biotecnologia pais vasco

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BioBasque Company Directory 7 The Basque bioRegion Company Directory lists companies that develop or produce applications deriving from the use of biotechnology and converging technologies and disciplines, and companies that either produce or commercialise services and products needed for the research, development and production activities of those applications. The Company Directory provides a brief portray of the companies, based on their own description of activities. The first part of the guide presents biocompanies related to human health and biomedicine, including pharmaceutical companies and CROs, biomaterials and medical devices, veterinary and agro-food, diagnostics, industrial and environmental biotechnology, and specialised services. In the second part, the guide offers contact information on suppliers and distributors. For more information and updates, please visit www.biobasque.org

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Page 1: Biotecnologia Pais Vasco

BioBasque Company Directory

7

The Basque bioRegion Company Directory listscompanies that develop or produce applicationsderiving from the use of biotechnology and convergingtechnologies and disciplines, and companies thateither produce or commercialise services and productsneeded for the research, development and productionactivities of those applications.

The Company Directory provides a brief portray ofthe companies, based on their own description ofactivities. The first part of the guide presentsbiocompanies related to human health andbiomedicine, including pharmaceutical companiesand CROs, biomaterials and medical devices,veterinary and agro-food, diagnostics, industrial andenvironmental biotechnology, and specialised services.In the second part, the guide offers contactinformation on suppliers and distributors.

For more information and updates, please visitwww.biobasque.org

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Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Environment and Industry.

Company profileTechnologically based company whose business is development and production of biological productsformulated with enzymes and microorganisms, for bioremediation and biodetergence applications.

A&B Laboratorios de Biotecnología combines biotechnology and clean technologies for the developmentof its innovating products under life cycle analysis for Industries and agro-food sector, and forenvironmental institutions.

The organisation develops its products in a management system backed by AENOR certification ofthe systems of quality, environment, R&D&I, and Ecodesign, under ISO and UNE standards.

Key wordsEnvironmental biotechnology, Bioremediation, Biodetergency, LCA, Ecolabel.

5 5-50 50

A&B LABORATORIOS DE BIOTECNOLOGÍA

Address:Polígono Industrial de JúndizPaduleta esquina Júndiz01015 Vitoria · ArabaSpainContact person:Jon Kepa IzaguirreTelephone:+ 34 945291616Fax:+ 34 945292939E-mail:[email protected]:www.ab-laboratorios.comFounding year:2001Employees:31Annual turnover (millionc)

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5 5-50 50

Address:Parque Tecnológico de BizkaiaEdificio 801 B · 2ª Planta48160 Derio · BizkaiaSpainContact person:Ainara HernandoTelephone:+ 34 944048080Fax:+ 34 944048081E-mail:[email protected]:www.abyntek.comFounding year:2006Employees:15Annual turnover (millionc)

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Human health, Suppliers and services, Support.

Company profileAbyntek Biopharma S.L. is a privately owned biotechnology company that centres its activity indeveloping, producing and commercialising antigens and antibodies.

Abyntek relies on its team of trained postdoctoral researchers to guarantee optimal technical supportand who will remain in close contact with the customer as part of the high quality service provided.

A strong investment in RDI constitutes one of the fundamental values on which the business strategyof Abyntek is based.

The R+D+i activities of Abyntek focus on two main areas:

· The development of new technologies to produce monoclonal antibodies.· The development of diagnostic and prognostic products, as well as products to predict the responseto treatment and for the treatment of lung diseases.

Abyntek is an integral part of the Progenika Biopharma S.A. and Proteomika S.L. group of companies.

Key wordsAntibody, Antigen, Mouse monoclonal, Rabbit polyclonal, Custom antibody, Antibody catalogue,Recombinant antigen, Peptide synthesis, Immunisation, Fusion, Screening, Cloning, Isotyping, Asciticfluid, Purification, IgG, Yeast, Bacteria, Protein, Lung diseases.

ABYNTEK BIOPHARMA

Page 4: Biotecnologia Pais Vasco

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Primary business / Areas of activityR&D, Manufacture, Production, Services, Distribution, Commercialisation.Human Health, Ophthalmology.

Company profileAJL Ophthalmic is the only company dedicated to manufacture intraocular lenses at national level.Our company has a commitment to R&D activities for the development of new medical devices whichcontribute to improvements in the sanitary field.

AJL has ISO 9001 and CE 0318, to be able to launch competitive, safe and high quality products.

Key wordsMedical devices, Ophthalmology, Clean rooms, R&D.

5 5-50 50

Address:Parque Tecnológico de ArabaEdificio E-301510 Miñano · ArabaSpainContact person:Eva LarraTelephone:+ 34 945298256Fax:+ 34 945298209E-mail:[email protected]:www.ajlsa.comFounding year:1992Employees:36Annual turnover (millionc)

AJL OPHTHALMIC

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Primary business / Areas of activityManufacture, Production, Services, R&D.Agro-food, Environment and Industry.

Company profileBiotalde Laboratories is a private company, located in Galdakao (Bizkaia), working within the FoodIndustry and Environmental Industries.

It is especially focused on Food Security, developing programs with the HACCP/APPCC system andfood and drinks microbiological control. In the environmental area, the objective is the analyticsupport to the diagnostic of the biological quality of air, environment and water through microbiologicaldeterminations.

Biotalde’s work is based on a Quality Management System according to ISO 9001:2000 with thefollowing scope:

· Food and drinks microbiologic control.· Water microbiologic, physical and chemical control.· Legionella preventive control.· Environmental and surfaces microbiologic control.

Biotalde, has obtained the ENAC acreditation according to UNE-EN ISO/IEC 17025:2005 for microbiologicalassays.

Key wordsFood safety, Environment, HACCP/APPCC, Microbiological control of food and water, Air quality,Legionellosis, Hygiene, Food Technology, Microbiological assays, Biosensors.

5 5-50 50

Address:Zabalea, 1348960 Galdakano · BizkaiaSpainContact person:Nieves ZabalaTelephone:+ 34 944566589Fax:+ 34 946009110E-mail:[email protected]:www.biotalde.comFounding year:1988Employees:11Annual turnover (millionc)

ANÁLISIS BIOLÓGICOS BIOTALDE

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Primary business / Areas of activityR&D, Manufacture, Production, Services. Agro-food, Human Food and Nutrition, Veterinary Science.

Company profileThe company works on the following areas:1. Analytical Services, focused on the diagnosis of animal diseases. With this purpose this lab counts

with microbiology, parasitology, biopathology, histology and molecular biology areas. Thesetechniques are applied to both cattle and small animals.

· Food safety: food microbiological analysis and services to agrofood and consultant companies.· Clinical approaches following the Good Clinical Practices: working directly for pharmaceuticalcompanies and other firms involved in the design of trials for the study and registration ofpharmaceutical compounds.

2. Veterinary Consulting:

· Design and lay out of sanitary development programmes for cattle, specially on the milk qualityimprovement area.

· Introduction of Good Clinical Practices quality system in cattle farms.

3. Training and dissemination:

· Design and management of training activities about animal diseases for vets, agronomic engineersand farmers. These activities include courses, publications and brochures.

4. Research and Development: projects aimed at the development of new diagnostic techniques ofinterest for the cattle-raising and the agrofood industry.

