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Cardiovascular SystemAntihypertensive Drugs
( A ) Diuretics1- Loop Diuretics:
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationFurosemide Lafurex 4.5 LE Nausea, Gastric discomfort, Skin It is used if the potential
Lasix 6 LE rash, and Orthostatic hypotension. potential risk. benefit gustifies the potential risk to the fetus.
experience salicylate toxicity.Bumetanide Edemex 3 LE Muscle cramps, Hypotension, There are no adequate and well
Burinex 4.3 LE dizziness, Headache, Nausea, they reduce its renal clearance lead to controlled studies in pregnant
Hyperuricemia, Hperglycemia, Gout lithium toxicity. women.Nursing should not be Hypochloramic alkalosis, skin rash undertaken,it may be excreted
Hyponatreamia, Hypokalemia. antihypertensive drugs. in milk.
2- Thiazide Diuretics:Indapamide Natrilix 13 LE Muscular cramps, Debility, The dosage of other antihypertensive It is not recommended to be hemihydrate Hypokalaemia, Hyperuriceamia agent reduced when used with natrilix,it administered during 1st trimester
and slight reduction in glucose potentiat action of diuretics, the need for of pregnancy or during lactation
tolerance. unless physician considers that It taken in the morning. benefites outweigh possible risk.
Hydrochlorothi- Hydretic 4 LE Although there is no evidence ofazide teratogenic effect in animal study
Headache, Nausea, constipation No interaction. the safety of the product during
and mild skin reactions. pregnancy and lactation has not been established.
Spironolactone Aldactone 18 LE Gynecomastia, breast enlargment, Muscle cramps, Diarrhoea, Ataxia, supplements is not recommended, it may It may cross placenta and it Postmenopausal bleeding, Urticaria induce hyperkalemia. It increase the half- requires that the anticipated
Mental confusion, Drowsiness, life of digoxin. benefit be weighed against Lethargy, Headache. possible hazard to the foetus, it
decrease effect of spironolactone appears in breast milk.
Aminoglycoside: increase the ototoxic
Acetylsalicylic acid:
Lithium: not given with diuretics because
Edemex: potentiates the effect of various
K+supplementation should be considered.
3- K+_ sparing Diuretics: The concomitant administration of K+
Carbenoxolone: cause Na+ retention and
4- Carbonic anhydrase Inhibitors:Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationAcitazolamide Cidamex 2.5 LE It is contraindicated for patient with
liver cirrhosis, it may cause very No interaction. NO evidence mild reaction similar to those reported from sulfonamide.
5- Combination of diuretics:Octosemide 5 LE No side effect. It isn't used with ethacrynic acid, Lithium NO evidence.
and salicylates.Spironolactone Aldactazide 3.9LE
Drowsiness, Gastrointestinal No interaction. It isn't taken because it appearsHydrochlorothi- intolerance. in milk.
azide.
Yostiretic 6 LEHydrochlorothi- Moduretic 7.5 LE Headace, weakness, fatigue, b.p, hypotension may occur There is no evidence of
azide. malaise, tachycardia, arrhythmia, a teratogenic effect. nausea, vomiting, diarrhea, thirst, of these drugs is required Diuretics don't prevent production gout, dehydration, hyponatremia, of toxemia.
rash, pruritus, flushing, diaphoresis. depletion, particulary hypokalemia. Thiazides appear in breast milk.
Spironolactone Lasilactone 8.5 LE
+ carbenoxolone.Furosemide Hyperkalemia, irregular pulse, If lasilactone has to be used in
drowsiness, muscular weakness in spironolactone. nursing mothers, breast-feeding lower limbs,increase tenderness should be stopped .
of the nipples, breast enlargement antidiabetic Drugs. It is not recommended during mental confusion, allergic reaction It potentiate the nephrotoxic effects of pregnancy .
hemolytic anemia, leukopenia, aminoglycosides. thrombocytopenia,increase serum The tablet should be swallowed with a cholesterol level, gastrointestinal sufficient amount of liquid, preferably with
disorders, hyponatremia, dizziness. breakfast or lunch, it is not advisable to take the drug in the evening because of
Kcl +Furosemid
+
Amiloride+ Alcohol, barbiturates: orthostatic
Antidiabetic Drugs: adjustment the dose
Corticosteroids: intensified electrolyte
Spironolactone: reduce effect of
Salicylates: attenuate the effect of
Furosemide: diminishes the potency of
the incresed urine excretion expected.
1- ACE inhibitors:Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Captopril Hypopress D 15 LECapoten 20 LE Cough, Angioedema, Anorexia,Rash antineoplastic, allopurinol, indomethacin, It isn't recommended in lactationCaptopril 6 LE Flushing, Nausea, Vomiting, Gastric and oral anticoagulants. and pregnancy.Farcopril 9 LE irritation, Hypotension, Tachycardia. tablet taken on an empty atomach one
hour before meals.Enalapril Ezaprile 9.5 LE Vertigoes, cephalalgy, sense of maleate fatiguing and asthenia, hypotension caution . No proper an well cotrolled study
orthostatic hypotension, syncope, Beta-blocking drugs, methildopa and on pregnant women, it is not be nausea, diarrhea, muscular cramps administered in case of
rash, cough and angioneurotic effect of enalapril maleate. ascertained or supposed
oedema with face, tongue, severe pregnancy, it is not known that respiratory difficulties. not advisable, lithium salts may cause an this drug is detectable in milk.
of the serum concentration of lithium.
Moexipril Hcl Primox 22 LE Hypotension, orthostatism,dizziness They must have been excludeddisturbances of vision rarly also with increas in the serum of potassium conc. . and the possibility of conception loss of consciousness,disturbances must be prevented.of kidney function, proteinuria,Dry effect of primox. Breast-fed infants must weaned
cough, Angioedema, sinusitis, owing to the lack of sufficientmyalgia, rhinitis, glossitis,headache therapeutic experience, it must
alopecia, onychlolysis, tiredness. not be used in pregnancy.Perindopril coversyl 4 24 LE Gastrointestinal disorders, dizziness No interactions. It is not recommended in lactation
cramps, an unproductive cough. and pregnancy.Lisinopril Zestril 7 LE Dizziness, headache, diarrhea, rash It can interacts with diuretics, (NSAIDs), It is not recommended to be used
Lisopril 8 LE cough, nausea, dry mouth, fever, lithium, insulin or oral antidiabetics, other in pregnancy and lactation.Sinopril 26 LE vometing, vertigo, hypoglycaemia. antihypertesive drugs.
Ramipril Tritace 18 LE Dizziness, headache, drowsiness, (NSAIDs) and acetylsalicylic acid: It must not be taken during Corpril 8 LE cough, skin reaction, impairment of attenuation of the antihypertensive effect of pregnancy, if tritace is necessary
Ramipril 4.7 LE renal function, tachycardia, edema, tritace is ti be anticipated, it potentiate the during lactation, the patient mustFlushing, Nausea, Vomiting, Gastric not breast-feed, prevent infant
( B ) Medication affect renin angiotensin system
It can interacts with K+ sparing diuretic,
Ganglioplegics blockers: used with
diuretics: enhance the antihypertensive
The association with Ca+2 antagonists is
K+ sparing diuretics: can lead to an
Diuretics: potentiat the antihypertensive
Lithium: increase the serum level of it Narcotics: pronounced decline in the B.p Alcohol : effect of alcohol is potentiated.
effect of alcohol, heparin: rise in serum K+
disturbances. cocentration possible. from ingesting ramipril with milk.
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Kanzar 12 LE hyperkelaemia, angioedema,losartan 18 LE hypotension, diarrhea, dizziness, diuretics(triamterene, amiloride) may leadCozaar 52 LE dry cough, myalgia, migraine, rash to increase in serum potassium It should not be used during
Losarmepha 13.5 LE urticaria, pruritus, anaemia, rarely The antihypertensive effect of losartan may pregnancy and lactation.hepatitis, vasculitis, leg pain, cramp be blunted by the NSAID indomethacin.
insomnia, nasal congestion.Valsartan Tareg 48 LE No clinically interaction when it is used
with amlodipine,atenolol,cimetidine,digoxinHeadache,dizziness, diarrhea,rash, It should not be used duringvertigo, cough, allergic reactions, drug. pregnancy and lactation.
dry mouth, myalgia,cramps,syncopevomiting,dyspnea,anorexia. diuretics(triamterene, amiloride) may lead
to increase in serum potassiumTelmisartan Micardis 66 LE back pain, chest pain,cystitis, Preclinical studies don't indicate
abdominal pain, diarrhes, dyspepsia teratogenic effect,but have shownGastrointestinal disorders, myalgia antihypertensive agents. fetotoxicity, it should preferably
Arthralgia, cramps, pharyngitis, Reversible increase in serum lithium not be used during first trimestersinusitis, skin disorders (eczema) concentrations and toxicity of pregnancy, it is contraindicated
during lactation,it appear in milkCandesartan Atacand 40 LE Dizziness,vertigo,headache,myalgia no clinically interaction when it is used It should not be used during
Atacand plus 120 LE back pain,arthralgia,renal failure, with,digoxin,warfarin,oral contraceptives, pregnancy, if pregnancy is Angioedema,rash,urticaria,pruritus, its antihypertensive effect may enhanced detected during treatment,nausea,hyperkalaemia,leukopenia, by other antihypertensive agents atacand should be discontinued
hypotension, Reversible increase in serum lithium it should not be used duringconcentrations and toxicity breast-feeding, it appears in milk.
