Biotechnology In Islamic Republic of Iran

Islamic Republic of IranIslamic Republic of Iran

28 Provinces Population 2003:

70000000 Urban %62Rural %38

Official Language:Persian

Religions (%):99.68 Muslims0.20 Christian0.07 Zoroastrians0.05 Jews

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1000

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1970 1975 1980 1985 1990 1995 2000 2005

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Total Number of the Papers Published By Iran in ISI Journals In Different Fields

Biotechnology In IRAN

Title NumberResearch Institutes 35Universities 42Private Companies (Equipments) 15Private Companies (Material) 10Scientific Societies 5Policy Maker Committees 5Products in the Market 58

Main Institutes involved in Biotechnology

• National Institute for Genetic Engineering and Biotechnology

• Pasteur Institute of Iran• Razi Institute for Vaccine development• Sharif University• Persian Golf Biotechnology Research center• Tarbiate Modarres University• Other Universities (Tehran, Shiraz, Mashhad,

Tabriz and Isfahan)• Agriculture Biotechnology Research Center

National Institute for Genetic Engineering and Biotechnology

Established at 1989

Under the Supervision of The

Ministry of Science, Research and Technology

Scope:Plant, Animal, Medical and Marine, Industrial and Environmental Biotechnology

Tehran, Islamic Republic of Iran

NIGEB Results47847

WorkshopsNo. of Trained Participants

5National & International Congresses

395

Total No. of TechnologiesNo. Transferred to Industry

115 24

Full Research PapersBooks

612

Article Presented at National & Int. Seminars

1627

PatentsGenes Submitted at Gene Bank

Pasteur Institute of Iran (1920)

– A primary center for research on infectious diseases– A center for production of biological products, vaccines, and

serums.

• Biotechnology Department (1993)

– The goal is conducting biotechnology- related research

Research Activities:

– Molecular diagnostics: include molecular detection of prevalent genetic disorders and various infectious diseases.

– Recombinant DNA technology: includes development of recombinant vaccines and pharmaceutics.

Razi Vaccine & Serum Research Institute (1925)

– Razi is one of the oldest and most important applied R&D organization in Iran.

– Razi produces over 3 billion doses of 55 different biological products, including human and veterinary vaccines and also diagnostic antigens, at an annual value of about $105m.

– Razi has 28 different departments and employs 1250 staff, including 133 scientists.

- The institute uses locally produced fermenters for vaccine production.

– Razi has links to the WHO and is part of the UN health care infrastructure.

List of products of Razi Institute

• Vaccines for medical use • Sera for Therapeutic medical use• Vaccines for Veterinary use • Veterinary antiparasitic drugs • Antigens and other biological products• Laboratory animals • Herbal medicinal products • Other biotechnological products

Medical Vaccines• Tetanus vaccine • Combined Diphtheria and Tetanus vaccine for children • Combined Diphtheria and Tetanus vaccine for adults • Combined Diphtheria, Tetanus and Pertusis vaccine (DTP)• Measles vaccine• Rubella vaccine • Mumps vaccine • Combined Measles, Rubella and Mumps vaccine (MMR)• Poliomyelitis vaccine

Molecular Medicine• Prenatal Diagnostic for the following genetic Disorders:

Beta ThelassemiaHemophiliaMuscular Dystrophy

• Molecular Diagnostic tests includingTBHCVHBVH.pyloriCMVLeishmaniasisToxoplasmosis

Recombinant Products• Hepatitis B Vaccine• Streptokinase• Interferon Alpha• Interferon Gamma• G-CSF & GM-CSF• HIV diagnostic Kits• HCV diagnostic Kits• HBS diagnostic kits• HTLV-I, II• Human Growth Hormone• Blood group typing (mAb)• Molecular Diagnostic kits for Infectious Diseases

Iranian Research Organization for Science &Technology (IROST) (1979)

IROST is affiliated with the Ministry of Science, Research and Technology.Biotechnology Department:• Persian Type Culture Collection (PTCC)• Bioprocess Engineering Projects:

– Biopesticides Production– Feed Production from Agricultural waste– SCP Production– Production of Biofertilizers

Agricultural Biotechnology Research Institute of Iran (ABRII) (2000)ABRII offers research activities in the field of advanced plant molecular biology and biotechnology.

