bioinformatics for discovery and global collaborations...
TRANSCRIPT
BioinformaticsforDiscoveryandGlobalCollaborations:ApproachesandLessonsLearned
An Academic Division of the Dept of Medicineat Harvard Medical Faculty Physicians at BIDMC, Inc.
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YuriQuintana,Ph.D.Director,GlobalHealthInformatics,BethIsraelDeaconessMedicalCenter
AssistantProfessor,HarvardMedicalSchool
OverviewofBioinformaticsYuriQuintana,Ph.D.
WhydoweneedBioinformatics?
OverviewofBioinformaticsYuriQuintana,Ph.D.
RiseofChronicDiseases• NCDsaretheleadingcausesofdeath(63%)inallregionsexceptAfrica.• NCDsprojectedtocostmorethanUS$30trillion(48%ofglobalGDPin2010)• Respiratorydiseasesandallergiesareamajorglobalproblem
Percentage of deaths from non-communicable diseases by country, 2013 (DOI: 10.4103/1658-600X.179820 Institute for Health Metrics and Evaluation
OverviewofBioinformaticsYuriQuintana,Ph.D.
DiversityofPatients• Peoplearemovingfromcountriesandregions(losthealthrecords)• MostclinicalresearchhasbeendoneinUSAandEurope(biasedsample)• Personalizedtreatmentoptimizedtogeneticsrequiresglobalapproach
Source: The global flow of people - Migration flows between and within regions for five-year periods http://www.global-migration.info
OverviewofBioinformaticsYuriQuintana,Ph.D.
EvolutionofPuttingResearchintoPractice
"TheLearningHealthcareSystem”,InstituteofMedicine.TheNationalAcademiesPress2007http://www.nap.edu/read/11903/chapter/1#ix.
Weneednotonlybetterdataandevidence-basedsciencebutbetterlearningnetworksandresearchcommunities
OverviewofBioinformaticsYuriQuintana,Ph.D.
Optimizing Healthcare
• Most clinical systems have incomplete data due to problems with data collection, interoperability, and data sharing
• Many centers have challenges integrating clinical and genomic data due to complexity and cost
• Many centers do not integrate family history or environmental history • Research has largely been focused on populations in high income
countries due to funding sources, biased genetic pool
• Future personalized treatments will need to be tailored to genetics, clinical, family history and environmental factors
OverviewofBioinformaticsYuriQuintana,Ph.D.
WhatisBioinformatics?
OverviewofBioinformaticsYuriQuintana,Ph.D.
BiomedicalInformatics
Biomedicalinformaticsisaninterdisciplinaryfieldthatdevelopsanalyticalmethodsandsoftwaretoolsforunderstandingclinicalandbiologicaldata.Itcombineselementsfromthefieldsofbasicsciences,biology,computerscience,mathematics,andengineering.
References:BiomedicalInformatics:ComputerApplicationsinHealthCareandBiomedicine,ShortliffeandCimino(editors),Springer,2013AMIABoardwhitepaper:definitionofbiomedicalinformaticsandspecificationofcorecompetenciesforgraduateeducationinthediscipline.Kulikowski2012DOI:10.1136/amiajnl-2012-001053
OverviewofBioinformaticsYuriQuintana,Ph.D.
EvolutionofField
Bioinformatics
BasicSciences
AppliedSciences
ClinicalSciences
ConsumerHealth
PopulationHealth
E-Health
Imaginginformatics
Consumerhealthinformatics
Researchinformatics
Publichealthinformatics
Healthinformationmanagement
TelehealthClinicalComputing
197019801990200020102020
ClinicalInformatics
OverviewofBioinformaticsYuriQuintana,Ph.D.
Applications
PrecisionMedicine
BasicSciences
AppliedSciences
ClinicalSciences
ConsumerHealth
PopulationHealth
PatientEducation,PatientPortals,MobileApps,Wearable,VR,SGH
AdvancedImageAnalytics
OnlinePatientEducation,OnlineCommunities,PatientGeneratedData
GenomicInformatics
PopulationHealthDatabasesandAnalytics
ClinicalWarehouse,HealthExchanges
Physician-PhysicianConsults,Patient-Physician,Patient-PatientLINC
197019801990200020102020
MedicalRecords,DecisionSupport,Alerts,MobileApps,Sensors
PaperChase
PubMed
OverviewofBioinformaticsYuriQuintana,Ph.D.
