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Biondi-Zoccai: CT & coronary angiography [email protected]metcardio.org Why coronary CT is Why coronary CT is inferior to invasive inferior to invasive coronary angiography coronary angiography Giuseppe Biondi Zoccai University of Turin, Turin, Italy [email protected] Convegno A.R.C.A: S. Vittoria d'Alba 24 October 2009 – 12:40-13:00

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Page 1: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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Why coronary CT is inferior Why coronary CT is inferior to invasive coronary to invasive coronary

angiographyangiography

Giuseppe Biondi ZoccaiUniversity of Turin, Turin, Italy

[email protected]

Convegno A.R.C.A: S. Vittoria d'Alba

24 October 2009 – 12:40-13:00

Page 2: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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SCOPE OF THE SCOPE OF THE PROBLEMPROBLEM

Page 3: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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LEARNING GOALSLEARNING GOALS

What CT angiography ISWhat CT coronary angiography IS NOT

ProsCons

Page 4: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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LEARNING GOALSLEARNING GOALS

What CT angiography ISWhat CT coronary angiography IS NOT

ProsCons

Page 5: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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WHAT CT CORONARY WHAT CT CORONARY ANGIOGRAPHY ISANGIOGRAPHY IS

Page 6: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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WHAT CT CORONARY WHAT CT CORONARY ANGIOGRAPHY ISANGIOGRAPHY IS

Computed tomography coronary angiography is a radiographic modality exploiting X-ray exposure and contrast media administration to non-invasively image coronary vessels

Page 7: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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WHAT CT CORONARY WHAT CT CORONARY ANGIOGRAPHY ISANGIOGRAPHY IS

Computed tomography coronary angiography is a radiographic modality exploiting X-ray exposure and contrast media administration to non-invasively image coronary vessels

Page 8: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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WHAT CT CORONARY WHAT CT CORONARY ANGIOGRAPHY ISANGIOGRAPHY IS

Computed tomography coronary angiography is a radiographic modality exploiting X-ray exposure and contrast media administration to non-invasively image coronary vessels

Page 9: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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LEARNING GOALSLEARNING GOALS

What CT angiography ISWhat CT coronary angiography IS NOT

ProsCons

Page 10: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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WHAT CT CORONARY WHAT CT CORONARY ANGIOGRAPHY IS NOTANGIOGRAPHY IS NOT

Page 11: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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WHAT CT CORONARY WHAT CT CORONARY ANGIOGRAPHY IS NOTANGIOGRAPHY IS NOT

Per-patient sensitivity

Hamon et al, JACC 2006

Page 12: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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LEARNING GOALSLEARNING GOALS

What CT angiography ISWhat CT coronary angiography IS NOT

ProsCons

Page 13: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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CONSCONSNot feasible if:

◦Allergy to CM◦Can’t hold breath◦Extensive coronary calcifications◦Morbidly obese◦Pacemaker◦Severe arrhythmia◦Severe hepatorenal insufficiency◦Small vessel disease◦Thick-strut stents

Page 14: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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CONSCONS

Pugliese et al, Radiology 2009

Increasing experience with coronary CT angiography improved the diagnostic performance of inexperienced physicians. However, acquiring expertise in coronary CT angiography was slow and may take more than 1 year.Mean evaluation time for trainees was 20 minutes at baseline and 13 minutes after 1 year. Mean evaluation time of the expert physicians was 10 minutes. However, it took an additional 5 minutes to achieve consensus.

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CONSCONS

Page 16: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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CONSCONS

Coles et al, JACC 2006

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CONSCONS

Einstein et al, JAMA 2007

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TAKE HOME MESSAGESTAKE HOME MESSAGES

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TAKE HOME MESSAGESTAKE HOME MESSAGESCT coronary angiography has higher costs

and risks (i.e. radiation and contrast) in comparison to other non-invasive tests

It also has inferior diagnostic performance in comparison to invasive coronary angiography

Thus, CT coronary angiography remains a promising diagnostic modality whose clinical use should be highly individualized, as shown by this recent example…

Page 20: Biondi-Zoccai: CT & coronary angiography gbiondizoccai@gmail.com – metcardio.org Why coronary CT is inferior to invasive coronary angiography Giuseppe

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rgThank you for your attentionThank you for your attention

For any correspondence: For any correspondence: [email protected]

For these and further slides on these topics feel For these and further slides on these topics feel free to visit the metcardio.org website: free to visit the metcardio.org website:http://www.metcardio.org/slides.html