Biosensor us-ing aptamer

ContentsWhat is biosensor?What is aptamer?How can we use aptamer?How can we find aptamer?

What is Biosensor?• Analytical device

using biological element

• Sensing organic molecule’s state or concentration

Biomarker of Heart attacks

What is aptamer?

• Piece of single strand DNA or RNA

• High affinity for cer-tain molecule

• Used for bioreceptor of biosensor

• Small size easy production, modification

• High stability easy to handle, regeneration

• Economically efficient

• No immune rejection response

• Adjust to many toxic material or complex pro-

tein

How can we find aptamer?

vitro selection

SELEX(Systematic Evolution of Lig-ands by Exponential Enrichment)

Different kind of SELEX Cell SELEX

Capillary electrophoresis SELEX (CE SELEX)

Speigelmer

How can we use aptamer?Sensor

Diagnosis

Cure

DiscussionWhere can aptamer be used in

another way?

Reference 장승훈 , 정기준 , 압타머 (Aptamer) 개발의 최근 연구 동향 ,

한국과학기술원 생명화학공학과 Li Cai, Ze-Zhong Chen, Min-Yan Chen, Hong-Wu Tang*,

Dai-Wen Pang, MUC-1 aptamer-conjugated dye-doped silica nanoparticles for MCF-7 cells detection, 2013, Biomaterials

Thank you!!