Key wordsAnimal disease diagnostics, Ruminant mastitis, Biochemistry, Microbiology, Serology, Milk quality,Clinic assay, Veterinary consulting, Food analysis, Diagnostic techniques.

5 5-50 50

Address:Aritz bidea, 18b48100 Mungia · BizkaiaSpainContact person:Iñigo EscobalTelephone:+ 34 946744251Fax:+ 34 946744251E-mail:[email protected]:www.analiticaveterinaria.comFounding year:1991Employees:< 10Annual turnover (millionc)

ANALÍTICA VETERINARIA

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Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Human health.

Company profileBial Industrial Farmacéutica, S.A. is a company focused on the manufacturing and commercialisationof allergenic extracts for diagnostic and treatment (vaccines) of allergic diseases.

It has a R&D Department especialised in immunotherapy with biological products, in which severalbiotechnological research lines are carried out (recombinant DNA and monoclonal antibody production).

Several Ethic specialities, also for human use, are commercialised, i.e. like antimicrobial agents,antiinflammatory agents, antiasthmatics, antihistaminics, glucocorticoids, etc.

Key wordsVaccines, Allergens, Ethic specialities, Immunoallergology.

5 5-50 50

Address:Alameda Urquijo 27, 1º48008 Bilbao · BizkaiaSpainContact person:Alberto MartínezTelephone:+ 34 944438000Fax:+ 34 944438016E-mail:[email protected]:www.bial.comFounding year:1941Employees:194Annual turnover (millionc)

BIAL INDUSTRIAL FARMACÉUTICA

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Primary business / Areas of activityManufacture, Production, Services, R&D. Human health

Company profileBiobide is a biotechnology company dedicated to in vivo High Throughput Screening (HTS) using thezebrafish model in an all-automated process. Biobide counts on the most modern technologies fortransgenic and/or mutant zebrafish generation to be used in the HTS platform, and facilities (tanks)with up to 150,000 adult zebrafish capacity.Biobide is structured around a Technology Platform with two key components: Biotechnology andAutomation, providing an innovative model for the drug development process. The zebrafish is usedas screening tool, an in vivo model (with a high degree of genetic homology with humans, 85%)for preclinical toxicity and efficacy prediction. Automation tools include robotics, optical analysis,bioinformatics, and other -omics. This platform allows Biobide to generate, quickly and at a reasonablecost, highly informative results giving pharma and biotech companies a competitive advantage, ascompared to other preclinical assays.Our Services:1. High Throughput Screening: In vivo automated HTS for toxicity and efficacy.

1.1. General and specific toxicity assays: Acute toxicity: Acutetox assay; Cardiotoxicity: Cardiotoxassay; Teratogenicity: Teratox assay; Ototoxicity: Ototox assay.

1.2. Efficacy assays: SNC (Alzheimer): AChE inhibition assay; Bone and cartilage: ageing assays;Cancer: antiangiogenesis assay.

2. Target identification and validation: by morfolines, etc.3. Animal model development in zebrafish for human diseases.4. Personalised Assays.

Key wordsHTS in vivo Zebrafish Automatized screening drug discovery services outsourcing fee for servicecardiotoxicity QT prolongation hepatotoxicity teratogenesis metastasis angiogenesis.

5 5-50 50

Address:Parque Tecnológico de San SebastiánPaseo Mikeletegi 5820009 San Sebastián · GipuzkoaSpainContact person:Arantza MurianaTelephone:+ 34 943309360Fax:+ 34 943309370E-mail:[email protected]:www.biobide.esFounding year:2005Employees:16Annual turnover (millionc)

BIOBIDE

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Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Environment and industry.

Company profileBiofinder is a biotechnological company offering innovative microbiological analysis methods.

Our core product is the result of a project developed by Inasmet- Tecnalia, and is based on aninnovative sensor for the detection of the most common microbiological parameters both inenvironmental and food industry. That is to say, E. coli, Enterococcus, total Coliform and totalAerobic count.

This product has been customised with a user-friendly design, allowing a remote and in-situ wateranalysis and showing quantitative results in less than 10 hours. Qualitative tests are available in ashorter period of time (3 hours). The offer is completed with specific growth medias and a field adapter.

Key wordsBiofinder, E.coli, Escherichia, Coli, Agar media, Bacteria, Coliform, Colony counting, Contamination,Culture media, Early warning, Fecal contamination, Food test, GMP, HACCP, HPC, Membrane filtration,Microbiology, Microcolonies, On-line, Presence/Absence, Rapid tests.

5 5-50 50

Address:Parque Tecnológico de San SebastiánPaseo Mikeletegi, 220009 · San Sebastián · GipuzkoaSpainContact person:Koro San VicenteTelephone:+ 34 943000926Fax:+ 34 943000927E-mail:[email protected]:www.biofinder.esFounding year:2006Employees:< 10Annual turnover (millionc)

BIOFINDER

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Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Human health.

Company profileBioftalmik is a biotechnology company specialised in the ophthalmology field. Our objective is todevelop diagnostics systems for ocular diseases through combined application of X-omics technologiesintegrated with molecular biology, cell biology and clinic diagnostic.

Bioftalmik combines different lines of business:

1. Development and commercialisation of its own diagnostic kits on ocular surface diseases andglaucoma disease.

2. Services: Diagnostic test of the ocular surface (impression cytology and Rapid diagnostic of cornealpathogens by PCR), autologous serum and clinical trials.

3. Biodispositives for ophthalmic surgeries.

Key wordsBiotechnology, Ophthalmic research, Impression cytology, Dry eye, Glaucoma, X-omics technologies,Diagnostic kits, Biodispositives.

5 5-50 50

Address:Parque Tecnológico de Bizkaia.Edificio 800 · 2ª Planta48160 Derio · BizkaiaSpainContact person:Tatiana SuárezTelephone:+ 34 944069659Fax:+ 34 946562379E-mail:[email protected]:www.bioftalmik.comFounding year:2007Employees:10Annual turnover (millionc)

BIOFTALMIK

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Primary business / Areas of activityManufacture, Production, Services, R&D.

Company profileBiofungitek is a new biotechnological company that develops different kinds of biofungicide products,to provide good plant protection, as well as a safe application for users, consumers and the environment.Our objectives are to develop and market efficient safe biofungicides.

Key wordsBiofungicide, Plant protection, Post harvest control.

5 5-50 50

Address:Parque Tecnológico de BizkaiaEdificio 800 · 2ª Planta48160 Derio · BizkaiaSpainContact person:Sergio AlavaTelephone:+ 34 685510350E-mail:[email protected] year:2008Employees:< 10Annual turnover (millionc)

BIOFUNGITEK

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Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Agro-food, Suppliers and services, Support.

Company profileBiolan is a biotechnology company whose main objective is to develop and commercialise newbiosensors capable of detecting molecules of interest in various fields. Initial developments werefocused on the food industry, especially in the wine subsector, with the development andcommercialisation of biosensors for the measurement of gluconic and malic acid in musts and wines,but the current pipeline also addresses developments for healthcare.

Moreover, Biolan is a R&D company that promotes research projects, development and innovation,taking as reference the biosensor expertise for the agrofood and healthcare industry.

Key wordsBiosensors, Food and agricultural industries, Wine/Musts, Gluconic Acid.