( C ) Calcium channel blockerAmlodipine alkapress 9 LE Headache,dizziness,nausea,edema Thiazide diuretics, beta blokers, NSAD safety of it on human pregnancy
besylate Amilo 28 LE fatigue, somnolence,abdominal pain long acting nitrates,oral hypoglycemic and lactation has not been Norvasc 67.5 LE flushing, palpitations established. It could be used onlyMyodura 9 LE with amlodipine if there is no safer alternative
2- Angiotensin ∏ Receptor antagonists:
Losartan K+ Concomitant use of it with K+ sparing
Warfarin: not affect on the action of this
Concomitant use of it with K+ sparing
Telmisartan: increase the effect of other
drugs:they have been safetly administered
( D ) Antiadrenergic druges
1- Beta - receptor Blocker:Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Atenolol6.6 LE Bradycardia,hypotension, fatigue, may have an additive effect when used with It used only if the benefit justifies 3.5 LE lethargy,depression, nausea, rash the potential risk, nursing should 5 LE cold extremeties, heart failure, bediscontinued by mothers
vomiting,dyspnea,diarrhea.requirement of insulin, oral antidiabetics in
previously stabilised diabetic patients.
Sotalol Hcl Betacor 4 LE Due to its beta-blocking action It is not recommended to be usede.g: hypotension, bradycardia and antiarrhythmic drug ,antihypertensive agent in pregnancy and lactation
conduction disturbances in AV node leading to increase pharmacological effect.Bisoprolol- Concor 14 LE
Furarate Bisocard 17 LE Dizziness,headache,nausea, other antihypertensive drugs,cocomitant It is not known that this drug passBistol 6.5 LE perspiration, insomnia, diarrhea, therapy of concor ® and reserpine, into milk.Therefore, breastfeeding
muscle cramps, increase in airway a-methyldopa,clonidine or guanfacine may is not recommended during resistance(asthmoid bronchitis) cause a considrable decrease in heart rate concor ® therapy
Propramolol Hcl Inderal 2.5 LE Caution must be exercised in( the use of itand hypoglycaemic therapy in diabetic It should not be used during
Bradycardia,hypotension, dizziness patients, indreal prolong effect of insulin) pregnancy unless its use is cold extremeties, heart failure, also in(prescribing a β- blocker with class1 essential,most β-blocker will pass
nightmares, insomnia, mood change antiarrhythmic drugs (disopyramide) into breast milk although to a hypoglycaemia in neonates Digitalis glycosies may increase the variable extent.Breast-feeding is
atrioventricular cnduction time when used not recommended following thewith beta-blockers administration of this compound
Metoprolol Betaloc 10 LE Bradycardia, postural hypotension It concomitant treatment with clonidine iscold extremeties, nausea, diarrhea, to be discontinued, β-blocker drugs should It should not be used during
dizziness, headache, dyspnea, be withdrawn several days before clonidine pregnancy and lactation unless constipation, abdominal pain, β-blocker drugs may enhance the negative its use is essential, most
palpitations. inotropic effect when metoprolol is used β-blocke will pass into milk
Ateno 50 3.2 LE Ca+2 channel blockers (diltiazem):Tenormin 50
Atelol 50 Ateno®.Catecholamine-depleting drugsBlokium 50 (Reserpine): have an additive effect when
used with Ateno®.It alter dosage receiving Ateno®
Ca+2 channel blockers (diltiazem),class 1
Concor ® may potentiate the effect of
2- Alpha, Beta - receptors Blockers:Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Carvediol Carvid 12.5 LE Bradycardia, postural hypotensionCardilol 20 LE dizziness, headache, insomnia
Carvipress 9 LE Gastrointestina disturbances NO evidence.Dilatrol 24 LE fatigue, cold extremeties, oedema increased risk of myocardial depression
dry mouth,impotence, eye irritation, leukopenia, thrombocytopenia, bradycardia and AV block with diltiazem
3- Alpha - receptor Blocker:Doxazosin Cardura 44 LE Although there is no evidence of
teratogenic effect in animal study, dizziness, headache, nausea, It has no effect on protien binding of safety of it on human pregnancy postural hypotension, diarrhea, digoxin, warfarin, phenytoin, indomethacin and lactation has not been
abdominal pain, fatigue, vomiting, It has been used without side effect with established, edema, rash, urticaria, pruritus, thiazide diuretics,frusemide, β- blockers it should not be used during
vertigo, (NSAIDs), or anticoagulants. pregnancy and lactation unless physician considers that benefite
outweigh possible risk.
Methyldopa Aldomet 18 LE
headache, muscular weakness, It is used under medical and sedation, nightmares, dizziness, should be monitored carefully for symptom obstetric supervision for the
bradycardia, orthostatic hypotension of lithium toxicity treatment of hypertension duringedema, rash, vomiting, nausea, pregnancy.there was no clinicaldiarrhea, constipation, flushing with methyldopa, the hypotension effect evidence that this drug caused
liver disorders, breast enlargement is potentiated,patient should be monitored fetal abnormalities,but it can passleukopenia, thrombocytopenia, carefully to detect side reactions or the placental barrier
nasal stuffiness , myalgia. unusual manifestation of drug idiosyncrasy Methyldopa appears in milk.therefor, caution should be is
methyldopa, this may adversely affect exercised if aldomet given to a blood pressure control breast-feeding mother.
with Ca+2 antagonists
ACE inhibitors, Alcohol: enhanced the hypotensive effect.(NSAIDs): antagonise
hypotensive effect.Antiarrhythmic:
Ca+2 channel blockers: increased risk of
4- Alpha 2 - receptor Blocker:
Lithium: when it used with methyldopa,
Other antihypertensive drugs:when used
Iron: it decrease the bioavailability of
( E ) CombinationsGeneric Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Normaten 10 LE dizziness, headache, cough It isn't recommended to be usedIndapamide hypersensitivity reaction,skin rashes in pregnancy and lactation
normaten.Capozide 31.5 LE dizziness, headache, diarrhea,
hydrochlorothiazid fatigue, Malaise, rash, nausea, production,elevation of serum potassium It is execreted in milk, therefor taste alteration, hypotension breast-feeding should be avoided
edema. the dose of captopril .
Lisinopril Zestoretic 23 LE dizziness, headache, diarrhea, It is contraindicated in the 2nd, Lisitens 15 LE orthostatic hypotension, cough, increas in the serum of potassium level . 3rd trimesters of pregnancy
hydrochlorothiazid nausea, vomiting, rash, fatigue, It isn't known that this drug pass muscle cramps, impotence, into milk.
asthenia, vertigo, leukopenia, efficacy of using hydrochlorothiazid.Enalapril Ezapril-co 14 LE dizziness,angioneurotic oedema
Enalazide 17 LE with face, tongue, lightheadedness, the antihypertensive effect of ezapril-co NO evidence.
hydrochlorothiazid the elderly
Co Dioven 57 LE dizziness, headache, diarrhea, Concomitant use of it with K+ sparing It isn't recommended to be usedhydrochlorothiazid Co-targ 56 LE insomnia, nausea, cough, myalgia, diuretics(triamterene, amiloride) may lead in pregnancy and lactation
muscle cramps, impotence. to increase in serum potassium level It isn't known that this drug pass into milk.
Tritace comb 25 LE headache, taste change, cnfusion It isn't recommended to be usedhydrochlorothiazid loss of appetite, depressed mood in pregnancy and lactation
anxiety It isn't known that this drug pass picture changes. into milk.
Hyzaar 52 LE dizziness, headache, nausea, rash, It isn't recommended to be usedhydrochlorothiazid Fortzaar 45 LE sweating, angioneurotic oedema in pregnancy and lactation
fatigue, depletion, particulary hypokalemia.Blokium dui 11.5 LE muscle cramps, fatigue, nausea it should not be used during
Chlorothiazide Tenedone 50 11 LE cold extremeties, sickness, No interaction. pregnancy and lactation except
Captopril + K+ retaining diuretics (spironolacton, triamterene,amilopide): not used with
Captopril + Captopril: decreases the aldosterone
(NSAIDs): Concomitant therapy with indomethacin may require an increase in
K+ sparing diuretics: can lead to an dehydrat +
Lithium: should not be given with diuretic indomethacin: diminish the hypotension
β- blockers and methyldopa: enhancemaleate +
and symptoms of K+ loss occur in Lithium: increase the serum level of it
Valsartan +
Ramipril + Lithium: increase the serum level of it methyldopa: possible hemolysis
Allopurinol:increase likelihood of blood
Losartan K+ + Lithium: increase the serum level of it Corticosteroids: intensified electrolyte
Atenolol +
leukopenia, thrombocytopenia. doctor decides necessary of it
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Atenoretic 14 LE cold extremeties, muscle cramps, It should used only if possiblehydrochlorothiazid fatigue, Bradycardia, hypoglycaemia benefit justifies the potential risk
glycouria, of atenolol to the foetus, It used with cautionin nursing mothers.
