bioreactor i photo bioreactor - rivers solutions · bioreactor i photo bioreactor fermentor....

FermentorBioreactor I Photo Bioreactor Fe

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1.5L~14L50RPM~

1,200RPM

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Autoclavable Fermentor

Biotron GXTYPE 1

Main Control Screen PC Monitoring Software

Features �Intelligent 7" wide touch screen fermentation controller�Self data logging system within fermentation controller�High density fermentation : DO-stat, pH-stat, Exponential feeding, etc�Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,

temperature sensor port�Easy control of external device by fermentation controller : O2/CO2 analyzer,

glucose analyzer, spectrophotometer, fluorescence, spectrophotometer, NIR,gas mixer, level, weight, etc

�Accurate PID temperature controller system�Hi-res color touch screen is built-in, hence it is easy to learn how to use

controller �Instead of wires, one-chip Micom is applied for minimizing noise and making

set-up process simpler�unified ATMega128 CPU and sensor board into One-board to handle problems

immediately in case of emergency

Specification

�Remote control by PC software Data Logging system�Easy to calibrate temperature, pH, DO, foam sensors in use of graphic

calibration mode�Reliable operation due to the automatic controllers. �Intelligent self diagnostic system to maintain fermentation process from start to

the end : Diagnostic, Setup, Dead Band, Offset, Warning, Feeding condition�Easy to setup feeding program�Programmable multi stage operation : Setting pH, DO, Foam, temperature for

each stage to the end of the fermentation process�Stainless steel ring-shaped sparger consistently supplies gas for manufacturing

process �Easily disassembling sprager for cleaning inside�Controls agitation speed precisely despite of viscosity changing of culture

media by servo motor which controls agitation speed in real time�Records monitored agitation speed to save extra emission

Agitation

Aeration

pH

RecordingDimensionVoltageWeight

DO

Peristaltic Pumps

Temperature

Exhaust system

Anti-foam

DriveRangeImpellerRange & SensorSparger & Gas modeInlet FilterFilter & CondenserRangeElectrodeRangeElectrodeElectrode

Control

pH, DO, Temp, Foam, Agitation, Peristaltic pump, etc.550(W) x 480(L) x 550(H) (Single Vessel 5L), Controller Size : 220(W) x 478(L) x 445(H))220V, 1�, 50/60Hz, 0.6kW35kg (Controller : 20kg, Vessel 5L 1set : 15kg)

Top drive motor(mechanical drive)50~1,200 rpm2-Rushton turbine impeller, 1-foam breakerAmbient + 3�C~80�C, RTD(Pt-100), PID controlRing sparger(Round Type), 2gas and 4 gas Mixer(Option)0.2� air filter cartridge0.2� air filter, SUS 316 Condenser2.0~12.0 pH of set point, PID controlGel Type0~200%, PID controlPolarographic TypeConductivity Type4 constant speed pumps each assignable to a wide variety of function focontrol of acid, base, foam and feed

�Please note that technical specifications subject to change.

Vessel : 1.5L ~ 14LTemp : Ambient +3�C ~ 80�CSpeed : 50RPM ~ 1200RPM

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1.5L~14L50RPM~

1,200RPM


Biotron GXTYPE 2





�Accurate PID temperature controller system

Specification

�Remote control by PC software Data Logging system�Easy to calibrate temperature, pH, DO, foam sensors in use of graphic

calibration mode�Reliable operation due to the automatic controllers.�Intelligent self diagnostic system to maintain fermentation process from start to


each stage to the end of the fermentation process

Agitation

Aeration

pH

RecordingDimensionVoltageWeight

DO

Peristaltic Pumps

Temperature

Exhaust system

Anti-foam

DriveRangeImpellerRange & SensorSparger & Gas modeInlet FilterFilter & CondenserRangeElectrodeRangeElectrodeElectrode

Control

pH, DO, Temp, Foam, Agitation, Peristaltic pump, etc.550(W) x 480(L) x 550(H) (Single Vessel 5L), Controller Size : 220(W) x 478(L) x 445(H))220V, 1�, 50/60Hz, 0.6kW35kg (Controller : 20kg, Vessel 5L 1set : 15kg)

Top drive motor(mechanical drive)50~1,200 rpm2-Rushton turbine impeller, 1-foam breakerAmbient + 3�C~80�C, RTD(Pt-100), PID controlRing sparger(Round Type), 2gas and 4 gas Mixer(Option)0.2� air filter cartridge0.2� air filter, SUS 316 Condenser2.0~12.0 pH of set point, PID controlGel Type0~200%, PID controlPolarographic TypeConductivity Type4 constant speed pumps each assignable to a wide variety of function focontrol of acid, base, foam and feed


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Vessel : 1.5L ~ 14LTemp : Ambient +3�C ~ 80�CSpeed : 50RPM ~ 1200RPM