5 5-50 50

Address:Parque Tecnológico de BizkaiaIbaizabal bidea · Edificio 800 · 2ª Planta48160 Derio · BizkaiaSpainContact person:Asier AlbizuTelephone:+ 34 946574161Fax:+ 34 946574164E-mail:[email protected]:www.biolanmb.comFounding year:2006Employees:11Annual turnover (millionc)

BIOLAN MICROBIOSENSORES

Page 13: Biotecnologia Pais Vasco

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Primary business / Areas of activityR&D, Manufacture, Production, Services.Human Health.

Company profilePharmaceutical company specialised in manufacturing/production of big-scale injectable solutionsfor third parties.

Key wordsCMO, Injectable solutions.

5 5-50 50

Address:Polígono Industrial s/n01118 Bernedo · ArabaSpainContact person:Jordi AltarribaTelephone:+ 34 945378238Fax:+ 34 945378228E-mail:[email protected] year:1992Employees:71Annual turnover (millionc)

BIOMENDI

Page 14: Biotecnologia Pais Vasco

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Primary business / Areas of activityDistribution, Commercialisation, R&DHuman health.

Company profileBRAINco offers a personal medicine approach to the psychiatric, neurologic and degenerative diseases,including diagnosis and treatment of these disorders. Based on this know-how, BRAINco is developingdiagnostics tools and treatments compounds for Nervous System diseases, including psychiatric andsome neurological diseases. BRAINco has identified new therapeutic targets and its developingtreatments for Schizophrenia, Bipolar Disorder, Major Depression, Multiple Sclerosis, etc.

In the last two years, a number of significant altered proteins in postmortem human brain have beenidentified in the patients’ brains.

These proteins have been validated and BRAINco is now developing a complete panel of assays todevelop compounds against this targets.

Transgenic mice have been created overexpressing the target proteins.

BRAINco is characterising these mice at cellular, biochemical and behavioural levels.

Key wordsHuman diseases, Psiquiatric diseases, Multiple sclerosis, Epilepsy, Major depressive disorder, Bipolardisorder, Genetic, Proteomic, Brain, Transgenic animal models, Therapeutic targets, Diagnosis techniques,Drug discovery, DNA chip, Proteins, Gens.

5 5-50 50

Address:Parque Tecnológico de VizcayaEdificio 80148160 Derio · Bilbao · VizcayaSpainContact person:Juan BuelaTelephone:+ 34 944064525Fax:+ 34 944064526E-mail:[email protected]:www.brainco.esFounding year:2008Employees:< 10Annual turnover (millionc)

BRAINCO

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Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Human health.

Company profileBTI Biotechnology Institute is a company dedicated to manufacturing and research in Implantologyand Biotechnology. It is focused mainly on three fields:1. The BTI Dental implant System.2. The "P.R.G.F. system": It deals with the use of the proteins contained in the patient’s own blood,which is drained at the doctor’s office just before the beginning of the treatment. Treated blood givesplace to a plasma rich in growth factors which, applicated on the surgery location, can speed upepithelialisation of tissues and reduce healing time to less than half time.3. BTI Scan: Software that helps the implantologist to get an accurate diagnosis.BTI dedicates much of its resources in R&D of its products to guarantee their biological safety andtherapeutic success. The result of this effort is the development and application of the PRGF techniquein diverse therapeutic areas, the generation of bioactivatable surface dental implants and theestablishment of various protocols and techniques which guarantee its products´predictability all ofthem sustained by scientific publications. The company owns 25 patents.On-Going Formation Courses in Oral Surgery & Implantology are held in different countries.BTI is also a partner of one of the largest dental publishing groups in Europe (Team Work), and ownsits own publishing companies.

Key wordsDental implant, Image planification and simulation, Tissue reparation and regeneration, Biomaterials,Engineering, Cellular cultures, Chemical synthesis, Oral surgery, P.R.G.F., Growth factors, Biotechnology,Diagnosis.

5 5-50 50

Address:Parque Tecnológico de ArabaLeonardo da Vinci, 14b01510 Miñano · ArabaSpainContact person:Eduardo AnituaTelephone:+ 34 945140024Fax:+ 34 945154187E-mail:[email protected]:www.bti-implant.es / www.prgf.orgFounding year:1999Employees:154Annual turnover (millionc)

BTI BIOTECHNOLOGY INSTITUTE

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Primary business / Areas of activityManufacture, Production, Services, R&D.Suppliers and services, Support.

Company profileDRO Biosystems is a young biotech enterprise within the bioprocess sector pursuing internationalexpansion and strategic alliances.

The company is engaged in the development of improved biotherapy treatments by providing theindustry and research groups with products and services that support the advance of biotherapy:

1. Contract manufacture, design and construction of biomolecules;

2. Development and transfer of production processes for biologicals and;

3. Standard or customised devices for production and purification of biologicals.

Our proprietary technology, Static Support Bed (SSB), has been developed to aid at different pointsin the production process of biologicals, from adherent cell culture to chromatographic steps.

Key wordsBiotherapeutics, Bioprocess, SSB technology, Biomolecules, Fermentation, Downstream processing,Purification, Plasmid, Protein, Cell culture.

5 5-50 50

Address:Parque Tecnológico de San SebastiánMiramón, 20020009 · San Sebastián · GipuzkoaSpainContact person:Marcos SimónTelephone:+ 34 943308011Fax:+ 34 943000990E-mail:[email protected]:www.dro.esFounding year:2001Employees:11Annual turnover (millionc)

DRO BIOSYSTEMS

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Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Suppliers and services, Support.

Company profileDynaKin collaborates with pharmaceutical and biotechnology companies, research sites, hospitalservices and universities in the development of new therapeutic strategies.

At DynaKin, we offer high quality, flexibility, rigor, high reactivity and short communication lines. Ourinnovative services and products within the area of Pharmacokinetics and Pharmacodynamics canbe applied to any of the phases of drug development, allowing to reduce time and costs associatedwith this process while optimising resources and possibilities of success for a new drug.

DynaKin provides bioanalytical support for regulatory Pharmacokinetic or Toxicokinetic studies incompliance with Good Laboratory Practices (GLPs). Our state-of-the-art laboratory offers specifictechnology that allows the quantification of a wide range of compounds in different biological matricesthrough all stages of R&D process (LC/MS-MS, HPLC-UV, etc.).

DynaKin offers a very strong know-how to optimise the development of drugs using pharmacostatisticalmodels that summarise Pharmacokinetic and Pharmacodynamic information from the different phasesof drug development. This new vision of investigation which constitutes an important componentof the FDA Critical Path Initiative offers the opportunity to increase the efficacy of drug developmentmanagement and decision making.

Key wordsBioanalysis, Therapeutic drug monitoring, Good laboratory practices, PK/PD analysis,Modeling&Simulation, CRO.

5 5-50 50

Address:Parque Tecnológico de BizkaiaEdificio 801 B · 1ª Planta48160 Derio · BizkaiaSpainContact person:Javier OndarraTelephone:+34 944045504Fax:+34 946559463E-mail:[email protected]:www.dynakin.comFounding year:2004Employees:10Annual turnover (millionc)

DYNAKIN

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Primary business / Areas of activityManufacture, Production, Services.Agro-food, Environment and industry.

