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016 BIOVIA Science Council

Introduction and Overview

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Our Company’s DNA is Science

a ScientificcompanyCombining Science, Technology and Art for a sustainable society

15,000passionate people• 132 nationalities/172 Sites• One global R&D / 60 labs • Game changing 3DEXPERIENCE

solutions

250,000enterprise customers• 12 industries in 140 countries• >30 million online users

12,600partners• Research & Education • Software & Technology• Sales & Services

Long-termdriven• Majority shareholder control • Revenue: $ 3.3 Bn*• Operating margin: 31.2%*

* Non-IFRS

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BIOVIA Mission

BIOVIA provides a scientific collaborative environment foradvanced biological, chemical and materials experiences. The sophisticated enterprise system of modeling, simulation, laboratory and quality management enables innovation for science-based industries.

Virtual BioSphere and Materials|

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BIOVIA – A Science-based Brand“BIOVIA is committed to speeding innovation for science-driven organizations, from product ideation through commercialization.”

BIOVIA aim to be at the scientific forefront in the fields of science relevant to our customers

The BIOVIA Science Council (BSC)is guiding and coordinating the scientific efforts of BIOVIA

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BIOVIA Science Council – Mission• Provide scientific guidelines and directions for BIOVIA

in the domains of Virtual BioSphere and Materials, by covering applied science innovation and strategy, from discovery to commercial production.

• Ensure scientific excellence & leadership for all chemical, material and biology based industries.

• Promote value and prestige for Dassault Systèmes scientific communities and solutions.

BSC

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WHO

WHAT

HOW

3DS and BIOVIA Science Driven Industries

Customers R&D, Functional Teams

Executive and Product Specific Scientific Meetings, Publications, PR, Experiences,

Scientific Advisory Board, External Collaborations

BIOVIA Science Council – Equity Pyramid

Providing Scientific Leadership,Guidelines and Directions for Virtual BioSphere & Materials

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BIOVIA Science Council – Areas of ExpertiseMaterials Science

Multiscale modelling of Materials to build a bridge between

BIOVIA and Simulia. This is part of the

strategic initiative on additive

manufacturing at 3DS.

Process Production

Integrating process development,

manufacturing and quality environments

to drive effective process design,

performance and improvement.

Statistical Application

Optimizing statistical applications to make

meaningful, data-driven business

decisions in scientific industries.

BioPLM

Improving the efficiency of

biological research with systemic modelling and

simulation tools.

LifeScience Research

Scientific support for product development

in the Life Science sector. Focusing on Virtual screening, Pharmacophore

modelling, Protein simulations and anti-

body modelling.

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BIOVIA Science Council – Members

* Senior Fellow ** Fellow

LifeScience Research

Dr. Hugues-Olivier BertrandSenior Director Life Science Research Pre-Sales*

Dr. Anne Goupil-Lamy, Principal Field Application Scientist**

Expertise in protein modeling, simulations of macrolecules, virtual screening and structure based drug design

Expertise in protein modelling, molecular dynamics simulations of macromolecules, antibody design, structure-based and ligand-based design projects.

3DEXPERIENCE PlatformLiaison BIOVIA – 3DS

Patrick Johnson3DS Vice President, Corporate Research & Science,ProductSphere & BioSphereResearch*

Expertise in 3DExperience Platform Scientfic foundations & technologies.Knowledge Engineering& Management, Virtual Product Design,Systems Biology

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BIOVIA Science Council – MembersMaterials Science

Dr. Victor MilmanSr. Director Quantum Mechanics and Nanotechnology R&D Team*

Dr. Marc MeunierPrincipal Field Application Scientist**

Dr. Johan CarlssonSenior Field Application Scientist**

Expertise in quantum-mechanical modellingof solids and surfaces

Expertise in nanodielectrics, simulation of polymeric materials and materials modelling

Expertise in electronic structure calculations,modelling of inorganic and carbon based materials

* Senior Fellow ** Fellow

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BIOVIA Science Council – MembersStatistical Application

Dr. Kate Lusczakoski, Manager of Value Engineering**

Expertise in application of statistical techniques in the pharmaceutical/biotechnology manufacturing and health care industry

Process Production

Dr. Justin NewayVice President and Managing Director BIOVIA, Process Production Operations*

Expertise in biotechnology and pharma-ceutical process development and manufacturing and the application of software solutions to operational issues and quality compliance in biotechnology and pharmaceutical manufacturing

* Senior Fellow ** Fellow

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BIOVIA Science Council – ActivitiesPromote scientific efforts

Scientific Outreach

Connect with other

brands

Guide product

development

• Manage external Collaborations

• Contribute to conferences

• Provide access to publications

• Award BIOVIA presentations

• Award portfolio contributions

• Collaborate with Product Management

• Establish a Scientific Advisory Committee

• Coordinate collaborations with other Dassault Systèmes brands

Scientific education of

the employees

Scientific Quality Control

• Review of BIOVIA publications before submission

• Establishing a Scientific mentoring program for young scientists in the company.

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Houston University - O. LichtargeSequence Analysis Evolutionary Trace DS

MIT- B. TroutAntibody Development AggMap

DS

Illinois Univ Urbana –ChampaignNAMD orce Field Based Simulation

Columbia - B. HonigPB Electrostatics Delphi

DS

CCDC - C. GroomDocking Engine GOLD DS

Harvard - M. KarplusCHARMm Force Field Based Simulation EngineDocking Engine MCSS ( Fragments) ( CHARMm Based)

DS

BASF - J. BohmDe Novo Design LUDI

DS

Univ. Strasbourg - D. RognanProtein Ligand Interactions PharmacophoresLigand Profiling

DS

UCSF - A SalijComparative Modeling MODELER

DS

Massachusetts Medical School - Z. WengProtein Protein Docking ZDOCK

DS

UCLA - D. EisenbergComparative Modeling Profiles-3D (Model verification)

DS

Cambridge Enterprise - M. C. PayneCASTEP (density functional general purpose engine)

MS

Erlangen University - T. ClarkVAMP (semi empirical quantum mechanics for molecules)

MSDS

Paul Scherrer Institute - B. DelleyDMol3 (density functional general purpose engine)

MSDS

Bremen University - T. FrauenheimDFTB+ (semiempirical general purpose quantum mechanics)

MS

Curtin University - J. GaleGULP (general purpose forcefield engine, focus on inorganics)

MS

Imperial College London - P. HaynesONETEP (linear scaling density functional general purpose)

MS

University College London - C. J. Pickard CASTEP NMR (specific CASTEP module)

MS

STFC - P. SherwoodQMERA/QUANTUMm (hybrid QM/MM calculations)

MSDS

University of Frankfurt - B. WinklerDFT applications for inorganic materials

MS

CCDC – N. FeederIntegration between Materials Studio and CCDC software

MS

Tamkang University - M.-H. LeePseudopotential development for CASTEP and ONETEP

MSTiberLab - A. PecchiaElectron transport engine

MS

Shanghai Jiao Tong University - H. SunCOMPASS forcefield

MS

Leiden University - H.FraaijeMesoDyn (mesoscale modeling of polymers)

MS

Cambridge University - J.ElliottPolymer and mesoscale modelling applications

MS

University of Akron - H.HeinzDevelops inorganic/organic forcefields

MS

University of Minnesota - M.NeurockCatalysts/reactions on surfaces

MS

Cornell University - R.HoffmanElectronic structure calculations

MS

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UMich, Ann Arbor – Charles BrooksDocking Engine CDOCKER DS

BIOVIA Research Collaborations

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