1.5L~14L50RPM~

1,200RPM

Vessel : 1.5L ~ 14LTemp : Ambient +3�C ~ 80�CSpeed : 50RPM ~ 1200RPMORP : MonitoringVariable Speed Pump

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Biotron GX



temperature sensor port�Easy control of external device by fermentation controller : O2 / CO2 analyzer,


�Accurate PID temperature controller system�Remote control by PC software Data Logging system�Easy to calibrate temperature, pH, DO, foam sensors in use of graphic

calibration mode�Reliable operation due to the automatic controllers�Intelligent self diagnostic system to maintain fermentation process from start to


each stage to the end of the fermentation process

Specification

�Stainless steel ring-shaped sparger consistently supplies gas for manufacturingprocess

�Easily disassembling sprager for cleaning inside�Variable speed motor control system: available for installing variable speed

peristaltic pump�ORP sensing: diagnostics (inverter selection)�4 gas signals : available to send control signals to directly 4 gas controller from

main control system�Multi-fermentor suitable for various experiments simultaneously�Multi-vessel : 2-6 channels�Individual experiment available by attached controller on each 6 fermentors�Available to perform experiment with different parameters, under the same

condition�Controller that accessible to multiple monitoring by PC and control systems.�Able to lock controller by setting password in order to prevent changing

culture-condition randomly�Saved measured data and control parameters in excel sheets and transmits to

computer

Agitation

Aeration

pH

Anti-foamPeristaltic PumpsPeristaltic PumpsRecordingDimensionVoltageWeight

DO

ORP

Temperature

Exhaust system

DriveRangeImpellerRange & SensorSparger & Gas modeCondenserControl Range ElectrodeControl Range ElectrodeControl Range ElectrodeElectrodeControlControlpH, DO, Temp, Foam, Agitation, Peristaltic pump, etc.550(W) x 480(L) x 550(H) (Single Vessel 5L), Controller Size : 220(W) x 478(L) x 445(H))220V, 1�, 50/60Hz, 0.6kW35kg (Controller : 20kg, Vessel 5L 1set : 15kg)

Top drive motor(mechanical drive)50~1,200 rpm2-Rushton turbine impeller, 1-foam breakerAmbient + 3�C~80�C, RTD(Pt-100), PID controlRing sparger(Round Type), 2gas and 4 gas Mixer(Option)0.2� air filter, SUS 316 Condenser2.0~12.0 pH of set point, PID controlGel Type0~200%, PID controlPolarographic Typemili voltGel TypeConductivity Typefixed speed 14.4 rpmvariable speed


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BiotronSmart GX

Main Control Screen Calibration Menu

Features �Control the Biotron Smart GX from your iPad�You can perform any action from your iPad. Uses WiFi for a local connection to

any cooperating�Self data logging system within fermentation controller�High density fermentation : DO-stat, pH-stat, Exponential feeding, etc�Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,

temperature sensor port�Easy control of external device by fermentation controller : O2 / CO2‚ analyzer,



calibration mode

Specification

�Reliable operation due to the automatic controllers�Intelligent self diagnostic system to maintain fermentation process from start to


each stage to the end of the fermentation process�Variable speed motor control system : available for installing variable speed

peristaltic pump�ORP sensing : diagnostics (inverter selection)�4 gas signals : available to send control signals to directly 4 gas controller from

main control system

Agitation

Aeration

pHDOAnti-foamPeristaltic PumpsRecordingDimensionVoltageWeight

Temperature

RF Operating Frequency

Exhaust system

2.4 GHz WiFiDriveRangeImpellerRange & SensorSparger & Gas modeFilter & CondenserRangeRangeElectrodeControlpH, DO, Temp, Foam, Agitation, Peristaltic pump, etc.550(W) x 480(L) x 550(H) (Single Vessel 5L), Controller Size : 220(W) x 478(L) x 445(H))220V, 1�, 50/60Hz, 0.6kW35kg (Controller : 20kg, Vessel 5L 1set : 15kg)

Top drive motor(mechanical drive)50~1,200 rpm2-Rushton turbine impeller, 1-foam breakerAmbient + 3�C~80�C, RTD(Pt-100), PID controlRing sparger(Round Type)0.2� air filter, SUS 316 Condenser2.0~12.0 pH of set point, PID control0~200%, PID controlConductivity Type4 constant speed pumps for control of acid, base, foam and feed


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RF Specification

Modulation Technique

Transmit power (Average)

Receive Sensitivity

Frequency Range

Data Rate

DSSS for 1, 2MbpsCCK for 5.5, 11Mbps

IEEE 802.11b : 1, 2, 5.5 and 11Mbps-84dBm ±1dB @ 11Mbps-88dBm ±1dB @ 5.5Mbps-90dBm ±1dB @ 2Mbps-94dBm ±1dB @ 1Mbps