ContributionstothefieldbyDCI
“LINCwithTomorrow”Dr.WarnerSlackonnationalTV,1967
TheOnlineMedicalRecord(OMR),Dr.CharlesSafran,1989
BabyCareLinktelemedicineapplication,Dr.CharlesSafran,Dr.JimGray,et.al.1996
PaperChase,thefirstsearchengineforbiomedicalliterature,Dr.HowardBleich,1977,precursortoPubMed
PatientSite(2000),OpenNotes(2010),patientaccesstomedicalrecordsandphysiciannotes,Dr.TomDelbanco,JanWalker,Dr.HenryFeldman,et.al.
InfoSAGEMobilecarecoordinationandcommunicationforeldersandfamilies,CSafran,Y,QuintanaBCrotty,et.al.
Connectingpatientsandfamiliestotheirdataandcarenetwork
Connectinghealthcareproviderstoclinicaldataandliterature
http://www.hmfpinformatics.org
OverviewofBioinformaticsYuriQuintana,Ph.D.
ComplexityofData
Image Source: Finding the Missing Link for Big Biomedical Data. JAMA. 2014;311(24):2479-2480. doi:10.1001/jama.2014.4228
OverviewofBioinformaticsYuriQuintana,Ph.D.
De-IdentificationLevels
ImageSource:https://fpf.org/2016/04/25/a-visual-guide-to-practical-data-de-identification/andShadesofGray:SeeingtheFullSpectrumofPracticalDataDe-Identification.publishedintheSantaClaraLawReview.
OverviewofBioinformaticsYuriQuintana,Ph.D.
HumanGenomeProjectTimeline
ImageSource:NIHhttps://www.genome.gov/imagegallery/viewimage/?imageID=26964377742
OverviewofBioinformaticsYuriQuintana,Ph.D.
ComplexityofData
genome
transcriptome
proteome
genomics
transcriptomics
proteomics
metabolome
metabolomics
DNASequencer
DNAmicroarray
Massspectrometer
ImageSources:Naturehttps://www.nature.com/scitable/topicpage/translation-dna-to-mrna-to-protein-393andWikimedia
AffymetrixchipsGeneexpressionheatmaps
OrbitrapmassspectrometerMassspectrumofapeptide
DNAsequencersManufacturersRoche,Illumina,LifeTechnologies,BeckmanCoulter,PacificBiosciences
OverviewofBioinformaticsYuriQuintana,Ph.D.
ImageSource:https://www.genome.gov/27565109/the-cost-of-sequencing-a-human-genome/
TheCostofSequencingaHumanGenome
OverviewofBioinformaticsYuriQuintana,Ph.D.
NetworksforCollaborationandLearningwithBioinformaticsData
OverviewofBioinformaticsYuriQuintana,Ph.D.
GlobalLearningHealthSystem
GlobalDataCommons
Analyze&developnewprecisiontreatments
Applytreatmentsinlocalcentersbutwithcommondataformats
Discusswithpeersandrefinetreatments
Contributeoutcomesandclinicaldatasetstoglobalcommunity
OverviewofBioinformaticsYuriQuintana,Ph.D.
GlobalPediatricCancerNetwork
Richardson,S.,Banks,M.S.,Kettinger,W.,andQuintana,Y.ITandAgilityintheSocialEnterprise:ACaseStudyofSt.JudeChildren’sResearchHospital’s‘Cure4Kids’IT-PlatformforInternationalOutreach.JournaloftheAssociationofInformationSystems.2014:15(1),pp1-32.QuintanaY,PatelAN,ArreolaM,AntillonFG,RibeiroRC,HowardSC.POND4Kids:AGlobalWeb-basedDatabaseforPediatricHematologyandOncologyOutcomeEvaluationandCollaboration.StudHealthTechnolInform.2013;183:251-6.QuintanaY,O’BrienR,PatelA,BecksfortJ,ShulerA,NambayanA,OgdonD,ChantadaG,HowardSC,RibeiroRC.Cure4Kids:Researchchallengesinthedesignofawebsiteforglobaleducationandcollaboration.InformationDesignJournal2008;16:3,243-249.
