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Biomedical Basics-‐Technological Developments-‐Medical Implementa4on
Research for Health
BioTechMed-‐Graz
• Inter-‐university research ac;vi;es of high biomedical relevance: – Lipid-‐ and energy metabolism – Lipid-‐associated and cardiovascular diseases, and inflamma;on – Infec;on biology and the development of novel an;bio;cs – Microbiome and genome research – Tumor biology and metabolism – Neurodegenera;ve diseases and the molecular basis of ageing
Molecular Biomedicine
2
• Inter-‐university research ac;vi;es of high biomedical relevance: – Lipid-‐ and energy metabolism – Lipid-‐associated and cardiovascular diseases, and inflamma;on – Infec;on biology and the development of novel an;bio;cs – Microbiome and genome research – Tumor biology and metabolism – Neurodegenera;ve diseases and the molecular basis of ageing
Molecular Biomedicine
3
Kohlwein (IMB, KFU); Berg (IEBT, TUG); Höfler (Patho, MUG) Moissl-‐Eichinger (Int.Med., MUG)
Av.$Number$of$Personnel
0 2.5$Mio
1 0.9$Mio
27 4.3$Mio
36 4.8$Mio $$
204 1.5$Mio
20030 9.8$Mio
00 7.1$Mio
00
45 11.5$Mio
20030 11.1$Mio
600120 91$Mio
30 8.7$Mio
30 8.9$Mio
2020
Grant$Volume$Approved
Wittgenstein
Project$Duration
2015
Kplus$a?b
Leducq
ERC$Grant
SFB$Biomembranes
SFB$Biocatalysis
GOLD$I$?$III
DK$Molin
DK$Molecular$Enzymology
1995 2000 2005 2010
COMET$K2:$ACIB
DK$MCD$
SFB$MOBIS
INGE.St
SFB$LIPOTOX
NANO?Health
Core facility Molekularbiologie
Core facility MS – Proteomics & Lipidomics
Integrated projects – past and future...
CB-‐Med 25 Mio
Av.$Number$of$Personnel
0 2.5$Mio
1 0.9$Mio
27 4.3$Mio
36 4.8$Mio $$
204 1.5$Mio
20030 9.8$Mio
00 7.1$Mio
00
45 11.5$Mio
20030 11.1$Mio
600120 91$Mio
30 8.7$Mio
30 8.9$Mio
2020
Grant$Volume$Approved
Wittgenstein
Project$Duration
2015
Kplus$a?b
Leducq
ERC$Grant
SFB$Biomembranes
SFB$Biocatalysis
GOLD$I$?$III
DK$Molin
DK$Molecular$Enzymology
1995 2000 2005 2010
COMET$K2:$ACIB
DK$MCD$
SFB$MOBIS
INGE.St
SFB$LIPOTOX
NANO?Health
Core facility Molekularbiologie
Core facility MS – Proteomics & Lipidomics
Integrated projects – past and future...
CB-‐Med
• Mul;ple na;onal and interna;onal research programs • Local ongoing research networks
– SFB LIPOTOX (KFU, MUG, TUG; 2007-‐) – DK Molecular Enzymology – DK MOLIN – DK Metabolic and Cardiovascular Disease – K1 Competence Center CB-‐Med – ACIB
• Interna;onal coopera;ons – Joint programmes w/Singapore (NUS, Duke-‐NUS, SBIC) in prepara4on – EuroBioimaging in prepara4on
Molecular Biomedicine
6
• ZMF, OMICS Center (MUG, KFU, TUG) – Imaging, ultrastructure analysis (confocal, mul;photon, electron microscopy) – Mass spectrometry (proteomics, lipidomics) – Transcriptomics, NextGen sequencing – Bioinforma;cs, Structural Biology, Biophysics – Clinical Research Center
• NIKON Center of Excellence (MUG, KFU) – Super-‐resolu;on microscopy
• NAWI Graz – Central Lab Core Facili;es – FACS Center GRACIA
• Core Facility Net
Infrastructure
7
Infrastructure
8
hfp://zmf.medunigraz.at/
hfp://omicscentergraz.at/
hfp://bioimaginggraz.at
hfp://www.nawigraz.at/de/research/infrastruktur/central-‐labscore-‐facili;es/
hfps://corefacilitynet.org/share/page/site/core-‐facility-‐net/dashboard
• We are microbes.
Molecular Biomedicine
9
C. Moissl-‐Eichinger Prof. for Interac;ve Microbiome research
Environment
• Flagship project:
Interac2ve Microbiome research
• Why is microbiome research
so important?
• Why do we need new (interdisciplinary) approaches and the view beyond?
• How can it bring different research disciplines together?
• MIGRobeZ: Mikrobiomini;a;ve Graz • Collabora;on of microbiome researches
from all BioTechMed universi;es • Provide standards, procedures/ Infrastructures • Joint publica;ons and acquisi;on of funding
• Our ques;ons for the future: • Bacteria and beyond? • Increase the efficiency of microbial cul;va;on? • How can we „control“ the microbiome? Interac;on of the microbiomes? • How does the microbiome influence our health, behaviour, well-‐being? • How can we influence the microbiome? • …
• Seeking for collabora;on partners with new, interdisciplinary ideas … and ques;ons! Imaging/ modelling/ microbe tracking/ method development: quan;fica;on/ func;on…
Interac;ve Microbiome Research
10
Molecular & Technical
Biosciences, Biomedicine
Pharmazeu2cal and Medical Technology
OMICS-‐CENTER
BIOIMAGING MR-‐UPGRADE Neurosciences
Quan2ta2ve Biomedicine,
Biomechanics & Modelling
Interac;ons
Post Docs Technical Staff
BioTechMed-‐Graz
• Stronger involvement of the Technical Biosciences
– Molecular Biotechnology, TUG
– ACIB (Industry)
• Befer tech support – Personnel (infrastructure without personnel support = waste of money)
– Relief from administra;ve work
• More Room for Research
What is missing...
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Biomedical Basics-‐Technological Developments-‐Medical Implementa4on
Research for Health
BioTechMed-‐Graz