WizFi210 : 8dBm ± 1dB @ 11MbpsWizFi220 : 17dBm ± 1.5dB @ 11Mbps

USA: 2.400 ~ 2.483GHzEurope: 2.400 ~ 2.483GHzJapan: 2.400 ~ 2.497GHzChina: 2.400 ~ 2.483GHz

Operating Channels

Antenna

USA/Canada: 11 (1~11)Major Europe Countries: 13 (1~13)

France: 4 (10~13)Japan: 14 for IEEE 802.11b (1~13 or 14th),

13 for IEEE 802.11g (1~13)Korea/China: 13 (1~13)

U.FL External Antenna SupportExternal Antenna Pad Support1dBi Chip Antenna (Optional)


Biotron Smart GX Network

Rack for i-pad connecting(charging in use available)

Data logging serial & USB port(front side)

Resistive OverlayTouch Screen

Smart Phone

Biotron Smart GX

IPADWiFiPC(Server)

Internet

Web App

Biotron Smart GX

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BiotronSmart GM

Main Control Screen Calibration Menu

Features �Control the Biotron Smart GX from your iPad�You can perform any action from your iPad. Uses WiFi for a local connection to

any cooperating�Self data logging system within fermentation controller�High density fermentation : DO-stat, pH-stat, Exponential feeding, etc�Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,

temperature sensor port�Easy control of external device by fermentation controller : O2 / CO2‚ analyzer,



calibration mode�Reliable operation due to the automatic controllers.�Intelligent self diagnostic system to maintain fermentation process from start to

the end : Diagnostic, Setup, Dead Band, Offset, Warning, Feeding condition�Easy to setup feeding program

Specification

�Programmable multi stage operation : Setting pH, DO, Foam, temperature foreach stage to the end of the fermentation process

�Variable speed motor control system: available for installing variable speedperistaltic pump

�ORP sensing : diagnostics (inverter selection)�4 gas signals : available to send control signals to directly 4 gas controller from

main control system�Use 1 i-pad with controllers up to 8 ea to manage data�One PC or one i-pad can monitor and manage all of data by network even each

controller is scattered.�Rack connecting i-pad to main body�Able to charge during using�Sensor port and communication port on front side for user's convinience�Pressure sensor to store data and control pressure, differentiated from other

existing fermentors�Able to monitor and manage data anywhere�Compatible with android based products such as smart phone, galaxy tab and etc�Save and manage data on PC by connecting controller to PC

Agitation

Aeration

Exhaust systempHDOHeating PlateRecordingDimensionVoltageWeight

Temperature

DriveRangeImpellerRange & SensorSpargerInlet FilterFilter & CondenserRangeRangeElectric Heater & ControlpH, DO, Temp, Agitation, Peristaltic pump, etc.1750(W) x 1200(Depth) x 700(H)220V, 1�, 50/60Hz, 3.6kW192kg (Controller : 102kg, Vessel 5L 1set : 15kg)

Top drive motor(mechanical drive)50~1,200 rpm2-Rushton turbine impeller, 1-foam breakerAmbient + 3�C~80�C, RTD(Pt-100), PID controlRing sparger0.2� air filter cartridge0.2� air filter cartridge, SUS 3162.0~12.0 pH of set point, PID control0~200%, PID control400 watt, PID control


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Biotron GM



temperature sensor port�Easy control of external device by fermentation

controller : O2/CO2 analyzer, glucose analyzer, spectrophotometer, fluorescencespectrophotometer, NIR, gas mixer, level, weight, etc

�Accurate PID temperature controller system�Remote control by PC software Data Logging system

Specification

�Easy to calibrate temperature, pH, DO, foam sensors using graphic calibration mode�Reliable operation due to the automatic controllers�Intelligent self diagnostic system to maintain fermentation

process from start to the end : Diagnostic, Setup, Dead Band, Offset, Warning,Feeding condition

�Easy to setup feeding program�Programmable multi stage operation : Setting pH, DO, Foam, temperature for

each stage to the end of the fermentation process�Multi-fermentor is suitable for the various experiments simultaneously�Multi-vessel : 2-6 channels

Agitation

Aeration

Exhaust systempHDOHeating PlateRecordingDimensionVoltageWeight

Temperature

DriveRangeImpellerRange & SensorSpargerInlet FilterFilter & CondenserRangeRangeElectric Heater & ControlpH, DO, Temp, Agitation, Peristaltic pump, etc.1750(W) x 1200(Depth) x 700(H)220V, 1�, 50/60Hz, 3.6kW192kg (Controller : 102kg, Vessel 5L 1set : 15kg)

Top drive motor(mechanical drive)50~1,200 rpm2-Rushton turbine impeller, 1-foam breakerAmbient + 3�C~80�C, RTD(Pt-100), PID controlRing sparger0.2� air filter cartridge0.2� air filter cartridge, SUS 3162.0~12.0 pH of set point, PID control0~200%, PID control400 watt, PID control


