1.DR IMRAN GAFOORDR DINESH RAWATFELLOW.DEPT. OF CCEMSGRH,NEW DELHIBLOOD & BLOOD PRODUCTS

2. INCIDENCE :: Anemia has an incidence of 29-37% in critically ill.: Recent cross-sectoinal analysis showed that,29%had Hb < normal & 37% required RBCtransfusions.[vincent et al;JAMA-02]:MOST SIGNIFICANT RISK assoc with anemia isthe harm resulting from decrease in Oxy carryingcapacity & plasma volume. 3. NATURAL HISTORY OFUNCORRECTED ANEMIA: Leung et al found ECG changes that may beindicative of myocardial ischemia in subjects ofisovol hemodilution to a conc. Of Hb 5gm/dl.[leung et al-anaesthesi. 2000]:Descriptive studies in pt refusing RBC transfusionhave demonstrated that pt can survive surgicalinterventions with Hb as low as 4.5gm/dl.[spencer et al-Am j surg 1990] 4. : Development of consequences of anemiadepends on pts ability to compensate.: less tolerating group of pts are a) olderb)severly illc) coronary,cerebrovas,resp co-morbidities 5. :Researches have revealed that increasing degrees ofanemia were associated with a disproportionateincrease in mortality rates in cardiac patients.[Hebert et al-Am j resp criti care 1997]:Anemia increases risk of death in patients of significantcardiac disease. 6. : CURRENT RECOMMENDATIONS - except in circumstances of ACS pt can betransfused for Hb