Biomedical Biomedical InformaticsInformatics

Definition of Biomedical Definition of Biomedical Informatics (BMI)Informatics (BMI)

The discipline dealing with the structure, The discipline dealing with the structure, organization, utilization, and communication of organization, utilization, and communication of health-related information.health-related information.

Pertinent to clinical care, research, education, Pertinent to clinical care, research, education, and administration.and administration.

What We DoWhat We Do

Clinical InformaticsClinical Informatics Bioinformatics Bioinformatics Regional InformaticsRegional Informatics Informatics EducationInformatics Education Organizational TransformationOrganizational Transformation Educational InformaticsEducational Informatics

Questions For Our DisciplineQuestions For Our Discipline

Clinical InformaticsClinical Informatics How can we improve the visualization of How can we improve the visualization of

medical data?medical data? How can we improve decision-making at the How can we improve decision-making at the

point of care?point of care? How can we make care safer using How can we make care safer using

technology?technology? BioinformaticsBioinformatics

Are there faster/better ways to diagnosis Are there faster/better ways to diagnosis cancer through bioinformatics techniquescancer through bioinformatics techniques

Questions For Our DisciplineQuestions For Our Discipline

Informatics EducationInformatics Education How can informatics support the education How can informatics support the education

of students and practitioners?of students and practitioners? Educational Informatics Educational Informatics

How can we improve education through How can we improve education through informatics? informatics?

Questions For Our DisciplineQuestions For Our Discipline

Regional InformaticsRegional Informatics Can we enable better health care by sharing Can we enable better health care by sharing

information from multiple patient care sites information from multiple patient care sites within a geographic area? within a geographic area?

Organizational TransformationOrganizational Transformation How can we improve the adoption of clinical How can we improve the adoption of clinical

systems?systems? Can we improve chronic care management Can we improve chronic care management

through informatics?through informatics?

Overview of Some Overview of Some Informatics ProductsInformatics Products

Copyright (C) 2003 Vanderbilt University Medical Center

WizOrder Main Screen Layout: Simple, fixed format: functionally oriented, designed with users

Physician enters order for antibiotic,Gentamicin, by partially typing its name

1) Active orders 2) Common usefulorders based onpatient location

3) What to do next in WizOrder

4) Buttons forcommonly usedfeatures

Drip infusion rate calculator for the PICU

Copyright © 2002, Vanderbilt University Medical Center

User then enters dose and rate

WizOrder pre-fills weight

Meet Our Informatics Meet Our Informatics Faculty Faculty

Clinical Informatics Clinical Informatics

Dario Giuse, Dr. Ing., MSDario Giuse, Dr. Ing., MS

The architect of the Star system that you will use during your clinical experience

Continuously exploring alternative ideas for different views of all the information in an electronic medical chart.

Daniel R. Masys, M.D.Daniel R. Masys, M.D. Knowledge representation issues Knowledge representation issues

and data management and data management infrastructure for international, infrastructure for international, multilingual clinical research. multilingual clinical research.

Vanderbilt’s DNA databank Vanderbilt’s DNA databank project and associated de-project and associated de-identified “Synthetic Derivative” identified “Synthetic Derivative” database derived from identified database derived from identified clinical information clinical information

Interpretation of gene expression Interpretation of gene expression patterns via linkage to literature patterns via linkage to literature databases databases

KevinKevin JohnsonJohnson, , M.D., M.S.M.D., M.S.

Evaluating Vanderbilt clinical information systems

Development of electronic prescription writer for Vanderbilt

The Informatics Emphasis Chair

Randolph Miller, M.D.Randolph Miller, M.D. Clinical decision support via order

entry system Order entry-related monitoring of

clinical activities to detect and correct excessive utilization and/or notify clinicians of important events

TIME NIH grant to review labs and orders to determine the “kinetics” of drug-induced side effects that are measurable through the clinical laboratory

Josh Peterson, M.D., MPHJosh Peterson, M.D., MPH

Geriatric and Renal dosing project that will insert dosing advisories at the point of prescription writing

Safe and effective monitoring of medication toxicities. This is a epidemiology/data mining project, but will transition to a decision support intervention project.

Trent Rosenbloom, M.D., MPHTrent Rosenbloom, M.D., MPH

Identifying and mapping clinical phrases to controlled vocabulary using Mayo Clinic tools

Growth charts impact survey Evaluation of completeness and

correctness of National Drug File Reference Terminology Physiologic Effects

Evaluation of StarNotes usage

Russ Waitman, Ph.D.Russ Waitman, Ph.D. Creating and improving viewing

medication history in WizOrder Adverse Drug Event Monitoring Impact of CPOE (Clinical Provider

Order Entry)—a VERY hot topic! Allergy capture refinement and

integration among multiple information systems.