1.5L~14L50RPM~

1,200RPMVessel : 1.5L ~ 14LTemp : Ambient +3�C ~ 80�CSpeed : 50RPM ~ 1200RPM2ch ~ 6ch

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Biotron GM


Features �Self data logging system within fermentation controller�High density fermentation : DO-stat, pH-stat, Exponential feeding, etc�Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,


glucose analyzer, spectrophotometer, fluorescence, spectrophotometer, NIR, gasmixer, level, weight, etc

�Accurate PID temperature controller system�Remote control by PC software Data Logging system�Easy to calibrate temperature, pH, DO, foam sensors in use of graphic calibration

mode�Reliable operation due to the automatic controllers.�Intelligent self diagnostic system to maintain fermentation process from start to


each stage to the end of the fermentation process�Intelligent 7" wide touch screen fermentation controller

Specification

�Multi-fermentor suitable for various experiments simultaneously�Multi-vessel : 2-6 channels�Stainless steel ring-shaped sparger consistently supplies gas for manufacturing

process�Easily disassembling sprager for cleaning inside�Variable speed motor control system: available for installing variable speed

peristaltic pump�ORP sensing : diagnostics (inverter selection)�4 gas signals : available to send control signals to directly 4 gas controller from

main control system�Individual experiment available by attached controller on each 6 fermentors�Available to perform experiment with different parameters, under the same

condition.�Controller that accessible to multiple monitoring by PC and control systems.�Able to lock controller by setting password in order to prevent changing culture-

condition randomly.�Saved measured data and control parameters in excel sheets and transmits to

computer.

Agitation

Aeration

Exhaust systempHDOPeristaltic Pumps Peristaltic Pumps RecordingDimensionVoltageWeight

Temperature

DriveRangeImpellerRange & SensorSpargerInlet FilterFilter & CondenserRangeRangeACID, BASEFEED PUMPpH, DO, Temp, Agitation, Peristaltic pump, etc.1750(W) x 1200(Depth) x 700(H)220V, 1�, 50/60Hz, 3.6kW192kg (Controller : 102kg, Vessel 5L 1set : 15kg)

Top drive motor(mechanical drive)50~1,200 rpm2-Rushton turbine impeller, 1-foam breakerAmbient + 3�C~80�C, RTD(Pt-100), PID controlRing sparger0.2� air filter cartridge0.2� air filter cartridge, SUS 3162.0~12.0 pH of set point, PID control0~200%, PID controlfixed speed 14.4 rpm variable speed


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1.5L~14L50RPM~

1,200RPMVessel : 1.5L ~ 14LTemp : Ambient +3�C ~ 80�CSpeed : 50RPM ~ 1200RPM2ch ~ 6chORP : MonitoringVariable Speed Pump

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Biotron GR

Features �IEasy operation�Space saving installation�Various sizes of vessel available�Air pump installed in the body to supply air into vessel. �Microprocessor on digital PID control. �LCD displayer

Specification

Agitation

Aeration

Temperature

RangeImpellersSensorDriveControlIndicationTemp.(�C)Control/Heater/SensorSpargerInlet Filter

50~1,200 rpm(In the condition of no load)2-Rushton turbine impeller, 1-foam breakerMagnetic hall sensorTop drive DC motor 60W(Option:150W)Microprocessor based PIDDigital display in 10 rpm incrementsFrom 3�C above the ambient temp. to 80�CPID / 200 watt / RTD(Pt-100)Ring sparger0.2� air filter cartridg


3L~7L50RPM~

1,200RPMVessel : 3L ~ 7LTemp : Ambient +3�C ~ 80�CSpeed : 50RPM ~ 1200RPM

Single Vessel

Accessory

�Basic vessel for microorganism fermentation�High-speed agitation by applying durable Tob

Drive Motor �Single glass type : Pyrex / Stainless 316�Temperature control : Heater plate in underbody,

coldfinger(from 3L) inside

Volume

Single 1.5LSingle 3LSingle 5LSingle 7LSingle 10

Order No.

101 0102101 0103101 0104101 0105101 0106

Description

I.D 115mm, V.H 170mm, 1:1.5I.D 133mm, V.H 220mm, 1:1.7I.D 170mm, V.H 220mm, 1:1.3I.D 170mm, V.H 310mm, 1:1.8I.D 190mm, V.H 355mm, 1:1.8

500mlSingle Vessel

�Small vessel for microorganism fermentation�High-speed agitation by applying durable Tob

Drive Motor �Single glass type : Pyrex / Stainless 316�Temperature control: Heater plate in underbody�Applied pH, DO, Inoculum port on side wall

Volume

Single 500ml

Order No.

101 0101

Description

I.D 85mm, V.H 120mm

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Double Vessel �Double glass type vessel�Circulating water in double jacket for effective

temperature control by large contact surface�Connected to extra Water Bath for temperature control

Volume

Double 1.5LDouble 3LDouble 5LDouble 7L

Order No.

