[brijesh]bioinformatics oppertunity

8/14/2019 [Brijesh]bioinformatics oppertunity

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(insight in to the IT Companies)K.P.Mishra (Director, URC Allahabad )

Brijesh Singh Yadav(Senior Research Associate &HeadBioinformatics Research)United Research Center, UIT Campus Allahabad,

E-mail: [email protected]

Ca reer inBio in formatic s


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What i sBioinformatics?

Bioinformatics is the application of

computer technology and statistics to

the management of biologicalinformation.

In the past decade bioinformatics has

become an integral component of

research and development in biologicalsciences.

The need for bioinformatics stems from

a fundamental change that is taking

place in biology.


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Bioin for matic s Is aMerg ing of D isc ipli nes


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Co re o fBio in form atic sTDQAAFDTNIVTLTRFVMEQGR

KARGTGEMTQLLNSLCTAVKAISTAVRKAGIAHLYGIAGSTNVTGDQVKKLDVLSNDLVINVLKSSFATCVLVTEEDKNAIIVEPEKRGKYVVCFDPLDGSSNIDCLVSIGTIFGIYRKNSTDEPSEKDALQPGRNLVAAGYALYGSATMLV

sequence 3D structure protein functions

Properties and evolution of genes, genomes, proteins, metabolicpathways in cells

Use of this knowledge for prediction, modelling, and design


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Need o fbioinformatics

Data growth is exponential

Difficult to understand life without BI Detection of new diseases

BI tools allow to save expr. Expend.

Rational Drug design

Computer-aided vaccine design


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Ne ed o fbioinformatics


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Need of bi oin format ic scont Handle the

growth of

information.

Knowledgediscovery.

Globalizing

theresearch.

Data

visualization

.


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Need ofbioinf orma tic s co nt


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BIOINFORMATI CSDE VELO PMENTS ININDIA Department of Biotechnology created in 1986

Bioinformatics programme started ever since

Biotechnology Information System Network

(BTISnet) in 1987. BTISnet today has 65 institutions and

universities.

Emphasis on infrastructure creation and human

resource development. Biotechnology in India has greatly benefited

from the capacity building in Bioinformatics

Dedicated virtual private network connecting

the major centres sharing of data as well ascom utin resources.


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Bioinf ormat icsFac iliti es in Ind ia


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Two forms of initiatives are in operationalTwo forms of initiatives are in operationalTwo forms of initiatives are in operational

Two forms of initiatives are in operational

Short-Term Training

Nationwide trainingsand workshops

Presently around 100organised per year inseven defined areas

More than 10000trainedso far

Long-Term Training

Advanced DiplomaCoursesin five universities

M.Sc., M.Tech., Ph.D.courses

in Bioinformatics

uca ona c v es oIndia i n Bi oin format ics


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Integrat ion o fBioinformatics &Biotechnology Collaborative effort

RFP (Request for Proposals) in

following areas: Parasitic diseases

Agro-biotech

Herbal medicine

BioPhara Development

Clinical Data management


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In -hous e sof twar edev elopm ent1. GeneScan, GenEvolve, PROCOR

2. PLHOST

3. APSSP (Protein structureprediction), MHCBN

4. PCR: s/w for setting PCR reactions5. LOOPSEARCH, CONFPLOT

6. VirGen, CE, AVIS

7. Micro array analysis (Avadis),Genome annotation (Acuris),Oligonucleotide probe design(Sarani)

8. BioSuite

JNU, DelhiIGIB, DelhiIMTECH, ChandigarhDevi Ahilya

UniversityBose Institute,

KolkattaUniversity of Pune,

Pune

Strand Genomics,BangaloreTCS, Hyderabad

These efforts needs to be strengthened withHuman resource development


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Bioinformatics Market

Global Bio-Informatics Market 1.2bn In 2004Overall Market Size Projected to reach USD 1.7 bnby 2006Indian Bioinformatics Market has touched USD22Million in 2004Indian Bioinformatics is growing at the rate of40% per annum

(Source: CII)


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Market sha re of dif ferentSegments o fBioinformatics Genomic 50%

Proteomics 20%

Chemoinformatics 19% Pharmacogenomics 15%


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Advanta ges fo r Ind ia Strong IT capabilities

R & D strength in Modern biology

Highly trained manpower inbiotechnology and Bioinformatics

Rich Biodiversity

Diverse ethnic population

Strong Biotechnology Infrastructure Wide Networking of Institutions and

Scientists.