Cure4Kids.org–GlobalEducationandCollaborationonPediatricOncologyPOND4Kids.org–GlobalSharedClinicalProtocolsandOutcomesDatabase
OverviewofBioinformaticsYuriQuintana,Ph.D.
CaBIG
• CancerBiomedicalInformaticsGrid(caBIG)wasaUSAgovernmentprogramfrom2004-2011todevelopanopensource,openaccessinformationnetworkcalledcaGridforsecuredataexchangeoncancerresearch.
• NCIpublishedreviewofCaBIGthatincludedalonglistofproblemswiththeprogram,andrecommendedthatmostprojectsshouldbediscontinued.KennethBuetow(April1,2008)."HeadingfortheBIGTime"(PDF).TheScientist.22(4),and
• BoardofScientificAdvisorsAdHocWorkingGroup(March3,2011)."AnAssessmentoftheImpactoftheNCICancerBiomedicalInformaticsGrid(caBIG®)"(PDF).NationalCancerInstitute.
OverviewofBioinformaticsYuriQuintana,Ph.D.
CancerLinQ™byASCO
CancerLinQ™(2015-)aggregatesClinicalRecordsfromoncologypractices,givesinsightsfromde-identifieddataonhundredsofthousandsofpatients,potentiallyidentifyingimportanttrendsandincreasingtheconfidenceofcaredecisions,visualizespatients’medicalhistoriesinpowerfulnewwaysAsofDec2017,100oncologypracticesin40states,12sourcesystems,600KcancerRecords,2,500oncologistsImageSource:https://cancerlinq.org/
OverviewofBioinformaticsYuriQuintana,Ph.D.
Alicanto™–GlobalCommunitiesofPractice
MainWebPortal
UserInterfaceInternationalizationandBandwidthMonitoring
AuthenticationSystem
LearningManagementSystem GroupCollaborationManagementSystem
TelemedicineConsultSystemLinkstoClinicaland
BiomedicalSharedDataSystems
SecurityMonitoringMobileAppAPI
MobileApp DesktopApp
© Yuri Quintana 2016 http://www.alicantocloud.com
AnIntegratedPlatformforEducation,CommunicationandDataSharing
OverviewofBioinformaticsYuriQuintana,Ph.D.
Alicanto™Networks
OPENPediatrics™fromBostonChildren’sHospitalhttps://www.openpediatrics.org
MADCAPNetworkfromDana-FarberCancerCenterhttps://www.madcapnetwork.org
OverviewofBioinformaticsYuriQuintana,Ph.D.
i2b2andTransmart
tranSMARTisaknowledgemanagementplatformthatenablesscientiststodevelopandrefineresearchhypothesesbyinvestigatingcorrelationsbetweengeneticandphenotypicdata,andassessingtheiranalyticalresultsinthecontextofpublishedliteratureandotherwork.ISource:http://transmartfoundation.org
OverviewofBioinformaticsYuriQuintana,Ph.D.
eTricks–EuropeanUnion
eTRIKSistheresultofacollaborationbetween17differentpartners.Eachcombiningtheirstrengthsinthedevelopmentofaplatformandservicesfordatastaging,explorationanduseintranslationalresearch.https://www.etriks.org/
OverviewofBioinformaticsYuriQuintana,Ph.D.
NIHGenomicDataCommons(USA)
https://gdc.cancer.gov/ImageSource:TowardaSharedVisionforCancerGenomicDataGrossmanRLetal.NEnglJMed2016;375:1109-1112.www.nejm.org/doi/full/10.1056/NEJMp1607591
OverviewofBioinformaticsYuriQuintana,Ph.D.