101 0201101 0202101 0203101 0204

Description

I.D 110mm, V.H 150mm, 1:1.3I.D 130mm, V.H 220mm, 1:1.7I.D 145mm, V.H 300mm, 1:1.2I.D 160mm, V.H 330mm, 1:1.7

Bowl Vessel �Stainless Double Jacket in upper body, Single Glass inunder body

�Circulating water in double jacket for effectivetemperature control by large contact surface

�Connected to extra Water Bath for temperature

Volume

Bowl 10LBowl 14L

Order No.

101 0301101 0302

Description

I.D 190mm, V.H 355mm, 1:1.8I.D 190mm, V.H 500mm, 1:2.6

Single RoundVessel

Accessory

�Single round vessel: round type under body�Temperature control: Glass surrounding heating

blanket�Usually applied in animal cell fermentation

Volume

Single Round 2LSingle Round 3LSingle Round 5LSingle Round 7L

Order No.

101 0405101 0402101 0403101 0404

Description

I.D 115mmI.D 133mmI.D 170mmI.D 170mm

Rushton turbineimpeller

�Rushton turbine impeller is located from middle tobottom and basically used to agitate liquid in vessel.

�It makes the flow to the same direction with turningradius and has features of paddle and propeller typesto be available for high-speed rotation by minimizingresistance.

�General model to be used due to the highestventilation efficiency

Foam Breaker �Installed in upper side of inside shaft, used in burstingfermentation foam.

�It is not used in the case of animal cell fermentationsince there is barely any foam.

�1 ea / 1 vessel

Marine Impeller �Applied to damageable cell�It stirs liquid from down to up rotating in low-speed

since it has the large surface of wings

Hollowed PaddleImpeller

�It stirs liquid from up to down rotating in low-speedsince it has the large surface of wings.

�Extra additional it

PBR SingleVessel

�Single vessel type, LED Bar inside to make growth byexposing light into algae

�LED inside / flourscent jacke

Volume

Single 1.5LSingle 3LSingle 5LSingle 7LSingle 10

Order No.

101 0102101 0103101 0104101 0105101 0106

Description

I.D 115mm, V.H 170mm, 1:1.5I.D 133mm, V.H 220mm, 1:1.7I.D 170mm, V.H 220mm, 1:1.3I.D 170mm, V.H 310mm, 1:1.8I.D 190mm, V.H 355mm, 1:1.8

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30L~100L

50RPM~1,200RPM

Vessel : 30L ~ 100LTemp : Ambient +3�C ~ 80�CSpeed : 50RPM ~ 1000RPM

200L~1,000L

50RPM~550RPM

Vessel : 200L ~ 1,000LTemp : Ambient +3�C ~ 80�CSpeed : 50RPM ~ 550RPM

In situ sterilizable Fermentor

Biotron SP(Pilot)

Features �Intelligent 17" wide touch screen fermentation controller�One-chip Micom is applied for minimizing size and making simple set-up

process�ATMega128 CPU and sensor board into One-board solve problems

immediately�High density fermentation : DO-stat, pH-stat, Exponential feeding, etc�Remote control by PC software Data Logging system�Automatic head lift system built-in to move Top plate easily�Everything on one skid frame : Easy to install and move additional vessels and

vessel controllers�Accurate temperature control with cooler and heater�Automatic flow control: mass flow controller

�Additional vessels for bigger capacities and peristaltic pumps for more accurateoperation

�User’s programmable sterilization process program : user password, set upsterilization time, and temperature

�If there is a problem with external steam supply, its own steam can begenerated to change sterilizing process. There is no need to change thestructure of pipes, but just need to change sterilizing valve sequence. User canmanage sterilization program directly when changing of valve sequence isneeded to sterilize in site

�Convenient DO management by one point calibration �Getting zero point available without nitrogen

Head Lifting System�Head plate is lifted by air cylinder and guided by the two sets of linear

motion guide�Safety pin is used to hold the lifted head plate�Lifting system is made of stainless steel(SUS 304) that it is rustles�Basic system with the 50L capacity

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Bottom Drive VesselVolume of 15L~1500L4 of Gas Mixers unified in one controller

50L~500L

50RPM~500RPM

100L~1000L

30RPM~300RPM

All-in-one system including seed fermentor andmain fermentorApplied stainless pipe transfer line for perfectsterilization and user’s convenience Vessel : 50-500 L / 100-1000 LRPM : 50~500 / 30~300

Specification

Agitation

Aeration

Control

Head LiftMaterials & FinishSterilizationTemperature

pHDOPressure Control

Data Storage

Drive & Range

ImpellerSensor & ControlThe head lift system is powered by air cylinder and guided by two sets of linear motion guideVessel/Piping Heat exchanger or inject steam into jacket.(105�C~130�C)Range & SensorSpargerFilterRange / ElectrodeRange / ElectrodeThe back pressure is controlled manually and/or automaticallyPanelCommunicationspH, DO, Pressure, Temperature and Agitation speed