Tenolate SR 10 LE Gastrointestina disturbances, Combination of nifedipine and atenolol is It isn't recommended to be usedNifedipine headache, dizziness, fatigue, usually well tolerated in pregnancy and lactation
oedema, hypotension, tachycardia,Teklo 16.5 LE Bradycardia, cold extremeties,
Amiloride postural hypotension, leg pain, headache, dizziness, vertigo, No interaction. NO evidence.
diarrhea,nausea, vomiting, drowsiness.
Lodoz 27 LE headache, dizziness, tiredness It isn't recommended to be usedhydrochlorothiazid 6 LE Gastrointestina disturbances, gout No interaction. in pregnancy and lactation
peripheral circulatory problemsBrinerdine 12 LEhypoten 6 LE
Dihydroergocristin Gastrointestina disturbances, and water , the dosage of Brinerdine may It isn't recommended to be used orthostatic hypotension, fatigue, have to be increased when such drugs are in pregnancy and lactation
thrombocytopenia,mental depression,muscle weakness serious potentiation of their CNS
depressant effect .
Antiarrhythmias DrugsPropafenone Rytmonorm 28 LE diarrhea,nausea, vomiting, vertigo, local anaesthetics: potentiate the effect of it should be given critical
loss of appetite,blurred vision, rytmonorm, it increases the plasma level consideration in accordance with convulsion, dizziness, of metoprolol, propanolol and digoxin present views on the use of drug
in the first trimester.Amiodarone Hcl Cordarone 18 LE Corneal deposition,occasionally
aociated with colored haloes in bright light.rarely, pigmentation or Like all active products this drug may It isn't recommended to be used
photosensitization may occur induce more or less in pregnancy and lactation
Amiloride Hcl + Ca+2 antagonists: potentiate effets of β- blockers. Diltiazem: enhance the effect
Atenolol
Alcnolol +
Atenolol +
Bisoprolol +concor-5-plus
Reserpine + thiazide: lower renal lithium clearanceclopamide + (NSAIDs): diminish the excretion of Na+
used concurrently.Reserpine: may cause
Thyroid dysfunction .Rarely, respiratory disorders may occur
Respiratory System( A ) Mucolytic Drugs
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationCarboxy methyl Mucosol 5 LE Gastric irritation, Skin rashes, in
cysteine hypersensitive patients. No interaction. NO evidence
Acetylcistein ACC Long 32 LE least 2 hours
Diarrhea, vomiting, heartburn, It should not be used during nausea, headaches, inflamations of congestion of secretion due to reduced pregnancy and lactation except the mucous membrane in the mouth cough reflex. doctor decides that this drug is
Tinnitus, bronchospasms. absolutely necessary. vasodilating effect of nitroglycerin.
the solution is to be drink after mealsBromohexine Bisolvon 3.3 LE
Gastro-intestinal disturbances. No interaction. NO evidence.
Bromohexine All vent 4.5 LE Safety of it hasn't been studied in Tremor, nervousness, palpitations, agonist such as terbutaline may be pregnancy and lactation probable
vomiting, dizziness, drowsiness, exacerbated by concomitant administration benefit should be weighed againstTerbutalline nausea, headache, muscle cramps of high doses of corticosteroids. possible risks before prescribing
All vent during pregnancy and lactation.
Ambroxol Hcl Bronchopro 7.25 LE Gastro-intestinal disturbances, Bronchopro should not be used Ambroxol 3.5 LE Diarrhea, Skin rashes, No interaction. during the first trimester of
pregnancy Mucosin 5 LE No disruption of gastric barriers and Not yet recommended in the first
Guaifenesin well tolerated No interaction. trimester of pregnancy Bromhexine Hcl Solvin 3.5 LE
Antibiotic: should taken at intervals of at
Antitussive: cause a dangerous
Nitroglycerin: using ACC long enhanc
Hcl
Adverse metabolic effects of high dose β2-Hcl +
Guaiphenesin +
Ephedrine: shouldn't taken with terbutalin
Ambroxol Hcl +
extract senega + It is well tolerated and no side effect Tablet should be given cautiously to patient NO evidence.ipeca, tolu syrup+ ocures. with gastric ulceration.
anise oil
( B ) Anti- tussive DrugsGeneric Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Pipazethate Hcl Selgon 5 LE Selgon® drops should preferably be taken Pregnant women are requested todrowsiness. on sugar or with some fluid inform their physician about the
Chlorophenira- Cyrinol 6 LEused with caution in hypertension No interaction. It is not recommended to be used
Pholcodine in pregnancy and lactation
Pentoxyverine Cabella 5 LE Cutaneous allergic reactions, vertigo The use of alcohol containing medicationcitrate Digestive trouble(nausea & vomiting) potentiates the sedative effect of centrally It is not recommended to be used
constipation, dry mouth, somnolenc, acting antitussives. in pregnancy and lactationbronchial hyposecretions
( C ) Bronchial Asthma + COPDSalbutamol Ventolin 13 LE It should be used in the first
Salbovent 3 LE Tremor, headache, palpitations, Non selective β-blocking drugs (propanolol) trimester only if absolutely Broncal SR 16 LE muscle cramps, slight tachycardia, shouldn't be taken with Salbutamol essential care is required in Salbutamol 1.5 LE urticaria, angioneurotic oedema also corticosteroids, diuretics, theophylline patients with ischaemic heart
hypokalemia shouldn't be taken with Salbutamol disease, it appears in breast milk
Clenil 14 LE the product is to be administeredin cases of renal necessity and
Beclomethasone local fungal infection in mouth and β-blocking drugs (propanolol) shouldn't be under the direct control of the throat, light muscular tremor taken with Salbutamol physician; in these cases the complained of hoarseness. interrupted use more than 10 day
should be avoided
Terbutaline Aironyl 2 LE Non selective β-blocking drugs (propanolol)Bricanyl 4 LE Tremor, headache, tachycardia, may inhibit the effect of beta stimulant the drug is only used during
palpitations, dizziness, hypokalemia pregnancy if cleary neededthe risk of hypokalemia it excreted into breast milk
ingestion of Selgon®
mine +
Salbutamol +Dipronionate +
corticosteroids, diuretics: may increase
Ketotifen Allerban 7.7 LE drowsiness, dry mouth, slight it potentiate the effect of sedatives, alcohol NO evidence. dizziness, hypnotics, antihistaminics
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationMontelukast Clear air 35 LE
There are no adequte and well-No side effect. No interaction. controlled studies to date using it
during pregnancy and lactation
Seretide 120 LE the administration of this drug fluticasone during pregnancy and lactation
paradoxical bronchospasm Non selective β-blocking drugs (propanolol) should only be considered if the Tremor, headache, palpitations, may inhibit the effect of beta stimulant expected benefit to the mother is
complained of hoarseness, greater than any possible risk to tachycardia, muscle cramps, the foetus or child
Foramoterol Foradil 87 LE The safety of foradil on pregnancyfumarate Tremor, palpitations, headache, and lactation has not yet been
oedema, nausea the risk of ventricular arrhythmia. established.
Fenoterol Berotec 4.9 LE during the first trimester ofhydrobromide Restlessness, palpitations, fine pregnancy, Berotec should only
tremor of the fingers, dizziness, counteract the action of Berotec be used after consultation with fatigue, headache, sweating the doctor
Anhydrous Quibron T/SR 60 LE There isn't evidence of teratogenictheophylline Minophyllin 6.15 LE Headache, nausea, vomiting, recptors. effect in pregnant woman
insomnia, cardiac arrhythmias, It excreted in breast milk causes diarrhea, tremor, tachycardia. of theophylline by induction of microsomal irritability of mild toxicity in
nursing human infants
Budesonide Pulmicort 40 LE Clinical experience from pregnant Rhinocort 27 LE Local irritation, slight haemorrhagic concentrations of oral budesonide, this women is limited .In common with
Salmeterol +
β-blocking drugs: inhibit effect of foradil Quinidine, procainamide: may increase
β-blocking drugs: in adequate doses
Adenosine:Theophylline blocks adenosine
Aminoglutethimide: increases clearance
enzyme activity.also with carbamazepine
Oral ketoconazole: increased the plasma
nasal secretion, epistaxis, angio- interaction is lacking for nasal budesonide other glucocorticosteroids, has oedema, urticaria, rash,dermatitis, but greatly increased plasma levels are been shown to cause
pruritus. expected there too malformation,it shouldn't be given during pregnancy and lactation
Central Nervous System( A ) Anti-parkinsonism Drugs
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationBiperiden Hcl Akeniton 13.5 LE Antihistamines, other anticholinergic
Gastro-intestinal disturbances, There isn't evidence of teratogenic dry mouth, mydriasis,photophobia, peripheral side effects. effect in pregnant woman constipation, nausea, tachycardia It excreted in breast milk. difficult urination, allergic reactions effects.
