bis437 bio-data engineeringcontents.kocw.or.kr/document/wcu/2012/bio_data... · 2012. 6. 15. ·...
TRANSCRIPT
![Page 1: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/1.jpg)
BiS437 Bio-Data Engineering
Spring 2012
Doheon LeeDept. of Bio and Brain Engineering, KAIST
Who I am
• Doheon Lee, Professor, Dept. of Bio and Brain Engineering, KAIST• Ph.D. in Computer Science (KAIST, 1995), KIT CS86• Stanford(2010), Indiana Univ.(2009), NIH(2002), Univ. of Texas(1999) etc.. • Certified information system auditor• Over 200 academic papers for bioinformatics and data mining• Director – Bio-Information System National Research Lab • Director – IBM-KAIST Bio-Computing Research Center• Director – WCU Neuro-Systems Research Group• Ways to reach
1. mailto: [email protected]. call: 042-350-43163. visit: CMS Building (E16), #1111 (Ace-Poker) 4. encounter: KAIST campus, outside sometimes
![Page 2: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/2.jpg)
3S for Saying Hello
1. Sense them(see, feel, guess) 2. Have them See you(gesture and sound)3. Show your Smile
Try !!!
Course Outline
• Three goals of this course1. Communicational knowledge of computer science and technology2. Actionable experience of information system implementation3. Primer appreciation of the essential power of bioinformatics
• Grading (Higher between two plans)
• Textbooks– J. Brookshear, Computer Science, Ed. 11(or Ed. 10), Addison-Wesley, 2011– D. Lee, Biomedical Information System for Personalized Medicine, BISL, 2012
• Course Website: Moodle• E-mail: [email protected]• TA: 황우창, 김준호, 류하선, 김광민 ([email protected])
Plan A Plan B
Class Participation and Quiz 10% 10%
Project 40% (10+15+15) 40% (10+10+20)
Mid-Term Exam. 20% 10%
Final Exam. 30% 40%
![Page 3: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/3.jpg)
Why you should take this course
Society Bio-Medical Science
Ancient Hunting, Collection, FarmingExperience,Observation
~20th Century IndustrializationControlled
Experiments
21st Century Information Bioinformatics
Future Dream, Emotion You create!
The Origin of Computing Machines
• Abacus: the ancient Greek and Roman, merely a data storage system• Technology of gears (19C)
– Pascal (France): Adder hard-wired in gears– Leibniz (German): Several selectable operations hard-wired in gears– Charles Babbage (England)
• Difference Engine• Analytical Engine: Read instructions in the form of holes in paper cards
– The first programmer: Ada Byron– cf. Jacquard’s loom
• Electromechanical machines: MARK I, Harvard, 1944• Vacuum tube machines
– 1941, Atanasoff-Berry machine at Iowa State Univ.– Colossus, to decode German messages in England during World War II– 1946, ENIAC (Electro Numerical Integrator And Calculator), Univ. of Penn.
• Semiconductor substrate-based bipolar digital logics– 1958: Jack Kilby’s IC (Nobel prize)– 1962: TTL (Transistor-transistor logic)– 1974: ECL (Emitter-coupled logic)
• CMOS (Complementary Metal Oxide Silicon)-based machines• Biochemical computing machines ?
![Page 4: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/4.jpg)
Jacquard’s Loom (1801) – The first programmed machine
• The steps to performed during the weaving process were determined by patterns of holes in paper cards
Mark-I (1944) – The first electro-mechanical computer
![Page 5: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/5.jpg)
ENIAC (1946)- The first electronic-digital computer
Stored-Program Concept
Single built-in ring
Selectable built-in rings
Downloadable rings(= color ring)
Single built-in program
(Calculator)
Selectable built-in programs
(Organizer)
Loadable programs(von Neumann Computer)
cf. Data vs. program
![Page 6: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/6.jpg)
How to Assemble Your PC - Components
• CPU: The processing part of a brain – e.g. Intel Pentium 4 2.0A GHz (Cache 512KB)
• RAM: The memory part of a brain– e.g. Samsung Elec. 256MB DDR SDRAM(PC2100)
• Main board: A scaffold– e.g. Unitec TANK ULTRA DDR (P4X266A)
• HDD: A notebook– e.g. Seagate Barracuda 4 60GB (7200RPM)
• FDD: A letter– e.g. Samsung 3.5 inch Floppy Disk Drive (becoming non-necessary)
• ODD: A long letter or a log– e.g. Samsung Elec. 52x CD-ROM Drive
• Power Supply: A digestive organ for energy supply– e.g. DAO for Pentium 4 250W
• Case: The outer skin– e.g. DAO C710(ATX)
• Monitor, Keyboard, Mouse, Speaker, Camera, LAN Card, Modem, Printer, etc
Tools
nipper
screwdriver
Pliers (long nose)
![Page 7: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/7.jpg)
Components in Wrappers
Main Board
![Page 8: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/8.jpg)
CPU and CPU Socket on the Main Board
CPU with Cooler Installation
![Page 9: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/9.jpg)
RAM Installation
Main Board in the Cabinet
![Page 10: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/10.jpg)
Sound Card Installation
Main Board Slots for CDD, FDD, and HDD
![Page 11: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/11.jpg)
CDD, FDD, HDD Installation
CDD FDD
HDD Assembly
Inside of a Completed PC
![Page 12: BiS437 Bio-Data Engineeringcontents.kocw.or.kr/document/wcu/2012/Bio_Data... · 2012. 6. 15. · BiS437 Bio-Data Engineering Spring 2012 Doheon Lee Dept. of Bio and Brain Engineering,](https://reader034.vdocuments.mx/reader034/viewer/2022052615/608ae7ac7cfad663db5f6859/html5/thumbnails/12.jpg)
PC and Supercomputer
How expensive your computer is
• You (or your parents) bought a PC: 2,000,000 KRW• Usually, you will use it for three years• Three years = 1,095 days• 2,000,000 KRW / 1,095 days = 1,826 KRW / day• 2,000,000 KRW / (1,095 days * 24 hours) = 76 KRW / hour
• Your PC is consuming ~2,000 KRW each day from your (or your parents’) pocket no matter how frequently you use
How to keep the value of your (or your parents’) money =>
Use it as frequently as possible