Company profileEliker is a company specialised in the food-processing and environmental sector. Through its laboratoryand consulting services Eliker delivers to customers the tools, monitoring and more appropriatetraining for improving quality and safety of their products and services.

The main objective is to make our services focused on identifying and meeting the needs andexpectations of all customers in the field of food and agricultural sector in a continuous and systematic,providing a fully comprehensive analysis, training and consultancy.

We have facilities to which they have incorporated the latest technology to our best performance andwith certification in ISO 9001:2008 and ISO 17025:2005 shortly to ensure the quality of our services.

Key wordsLegionella, Salmonella, Food, Bacteria, HACCP, Manipulative, Food, Water, Environment, Research,Microbiology, PCR, ISO 17025.

Address:Jesús María Olagüe · Txuma 148950 · Asua-Erandio · BizkaiaSpainContact person:Naiara AyoTelephone:+ 34 944710519Fax:+ 34 944712177E-mail:[email protected]:www.eliker.esFounding year:2008Employees:< 10Annual turnover (millionc)

ELIKER

5 5-50 50

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Primary business / Areas of activityManufacture, Production, Services, R&D.Human health.

Company profileEmbryomics is devoted to the non-invasive diagnosis of chromosome abnormalities in the pre-implantation embryo using metabolomic techniques. This will not only improve and simplify thecurrent preimplantation diagnostic techniques that determine the viability of the embryo, but willalso lower the costs involved in the process.

Address:Parque Tecnológico de BizkaiaEdificio 800 · 2º48160 · Derio · BizkaiaSpainContact person:Francisco DomínguezTelephone:+ 34 944040694Fax:+ 34 944030609E-mail:[email protected]:www.embryomics.comFounding year:2009Employees:< 10Annual turnover (millionc)

EMBRYOMICS

5 5-50 50

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Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&DEnvironment and industry, Human health.

Company profileFaes Farma is a Spanish Pharmaceutical Company that has been consistently established within theSpanish Stock Market since the past fourties and has its own R&D and Innovation centre almost sincethe company's foundation, 75 years ago.Currently, Faes Farma consists of three business units located in Leioa (Biscay), Madrid and Amadora(Portugal), with manufacturing facilities in Leioa and Amadora, accounting for a surface of almost20,000 m2 taking both manufacturing plants together.Offices are in all three business units and management responsibilities for the different areas ofactivity are shared and co-ordinated.The main R&D areas of interest, in which some lead and head compounds have been developed are:cancer, immune diseases and central nervous system diseases, including anxiety and Alzheimer disease.Recently (February 2009), a new chemical entity entirely developed by Faes Farma has been submittedto the European Health Authorities in order to obtain the approval for commercialisation as a treatmentfor allergic rhinitis and urticaria. This will be an important boost in the worldwide consideration ofits R&D quality, creativity, and capabilities.Faes Farma is clearly focused on research. At the same time, it develops, manufactures and marketsprescription, OTC and biotechnological drugs.

Key wordsPrescription drugs, Over-the-counter medications, Raw material, Skin-care treatments, Central nervoussystem, Osteoporosis, Cancer, Inflammation, Cardiovascular diseases, Allergy, Autoimmune diseases,Chemistry, Chemical synthesis, Biopharmacy, Pharmacology, Toxicology. 5 5-50 50

Address:Máximo Aguirre · 1448940 · Leioa · BizkaiaSpainContact person:Ana MuñozTelephone:+ 34 944818300Fax:+ 34 944818309E-mail:[email protected]:www.faes.esFounding year:1933Employees:419Annual turnover (millionc)

FAES FARMA

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5 5-50 50

Primary business / Areas of activityManufacture, Production, Services, R&D.Human health.

Company profileGenetadi Biotech is a company that develops new genetic diagnosis kits specialised in the gynecology,paediatrics and oncology biomedical sectors.

Our company is integrating its projects of research and development in Systems Biology applyingthe most modern techniques developed after the sequentiation of the human genome.

Genetadi Biotech combines two lines of business:

1. Development and commercialisation of its own products: new tests of prenatal diagnosis, neonatalscreening, infertility, endometriosis and endometrial cancer.

2. Human genetic diagnosis services: cytogenetic, molecular genetics, quantitative PCR, gene-expression analysis and microarrays of comparative genomic hybridisation (aCGH).

Key wordsGenetic Human diagnostics, Gynecology, Andrology, Paediatrics, Oncology, Infertility, Endometriosis,Endometrial cancer, Prenatal cancer, Breast cancer.

Address:Parque Tecnológico de BizkaiaEdificio 502 · 2ª Planta48160 Derio· BizkaiaSpainContact person:José Luis CastrilloTelephone:+ 34 944044343Fax:+ 34 946566628E-mail:[email protected]:www.genetadi.comFounding year:2004Employees:10Annual turnover (millionc)

GENETADI BIOTECH

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5 5-50 50

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Agro-food, Environment and industry.

Company profileGuserbiot is a technology-based company dedicated to the research, development and productionof wildtype microorganisms for their application in industrial sectors (chemistry, pharmaceutical,agro-food) and in environmental issues (bioremediation, biosensors), as well as to the developmentand production of water pathogen detection kits.

Key wordsIndustrial biotechnology, White biotechnology, Fermentation, Industrial microbiology, Environmentalbiotechnology, Bioremediation, Food biotechnology.

Address:Polígono Industrial de JúndizJúndiz, 2601015 Vitoria · ArabaSpainContact person:Francisca BarberoTelephone:+ 34 945292700Fax:+ 34 945292919E-mail:[email protected]:www.guserbiot.comFounding year:2003Employees:< 10Annual turnover (millionc)

GUSERBIOT

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5 5-50 50

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Human health.

Company profileHistocell is a biotechnological company that works on tissue engineering and develops new productsfor regenerative medicine.

Histocell main activity areas are:

· Tissue engineering.· In vitro biocompatibility studies.· Biologic research service.

Histocell activity is directed to the following sectors: Pharmaceutics, health, cosmetics, food industry,chemical and engineering.

Key wordsTissue engineering, Regenerative medicine, Cellular biology.

HISTOCELL

Address:Parque Tecnológico de BizkaiaEdificio 800 · 2ª Planta48160 Derio · BizkaiaSpainContact person:Begoña CastroTelephone:+ 34 946567900Fax:+ 34 944036999E-mail:[email protected]:www.histocell.comFounding year:2004Employees:12Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Agro-food, Environment and industry.

Company profileIdoki is a company dedicated to the research, development and production of ingredients and naturalactive principles for food, cosmetic and other uses, using mainly the supercritic fluids technology inthose 3 proceses,

· Formulation of natural cosmetics and food suplements under the PlusKRITIK brand.· Formulation of natural food aditives.· Industrial aplication development using supercritical technology.

Key wordsSupercritic fluids, Extraction, Purification, Active principles, Natural ingredients, Natural cosmetics,Natural foods aditives, Natural food suplements.

IDOKI

Address:Parque Tecnológico de BizkaiaIbaizabal Bidea · Edificio 502 - 1ª planta48170 Zamudio · BizkaiaSpainContact person:Nagore ArdanzaTelephone:+ 34 944048690Fax:+ 34 944048692E-mail:[email protected]:www.idoki.comFounding year:2006Employees:< 10Annual turnover (millionc)

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Primary business / Areas of activityManufacture, Production, Services, R&D.Human health.