BiobankingandBioMolecularResourceResearchInfrastructure(Europe)
InformaticsTools
CDSKB|CatalogsandsharesclinicaldecisionsupportimplementationartifactsanddesignsconsiderationforgenomicmedicineprogramseleMAP|HarmonizeslocalphenotypedatadictionariestoexistingmetadataandterminologystandardseRecordCounter|ProvidesexploratorydatafiguresforresearchplanningpurposesandfeasibilityassessmentPheKB|OffersacollaborativeenvironmenttobuildandvalidateelectronicalgorithmstoidentifycharacteristicsofpatientswithinhealthdataPheWASCatalog|FunctionsasaplatformforanalysisofphenotypesagainstasinglegenevariantSPHINX|Operatesasatoolforexploringdataforhypothesisgeneration,especiallyarounddrugresponseimplicationsofgeneticvariationacrosstheeMERGEPGxcohortClinicalReportFileFormats|Listsclinicalreportsandresearchmaterials(e.g.consentforms)GenotypingTools|PennCNV,Biofilter,Biobin,PLATO,ATHENA,Synthesis-View,PheWAS-View,andPhenogramPhenotypingTools|PheKB,eleMAP,andPheWAS
OverviewofBioinformaticsYuriQuintana,Ph.D.
USANIHBigDatatoKnowledge(BD2K)
TheBigDatatoKnowledge(BD2K)programisatrans-NIHinitiativethatwaslaunchedin2013tosupporttheresearchanddevelopmentofinnovativeandtransformativeapproachesandtoolstomaximizeandacceleratetheintegrationofbigdataanddatascienceintobiomedicalresearch.TheBD2KProgramalsosupportedinitialeffortstowardmakingdatasets“FAIR”Findable,Accessible,Interoperable,andReusable.Initsfirstphase(FY2014-FY2017),BD2Kinvested$200millioningrantawardstoaddresssomemajordatasciencechallengesandtostimulatedata-drivendiscoveryhttps://commonfund.nih.gov/bd2kandhttps://datamed.org/andhttps://biocaddie.org/
DataDiscoveryIndex(DataMedv3.0)
OverviewofBioinformaticsYuriQuintana,Ph.D.
GenomicsEngland-100,000GenomesProject
GenomicsEngland,withtheconsentofparticipantsandthesupportofthepublic,iscreatingalastinglegacyforpatients,theNHSandtheUKeconomy,throughthesequencingof100,000genomes.Objectives:1)Tobringbenefittopatients2)Tocreateanethicalandtransparentprogrammebasedonconsent3)Toenablenewscientificdiscoveryandmedicalinsights4)TokickstartthedevelopmentofaUKgenomicsindustry ImageSource:https://www.genomicsengland.co.uk
OverviewofBioinformaticsYuriQuintana,Ph.D.
eMERGENetwork(USA)
eMERGEisanationalnetworkorganizedandfundedbytheNationalHumanGenomeResearchInstitute(NHGRI)thatcombinesDNAbiorepositorieswithelectronicmedicalrecord(EMR)systemsforlargescale,high-throughputgeneticresearchinsupportofimplementinggenomicmedicine.7clinicalsites2pediatricsitesin2012.https://emerge.mc.vanderbilt.edu/
OverviewofBioinformaticsYuriQuintana,Ph.D.
AllofUS-PrecisionMedicineInitiative(USA)
PMIlaunchedinfiscalyear2016when$130millionwasallocatedtoNIHtobuildanational,large-scaleresearchparticipantgroup,calledacohort,and$70millionwasallocatedtotheNationalCancerInstitutetoleadeffortsincancergenomicsaspartofPMIforOncology.Source:https://allofus.nih.gov
ThemissionoftheAllofUsResearchProgramistoacceleratehealthresearchandmedicalbreakthroughs,enablingindividualizedprevention,treatment,andcareforallofus.Buildingarepositoryofdatafor1,000,000+people.
OverviewofBioinformaticsYuriQuintana,Ph.D.
USAVeteranAffairsMillionVeteranProgram
ImageSource:https://www.research.va.gov/MVP/
MVPisanational,voluntaryresearchprogramfundedentirelybytheDepartmentofVeteransAffairsOfficeofResearch&Development.ThegoalofMVPistopartnerwithVeteransreceivingtheircareintheVAHealthcareSystemtostudyhowgenesaffecthealth.Todothis,MVPwillbuildoneoftheworld'slargestmedicaldatabasesbysafelycollectingbloodsamplesandhealthinformationfromonemillionVeteranvolunteers.DatacollectedfromMVPwillbestoredinasecuremannerandwillbecodedforresearcherssothatresearcherscannotdirectlyidentifyparticipants.Researcherswillstudydiseaseslikediabetesandcancer,andmilitary-relatedillnesses,suchaspost-traumaticstressdisorder
OverviewofBioinformaticsYuriQuintana,Ph.D.