Sinemet 20 LE Dyskinesias, dystonic, nausea, using of levodopa in women of Carbidopa Levocar 12 LE muscle twitching, blepharospasm , childbearing potential require that
syncope, chest pain, anorexia, of levodopa. the anticipated benefits of a drug palpitation, hypertension, phlebitis be weighed against possible
vomiting, diarrhea, leukopenia, of levodopa. hazards should pregnancy occur. angioedema. it isn't known that levodopa is
excreted in human milk.
( B ) Anti-epileptic DrugsGabapentin Conventin 14.5 LE Somnolence, backache, dizziness, It should be administered 2hr after the It should used only if possible
fatigue, headache, nausea, vomiting intake of antacids. benefit justifies the potential riskto the foetus.
( C ) Anti-depressant DrugsTianeptine Stablon 15 LE Fatigue, nausea, constipation, loss It should used only if doctor
of appetite, insomnia, drowsiness, discontinuation of treatment with MAOIs decides that this drug is palpitation, headache, dry mouth. absolutely necessary.
Escitalopram Cipralex 86 LE Nausea, sinusitis, loss of appetite, It should used only if doctor dizziness, diarrhea, fatigue, fever, decides that this drug is sexual disturbances, constipation. it administered with Cipralex. absolutely necessary.
psychotropic drugs : aggravate the CNS
Quinidine: enhance the cardiovascular
Levodopa + Antihypertensives: Postural hypotension occurred.Risperidone: reduce the effect
High protein diet: impair the absorption
MAOIs : should leave 2 weeks after
Lithium: high fever, muscle contraction Imipramine: eliminate more slowly when
Sertraline Hcl Moodapex 18 LE Nausea, vomiting, dry mouth, It should used only if possible dizziness, diarrhea, sweating, sertraline and may result in decrease in benefit justifies the potential risk
rhinitis, weight loss, vertigo, the clearance. to the foetus. hyperkinesia, myalgia
Gastrointestinal Tract( A ) Anti-Spasmodic Drugs:
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationSpasmotal 3 LE
Pipenzolate Br Dry mouth, constipation, sedation effect of pipenzolate Br NO evidence. urine retention.
of metoclobromide.Zingeber, Dill Aqua Ream 8.5 LE
seed oil,caraway vomiting is rare No interaction. NO evidence.
Hyoscine-N- Scopinal 5 LE Dry mouth, constipation, safety of it on pregnancy/lactationbutylbromide Buscopan 4 LE drowsiness. absorption of anticholinergics. has not yet been established.
Hyoscine-N- Buscopan plus 3.6 LE Available but limited preclinicalbutylbromide Rubefaction, thrombocytopenia, liver damage when it taken with hypnotics data has shown no hazard, but
+ leukopenia, allergic reactions, and anti-epileptics The safety of it on pregnancy Paracetamol agranulocytosis, pancytopenia, and lactation has not yet been
bronchospasm, liver damage. rate of paracetamol established.
Propyphenazone Spasmo- 1.75 LE Hypersensitivity reactions, urticaria, It should used only if possiblecibalgin pruritus, exanthema, angioedema, benefit justifies the potential risk
bronchospasm, shock, nausea, increase the anticholinergic effects of to the foetus, it pass into breast tachycardia, leucopenia, vomiting. amantadine, quinidine. milk.
Mebeverine Hcl Colospasmin 6.8 LE Gastro-intestinal disturbances, fort dizziness, headache, insomnia, No interaction. It is better to avoid using this
Cimetidine: inhibits the metabolism of
Phenobarb + other anticholinergics: potentiate the
Antihistamines: antagonizes the action
fennel, ZnSO4
Antacids, antidiarrheais : reduce the
Paracetamol : in high doses, may cause
Metoclopramide : increase absorption
Rifampicin : alter the half-life of propyph- / Drofenine Hcl enazone.Hexahydro-adiphenin Hcl :
allergic reactions, urticaria. drug during pregnancy.
Cloxide 4.5 LE dry mouth, constipation, urinaryChlordiazepoxid hesitancy, thickness of bronchial with alcohol, cimetidine, atropine, some It isn't recommended to be used
Hcl secretion, decrease of lachrymal antiarrhythmics, anticholinergics, CNS in pregnancy and lactation secretion, drowsiness. depressants, antitussives.
( B ) Antidiarrhoeal Drugs :Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationMetronidazol Elyzol 5 LE It inhibit metabolism of warfarin and thus It crosses the placenta and not
Flagyl 6 LE Gastro-intestinal disturbances, enhance its effect. Metronidazole and be given in the 1st trimester, it nausea, headache, insomnia, disulfiram has been reported to cause occurs in breast milk,so nursing
vertigo, drowsiness, skin rashes acute psychosis or confusional state mothers shouldn't be given it.
Tinidazole Protozol 6 LE nausea, dizziness, headache, tablets should be given during or after It is not recommended to be used vomiting, dry mouth, metallic taste. meals. No interaction in pregnancy and lactation
Furazol 4.5 LE Gastro-intestinal disturbances, It inhibit metabolism of warfarin and thusMetronidazol vomiting, metallic taste, nausea, enhance its effect. When given with It is not recommended to be used
urticaria, headache, ataxia, dark in alcoholic beverages, Furazol may in pregnancy and lactation urine colour, angioedema. produce abdominal cramps, vomiting.
Dioctahedral Smecta 5 LE It is recommended not to administer any smectite constipation in very rare other drugs at the same time as Smecta NO evidence.
Mesalazine Pentasa 9 LE Gastro-intestinal disturbances, It should used only if possible headache, vertigo, allergic reaction benefit justifies the potential risk
to the foetus.
( C ) Laxative Drugs :Lactulose Lactulose 10 LE It must never be taken on an empty
Flatulence, diarrhea stomach, but only after meals NO evidence.
Norethisterone Cidolut Nor 5 LE phenylbutazone, hydantions, rifampicin, in rare case nausea may occur ampicillin, barbiturates, since they impair It is not recommended to be used
Clidinium Br + Cloxide : should be taken cautiously
Diloxamide +
Corticoids : increase the bleeding of GIT Furosemide : decrease action of diuretic
the action of steroid hormones. in pregnancy and lactation
Phenolphthalan Compound 0.5 LE It should not be given to patientsSenna, lichen laxative with symptoms of appendicitis, No interaction. It is not recommended to be used
intestinal obstruction, abdominal in pregnancy and lactation pain of unknown cause.
( D ) Anti-peptic ulcer drugs :Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Ramitidine Rani 4 LEEpiran 6 LEAciloc 6 LE headache, skin rashes, dizziness, of this drug. It should be used duringZantac 20 LE constipation, nausea, diarrhea, pregnancy and lactation if clearly
mental confusion. effect of glipizide. indicated.It decrease renal clearance of procainamid and interfere with the clearance of warfarin.
Famotidine servipep 15 LE It isn't recommended to be usedAntodine 9 LE headache, dizziness, constipation, in pregnancy and lactation
diarrhea, nausea, vomiting, dry No interaction. It should used only if doctor mouth, fatigue, decides that this drug is
absolutely necessary.
Pantoprazole Controloc 90 LE headache, constipation, diarrhea, it isn't known that pantoprazole abdominal pain, allergic reactions, is excreted in human milk. nausea, dizziness, muscular cramp It may increase or reduce the absorption Clinical experience from pregnant swelling of the lower arms and legs of Ketoconazole. women is limited, It should used
fever, depression, flatulence, only if possible benefit justifies visual disturbance. the potential risk to the foetus.
Omeprazole Gastroloc 21 LE Headache, skin rashes, dizziness, constipation, nausea, diarrhea, It should used only if possible
vertigo, alopecia, myalgia, arthralgia No interaction. benefit justifies the potential risk mental confusion, agitation, dry to the foetus.
Antacids : decrease ranitidine absorption. Ketoconazol : ranitidine decrease effect
Ranitidine : increase the hypoglycemic
mouth, abdominal pain, somnolence it isn't known that omeprazole fatigue is excreted in human milk.
Nizatidine Ulcfree 17 LE Headache, abdominal pain, Interaction may occur with high doses of dizziness, diarrhea, constipation, asprin and other salicylates so should be It isn't recommended to be used
sneezing or skin rashes. take antacids 1 or 2 hr of taking Ulcfree. in pregnancy and lactation.