Industrial enterprise.

HHBIO


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The Role of IT inBioinformatics

1. Electronic Data Capture2. Data Mining3. Data Warehousing

4. Data Visualization5. Customized Software


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Indian IT Companies Indian IT companies such as Tata Consultancy

Services (TCS), Cognizant Technologies,Infosys, Wipro, and Satyam have already set up

their bioinformatics divisions.

TCS, for instance, is entering the bio-informaticsmarket with its indigenously developedcomputing platforms and applications within this

year. The company is nurturing a 40-memberteam that is working on developing bio-informatics software solutions.


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Ind ian IT C omp ani es Cont.. A database application, specially created for the

bioinformatics segment is in the pipeline. TCS is alsolooking at developing bio-informatics softwareapplications in collaboration with biotech and pharma

companies.

Satyam's Center of Excellence has identified Data

warehousing and Datamining as a key initiative area inthe field of bio-informatics since the field is an emergingdomain where data warehousing and dataminingtechniques and concepts are used extensively fordeciphering complex patterns and to correlate and

analyze the vast volumes of data generated.


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Ind ian Ph ar maCompanies Pharmaceutical companies too, are making

moves into the bioinformatics arena. GVKBiosciences, Dr. Reddy's Laboratories, Biocon,

Astra Zeneca, Ranbaxy, Biological E, andNicholas Piramal are some of the names thathave either opted for the joint venture route orhave tied up with start-up companies.


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people requ ir ed by aIndust ri es Computer Programmer, who develop

software tool and application for

biotechnology and life science

companies.A good Programmerhaving knowledge ofHTML, XMLSAS-CGICGI between web and

databaseBuild HTML page tointerfaceKnow DNA analysisprograms

Understand:Basic MolecularBiologyHow a networkworksHow databasesare structured


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Peo ple req uired byaInd ustrie s c ont..

People with a background in life scienceswho are the end user of such programs andpackages and they use these tools to

translate the information into tangibleproducts such as new molecules, drugs,enzymes etc.

They can conduct their R&D program moreeffectively if they are cross-trained in

computing skills. They can also be business analysts for life

science companies.


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Skills needed for the Desing of Experiments Using Bioinformatics

Systems

Administration/Networking

2%

General Computer Sciences

7%

Artificial Inte lligence

3%Advanced algorithms

Data Structures

8%

Biochemistry

10%

Biophysics

6%

Structural Biology

7%

Genetics

11%

Molecular Biology

12%

Evolution

7%

Statistics

12%

Mathematics

6%

Computational Chemistr y

6%

Software Engineering3%


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What Is a Bioinformatics

Company L ike? Consists of Biologists, Computer Scientists,

Mathematicians and Marketing people.

Bioinformatics companies should expect

revenues in a few million dollars only. Only those companies who are able to adapt

and innovate will survive.

A great deal of competition exists in the field.

For any new company offering bioinformaticsservices or products, proof of concept, will beessential. This means that a nascent companywill need to demonstrate its ability before

getting business.


