refrigeration Required

Electricity Required

Lab Technician Required

Maintenance and Service Technician Required

Blood sample transport system

The Problem of Health Disparity

Portable

Easy to use

Rugged

Accurate

+ / -

Product Examples

NU partners with private industry, nonprofit donors and academia to achieve its mission to develop products that address health issues facing underserved communities around the world

NU partners with private industry, nonprofit donors and academia to achieve its mission to develop products that address health issues facing underserved communities around the world

What is NU doing about this?

NU Participants - Faculty

David KelsoMcCormick

Daniel DiermeierKellogg

Kara PalamountainKellogg

Robert MurphyFeinberg

Tim FeddersenKellogg

Kearsley StewartWeinberg

Bob SchiefferKellogg

Sarang DeoKellogg

Julie HennessyKellogg

Matt GlucksbergMcCormick

Robert ElghanianMcCormick

Sally McFallMcCormick

7

Patients

Prioritizing and Defining User RequirementsThe Patient Perspective

National Measles Immunization CampaignNdola, Zambia

Healthcare Workers

International Agencies

Governments

Distributors

1.2 M Births

Accessing Immunization Services:

89%

Delivering in health facility:

15%

Est. # of HIV Exposed Infants Per Year:

8-10%

Accessing PMTCT Services:

25%

Est. # of HIV Infected Infants Per Year:

2%

Est. # of HIV Tested Infants Per Year:

0.007%

Where is the “Point of Care”?Uganda Example

9

Patients

Healthcare Workers

International Agencies

Governments

Distributors

Prioritizing and Defining User RequirementsThe Healthcare Worker Perspective

10

Patients

Healthcare Workers

International Agencies

Governments

Distributors

Prioritizing and Defining User RequirementsThe International Agency Perspective

11

Patients

Healthcare Workers

International Agencies

Governments

Distributors

Prioritizing and Defining User RequirementsThe International Agency Perspective

12

Patients

Healthcare Workers

International Agencies

Governments

Distributors

Prioritizing and Defining User RequirementsThe Distributor Perspective

+ / -

Our current area of focus is a handheld test used for early infant diagnosis of HIV (EID)

Our First Product

There are a number of steps and handoffs associated with the current tests available for EID

1. Collecting Samples 2. Drying Samples 3. Packing Samples

5. Processing Samples6. Delivering Results 4. Transporting Samples7. Patient receives results

What Our First Product Replaces

15

The hurdles of getting the blood specimens to and from the equipped labs in a timely fashion poses sizable ongoing challenges

15

Countries~ Observed

Time to Result

Botswana 2-16 weeks

Cambodia 3 weeks

Mozambique3 months or greater

Namibia 1-4 weeks

South Africa 1-3 weeks

Tanzania N/A

Uganda 4-6 weeks“Uncollected Test Results”

What Our First Product Replaces