30L ~100L : AC motor Top drive(mechanical seal driving) 50~1,000 ±1 RPM(In the condition of no load)200L ~1,000L : AC Geared motor Top drive(mechanical seal driving) 50~550 ±1 rpm(In the condition of no load)Rushton turbine impeller, Foam breaker(SUS 316L)Magnetic hall sensor, PID control

SUS 316L, SUS 304(electrolytic polishing)

Ambient + 3�C~80�C (0.1�C ), RTD(Pt-100), PID controlRing sparger(SUS 316L)Inlet(0.2�), Outlet filter(0.2�)2.0~12.0 pH of set point, PID control / Gel Type0~200%, PID control / Polarographic Type

17” Touch Screen Color LCDMemory stick, printer, computer, etc with the RS-232C communication protocol


�In situ sterilizable pilot scale fermentor ; for bio reaction or bio response such as microbial fermentation, conversion and enzyme bioconversion.�Applicable to the special culturing processes such as tissue culture, animal cell culture and insect cell culture with the attachment of additional devices.�The sterilization in place procedure done automatically by using the external steam supply and conveniently changeable of the parameters and

sequences on the basis of user’s experience or designated data.

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861Ton~35Ton

50RPM~200RPM

Vessel : 1Ton ~ 35TonSpeed : 50RPM ~200RPM

In situ sterilizable Fermentor

Biotron SP(Plant)

Features �ntelligent 17" wide touch screen fermentation controller�High density fermentation : DO-stat, pH-stat, Exponential feeding, etc�Remote control by PC software Data Logging system�Automatic flow control : mass flow controller and data logging system�User’s programmable sterilization process program : user password, valve step,

sterilization time, pressure and temperature

�Reliable operation due to the automatic controllers�Intelligent self diagnostic system to maintain fermentation process from start to

the end : Diagnostic, Setup, Dead Band, Offset, Warning, Feeding condition�IQ/OQ documentation compliant to cGMP level

�In situ sterilizable pilot scale fermentor ; for bio reaction or bio response such as microbial fermentation, conversion and enzyme bioconversion.�Applicable to the special culturing processes such as tissue culture, animal cell culture and insect cell culture with the attachment of additional devices.�The sterilization in place procedure done automatically by using the external steam supply and conveniently changeable of the parameters and

sequences on the basis of user’s experience or designated data.

Specification

Vessel

Agitation

Materials & Finish

Power Supply

Temperature

Data Storage

Total Vol.Working Vol.Dia:HeightMotorRange

Impellers

ControlVesselPipingO-ring / GasketsSensorController system : 220V 50/60Hz, single phaseFermentor system : 440V~220V 50/60Hz, single and/or three phasepH, DO, Pressure, Temperature and Agitation speed

Top mount type AC geared motor50~300rpm ±1rpmStandrad : Rushton turbine impeller and Foam breaker (316L stainess steel)Optional : any kinds of blade type impellerInverterUsing 316L stainless steel and polishing316L stainless steel to prevent contaminationViton or silicone material is used for the O-ring and the EPDM is used for gasket.RTD(Pt-100)

1,000L700L1 : 2

1,500L1,000L1 : 2

2,000L1,500L1 : 2

3,000L2,000L1 : 2

5,000L3,500L1 : 2

10,000L7,000L1 : 2


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Consist of 100L animal cell fermentor, 4 gas mixer, perfusion system byouter spin filter Including steam generator for Biosimilar such as Interferonhas been producing by using animal cell fermentor in Russia company.

Reference

Applied in eco-friendly microbial study for using pesticide microbialparasitic on pest Turn-Key process : Systemization from fermentation in1000L tank, Refinement by industrial centrifuge and stabilization of strainculture by Spray Dryer

Head Lift function: automatic slab lifting Pilot fermentor installed Analyzerfor analyzing ingredients of exhaust emissions

Production line in scale of 35 Ton 50L, 500L, 5ton, 35ton Fermentor4ton Seed Tank 10ton Feed Tank Fermentor producingantibiotic(Vancomycin-resistant staphylococcus) in scale of 35 Ton.

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Reference

75L 20L 15L - 150L

100L 100L 75L

70L

20L

100L 15L

350L 15L - 50L - 200L

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Interconnected with Biotron SP to collect data, save and correct chart, on and off valve,and run and stop controller in PC by excel form.

PC Monitoring Software

Interconnected with Biotron SP to collect data, save and correct chart, on and off valve,and run and stop controller in PC by excel form.