Potentially study one of the advisors within WIZ Order, such as anticoagulant advisor

Regional InformaticsRegional Informatics

Mark Frisse, M.D.Mark Frisse, M.D.

Tennessee-wide regional Tennessee-wide regional informatics infrastructure informatics infrastructure projectproject

Using Vanderbilt developed Using Vanderbilt developed systems in a regionsystems in a region

Located in the three Located in the three counties surrounding counties surrounding Memphis Memphis

Organizational Organizational TransformationTransformation

William W. Stead, MDWilliam W. Stead, MD Associate Vice Chancellor for Associate Vice Chancellor for

Health Affairs and Director of the Health Affairs and Director of the Informatics Center at Vanderbilt Informatics Center at Vanderbilt University. University.

Chief Information Officer of the Chief Information Officer of the Vanderbilt Medical Center Vanderbilt Medical Center

Had fostered the development of Had fostered the development of informatics that has transformed informatics that has transformed Vanderbilt. Vanderbilt.

Nancy M. Lorenzi, Ph.D.Nancy M. Lorenzi, Ph.D.

Patient Focused: Patient portal, MyHealthAtVanderbilt.edu, establishing consumer access

Technology Acceptance/Human Factors: Physician acceptance and use of information from electronic systems for decision making

Usability of our information software systems developed at VUMC

Dominik Aronsky, M.D., Ph.D.Dominik Aronsky, M.D., Ph.D.

Created a Whiteboard for the Emergency Department that facilitates the clinical and organizational management of patients in the ED

Created decision support systems for the Emergency Department—that transformed our ED to a state of the art system

Cynthia Gadd, PhDCynthia Gadd, PhD

Research, implementation and Research, implementation and evaluation of integrated clinical evaluation of integrated clinical information systems, including information systems, including electronic medical records (EHR) electronic medical records (EHR) systemssystems

Addresses system functionality Addresses system functionality and effectiveness, as well as and effectiveness, as well as user and organizational impacts.user and organizational impacts.

William (Bill) Gregg, M.D., M.S.William (Bill) Gregg, M.D., M.S.

Focuses on the transformation of how we handle chronic disease management

Created a system that is called StarTracker

Is in the process of testing StarTracker with a diabetic population

Ed Shultz, M.D., M.S.Ed Shultz, M.D., M.S.

Computer-based documentation

Has transformed our organization through his knowledge about

Application Development Vendor system integration Technical architecture

Jack Starmer, M.D.Jack Starmer, M.D.

Oversees the evidence-based medicine at the point of care organizational process

Has transformed our organization through his efforts

Providing feedback to clinical teams Created Evidence Central Order-set usability

Stuart Weinberg, M.D.Stuart Weinberg, M.D.

A specialist in clinical information systems and Pediatric informatics

Has transformed our organization through the creation of

A major outpatient whiteboard tracking system

Advisors within the WIZ Order system

BioinformaticsBioinformatics

Constantin Aliferis, MD, Ph.D.Constantin Aliferis, MD, Ph.D.

Machine learning algorithms for: large-scale computational causal discovery feature selection/construction for classification text categorization

Medical Decision Support Systems molecular (gene expression and mass-

spectrometry-based) prognostic, diagnostic, and treatment selection models

Normative/evidence-based medicine Temporal Representation and Reasoning in

biomedicine Bayesian Networks / Causal Probabilistic

Networks

Shawn E, Levy PhDShawn E, Levy PhD His research interests

include technology and methods development in

High-density gene expression profiling,

Structural and functional genomics,

Development of bioinformatics tools for the integration of molecular profiles of protein and gene expression with genotype information with an emphasis on colorectal cancer.

Bradley Malin, Ph.DBradley Malin, Ph.D Focuses on data privacy and Focuses on data privacy and

management issues in management issues in biomedical research and clinical biomedical research and clinical management systems.management systems.

Numerous articles on data Numerous articles on data privacy, fraud detection, and privacy, fraud detection, and surveillance within various surveillance within various technologies, including text technologies, including text databases, biomedical databases, biomedical databases, and face recognition databases, and face recognition systems. systems.

Jay Snoddy, PhD.Jay Snoddy, PhD.

Modularity in regulatory Modularity in regulatory networks networks

Regulatory signals in Regulatory signals in genome sequences genome sequences

System biology— System biology— development, and evolution development, and evolution

Bioinformatics of genes Bioinformatics of genes networks with the Integrative networks with the Integrative Neuroscience Initiative on Neuroscience Initiative on Alcoholism. Alcoholism.

                 

    

Informatics EducationInformatics Education

Anderson Spickard, MDAnderson Spickard, MD

All aspects of medical All aspects of medical education education

Special focus on the Special focus on the design and application of design and application of innovative informatics innovative informatics approaches to medical approaches to medical education.education.

Informatics EducationInformatics Education

Questions?Questions?