Antimicrobial DrugsSulfa drugs :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactationsulphamethox -- Sutaprim DS 5 LE
Septazol 4 LE Nausea, vomiting, diarrhea, skin Co-administration of Septazol, warfarin, It isn't recommended to be usedTrimethoprim Sutrim 3 LE rash. phenytoin, pyrimethamine, oral, hypogly- in pregnancy and lactation.
Septrin DS 7 LE cemics are not recommended.Chemotrim 1.7 LE
Anti-tuberculosis & Leprosy :Rifampicin Rimactane 8 LE Reddish discoloration of body fluids Antacids, opiates, anticholinergic, It isn't recommended to be used
uriticaria, exudativecongunctivitis, in pregnancy and lactation. pemphigoid reactions. of rifampicin. It passes into the breast milk.
Rimactazid 6.6 LE Reddish discoloration of body fluidsRifampicin uriticaria, exudativecongunctivitis, Antacids, opiates, anticholinergic, It isn't recommended to be used
pemphigoid reactions, Nausea, in pregnancy and lactation. diarrhea, abdominal pain, hepatitis, of rifampicin. It passes into the breast milk.
headache, dizziness, mental concomitant use of halothane & isoniazide confusion, ataxia, leucopenia, may increase the risk of hepatotoxicity.
Anti-helminthes :Mebendazole Antiver 2 LE Gastro-intestinal disturbances, It isn't recommended to be used
diarrhea, abdominal pain. No interaction. in pregnancy and lactation.
Flubendazole Fluvermal 12 LE It isn't known that fluvermal is
azol +
ketoconozole : reduce the bioavailability
Isoniazide +
ketoconozole : reduce the bioavailability
diarrhea, abdominal pain, rashes, excreted in human milk. exanthema, urticaria, angioedema. No interaction. It isn't recommended to be used
in pregnancy and lactation.
Albendazole Bendax 5 LE diarrhea, abdominal pain, Dexamethasone, praziquantel andAlzental 2.3 LE leucopenia, headache, dizziness, It isn't recommended to be used
Vermizole 1.5 LE thrombocytopenia. ions of albendazole sulphoxide. in pregnancy and lactation.
Antifungal Drugs ( systemic ) :Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationGriseofulvin Ultragrisofulvin 3.5 LE rashes, itching, headache, fatigue It isn't recommended to be used
dizziness, leucopenia, proteinuria, in pregnancy and lactation. paraesthesia of hands & feet, the male partner must stop the
oral thrush and photosensitivity. inhibit the action of griseofulvin. drug for at least 6 months.
Terbinafine Lamisil 54 LE Plasma concentration of terbinafine may Terbin 26 LE diarrhea, nausea, anorexia, rashes be increased by drugs that inhibit its It isn't recommended to be used
Fungisafe 7 LE headache, urticaria, arthralgia, metabolism by cytochrome P450 in pregnancy and lactation. photosensitivity, hepatitis, jaundice, ( cimetidine ) & decreased by drugs that
induce cytochrome P450 (rifampicin ).
Itraconazol Itrapex 16 LE nausea, constipation, dyspepsia, headache, irregular menstruation, phenytoin, terfenadine, astemizole, It isn't recommended to be used
pruritis, urticaria, hypokalemia. cisapride, midazolam, triazolam, digoxin. in pregnancy and lactation.
Fluconazole Fungicam 10 LEFlucoral 14 LE diarrhea, abdominal pain, vomiting, It isn't recommended to be used
Flocazole 9 LE nausea, flatulence, headache, trations of fluconazole. in pregnancy and lactation. dizziness, leucopenia, skin rahes It passes into the breast milk.
thrombocytopenia. concentrations of fluconazole.
Topical Antifungal Drugs :Bifonazole Mycospor 13 LE Slight reddening, irritation, burning,
allergic reactions may occur. No interaction. NO evidence.
cimetidine : increase plasma concentrat-
Griseofulvin : it reduce the anticoagulant effect of coumarins. Barbiturates : may
Itrapex : may iteract with rifampicin,
Concomitant administation of rifampicin with fluconazole reduce plasma concen-
Hydrochlorothiazide : increase plasma
Tioconazol Topzol 6 LE Local irritation, hypersensitivityTrosyd 6.6 LE reaction appear in some patients. No interaction. NO evidence.
Nice--Baby 3.5 LE It is well tolerated but rare cases of local irritation may occure No interaction. NO evidence.
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationLotriderm 4.5 LE paresthesia, edema, maculopapular
Betamethazone rash, burning, itching, irritation, It isn't recommended to be used dryness, folliculitis, hypertrichosis, No interaction. in pregnancy and lactation.
allergic contact dermatitis, skin atrophy.
Clotrimazole Closol 6.5 LE Synergism or antagonism between This drug should be used only ifCanesten 4 LE Erythema, stinging, bistering, clotrimazole, nystatin, amphotericin B clearly indicated during the firstLocasten 3.25 LE edema, urticaria, buning, general trimester of pregnancy. CautionDermatin 1.3 LE irritation of the skin. has not been reported. should be exercised when it is
used by a nursing womanMiconazole Daktarin 5.5 LE It isn't systemically absorbed,
Miconaz 4.15 LE irritation of skin, buning, allergic No interaction. can be used during pregnancy Micoban 4.7 LE reactions. and lactation.
Miconaz H 5.5 LE Caution is recommended duringHydrocortisone Daktacort 5.6 LE local irritation, burning sensation, No interaction. pregnancy and lactation period.
Mycuten D 4 LE allergic reaction, telangiectasis, treatment of large surfaces underMonicort 5 LE hypertrichosis, atrophy. occlusive dressing should be
avoided.Econazole nitrat Pevaryl 5 LE local irritation may occur on It's advisable to apply an antieczematous
eczematous skin areas. drugs with pevaryl. NO evidence.
Econazole nitrat Pevisone 5.5 LETrimcinolone Hypersensitivity was observed in No interaction. it is recommended in the first
Nystatin + ZnO
Clotrimazole +
,flucytosine against strains of C.albican
Miconazole +
acetonidum very rare cases only. trimestere of pregnancy.
Ciclopirexol-- Batrafen 5.5 LE burning sensation, irritation of skin, It isn't recommended to be usedamin itching. No interaction. in pregnancy and lactation.
Neofungicil 2.5 LE Effect of benzoic acid is deminished by Hypersensitivity, non immunological non ionic surfactant or due to absorption NO evidence.
ZnO contact dermatitis can occur. by kaolin, it is inactive at PH above 5
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationNaftifine Hcl Exoderil 6.5 LE burning sensation, reddening The drug I unlikely to have any
dryness. No interaction. effects on fetus.
Iodochlorhydro- Vioderm 3 LExyquin No side effect. No interaction. NO evidence.
Tolnaftate Tineacure 3 LE No side effect. No interaction. NO evidence.
Sertaconazole Dermofix 15 LE the risk benefit ratio should be mild local, transient erythematous No interaction. evaluated before its use during
reaction. pregnancy and lactation.
Ketoconazole Ketoderm 5 LE It should used only if doctorHcl Nizoral 6.3 LE burning sensation, irritation of skin, No interaction. decides that this drug is
dermatitis absolutely necessary.
Terbinafine Hcl Terbin 9 LEFungiban 8.5 LEFungisafe 7 LE itching, redness, stinging No interaction. It isn't recommended to be used
Lamisil 13 LE in pregnancy and lactation.
Miconazole Miconaz 4.7 LE Mild GI disturbances, in rare caseDaktarin 18.5 LE allergic reactions may occure No interaction. NO evidence.
Chlorphenesin+Benzoic acid +
Clovacaine 3.5 LENo side effect. No interaction. NO evidence.
Clove oil
Anthraquinote Salivex - L 4.9 LE Hypersensitivity reactions to the Food shouldn't be ingested for 60 minutes NO evidence. drug componant are very rare. following the use.
Lidocaine Hcl
Antibiotic Drugs( A ) Penicillin group :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationPhenoxymethyl Ospen 5 LE Diarrhea, allergic reactions,
vomiting. No interaction. NO evidence.
Ampicillin Ampicillin 7 LEtrihydrate Epicocillin 4.5 LE
Hiconcil 9.6 LE Allergic reactions, skin rashes, oestrogen and affect on the absorption of When antibiotic therapy isIbiamox 8 LE (maculopapular eruptions), diarrhea other drugs. required during pregnancy it may Emox 13 LE vomiting, nausea, pruritus, Increased frequency of rashes when it is be considered appropriate.
Amoxicillin 6 LE pseudomembranous colitis, used with allourinol. Trace quantities of it can be Amoxil 7 LE hemolytic anemia, eosinophilia. Renal elimination is retarded by the detected in breast milk.Biomox 7 LE concomitant use of probencid.