• Research Departments:– Genomics – Tissue culture & Gene Transformation– Genetics, Cellular and Molecular Biology– Microbiology & Biosafety– Plant Physiology, Biochemistry and Proteomics– Technical Service and Research Support

NGOs Involved in Biotechnology

• Iranian Society for Biotechnology (ISB), established 1997, 600 members, four branches in different provinces

• Iranian Genetic Society (IGS), established 2001, 500 Members

• Iranian Biosafety Society (IBS), established 2003, 150 members

• Ethics Society In Science and Technology (ESST), established 2004

• Biotechnology Private Companies, total No. 25

Education in Biotechnology

TitleTitle NumberNumber

Educational Programs Total 35

(PhD 14 & MSc 19)

Molecular Biology and Genetic 8

Agriculture Biotechnology 11

Industrial Biotechnology 9Medical & Intellectual

Property Right 5

Biotechnology Human ResourcesInstitute PhD

ResearchersMScResearchers

Capacity for Training PhD/year

Capacity for Training MSc/year

NIGEB

Pasture InstituteRaziInstituteResearch Centers (35)Universities (42)Total

75253146129

47

30

233

24

300

59

108 30

241

133

10

139

755 572

480

653

97

871

1103

Research Capacities in Biotechnology

Institute Laboratories Animal or Green House

Gene or Cell Bank

NIGEB

Pasture Institute

Razi Institute

Research Centers (35)Universities (42)

Total

10 3 3

22 1 1

5 1 1

300 63 5

478 12 2

815 80 12

Research Projects in Biotechnology

Subject Projects in Demand

Finalized Projects

Total

Agriculture 210 433 643Medical 110 360 470Industry & Environment

140 432 572

Basic Science 100 226 326

Total 560 1451 2011

International Value of Biological Products (per year)

Product Producer UNICEF Price (million $)

Private Market Price (million $)

Vaccine & Serum for human

Razi Inst. 17.2 55.5Vaccine & Serum for Animal

Razi Inst. 182.8 585Vaccine, serum and Cell Culture

Pasture Inst. 28 89.6Antibiotics (217 tones/year)

Pharmacut. Companies

20 64Total 248 794.1

Biotechnology Equipments

Name Producer Price Per Unit

Trans Laminator

Spray Dryer

Nitrogen Tank

Evaporator

Crystallizer

Freezer (-70oC)

Press Filters

Cold and Hot room

500 $Cadoos Sepand Co.

Iran Khoshk Co.

Raham Gaz Co.

Jihad Research Co.

Jihad Research Co.

Jall Co.

Kara Sanat Co.

20,000 $

10,000 $

20,000 $

20.000 $

5,000 $

5,000 $

Private Co. 5000 $/Sq. meter

Biotechnology Equipments

Name Producer Price Per Unit

Spectrophotometer (Visible)

Jahesh Teb Co. 2000 $

Electrophoresis Paya pajoohesh Co. 500 $

Shaker Incubator Jall Co. 5000 $

Fermentors (20 10,000 liters)

IROST & Private Co.

>9000 $

Clean Room Besat & Tehran Sakkoo Co.

1000 $/ Sq. meter

Clean Steam Pro. IROST 12000 $

Laminar Fellow Pars teb, 2000 $

Chemical and Food ProductsProduct Capacity

(tones/year)Value (million $)

Ethanol from molasses

1,890 40

Protein for Feed from molasses

4,700 -

Vinegar from apple 500 0.9Yeast 11,137 52Citric acid 29,780 -

Biotechnology priorities• Molecular detection of infectious and genetic

diseases• Production of Recombinant medicines and

vaccines • Bioremediation • Bioinformatics, Bisafety and Bioethics• Transgenic plants Resistance to Biotic and

Abiotic Stress• Human Genome Diversity• Bioleaching of Cooper• Oil desulphurization• Privatization of Biotechnology Industry

Biotechnology Policy

• National Biotechnology Committee at Ministry of Science, Research and Technology

• National Strategic plan of Biotechnology• Biotechnology Committees at Ministry of

Industry and Mine, Ministry of Health, Ministry of Agricultural jihad, Department of Environment protection

Suggestions for Cooperation

• Coordination and support of collaborative research projects and scientific programs between the institutes and scientists of theBINASIA member countries.

• Establishing contacts and developing collaboration between scientists and research centers of the member countries, in order to exchange scientific information, and share experience in all different fields of biotechnology, by organizing meetings, symposia, conferences and workshops

• Facilitate and support for exchange scientists and post graduate students between the member countries for short term visit and training.

• Development of an active collaborative network• Establishing contacts between companies manufacturing the

biotechnology equipments and companies producing the biological materials.

• Facilitate and support the admission of the postgraduate students from member countries

• Facilitate and support the technology transfer between the member countries