Company profileA spin-out of a leading academic research team of the Organic Chemistry I Department of theUniversity of the Basque Country (UPV/EHU). IkerChem is a chemistry-focused drug discovery anddevelopment company that is dedicated to the design and synthesis of valued-added Novel ChemicalEntities (NCEs) for pharmaceutical and biotechnological applications.

IkerChem has an in-house platform technology that combines drug design and molecular modellingwith chemical synthesis, capable of generating new product candidates on a sustainable basis andwith a competitive advantage.

The objective of IkerChem is the development of our own molecule pipeline, created in-house andprotected by patents, which would consolidate our position in the pharmaceutical industry.

The main research lines are focused on therapeutical targets related to cancer epigenetics.

Key wordsDrugs, New chemical entities, Materials, Design, Chemical synthesis, Chemistry, Cancer, Epigenetics,Computational design, Modelling.

IKERCHEM

5 5-50 50

Address:Pº Mikeletegi, 5620009 San Sebastián · GipuzkoaSpainContact person:Eider San SebastiánTelephone:+ 34 943003460Fax:+ 34 943003476E-mail:[email protected]:www.ikerchem.comFounding year:2006Employees:< 10Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Agro-food, Environment and industry, Human health, Suppliers and services, support.

Company profileThe company was founded in 2000 and its activity is directed to chemistry and micro- andnanotechnology related with diagnostics and biological/biotechnological fields. In this sense, althoughwe are chemists, we develop and manufacture organic and inorganic dispersions that other companiesuses for diagnostics and/or other biological/biotechnological applications. Other applications of ourproducts are directed to the fields of conducting polymers, model colloids, and calibration of scientificmachinery.

Key wordsMicro - and nanotechnology related to biological sciences, Sensors and detectors for diagnostics,Organic and inorganic dispersions for clinical diagnostics, Veterinary diagnostics, Products for separationand purification of proteins, Fluorescent particles, Magnetic particles, Colloidal dispersions, Polymericdispersions, Polymer latexes, Latex particles, Conducting polymers, Model colloids...

IKERLAT POLYMERS

Address:Zirkuitu Ibilbidea, 2Local 2820160 Lasarte · GipuzkoaSpainContact person:Joxe SarobeTelephone:+ 34 943164724Fax:+ 34 943880727E-mail:[email protected]:www.ikerlatpolymers.esFounding year:2000Employees:< 10Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityR&D.Human health.

Company profileiLine Microsystems is dedicated to the development and industrialisation of Point-of-Care (POC)devices for medical self-diagnosis and selfcontrol.

iLine Microsystems core technology is based on microfluidics.

The key advantages of such technology are:

· Polymer based (extremely low cost at high production volumes).· Passive platforms, as samples are driven by capillary forces only.· Significant reduction of required sample volume.

This technology allows a new approach to Test Strip devices.

Key wordsMicrofluidics, Capillary, Point-of-care, POC, Test Strip.

ILINE MICROSYSTEMS

Address:Parque Tecnológico de San SebastiánPaseo Mikeletegi 5420009 Donostia · GipuzkoaSpainContact person:Jon PeónTelephone:+ 34 943005651Fax:+ 34 943000990E-mail:[email protected]:www.ilinemicrosystems.comFounding year:2007Employees:< 10Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityManufacture, Production, Services, R&D.Agro-food, Environment and industry, Suppliers and services, support.

Company profileInkoa Sistemas is an Engineering Company specialised in supplying integral solutions directed to theAgro-Food and Environmental sectors.

Since its beginnings, Inkoa has followed a strategy expansion, diversification and technologicalinnovation that it has brought about the creation of a group company, which are present in the Agro-Food and Enviromental sectors in the internacional sphere.

The solutions contributed by Inkoa start from the prior studies up to the introduction and start upof the projects, including the elaboration of the preliminary designs and technical projects, technicalmanagement, introduction and management of the installations, as well as the training andtechnical assistance.

Key wordsAgro-alimentary, Electronic, Informatic, Sensors, Biosensors, Environment.

INKOA SISTEMAS

Address:Ribera de Axpe,11Edificio D1 · Local 20848950 Asua-Erandio · BizkaiaSpainContact person:Idoia UnzuetaTelephone:+ 34 902998367Fax:+ 34 902998366E-mail:[email protected]:www.inkoa.comFounding year:1992Employees:34Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityManufacture, Production, Services, R&D.Human health.

Company profileInnoprot is a biotechnology company focused on the generation of recombinant cell lines intendedfor use in cell-based drug screening. Our efforts are directed to increase speed and efficiency of invitro assays, allowing the collection of more information about the compounds in less time thanother biological systems.

The types and formats of our products fit the specific needs of our customers, which lets them choosebetween kits for simple cell-based assays, kits for High Content Analysis and kits with higher quantityof cells for High Throughput Screening. Innoprot offer also includes customised products/services,which allow us to offer a global solution to the compound screening needs.

Key wordsCell based assay, HTS, HCS, Primary cells, High throughput screening, Stable transfected cell lines,Cell line development, Assay development, Protein interactions, Screening services, Fluorescent celllines, DNA cloning and protein expression.

INNOPROT

Address:Parque Tecnológico de BizkaiaEdificio 502 · 1ª Planta48160 Derio · BizkaiaSpainContact person:Clarisa SaladoTelephone:+ 34 944005355Fax:+ 34 946579925E-mail:[email protected]:www.innoprot.comFounding year:2007Employees:< 10Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Environment and industry.

Company profileInteman SA was founded in 1980 and has been developing, manufacturing and marketing chemicalproducts for more than 20 years. Over the last 10 years Inteman SA has reorganised its business byimplementing the biotechnology in his R&D&I process.

At this moment, Inteman SA is a company specialised in biodetergency cleaning products, with highstandards of workplace health & safety and environmental protection, to be used by the institutional,industrial and commercial cleaning industry.

The biotechnological products, sold under the trademarks: KENBI and Bioteman, are formulated witha proprietary blend of microorganism plus a mixture of enzymes and biodegradable surfactants.

Inteman SA has implemented and maintains a Quality Management System and an EnvironmentalManagement System.

Inteman is certified in ISO 9001:2000, ISO 14000:2004 and EMAS (Eco-Management and Audit Schemeof the EU), and recently in the Spanish standard UNE 150301:2003 "Environmental management ofthe process of design and development. Eco-design". Inteman has 17 ecodesigned products, threeof them are EU ecolabel.

Key wordsKENBI, Bioteman, Ecolabel, Ecodesigned products, Green Public Purchase, Biodetergency, Bioremediation,Cleaning.

INTEMAN

Address:Polígono Industrial de JúndizLermanbide 2301015 Vitoria · ArabaSpainContact person:Miguel Ángel PérezTelephone:+ 34 945292100Fax:+ 34 945290327E-mail:[email protected]:www.inteman.comFounding year:1980Employees:11Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityR&D, Manufacture, Production, Services, Distribution, Commercialisation, Agro-Forest-Ornamental,Plant Micropropagation, Nursery Industry.

Company profileInvitrotek S.L. is a recent spin-off from the Basque Institute for Agrarian Research and Development(NEIKER-Tecnalia). Invitrotek S.L. commercialise products and techniques developed at Neiker-Tecnaliathat have a commercial potencial.