( B ) Aminoglycoside group :Gentamycin Garamycin 8.6 LE Nephrotoxicity, neurotoxicity,
Apigen 7 LE vertigo, dizziness, skin tingling It isn't recommended to be usedQuadriderm 9 LE muscle twitching, leukopenia. No interaction. in pregnancy and lactation.
Allergic reactions, it may cause fetal harm
Optidex T 14 LE It isn't recommended to be usedDexamethasone Glaucoma, affect optic nerve No interaction. in pregnancy and lactation.
Lignocaine +Geranium oil +
glycoside +Salicylic acid +
penicillin Na+
Ampicillin may decrease the efficacy of
Tobramycin +
it may cause fetal harm
Neomycin Neomycin 6 LE Use of Neomycin in pregnancy sulfate hasn't been established and risk
benefit should be considered Gastro-intestinal disturbances, No interaction. Because of the potential serious ototpxicity and nephrotoxicity. side effect, discontinue the drug
taking into consideration the importance of the drug to the
mother.
( C ) Lincosamides group :Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Clindamycin Hcl Clindam 15 LEDalacin c 35 LE
Gastro-intestinal disturbances, appears to have neuromascular blocking It can pass through the placenta. vomiting, nausea, diarrhea, properties tat can enhance the effect of it should only be used during
abdominal pain, local irritation other neuromascular blockers. In patients pregnancy if necessary. hypotension, leukopenia, pruritus, treated with such drugs, clindamycin it appears in breast milk.
eosinophilia, hypersensitivity. should, therfor,be used with caution.
Lincomycin Lincocin 18 LE Vomiting, nausea, diarrhea, pruritus, leukopenia, enterocolitis,
neutropenia, thrombocytosis, No interaction. Safety for use in pregnancy has hypersensitivity reactions, edema, not been established. It is not skin rashes, urticaria, hypotension, indicated in the newborn.
local reactions.
( D ) Macrolide Drugs :erythromycin Erythrocin 12 LE Gastro-intestinal disturbances, Safety for use in pregnancy has
stearate vomiting, nausea, diarrhea, No interaction. not been established. allergic reactions, urticaria, It can pass through the placenta.
erythromycin Eryped 9.7 LE Gastro-intestinal disturbances, Safety for use in pregnancy has
An antagonism is demonstrate between clindamycin, erythromycin. Clindamycin
erthylsuccinate vomiting, nausea, diarrhea, not been established. allergic reactions, urticaria, No interaction. It can pass through the placenta. abdominal pain, anorexia it appears in breast milk.
erythromycin Primomycin 6.5 LE It potentiates effect of carbonazepin,Erythroprim 8 LE corticosteroid, digoxin, warfarin,
Trimethoprim Vomiting, nausea, diarrhea, drugs isn't recommended because It isn't recommended to be used hypersensitivity reactions. competitive inhibitions with erythromycin in pregnancy and lactation.
it may cause fetal harm. clioramphenicol.
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationSpiramycin Spirex 17 LE Pseudomembranous colitis, rashes
Rovamycin 24 LE urticaria, pruritus, angioedema, Safety for use in pregnancy has Rovapex 17 LE anaphylactic shocks, carbidopa with decreased levodopa not been established.
Rovac 17 LE vomiting, nausea, diarrhea, plasma levels it appears in breast milk.
Spirazole 12 LE Gastro-intestinal disturbances, Metronidazole nausea, diarrhea, unpleasant taste The effect of oral anticoagulants is It isn't recommended to be used
darkening of urine enhanced. in pregnancy and lactation.
Clorithromycin Klacid 18 LE vomiting, nausea, diarrhea, It inhibit the metabolism of these drugs Klarimix 15 LE headache, allergic reactions, ( warfarin, trizolam, midazolam, phenytoin ) Safety for use in pregnancy and
dyspepsia, abdominal pain, CNS It potentiates theophylline toxicity. lactation hasn't been established. side effects.
Azithromycin Xithrone 18 LE Antacids reduce the absorption of Azrolid 18 LE azithromycin.Mazit 17 LE Diarrhea, vomiting, nausea Azithromycin potentiate the effect of the drug shouldn't be used during
Aziwok 30 LE Gastro-intestinal disturbances, carbamazepine, digoxin, ergot alkaloid, pregnancy and lactation exceptZithrodose 13 LE dizziness, insomnia, skin rashes, valporate, cyclosporine. when necessary because safetyZithrokan 18 LE headache, anorexia, constipation Food decreases the absorption of of it hasn't been established. Neozolid 18 LE somnolence, pruritus, urticaria azithromycin, to be taken 1hr before or
stearate + theophylline. Cercurent use of these
may occur : Lincomycin, clindamycin,
Levodopa : inhibition of absorption of
Spiramycin + Alcohol : it cause Disulfiram-like reaction
Zithromax 54 LE 2hr after a meal.Zisrocin 18 LE
( E ) ChloramphenicolChloramphe- Streptophe- 9 LE Diarrhea, vomiting, nausea It isn't recommended to be used
nicol gastro-intestinal disturbances, It enhance the effects and / or toxicity of in pregnancy and lactation.Streptomycin bone marrow depression, anaemia, warfarin, oral hypoglycemic agents, oral it passes into milk and crosses
allergic reactions, conjunctivitis the placenta.
Chloramphe- Cidocetin 1.5 LE Diarrhea, vomiting, nausea, mental Rifampicin, phenobarbital accelerate the It is contrainicated in lactationnicol confusion, urticaria, hypoplastic metabolism of Chloramphenicol, it enhanc and pregnancy.
anaemia, headache. effect of warfarin, sulphonylurea.
( F ) Cephalosporin ( 1st generation ) :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationCephradine Velosef 12 LE Gastro-intestinal disturbances,
urticaria, abdominal pain, nausea This drug should be used during Diarrhea, vomiting, leukopenia, No interaction. pregnancy only if clearly needed
pseudomembranous colitis, it is excreted into breast milk.
Cephadroxil Duricef 12.5 LEmonohydrate Ibidroxil 9.9 LE Gastro-intestinal disturbances, A false- positive glycosuria reaction when It isn't recommended to be used
Curisafe 8 LE pseudomembranous colitis, tested with Benedict's, Fehling's solution in pregnancy and lactation.Biodroxil 7.5 LE nausea, vomiting, dyspepsia, Aminoglycoside, colistin may potentiate it passes into milk .Longicef 7 LE allergic reactions, urticaria, the nephrotoxic effect when taken with it.Keflex 23 LE headache, dizziness, fatigue
ceporex 15 LE eosinophilia.
( 2nd generation ) :Cefuroxime Zinnat 25 LE Erythema multiform, anaphylaxis, drugs which reduce gastric acidity may
skin rashes, urticaria, pruritus, result in a lower bioavailability of Zinnat It should be asministered with serum sickness, exanthematic compared with that of the fasting state, caution during the early months necrolysis, gastro-intestinal tend to cancel the effect of enhanced post of pregnancy, it is excreted in
nicol +
estrogen, It decrease absorption of vit.B12
disturbances, nausea, vomiting. -prandial absorption. the human milk.
Cefixime Ximacef 32 LE Gastro-intestinal disturbances, nausea, vomiting, mild diarrhea, Considration should be given to
skin rashes, pruritus, eosinophilia, No interaction. discontinuing nursing temporally headache, dizziness, leukopenia. during treatment with cefixime.
Cefaclor Bacticlor 12 LE skin rashes, urticaria, pruritus, ceclor 18 LE nausea, vomiting, diarrhea, serum It should be used during lactation
sickness, dizziness, insomnia, alter the rate or the extent of absorption of pregnancy only if clearly needed pseudomembranous colitis, bacticlor, renal excretion of it inhibited by it passes into milk .
probenicid.
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationCefprozil Cefzil 34 LE skin rashes, urticaria, pruritus,
nausea, vomiting, diarrhea, serum it may cause nephrotoxicity, concomitant It should be used during lactation sickness, dizziness, insomnia, administration of probenecid doubled the pregnancy only if clearly needed abdominal pain, eosinophilia, area under the curve for cefprozil. it passes into milk .
Cefpodoxime Orelox 29 LE H2 blockers and antacids reduce the abdominal pain, diarrhea, vomiting, bioavailability of Orelox and increased if NO evidence.
skin rashes. the drug taken during meals
( 3rd generation ) :Cefotaxime Foxime 18 LE Skin eruptions and fever, diarrhea,
Ceforam 8 LE eosinophilia, leukopenia, urticaria, renal excretion of it inhibited by probenicid It should be used during lactationCefotax 8 LE pseudomembranous colitis, pregnancy only if clearly neededClaforan 15 LE nausea, pruritus. drug, it may cause nephrotoxicity.