BGI-Shenzhen-ChinaNationalGeneBank(China)
ImageSource:http://www.genomics.cn
EstablishedbyBGI-Shenzhen,theChinaNationalGeneBank(CNGB)isthefirstnationalgenebankintegratingalarge-scalebio-repositoryandanomicsdatabase.ItisapprovedbyChinesegovernment,withthemissionofcollecting,preservingandexploitinggenomicsresources,andtobuildanetworkfosteringglobalcommunicationandcollaborationonbiodiversityconservationandgeneticresourcesutilization.Inaddition,CNGBissupportedbyBGI’shigh-throughputsequencingandbio-informaticscapacity,anditwillnotonlyprovidearepositorysystemforbiologicalcollection,butmoreimportantlydevelopanovelplatformtofurtherunderstandgenomicmechanismsoflife.
OverviewofBioinformaticsYuriQuintana,Ph.D.
BiomedicalNetworkKeyRoles• ChiefScientist• Biomedical,LifeSciences,ClinicalScientists• ResearchInformaticsDirector• ClinicalInformaticsDirector• BiomedicalPlatformsArchitect• BiomedicalEngineersandProgrammers• ClinicalandGenomicClassificationExperts• QualityAssuranceEngineersandAnalysts• DataScientists• MachineLearning/AIResearchers• VisualizationandUserInterfaceExperts• ResearchEthicsandPrivacyDirectors• Communication(Internal&External)Directors• EducationandTrainingDirectors• CybersecurityExperts• CloudComputingArchitectsandEngineers• ExternalPartnershipsDirector
OverviewofBioinformaticsYuriQuintana,Ph.D.
ChallengesinImplementation• LackofFocus(Featurerich,functionpoor)• LackofAdequateTrainedPersonnel• LackofMultidisciplinaryTeam• PoorGovernance• PoorLeadership• LackofAdequateFunding(butnotthebiggestproblem)• CollectingandManagingDataUsageConsents• DataUseAgreementsbetweeninstitutions• Lackofdiversityinpatientdatasets• AgreementonDataformats,taxonomiesandindexingneedstosupport
scientificquestions• Usabilityoftools• De-identificationstrategy• LegalandComplianceRegulations• Sustainablefundingmodels
OverviewofBioinformaticsYuriQuintana,Ph.D.
ClinicalandBioinformaticsTraining
• GraduateProgramsinBioinformatics,ClinicalInformaticsandBio-Engineering
• AmericanMedicalInformaticsAssociationandJournalswww.amia.org
• IEEELifeSciencesSocietiesandConferenceslifesciences.ieee.org• ClinicalInformaticsSubspecialtyBoardExamination-AmericanBoardof
PreventiveMedicine(ABPM)• AmericanNursesCredentialingCenter(ANCC)offersaboardcertificationin
NursingInformatics• CIIP(CertifiedImagingInformaticsProfessional)certificationbyABII(The
AmericanBoardofImagingInformatics)• AmericanHealthInformationManagement
RegisteredHealthInformationAdministratorandCertifiedCodingAssociate
OverviewofBioinformaticsYuriQuintana,Ph.D.
Roadmap
• Selectcarefullyforkeyleadershippositions
• Assembleamulti-disciplinaryteam
• Involvepatientsastruepartners
• Startwithfocusedandfeasibleinitialplan,butscalable
• Havecleartransparencyandethics
OverviewofBioinformaticsYuriQuintana,Ph.D.