We offer advanced technology for vegetative multiplication and plant micropropagation (organogenesisand somatic embryogenesis) of adult individuals to the nursery industries. Our two business lines are:

· High efficiency protocols for in vitro propagation of vegetable species.· “Customises” production of high quality and improved plant by micropropagation.

Key wordsTechnology transfer, Biotechnology, Plant sciences, Plant micropropagation, Organogenesis, Somaticembryogenesis, Adult individuals, Nursery industry, Neiker-Tecnalia.

INVITROTEK

Address:Parque Tecnologico de BizkaiaEdificio 800 · 2ª Planta48160 Derio · BizkaiaSpainContact person:Eneko OchoaTelephone:+ 34 680118418Fax:+ 34 944030609E-mail:[email protected] year:2008Employees:< 10Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityR&D, Manufacture, Bioinformatics.

Company profileKB data mining S.L. was created on 2007 to offer bioinformatic products for pharma and biosciencesmarket. The company is based on horizontal software based technologies, oriented to simulation,optimisation and analysis applied to pharma and biosciences vertical markets. Following this, weoffer PAT related simulation and optimisation solutions, genomic and proteomic potential biomarkerdiscovery software, LIMS and on demand data analysis as well as turnkey projects.

Key wordsPAT software, LIMS, On demand data analysis, Software development, Bioinformatics, Biomarkerdiscovery software, Applied machine learning.

KB DATA MINING

Address:Plaza Aristondo 4, bajo20740 Zestoa · GipuzkoaSpainContact person:Josu GaldianoTelephone:+ 34 943897297Fax:+ 34 943132445E-mail:[email protected]:www.kbdatamining.comFounding year:2007Employees:< 10Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityR&D, Manufacture, Production, Services.Agro-food, Environment and Industry, Cosmetics.

Company profileIndependent company dedicated to the research and provision of services around microbiologicaland chemical essays in food, water and cosmetics. Certified by Spanish ENAC according to ISO 17025and homologated for training in the food sector. It has two labs, in Vitoria and Bilbao.

Key wordsMicrobiological and chemical analyses, Quality systems, APPCC, ISO - 9000, BRC, Training, ENACcertification.

LABORATORIOS BROMATOLÓGICOS ARABA

Address:Pintor Obdulio Lopez de Uralde 301008 Vitoria · AlavaSpainContact person:Fernando PérezTelephone:+ 34 945200015Fax:+ 34 945225934E-mail:[email protected]:www.laboratoriosaraba.comFounding year:1989Employees:22Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityManufacture, Production, Services, R&D.Human health, Suppliers and services, Support.

Company profileLaboratorium Sanitatis, S.L. is a recently created pharmaceutical company, conceived to give answerto the requirements of the sanitary and pharmaceutical sector from our environment.

The main goal of Laboratorium Sanitatis is to provide a pharmaceutical development area, under the mostsevere control of GMPs, GLPs and CFR 21. The aim of the company is to contribute to new pharmaceuticalproduct launching by promoting their development into the industrial manufacturing area.

Our laboratory is located in the Technology Park of Alava within a 1470 m2 ground area. LaboratoriumSanitatis, S.L. has specific equipment and facilities to manufacture different dosage forms:

· Solid forms (tablets, capsules).· Semi-solids forms (creams, ointments, emulsions, gels).· Liquid forms (syrups, drops, solutions).

Key wordsPharmaceutical development, Contract manufacturing, Pilot batches, Clinical testing batches.

LABORATORIUM SANITATIS

Address:Parque Tecnológico de ArabaLeonardo Da Vinci 1101510 Miñano · ArabaSpainContact person:Itziar EchevarríaTelephone:+ 34 945298144Fax:+ 34 945298217E-mail:[email protected]:www.labsan.comFounding year:2004Employees:< 10Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityR&D.Human health.

Company profileThe company is focused on development and subsequent comerzialisation of surface functionalisedbiomedical devices.

Key wordsFuncionalisation, Surface treatments, Protheses, Implants, Tissue regeneration.

LIFENOVA BIOMEDICAL

Address:Parque Tecnológico San SebastiánMikeletegi Pasealekua 2 · Edificio Inasmet20009 San Sebastián · GipuzkoaSpainContact person:Iñigo BracerasTelephone:+ 34 943000924Fax:+ 34 943000927E-mail:[email protected]:www.lifenova.comFounding year:2002Employees:< 10Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityR&D, Manufacture, Import/Export, Distribution and Commercialisation.Human Health.

Company profileFrom its beginnings, Laboratorios Litaphar has assumed a commitment with the society and theinstitutions related with the health.

The basis of Litaphar lies on a research group of scientists with experience in chemistry-pharmaceuticalprojects. The human team of Litaphar is highly qualified in the generation of active principles,reformulation of medicaments and in the development of industrial chemistry processes.

Litaphar develops generic medicines throughout bioequivalence studies, the acquisition of registriesfor the generic medicine commercialisation and the specific medicine development by means ofcollaboration agreements.

Key wordsGenerics, phytotherapy, Gynaecology, Pharmaceutical, Medicinal, Cosmetic, Sanitary products.

LITAPHAR

Address:Orendaundi, 9Bº Landeta20730 Azpeitia · GipuzkoaSpainContact person:Iñigo JuaristiTelephone:+ 34 943157299Fax:+ 34 943127297E-mail:[email protected]:www.litaphar.comFounding year:2001Employees:< 10Annual turnover (millionc)

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Primary business / Areas of activityR&D.Human health.

Company profileMDRenal is a privately held biotechnology company focusing on the development of mass-spectrometrybased tools for targeted metabolomics, the analysis of hundreds of metabolites in complex mixturesas blood or urine.

Metabolomics holds the promise of significantly reducing attrition rates in the drug discovery process bygiving valuable early information for lead selection, on mechanism of action and in drug safety assessment.

At MDRenal we are using our extensive knowledge in biochemistry, organic chemistry, mass-spectrometry, and bioinformatics to create ground-breaking solutions for the rapid identification,quantification and interpretation of metabolite biomarkers in blood and urine.

MDRenal is currently tuning its technology for metabolite identification and data analysis into acomplete bioanalytics platform to make massspectrometry based metabolomics easier and moreaccurate than ever.

The bioanalytical challenge of quantification and identification of biological matrix constituents areat the very heart of MDRenal product development. A mixture of short-, mid- and long term researchdriven projects addresses the metabolomics and personalised diagnostics markets with a series oftailored and innovative products.

We are currrently developing kits for the market’s fastest massspectrometric identification andquantification of hundreds of metabolites with broad metabolite coverage.

Key wordsMetabolic profiling, Metabolomics, Kits, Mass spectrometry, Bioinformatics, Liquid chromatography.

MD RENAL

Address:Parque Tecnológico de San SebastiánPaseo Miramon 18220009 San Sebastián · GipuzkoaSpainContact person:Niels-Christian ReichardtTelephone:+ 34 943005309Fax:+ 34 943530014E-mail:[email protected]:www.mdrenal.comFounding year:2007Employees:< 10Annual turnover (millionc)

5 5-50 50

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Primary business / Areas of activityR&D, Manufacture, Production, Services, Human Health, Infectious Diseases, Central Nervous System,Oncology.