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Sterilization

Graph View

pH Control-Acid & Base

pH Setting

Agitation/RPM Setting & Control

DO Setting

Foam Setting Control

Pressure Setting Control

Temp Setting Control

Fed Batch Control

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Biotron Photo Bioreactor

Specification

Agitation

pH

DO

AerationExhaust system

Temperature

Peristaltic PumpsRecording

Anti-foam

DriveRangeImpellerRange & SensorSparger & Gas modeFilter & CondenserRangeElectrodeRangeElectrodeElectrodeControlpH, DO, Temp, Foam, Agitation, Peristaltic pump, etc.

Top drive motor(mechanical drive)50~1,200 rpm2-Rushton turbine impellerAmbient + 3�C~80�C RTD(Pt-100), PID controlRing sparger, 2gas with CO20.2� air filter cartridge, SUS 3162.0~12.0 pH of set point, PID controlGel Type0~200%, PID controlPolarographic TypeConductivity Type4 constant speed pumps each assignable to a wide variety of function for control of acid, base, foam and feed


1.5L~10L Volume : 1.5L ~10LTemp : Ambient +3�C~80�CIllumination : 430nm, 680nm, WHITE LED

WHITE RED BLUE

Features �Intelligent 7" wide touch screen fermentation controller�Self data logging system within fermentation controller�LED illumination with Full spectrum imitates natural sunlight as closely as possible

by emitting light peaks at 430nm and 630nm, without NDIR and ultravioletspectrum components

�Parallel design of vessel and controller : 4 peristaltic pump and pH, DO, foam,temperature sensor port

�Remote control by PC software Data Logging system�Easy to calibrate temperature, pH, DO, foam sensors using graphic calibration mode

�Intelligent self diagnostic system to maintain fermentation process from start tothe end

�Programmable multi stage operation : Setting pH, DO, Foam, temperature foreach stage to the end of the fermentation process

�Easy control of external device by fermentation controller : O2 / CO2‚ analyzer,glucose analyzer, spectrophotometer, fluorescence spectrophotometer, NIR, gasmixer, level, weight, etc

�Accurate PID temperature controller system

These days, lots of studies demonstrated that ordinary plants could be grown byLight Emitting Diodes instead of sun light. LED are very small semiconductorchips generating light when power supplied.The elements of diode determine the light spectrum emitting, these solid statedevices have been progressed over the years. And now, it has greatly improvedlight intensity and specific wavelengths. Light power and spectral coomposition,temperature and aeration gas composition can be set control.

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Biotron Plate PhotoBioreactor

Specification

Sterilization autoclavePhotosynthetic module

Illumination unitIllumination control

IlluminationAir Flow rate

pH-ValuepH-Control

TemperatureOptical density

Total volume illuminated 20 L 100 L

possibleplate

430nm, 680nm, WHITE LEDdimmercontrol5 l/min

measurement & controlCO2 Gas

measurement & controlturbidity sensor

possibleplate

430nm, 680nm, WHITE LEDdimmercontrol

20 l/min

measurement & controlCO2 Gas

measurement & controlturbidity sensor


20L~100L

Volume ; 20~100LIllumination : 430nm,680nm, WHITE LEDTemp, pH, DO

Features �Able to measure precise growth of biomass�Sensor monitoring in real time�Innovative offering light source for photosynthesis�Controlling system for adequate light source�Easy scale-up�Various type of photo bio reactor (flat, �-type, pipe and etc)

Specialized in chlorella, ocean-bio industryUsing for producing clean fuelPhotosynthetic microorganism cultivationAlgae are a natural renewable resource of unique products, Microalgae requireonly sunlight, carbon dioxide, phosphor and nitrogen to grow rapidly. They producea broad variety of basic chemical substances such as vitamins, fatty acids andcarotenoids with high added value potential for the pharmaceutical and foodindustries.Plate photobioreactors have received much attention for cultivation ofphotosynthetic microorganisms due to their large illumination surface area.Platephotobioreactors are very suitable for mass cultures of micro algae ,developed byusing thick transparent PC materials.

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Supercritical Fluid Extraction System

Supercritical Fluid Extraction System

Specification

Supercritical fluid

Extractor

Separator

Division Biotron SFE I Biotron SFE II

CO2

Capacity : 100ml.Design Pressure : 400 bars

Operating Pressure : 350 barsDesign Temperature : 90�C

Capacity : 100 mlNo. In the System : 2 or 3Design Pressure : 300 bars


CO2

Capacity : 10 Liters. 2 eaDesign Pressure : 400 bars


Capacity : 2 Liters 2eaNo. In the System : 2 or 3Design Pressure : 300 bars



Biotron SFE

Features �Material: SS316 �loading type: easy head open type �safety: one Relief Valve, one power failure �Material : Stainless Steel 316L �Volume : 10 Liter �Weight : 200kg �Operation Pressure : 300bar �Temperature control limit : 0~100

SFE is a green technology, as this method of extraction does not utilise organicsolvents, which have harmful effects. Supercritical Fluid Extraction (SFE) technology takes advantage of the uniqueproperties of a gas Carbon Dioxide, at temperatures and pressures approachingand exceeding its critical point. At this state, it has a high density, typical of aliquid, as well as a high diffusivity, characteristic of a gas. The critical temperatureof CO2 is 31ºC. This means, an extraction in the supercritical region will be atrelatively mild temperatures compared to distillation.

