Åbo, finland - the marcus wallenberg...
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Bjarne HolmbomChrister EckermanÅbo, Finland
Bjarne HolmbomChrister EckermanÅbo, FinlandRecipients of the 2008 Marcus Wallenberg PrizeRecipients of the 2008 Marcus Wallenberg Prize
The Relevance of Science for Innovations
Is science really relevant ?
Bjarne HolmbomChrister Eckerman
The Marcus Wallenberg Prize Symposium, 7 October 2008
Need of InnovationsEspecially in the Forest Industry
1. Getting / Creating Ideas2. Refining to Products / Innovations
The role of scientists / researchers ?
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Timber, pulp, paperBiorefinery productsProcesses
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Timber, pulp, paperBiorefinery productsProcesses
Scientificanalyses
Fundamental knowledge base
Publications
Timber, pulp, paperBiorefinery productsProcesses
Scientificanalyses
Technical ideasInventions
Fundamental knowledge base
Publications
Message of MSc student
To really understand these phenomena we have to dive into the world of molecules -----
and then come back to the surface.
Tea Hannuksela, M.Sc. Thesis 1998, p. 5Partial carboxymethylation of parenchyma cell cellulose
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Timber, pulp, paperBiorefinery products
Fundamental knowledge base
Processes
Scientificanalyses
Publications
Technical ideasInventions Innovations
How are ideas created (pop up)By passionate creative mindsIn small groupsIn a free trusting atmosphereTime and freedom to think, and try all kinds of things Usually not during ordinary working hours
Big technical projects deactivate creative minds
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Ideas -> -> -> -> Innovations
Ideas should be tested and refinedWho should do it - - -Scientists and researchers should have a central role
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Science is an exciting adventure
Like an adventurous search in a vast forest
where nobody has been before
trying to understand ”Nature’s Wisdom”
Trying to find treasures - - -
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We found a knot
10% of lignans
Nature’s richest source of bioactive polyphenols
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R & D on knots at ÅA6-29% lignans
More spruceknots Analysis
10% lignans !Knots from other treespecies
50+ species5-15% polyphenols
Polyphenol fundamental chemistry Isolation, purificationBiotesting
1998 Technicalsep. of knots
”ChipSep”
Applications
About 30 scientific publications5 PhD Theses
6 – 29 %< 1 % 0.1 %
Hydroxymatairesinol (HMR)
Lignans in Picea abies
70-85% of the lignans
O
OMeO
OH
OH
OMe
OH
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The Norway spruce lignanHydroxymatairesinol (HMR)
• Strong antioxidant • Inhibits breast cancer growth (Univ. of Turku)
• Hormos Medical Corp., Turku, product development 1997 ---• Clinical test on humans: no adverse effects• New dietary ingredient clearance from US FDA 2004• License Hormos Linnea S.A. in 2005• HMRlignanTM on the market in 2006
O
OMeO
OH
OH
OMe
OH
Knots can be separated from wood chips
Chipping Pulping
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Stem wood ScreeningTMPCTMP
Kraft pulp
Over-thick chips
Normalwood
ChipSepKnot wood
The ChipSep ProcessFI Pat Appl. Aug. 2000 by C. Eckerman and B. Holmbom
Pulping
Over-thickchips
RechippedNormalwood
ChipDryer
Sep. tank
Warmair
Knotwood
Still much normal wood in knot-chips
Drying of over-thick chips for pilot experiments
First separator prototype 2001
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Farm production of knots 2005 - 2007
Continuous chip dryer
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Continuous ChipSep separatorChips in
Knot productNormal wood out
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Timber, pulp, paperBiorefinery productsProcesses
Scientificanalyses
ChipSep
1998
2000
IdeasInventions Innovations
Fundamental knowledge base
1998 --- 2006
A novel platform for valuable bioactive compounds
PaperBoard
Pulping Papermaking
Dietary suppl. Health foodsCosmeticsTechn. antiox.Natural biocides
LignansFlavonoidsStilbenes
Knots
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The Relevance of Science for Innovations
Bjarne HolmbomChrister Eckerman
The Marcus Wallenberg Prize Symposium, 7 October 2008
Is science really relevant ?
Yes, it is creating a solid knowledge baseessential for industrial renewal
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We academic scientists hope ---
To get resources and freedom to do what we are passionate at: doing creative researchWe can create the knowledge base essential for technical ideas Come and ask us if we have got any new ideasPush us, and support us, to bring our ideas forward to innovations
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AcknowledgementsScientific work at ÅA
Senior researchersRainer Ekman (t)Rainer SjöholmJorma MattinenMarkku ReunanenKenneth SundbergJarl HemmingAnnika Smeds
PhD students (PhDs)Lari VähäsaloStefan WillförSuvi PietarinenPatrik EklundHeidi MarkusLinda Nisula
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AcknowledgementsScientists at University of Turku
Risto SanttiSari MäkeläNiina SaarinenMarkku Ahotupa
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AcknowledgementsSupport for R&D
Research Academy of FinlandTekes
Innovation developmentThe Foundation for Finnish InventionsRunar Bäckströms Stiftelse
Business developmentHormos Medical UPM-KymmeneLinnea AS
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AcknowledgementsInnovation development
Thomas HolmbomStig-Björn BrandtMikael Söderholm & Sons
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