Cefoperazone Cefazone 7.5 LE renal excretion of it inhibited by probenicidCefobid 16 LE skin rashes, urticaria, pruritus, It should be used during lactation
mild diarrhea, leukopenia. drug, it may cause nephrotoxicity. pregnancy only if clearly needed
Ceftriaxone Rocephin 26 LE diarrhea, nausea, vomiting,
AloH / MgoH in antacids diminish the absorption of bacticlor. H2 blockers don't
Aminoglycoside : when used with cefzil
Aminoglycoside : when used with this
Aminoglycoside : when used with this
Ceftriaxone 18 LE eosinophilia, leukopenia, hemolytic There aren't any interactions and the It should be used during lactation anemia, skin rashes, urticaria, elimination of Rocephin isn't altered by pregnancy only if clearly needed pruritus, dizziness, headache, probencid. it passes into milk .
( 4th generation ) :Cefepime Hcl Maxipime 22.5 LE skin rashes, urticaria, pruritus,
diarrhea, nausea, vomiting, colitis, headache, fever, eosinophilia, There aren't any interactions It should be used during lactation
leukopenia, erythema multiform, pregnancy only if clearly needed Stevens-Jonhnson syndrome, it passes into milk .
hemolytic anemia, exanthematic necrolysis.
( G ) Quinolone Drugs :Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationCiprofloxacin Ciproquin 25 LE
Hcl Ciprobay 46 LE skin rashes, urticaria, pruritus, by ciprofloxacin. Ciprofloxacin crosses placentaCiprofloxacin 16 LE diarrhea, nausea, vomiting, colitis, its use isn't recommended in
Ciprocin 20 LE dizziness, abdominal pain, absorption of ciprofloxacin. pregnancy. It secreted in breastCiprofar 15 LE Stevens-Jonhnson syndrome, milk. Breast feeding should beServiflox 15 LE hemolytic anemia, exanthematic ciprofloxacin. discontinued.Bactiflox 16.5 LE necrolysis.Cipromax 33 LE quinolones.
Ofloxacin Kiroll 34.5 LE dizziness, abdominal pain, Safety for use in pregnancy and Ofloxin 18 LE diarrhea, nausea, vomiting, colitis, absorption of ofloxacin. lactation hasn't been established. Ocuflox 15 LE hemolytic anemia, exanthematic It increase the effect of cuomarin drugs its use isn't recommended inTarivid 47 LE necrolysis, skin rashes, urticaria, pregnancy and lactation because
pruritus, restlessness. increased by ofloxacin. it secreted in breast milk.
Sparfloxacin Parox 32 LE diarrhea, nausea, dyspepsia,Sparatec 36 LE dizzines, abdominal pain, flatulence absorption of sparfloxacin by chelation. It isn't recommended to be used
QT interval prolongation. also in Zinc / Iron salts in pregnancy and lactation.
Theophylline : its serum level increased
AloH / MgoH in antacids diminish the
Probencid : inhibit the renal excretion of
(NSAIDs): it increase the CNS effect of
AloH / MgoH in antacids diminish the
Glibenclamide : its serum level
AloH / MgoH in antacids diminish the
Levofloxacin Levoxin 25 LEUnibiotic 25 LE diarrhea, nausea, sleep disorders absorption of levofloxacin by chelation.Leo-flox 20 LE increasein liver enzymes ALT/ AST also in Zinc / Iron salts It isn't recommended to be usedTavanic 85 LE hemolytic anemia, vomiting in pregnancy and lactation.Tavacin 27 LE Stevens-Jonhnson syndrome, quinolones.Larivex 30 LE hemolytic anemia, exanthematic
necrolysis. levofloxacin.
Lomefloxacin Lomex or 25 LELomax diarrhea, nausea, vomiting, Lomefloxacin. It isn't recommended to be used
dizziness, in pregnancy and lactation. absorption of Lomefloxacin.
( H ) Tetracycline Drugs : Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Tetracycline Hcl Tetracid 3.5 LE diarrhea, nausea, vomiting, subtherapeutic serum concentration of it. It isn't recommended to be used flatulence, pruritus, glossitis. in pregnancy and lactation.
exacerbated the nephrotoxic effect of it.
Oxytetracycline Tetra 2.5 LE It should be used during lactationOxypol 5 LE Hypersensitivity, allergic reactions, There aren't any interactions. pregnancy only if clearly needed
Terramycine 3 LE dermatitis. it passes into milk .
Doxycycline Doxy 7 LE It advisable to avoid administration of diarrhea, nausea, vomiting, urticaria It isn't recommended to be used
anorexia, oesophagitis, oedema, in antacids diminish the absorption of in pregnancy and lactation. 2nd infection. doxycycline.
Doxycycline Hcl Tolexine 11 LE Dental dyschromia or enamel Doxycycline crosses placentaVibramycin 16 LE hypoplasia, nausea, epigastric pain It potentiate the activity of antivitamin K It should be used during lactationFarcodoxin 9 LE diarrhea, anorexia, glossitis, rash, pregnancy only if clearly needed
AloH / MgoH in antacids diminish the
(NSAIDs): it increase the CNS effect of
Probencid : inhibit the renal excretion of
Probencid : inhibit the renal excretion of
AloH / MgoH in antacids diminish the
Tetracid with antacids,milk may result in
Diuretics, Methoxyflurane may be
doxycycline with penicillin AloH / MgoH
Retinoids :Intracranial high blood pressure
compounds.AloH / MgoH in antacids
Doxymycin 4 LE pruritis,urticaria, hemolytic anaemia diminish the absorption of doxycycline. it passes into milk .
( I ) Antibiotic combination :Klavox 32 LE
Clavulanic A Curam 21 LE diarrhea, nausea, vomiting, urticaria It reduce the effect of oral contraceptives It should be used during lactationAugmentin 28 LE pseudomembranous colitis, pregnancy only if clearly needed
Magna biotic 12 LE Stevens-Jonhnson syndrome, this drug. it passes into milk .E moxdar 18 LE hemolytic anemia, exanthematicHibiotic 22 LE necrolysis.
Ampicillin Na Ampiclox 6.6 LE diarrhea, indigestion, urticaria, It isn't recommended to be used
Cloxacillin hypersensitivity, erythematous rash this drug. in pregnancy and lactation.
Analgesic and Antipyretic Drugs( A ) Acetysalicylate Drugs :
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationAcetysalicylate EZ Acard 7.5 LE
Aggrex 1 LE Bronchospasm, gastro-intestinal It isn't recommended to be usedAspocard 1.25 LE haemorrhage, nausea, vomiting, in pregnancy and lactationAspocid 2 LE allergic reactions,implicated in increase risk of gastro-intestinal bleeding, It should used only if doctor
Alexoprine 1 LE some cases of Reye's syndrome decides that this drug isRivo micro 1 LE in children. enhance asprin effect. absolutely necessary.
( B ) Paracetamol Drugs :Panadol 18 LE Although there is epidemiological
Adol 4 LE urticaria, skin rashes, blood evidence of the safety of Cetal 2 LE disorders have been reported. bleeding. Paracetamol in pregnancy and
Paramol 4 LE allergic reactions, impair hepatic or lactation, medical advice should renal function. of Paracetamol. be sought befor using this product
Pronto plus 5 LE Although there is epidemiological
Amoxicillin +
Probencid : inhibit the renal excretion of
trihydrate + Probencid : inhibit the renal excretion of
With anticoagulants increase risk of the bleeding.With antacids increase excretionso decrease its effect.With corticosteroid
With Metoclopramide + Dompridone
Paracetamol With anticoagulants increase risk of the
Cholestyramine: diminish the absorption
Paracetamol +
Caffeine Panadol extra 12 LE hypersensitivity reactions, skin evidence of the safety of Abimol extra 5 LE reddening, allergic reactions with bleeding. Paracetamol in pregnancy and
exanthems & disorder in blood cell lactation, medical advice should of Paracetamol. be sought befor using this product
Panadol cold 30 LE allergic reactions,skin reactions,Pseudoephedrin & flue restlessness, insomnia, anxiety, It isn't recommended to be used
Europack 20 LE tachycardia, urinary retention bleeding. in pregnancy and lactation.acid Ezamole-C 3.5 LE disorder in blood cells, vomiting,
Efferalgan 9 LE nausea. of Paracetamol.
( C ) Non steroidal analgesicKetoprofen Bi alcofan 2.5 LE gastro-intestinal haemorrhage, It isn't recommended to use asprin with It should used only if possible
Ketoprek 5 LE diarrhea, anorexia, flatulence, ketoprofen also probenecid not taken with benefit justifies the potential riskKetofan 5 LE abdominal pain, dizziness, ketoprofen. to the foetus.Fastum 3.6 LE
Anti-inflammatory Drugs :Systemic and Topicaly
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationTenoxicam Epicotil 11.8 LE It should used only if possible
Gastralgia, heartburn, nausea, benefit justifies the potential risk dizziness, headache, itching, rash sparing diuretics. to the foetus.it passes into milk.