�Pilot Scale

Biotron SFE�Lab Scale

10 liter0 ~

400bar

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Biotron MiniBioreactor

Features �Generate more data in less time�Cultivate using less medium�Cultivate using les bench space�Generate scalable results

50ml ~300ml 250RPM

Vessel : 50ml ~ 300mlTemp : Ambient +3�C ~ 80�CSpeed : 250RPM

Mini bioreactor with working volumes from w 40 ml up to w100 ml.The small volume reduces medium costs and reduces the use expensivebench space.mini bioreactor comes with a Control Tower configured for temperature,heater, pump module and 2-gas mixer , stirrer speed controler, vesselwith 4, temperature sensor, sparger; filters; and storage bottle.

Specification

Stirring speedTemperature

Aeration

Exhaust system

Vessel volume

Meida In/out pump

100ml(w50ml), 300ml(w100ml)5~120rpmRange & SensorSparger & Gas modeInlet FilterFilter400A Peristaltic pump

Ambient + 3�C ~80�C, RTD(Pt-100), PID controlRing sparger0.2� air filter cartridge0.2� air filter cartridge, SUS 316


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Disposable Bioreactor

Specification

PowerBag Volume

Dimensions (W x H x D)WeightHousing

Temperature control rangeRocking angleSpeed range

Division Rocker Wave Bag

120V,230V 50Hz,60Hz

540.5 x 326 x 656 mm26Kg

Stainless steelambient Temp +5~60�C

10 degree2 ~ 50 rpm

Bag VolumeDisposable bag

Pre SterileAir Inlet, Air Outlet

Sample Port, Harvest PortSensor Port for pH and DO

Spare Port


Biotron Wave TidalBioreactor

Features �Easy to scale-up�Keep sterile environment in the culture using presterile bag�No cleaning, No sterilization�Easy to built in and remove disposable bag�High process security�Multiple instrument configuration specifically designed for suspension�Simple to operate, Use conveniently�Well mixing, High oxygen transfer by the wave motion 9

Application �Insect cell culture�Plant cell culture�Virus production�Inoculums scale-up�High-containment system�Gene therapy�GMP Production�Cell therapy�Monoclonal antibody�Protein expression�Primary cell line expansion

Wave Tidal Bioreactor is disposable cell culture bioreactor. This bioreactor consists of a sterile wave bag and a rocker. The single-use bag can be eliminated any need for cleaning or sterilization. Therocker can be set and control temperature. Also, It makes regularrocking motion that induces waves in the culture fluid. The wave actionsweeps up cells and prevents settling. These waves provide mixing andoxygen transfer, resulting in a perfect environment for cell growth. It is suggested that their use could improve process efficiency and resultsby reducing the time-to-market of new products.

Wave Bag

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Dry Block Heater

Specification

Optional Block Accessory

Temperature RangeTemperature ControllerTemperature IncreaseTemperature Accuracy

Temperature UniformityTemperature Resolution

DisplayOperating Mode

Dimensions(W x D x H)Number of blocksBlock Chamber

Weight (with Block)Power supply

Various types of aluminumblocks are supported

Division Doctor-T(SB) Doctor-T(DB)

150W x 200D x 100HOne

2.7kg

ambient +5�CPID controller

0.1�C�0.1�C�0.2�C0.1�C

16 x 2 Mono LCDTemp. Control mode / Timer mode / 3Cycle mode(PCR mode

Fast heating aluminum

110/220v 50/60Hz

they can accommodate various sizes of tubes, Microplate, and etc.

190W x 220D x 100HTwo

4.4kg


Doctor-T(SB)

Features �uniform temperature distribution �normal sample culturing �Coombs test �Compatibility and antibody testing �Colormetric tests

�VDRL Test �Serology procedures �the system supports timer mode and multi step

thermo-cycling mode also�RIA-aldosterone culturing

�Blood Chemistries� Immunohematologic incubating�Coagulation studies�Activated clotting times�Urine and blood cultures

Doctor-T(DB)

35-6mmTubes

20-10mmTubes

20-13mmTubes

12-16mmTubes

6-20mmTubes

6-25mmTubes

24-1.5mlTubes

24-0.5mlTubes

48-0.2ml,PCR stripsor Tubes

96 wellMicroplate

Combination(3-25mm,6-13mm,12-6mm)

96 well0.2ml Microplate,

PCR stripsor Tubes

Doctor-T(DB)

Doctor-T(SB)

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