Company profileMidatech Biogune S.L. is a state of the art facility for the design and manufacture of glyconanoparticlesto cGMP standards. The facility, which opened in March 2007, is part of Midatech Group Ltd, a companydedicated to developing its glyconanoparticles for a wide range of therapeutical applications.

Midatech Group Ltd is a world leader in the design, synthesis and manufacture of biocompatiblenanoparticles. These nanoparticles can be used to create a wide variety of products with novelcharacteristics, functions and applications that have the potential for multiple diagnostic and therapeuticapplications. The creation of the Midatech Biogune plant is a key part of the business strategy.

Midatech has IP covering design, manufacture and application/use of nanoparticles in both diagnosticand therapeutic pharmaceutical areas. As well as in-house product development it is prepared tolicence this IP to 3rd Party pharmaceutical and diagnostic development partners whilst retainingmanufacturing rights. Midatech has exclusive world-wide rights for technology relating to the synthesisand applications of self-assembling nanoparticles.

Key wordsNanotechnology, biotechnology, drug delivery, synthetic vaccines, nanoparticles, glyconanoparticles,diagnostics, imaging.

MIDATECH BIOGUNE

Address:Parque Tecnológico de BizkaiaEdificio 800 · 2ª Planta48160 Derio · BizkaiaSpainContact person:Justin BarryTelephone:+ 34 944034020Fax:+ 34 944034006E-mail:[email protected]:www.midatechgroup.comFounding year:2005Employees:< 10Annual turnover (millionc)

5 5-50 50

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5 5-50 50

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Human health.

Company profileNeos Surgery S.L. is a company focused in R+D, manufacturing and commercialisation of neurosurgicalimplants.

Neos join the efforts of two well known Technological Centers, and knowledgeable professionals ofthe Medical Technology sector.

At the present moment Neos has two work centers, placed respectively in Donostia-San Sebastián(Guipúzcoa) and Cerdanyola del Vallès (Barcelona).

Currently Neos is present in the market with two products:

1. BHID, an innovative craniotomy bone fixation system based on Shape Memory material, focusedin closing the burn hole.2. Cranial LOOP, a new craniotomy bone fixation system, totally made in PEEK (it means that it is100% radiolucent).

Besides, the company has other new products in its pipeline, oriented to neurosurgical area as wellas other medical areas.

Key wordsNeurosurgery, Craniotomy, Cranial fixation, Medical device, Surgery, Research, Development, Innovation,Shape memory, Spinal implant, Nitinol biomaterials.

NEOS SURGERY

Address:Paseo Mikeletegi 220009 San Sebastián · GipuzkoaSpainContact person:Lluís ChicoTelephone:+ 34 943000917Fax:+ 34 943000927E-mail:[email protected]:www.neosurgery.comFounding year:2003Employees:< 10Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Suppliers and services, Support.

Company profileNoray Bioinformatics SLU (NorayBio) is a bioinformatics company that supports the life sciencessector: biotechnology, biomedicine and biopharmaceuticals by developing new computing solutions.

With the creation of its products, NorayBio intends to cover work requirements in all aspects of lifesciences.

· For animal research centres: AniBio, AniBio Aquatic, AniTrans.· For biobanks: NorayBanks.· For centres of assisted reproduction and infertility: Fivisoft.· For laboratories and research units: ServiLIMS, NorayLIMS.· For basic research labs: NorayLab Enzyme, Histomass, NorayLiver.· For the pharmaceutical industry: Noraymet ADME, Noraymet BioEquiv.

NorayBio does also provide tailored bioinformatics services:

· Bioinformatics consultancy.· Biological information management and integration software design and development.· Bionformatics outsourcing projects.· Software for diagnosis kits and biosensors.· Biological data integration bioinformatics platforms.

Key wordsBioinformatics, Software, Biomedicine, Biopharmacy, Functional, Genomics, Proteomics, Metabolomics,Computing Platforms, LIMS.

NORAY BIOINFORMATICS

Address:Parque Tecnológico de BizkaiaEdificio 801 A48160 Derio · BizkaiaSpainContact person:Marta AciluTelephone:+ 34 944036998Fax:+ 34 944036999E-mail:[email protected]:www.noraybio.comFounding year:2002Employees:35Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityR&D, CRO, Consulting, Pharmaceutical Product Development, Human Health, Veterinary Science.

Company profileOndax Scientific is an independent Contract Research Organisation (CRO) dedicated to the provisionof clinical development services for the pharmaceutical industry (Human and Veterinary).

Ondax Scientific is committed to the principles of confidentiality, ethical and scientific quality andoperates in accordance with the principles of the International Co-operation on Harmonisation ofTechnical Requirements for Registration of Medicinal Products.

We are specialists in the conduct of clinical trials for registration purposes. Our main services include:

· Clinical Trials design and conduct.· Monitoring of clinical trials.· Quality Assurance and Regulatory affairs services.· Data management and Biostatistics.· Epidemiological studies.

Key wordsContract research organisation (CRO), GCP, Quality assurance, Data management, Clinical trials, Productregistration, Animal health studies, Human health studies.

ONDAX SCIENTIFIC

Address:Aptdo. 33620280 Hondarribia · GipuzkoaSpainContact person:Patxi SarasolaTelephone:+ 34 943646087Fax:+ 34 943646158E-mail:[email protected]:www.ondax-scientific.comFounding year:2000Employees:< 10Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Human health.

Company profileOWL Genomics is a biotech company focused on the identification and validation of biomarkers andtherapeutic targets with the aim of developing early diagnostic and treatment systems. To accomplishthis we utilise innovative technology in genomics, proteomics, metabolomics and bioinformatics andhave established a complete and highly productive platform which supports the advance of ourdevelopments.

OWL Genomics is currently introducing the first in vitro plasma based diagnostic for Steatosis andNASH In addition to our ongoing research, initially focused on hepatic diseases, we offer our expertiseand technology platform to collaborate with pharmaceutical companies and research centres in theirR+D when metabolomic analyses are required.

Key wordsMetabolomics, Liquid Chromatography, Mass Spectrometry, Hepatic diseases, Diagnosis, Biomarkers,therapeutical targets, Genomics, Proteomics, Obesity, Non alcoholic Steatohepatitis, NASH, Steatosis.

OWL GENOMICS

Address:Parque Tecnológico de BizkaiaEdificio 502 · Planta 048160 Derio · BizkaiaSpainContact person:Azucena CastroTelephone:+ 34 944318540Fax:+ 34 944317140E-mail:[email protected]:www.owlgenomics.comFounding year:2004Employees:12Annual turnover (millionc)

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Primary business / Areas of activityR&D, Manufacture, Production, Services, Human Health, Oncology.

Company profilePharmakine is a biotechnological company that has been designing, developing and commercialisingproducts and bioassays through comprehensive technologies involved in cancer and metastasisresearch, contributing to the understanding of the regulation of cancer in organ-specificmicroenvironments.As part of these bioassays, we offer preclinical evaluation of potential therapeutic drugs through ourwell-established in vivo animal models in which primary and secondary experimental human/murinetumors are studied. These are of great interest for those researchers focusing on the pathophysiologyof cancer and host cell behavior during tumor progression, angiogenesis and metastasis. Researchinvolving other pathogenic processes such as inflammation may also take advantage of our services.In addition, within our clinical research department we focus our efforts towards the developmentof novel approaches that seek for new biomarkers associated to cancer progression.Finally, we provide assistance through collaborative research and we are also willing to establishpartnerships that enforce business development.