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Ar eas of opport un ity inIndia Bioinformatics

Vaccines, dignostics and therapeutics

Biomedical devices, instruments andsensors

Bioartificial organs using tissueengineering and stem cells

Clinical trial and contract research

Agriculuture disease and pest resistant,drought and salinity tolerant seeds andplants

Biofertilisers and Biopesticides


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Carrie r oppo rtun it y ava ilablein bioinformatics Life Science: Scientific Curator, Gene Analyst,

Phylogenitist, Protein Analyst,Research Scientist/Associates

Compu ter Sc ience: Database Programmer,Bio-informatics

Software Developer,Nerwork

Administrator/Analyst

Pha rama cu iti ca l Sc ience :Chemoinformatician,Pharmacogenetician,

Pharmacogenomics, Research


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Job opportuni ti es inBioi nfo rmati cs Postgraduatesand,Do ctorates

Bachelordegrees / 3ye ar dip lomaholders 3) Degreewith oneye ar courseincomputers

Qualification Experience Job Title

Formal Training andunderstanding marketrequirement ofBioinformatics

Sound knowledge inMolecular Biology andprogramming

Good typing speed,Knowledge in molecularBiology and computerapplication

Group leaders /Sr. Executives /Scientists/Faculties

System AnalystTechnical Asst./Programmer /

COs / DEOs


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Majo r Re search Areas i nBioinformaticsResearch Activities [%]

Gene Analysis

Prot. Struc. Pred.

Prot Design & Folding

Macr. Modelling

Evol. Biol.

Struc-Func Studies

Mech. of Dis.

Data Mining Stud


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Business Opportunitiesin BI Software development

Web servers development

Train manpower in Field of BI Database management

Rational Drug design

Develop Diagnostic kits

Assist user in Vaccine development Consultant to Biotech Companies


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u so urc n g o einTechno log yBusine ssesOutsourcing has developed as an

important concept in today'sbusiness.

1) Focus on core strength - theopportunity cost of adding a newsegment of services to an existing

business is high. Companies prefer tonot diverge from their focus on theircore competencies, and staycompetitive.


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Outso urcin g con t. 3) Leverage top talents from the bioinformatics

companies companies can make use of thebest resources engaged in IT services withouthaving to worry about recruiting, training andretaining professionals

4) Minimize on total cost of ownership the rateof obsolescence is very high in the IT sector.Companies who outsource do not have to bearthe replacement costs that accompany

obsolescence.


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Outso urcing con t. 5) Improve service delivery to

customers the company can dictateto the outsourcing partner the

timelines it is required to meet. 6) Reduce cost and time the time

spent otherwise on planning anddevelopment is saved and better

utilized to managing the existingresources.

7) Expand service portfolio companies can extend their serviceswithout having to invest on building inhouse capabilities


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Ou tso urcin g Inspite of a tremendous increase in

demand, the US educational stream hasnot significantly increased the

production of scientific workforce. As a result cost of research has gone

higher.

Many companies are realizing that they

can get their research done abroad, atcheaper cost, without any compromisein quality.

In clinical trials for example, GSK

(Glaxo smith Kline)has announced thatit will shift 30% of its clinical trials to


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The Ultimate Goals of Bioinformatics is

to:Implement LaboratoryInformation Manageme nt

Systems

14%

Design experiments using

bioinformatics

9%

Provide training and

assistance in the use of

bioinformatics software

tools

10%

Use existing software for

bioinformatics analyses

10%

Discover new insights or

hypotheses in molecular

genetics or evolutionary

processes

10%Rese arch new

technologies (algorithms,

principles, models,

databases) to ascertain

their potential for

bioinformatic analysis

11%

Develop software for

bioinformatics applications

12%

Implement web-interfaces

for bioinformatics

applications/data bases

12%

Create & maintain

laboratory research

databases

12%


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Bioinformatics Jobssea rch engines Medzilla(Biotech,Medical,etc job listings)

BioSpace (job listings)

BioView (job listings)

Bio online Carrier Center Symbios Career Service

(Biotech,MedDevice,Pharm )

Genomics ,Bioinformatics and

Biocomputing Jumping pills Biotech jobs

NEE-HOW Bioresource Finder jobs

JobsScience

http://www.bhrc.ca/


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[brijesh]bioinformatics oppertunity

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