The use of epicotil during late volume of distribution of tenoxicam. pregnancy should be avoided
Piroxicam Inflacam 4 LE Stomatitis, anorexia, nausea, Brexin 12 LE constipation, abdominal pain, piroxicam.
flatulence, indigestion, ulceration, It isn't recommended to be used dizziness, headache, insomnia, higher than using the drug alone. in pregnancy and lactation.
depression, nervousness, hypersensitivity reactions. effect of ACE inhibitors.
With anticoagulants increase risk of the
Cholestyramine: diminish the absorption
Paracetamol + With anticoagulants increase risk of the
Hcl + Ascorbic Cholestyramine: diminish the absorption
It shouldn't be administered with K+
(NSAIDs): it increase the clearance and
Aspirin : decrease the plasma levels of
Warfarin : cause serious GIT bleeding
Piroxicam : diminish the antihypertensive
Diclofenac Na Olfen 9 LE nausea, vomiting, diarrhea, GIT It must not be taken in the last 3 Voltaren 11.2 LE bleeding, headache, dizzness, bleeding. monthes of pregnancy. The use
Rheumarene 4.8 LE drowsiness, bronchospasm, of diclofenac in first 6 monthes Clofen 23.5 LE hypersensitivity reactions, level of diclofensac. of pregnancy and lactation shouldDivido 23.5 LE Stevens-Jonhnson syndrome, only be considered after a
exanthematic necrolysis. digoxin, phenytoin, lithium drugs. medical appraisal of benefit risk.
Diclofenac K Rapidus 11.5 LE nausea, vomiting, diarrhea, GIT Safety for use in pregnancy and Cataflam 18 LE bleeding, headache, dizzness, digoxin, phenytoin, lithium drugs. lactation hasn't been established.Catafast 18 LE drowsiness, bronchospasm, It should not be given especially
hypersensitivity reactions, higher than using the drug alone. in 3rd trimester of pregnancy.
Aceclofenac Bristaflam 10 LE dyspepsia, abdominal pain, nausea diarrhea, constipation, vomiting, It isn't recommended to be used flatulence, dizziness, insomnia. effect of ACE inhibitors and diuretics. in pregnancy and lactation.
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationIbuprofen Brufen 3.3 LE Dyspepsia, GIT bleeding, skin rash It should be used during lactation
thrombocytopenia, toxic amblyopia lithium drugs. pregnancy only if clearly needed
Cetafen 5.5 LE Gastro-intestinal disturbances, Paracetamol Contafever 10 LE nausea, vomiting, mild diarrhea, It isn't recommended to be used
dyspepsia, gastritis, hypersensitivity There aren't any interactions. in pregnancy and lactation. reactions, thrombocytopenia.
Meloxicam 10 LE nausea, abdominal pain, stomatitis It isn't recommended to be usedMelocam 12 LE dizziness, headache, itching, rash meloxicam. in pregnancy and lactation.
Sulindac Rudac 13 LE dyspepsia, nausea, diarrhea, rash constipation, dizziness, headache higher than using the drug alone. It isn't recommended to be used
GIT bleeding, in pregnancy and lactation.
Rofecoxib Arthidol 9.5 LE nausea, heartburn, dyspepsia, It isn't recommended to be used
Glucocorticoids : increase risk of GIT
Acetylsalicylic acid : decrease serum
Diclofenac : increase the serum levels of
Diclofenac : increase the serum levels of
Warfarin : cause serious GIT bleeding
(NSAIDs): enhance effect of Li, digoxin. Aceclofenac : diminish antihypertensive
Ibuprofen : increase the serum levels of
Ibuprofen +
Anticox ∏ Cholestyramine: increase elimination of
Warfarin : cause serious GIT bleeding
Aspirin : may decrease its effectiveness.
diarrhea, headache, hypertension, There aren't any interactions. in pregnancy and lactation. dizziness, GIT bleeding. it should be avoided in late stage
Celecoxib Celoxib 16 LE It should used only if possibleCelebrex 24 LE GI manifestation such as dyspepsia effect of ACE inhibitors and diuretics. benefit justifies the potential risk
abdominal pain. It should not taken with fluconazole to the foetus.
Lornoxicam Xefo 15.5 LE stomach pain, diarrhea, indigestion it may interacte with Li, anticoagulants, It isn't recommended to be used dizziness, nausea, vomiting antidiabetic, ACE inhibitors, diuretic drugs in pregnancy and lactation.
Glucosamine Dorofen 31.5 LE heartburn, diarrhea, nausea, it may interacte with anticoagulants, It isn't recommended to be used
Flavonoid dyspepsia, headache, constipation, in pregnancy and lactation.
Unsaponifiables Piascledine 30 LEof Avocado and No side effect if taken during meal There aren't any interactions. Usage during pregnancy and
Soya. lactation is not yet investigated
Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / LactationGlucosamine Glucosamine 14 LE Gastro-intestinal disturbances,
drowsiness, headache, kin rashes There aren't any interactions. NO evidence.
Glucosamine Cartilgin 13 LE Gastro-intestinal disturbances, It isn't recommended to be used
Chondrotin nausea, vomiting, abdominal pain, There aren't any interactions. in pregnancy and lactation. constipation, diarrhea,
Herpago phytum Herpago 13 LEprocumbens No side effect. Avoid during first trimesters of
extract patients should be monitored regularly pregnancy.
Leflunomide Apetoid 15 LE Diarrhea, elevation of liver enzymes Aspirin, NSAIDs and corticosteroids may ( ALT/ AST ), alopecia, rash, be continued during treatment with It isn't recommended to be used
(NSAIDs): diminish antihypertensive
sulfate + Ginko
sulfate + vit C
sulfate + vit C
sulfate
Herpago : may affect action of warfarin,
pancytopenia. Leflunomide. in pregnancy and lactation.
Indomethacine Indotopic 3.25 LE Redness, itching, it should be avoided to contact with eye, ulcers, There aren't any interactions. It isn't recommended to be used traumatic wounds, mucous tissues in pregnancy and lactation.
Prednisolone Predsol 10 LE Sodium retention and potassium Na phosphate loss occur only very rarely. administration of anticonvulsants, rifampin
Symptoms of hypercorticoidism bronchodilators. Its dose should be Pregnant women should take only occur after prolonged therapy reduced upon administration of estrogens, this drug under strict medical with high doses. Milder phenomena ketoconazole, erythromycin. supervision.
of autonomic unbalance which Breast feeding should be avoided occurs occasionally does not as a It may interacte with anticoagulants like during therapy by the product.
rule require special measures.
Welevon 12 LE Hyperensitivity reactions to its The doses of anticoagulants must be component like acetyl salicylate adjusted with concomitant treatment with NO evidence.
drugs Welevon
Anti-Allergic Drugs :Generic Name Brands Price Adverse Effects Drug / drug or food Interactions Pregnancy / Lactation
Dexamethasone Phenadone 7 LE it is contraindicated in active and Chlorphenir- questionably healed tuberculosis, There aren't any interactions. NO evidence.
amine maleate peptic ulcer, diabetes, osteoporosis marked emotional instability
Desloratadine Aerius 5 LE fatigue, headache, dry mouth, It should used only if possible hypersensitivity reactions, There aren't any interactions. benefit justifies the potential risk tachycardia, palpitations, to the foetus.
Loratadine Claritine 23 LE Safety for use in pregnancy and fatigue, headache, sedation, alcohol, loratadine has no potentiating lactation hasn't been established.
nervousness, alopecia. effects. It should used only if possible
Glucocorticoids : is recommended upon
(NSAIDs): increase risk of GI ulceration
Warfarin or Heparin.
Fever few +White willow +Estere C , Vit B6
benefit justifies the potential risk to the foetus.
Chlorphenox- Allergex 2.5 LEamin Hcl dryness mouth. There aren't any interactions. NO evidence.
Pseudoephedrin Clarinase 12.5 LE insomnia, dry mouth, headache, alcohol, loratadine has no potentiating somnolence, dizziness, fatigue, Safety for use in pregnancy and
Loratadine nausea, abdominal pain, anorexia. increase plasma level of Loratadine. lactation hasn't been established.
Cyproheptadine Triactin 4 LE drowsiness, dryness of mouth, To be used only when clearly Hcl throat, thickening of the broncial There aren't any interactions. indicated in the 1st trimester &
secretion, dizziness, skin rash. should be avoided in last stage
Fexofenadine Telfast 30 LE drowsiness, dizziness, headache, It isn't recommended to be usedHcl nausea, fatigue, urticaria, pruritus. plasma level of Fexofenadine Hcl. in pregnancy and lactation.
Cetirizine Di Hcl Cetrak 6 LE Gastro-intestinal disturbances, Safety for use in pregnancy and Clearet 10 LE headache, tachycardia, dizziness. There aren't any interactions. lactation hasn't been established.
Hcl + effects, ketoconazole, erythromycin
ketoconazole, erythromycin increase