Key wordsCancer animal models, Experimental Metastasis models, Preclinical studies, Skin xenografts, Orthotopictumor models, Tumor in vitro assays, Tumor in vivo models, Therapeutic evaluation, Drug evaluation,Pharmacogenomic studies, Molecular cytogenetics, Gene expression analysis, Laser microdissection,Histology services, Immunohistochemistry services, Diagnostic research, Diagnostic devices, FISHprobes, Comparative genomic hybridisation, Transcriptomic services, Quantitative PCR services,Prognostic biomarkers, Tissue culture, Primary Cell culture, Chondrocytes, Mesenchymal Stem Cells,3D-cell cultures, 3D proliferation kit, 3D angiogenesis kit, Spheroids, Customary tissue arrays,Directed therapy.

5 5-50 50

Address:Parque Tecnológico de BizkaiaEdificio 801 · 1º48160 Derio · BizkaiaSpainContact person:Lorea MendozaTelephone:+ 34 944317037Fax:+ 34 944317039E-mail:[email protected]: www.pharmakine.comFounding year:2002Employees:22Annual turnover (millionc)

PHARMAKINE

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5 5-50 50

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Human health.

Company profilePioneering Personalized Medicine.

Progenika Biopharma S.A. is a privately owned Spanish company founded in April 2000, with theaim of designing and developing tools for Personalized Medicine. The company develops andmanufactures novel DNAchips for Genotyping that can be used in the diagnosis and prognosis ofhuman diseases.

More than 80 scientists work at Progenika (over 140 in the Progenika Group), whose state of theart facilities are situated in the Bizkaia Technology Park in the outskirts of Bilbao (Spain). Progenika'sfully equipped installations are specifically designed for the production and analysis of DNAchips.This state of the art equipment is backed up by a team of Computer experts who develop thealgorithms and software that facilitate the automatic interpretation of DNAchip results.

Proteomika S.L., a subsidiary of Progenika that provides complementary skills in protein biomarkerdetection. Proteomika is involved in the development of protein arrays for the detection of diseasebiomarkers in human fluids.

Key wordsPioneering Personalized Medicine, DNAchips, Genotyping, Diagnosis, Prognosis, Human diseases.

PROGENIKA BIOPHARMA

Address:Parque Tecnológico de BizkaiaEdificio 50448160 Derio · BizkaiaSpainContact person:Laureano SimónTelephone:+ 34 944064525Fax:+ 34 944064526E-mail:[email protected]:www.progenika.comFounding year:2000Employees:102Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityR&D.Human health.

Company profileProteomika was established in January 2002 as a subsidiary of Progenika Biopharma S.A in order toprovide R&D services in protein analysis and characterisation. The aim of the company is to deliverthe highest level of research and development capabilities to commercial and academic customersin the rapidly evolving field of proteomics. The protein-related services and research performed byProteomika complement the high-throughput transcriptional analysis services offered by Progenika.Based in the Bizkaia Technological Park Proteomika is the first company in Spain to provide acomprehensive proteomics research platform. Together with Progenika, Proteomika seeks to establisha leading position within the European Research Area in the field of postgenomics through innovationand excellence in the provision of services and support to industry and academia.

In addition to providing protein-related services to the biotechnology and pharmaceutical industriesthe company is actively involved with in-house R&D projects and collaborates widely with leadingacademics and clinicians. Research is focused on the identification and functional validation ofdiagnostic and prognostic disease markers as well as the identification of potential therapeutic targets.Primary areas of research interest include pancreatic and bladder cancer as well as neurologicaldiseases including multiple sclerosis and depression.

Key wordsProteomics, Pancreatic & Bladder Cancer, Multiple sclerosis, Depression, Human diseases, Diagnostic,Prognostic, Biomarkers.

PROTEOMIKA

Address:Parque Tecnológico de BizkaiaEdificio 801 B · 2ª Planta48160 Derio · BizkaiaSpainContact person:Antonio MartínezTelephone:+ 34 944064525Fax:+ 34 944064526E-mail:[email protected]:www.proteomika.comFounding year:2002Employees:29Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Agro-food.

Company profileVacunek S.L. is a recent spin-off from Neiker-Tecnalia (Basque Institute for Agrarian Research andDevelopment). Our two objectives are the development of an efficacious vaccine against paratuberculosisin cattle that does not interfere with the diagnosis of tuberculosis and the production of robust PCR-based diagnostic kits for animal diseases.

Our first marketed products are PCR-based diagnostic kits for animal diseases developed at Neiker.However, Vacunek’s main focus is to develop, register and commercialise a new vaccine againstparatuberculosis for use in cattle. Johne’s disease or paratuberculosis is an infectious disease producedby Mycobacterium avium subsp paratuberculosis that affects primarily ruminants but can also infectmany other animals (foxes, rabbits, mice, etc). It has also been suggested that this bacterium mightbe a factor for the development of Crohn’s disease in humans. Available commercial vaccines againstparatuberculosis cannot be used in cattle due interferences with the test for tuberculosis.

Key wordsTechnology Transfer, Biotechnology, Diagnostics, Polymerase Chain Reaction, Infectious Diseases, AnimalSciences, Veterinary Sciences, Vaccine, Paratuberculosis, Avian influenza, Pestivirus, Myxomatosis,Neiker-Tecnalia.

VACUNEK

Address:Parque Tecnológico de BizkaiaEdificio 80048160 Derio · Bizkaia · SpainContact person:Felix BastidaTelephone:+ 34 615700036Fax:+ 34 946573565E-mail:[email protected]:www.vacunek.comFounding year:2006Employees:< 10Annual turnover (millionc)

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5 5-50 50

Primary business / Areas of activityDistribution, Commercialisation, Manufacture, Production, Services, R&D.Agro-food, Suppliers and services, support.

Company profileVita Aidelos was set up with the objective of creating a positive attitude towards Biotechnology whilemaintaining scientific rigour. We aim at bridging the gap between the scientific community andsociety.

We collaborate with foundations, museums and scientific sites. We spread scientific advances madein the field of Biotechnology and help society understand science by encouraging critical analysis.

Vita Aidelos collaborates with the Genome Service: DNA Bank in the University of the Basque Country(UPV/EHU). Thanks to this combination of knowledge and technological experience we have already

obtained three Spanish patents and three European ones. New educational material has also beendeveloped: practice kits in Biotechnology to experiment in class or in scientific sites.

Key wordsBiotechnology, Laboratory, Molecular biology, Microbiology, Practice Kits, Biotechnology kits, Didacticmethod, Educative method, Formation, Diagnosis, Rapid diagnosis kits, Practice equipment, DNA,Transgenic, Bioproduction, Enzymes, Identification.

VITA AIDELOS

Address:Parque Tecnológico de BizkaiaEdificio 801 A · 2ª Planta48160 Derio · BizkaiaSpainContact person:Melania RosiqueTelephone:+ 34 944069689E-mail:[email protected]:www.vita-aidelos.comFounding year:2003Employees:< 10Annual turnover (millionc)