ReferencesBioinformatics• BiomedicalInformatics:ComputerApplicationsinHealthCareandBiomedicine(HealthInformatics)4thed.2014EditionByEdwardH.ShortliffeandJamesJ.Cimino(Editors)• AMIABoardwhitepaper:definitionofbiomedicalinformaticsandspecificationofcorecompetenciesforgraduateeducationinthediscipline.Kulikowski2012DOI:10.1136/
amiajnl-2012-001053• MethodsinBiomedicalInformaticsAPragmaticApproach.EditedbyNeilSarkar• JournalofBiomedicalInformatics,Springer
QuintanacitedworkonGlobalHealthInformatics• GlobalHealthInformatics—AnOverview.ByYuriQuintana,CharlesSafran.InHeimardeFátimaMarin,EduardoMassad,MarcoAntonioGutierrez,RobertoJ.RodriguesandDaniel
Sigulem,editors:Marin-GlobalHealthInformatics,Oxford:AcademicPress,2017,pp.1-13.• Quintana,Y.ChallengestoImplementationofGlobalTranslationalCollaborationPlatforms.MOJProteomBioinform.2015;2(6):65.• QuintanaY,PatelAN,ArreolaM,AntillonFG,RibeiroRC,HowardSC.
POND4Kids:AGlobalWeb-basedDatabaseforPediatricHematologyandOncologyOutcomeEvaluationandCollaboration.StudHealthTechnolInform.2013;183:251-6.• QuintanaY,SafranC.eCareataDistance:OpportunitiesandChallenges.ResearchontheuseofInformationandCommunicationTechnologiesinBrazilianhealthfacilities-HealthICT
2014.Pgs167-177.August20,2015• Richardson,S.,Banks,M.S.,Kettinger,W.,andQuintana,Y.
ITandAgilityintheSocialEnterprise:ACaseStudyofSt.JudeChildren’sResearchHospital’s‘Cure4Kids’IT-PlatformforInternationalOutreach.JournaloftheAssociationofInformationSystems.2014:15(1),pp1-32.
• MayD,QuintanaY,ChantadaG,RibeiroR.DevelopingOncopedia:CreatingandEditinganOnlineCollaborativeEducationalResourceforaGlobalAudience,ScienceEditor,CouncilofScienceEditor,May–June2009,Vol32,No3,pp.75-77.
• QuintanaY,O’BrienR,PatelA,BecksfortJ,ShulerA,NambayanA,OgdonD,ChantadaG,HowardSC,RibeiroRC.Cure4Kids:Researchchallengesinthedesignofawebsiteforglobaleducationandcollaboration.InformationDesignJournal2008;16:3,243-249
• "TheLearningHealthcareSystem”,InstituteofMedicine.TheNationalAcademiesPress2007.http://www.nap.edu/catalog/13301/the-learning-health-system-seriesTraining• DefiningtheMedicalSubspecialtyofClinicalInformatics.DonEDetmer,JohnRLumpkin,JeffreyJWilliamson.JAMIA2009;16:167-168• AMIABoardWhitePaper:ProgramRequirementsforFellowshipEducationintheSubspecialtyofClinicalInformatics.CharlesSafran,MMichaelShabot,BensonSMunger,JohnH
Holmes,ElaineBSteen,JohnRLumpkin,DonEDetmer,fortheAMIABoardofDirectors.JAMIA2009;16:158-166• AMIABoardWhitePaper:CoreContentfortheSubspecialtyofClinicalInformatics.ReedMGardner,JMarcOverhage,ElaineBSteen,BensonSMunger,JohnHHolmes,JeffreyJ
Williamson,DonEDetmer,fortheAMIABoardofDirectors.JAMIA2009;16:153-157• Bestpracticesinbioinformaticstrainingforlifescientists• Rosalindhttp://rosalind.info/• BioinformaticsEducation,OntarioInstituteforCancerResearchhttps://bioinformatics.ca
BioinformaticsDataNetworks• NIHGenomicDataCommonshttps://gdc.cancer.gov/• NIHAllofUS-PrecisionMedicineInitiativehttps://allofus.nih.gov• USVeteranAffairsMillionVeteranProgramImageSource:https://www.research.va.gov/MVP/• TransmartFoundationhttp://transmartfoundation.organdi2b2:InformaticsforIntegratingBiology&theBedsidehttps://www.i2b2.org• GenomicsEngland-100,000GenomesProjecthttps://www.genomicsengland.co.uk• BGI-Shenzhen,theChinaNationalGeneBank(CNGB)BGI-Shenzhen,theChinaNationalGeneBank(CNGB)http://www.genomics.cn
OverviewofBioinformaticsYuriQuintana,Ph.D.
RelatedMedicalInformaticsSpecialties• Bioinformatics-Informaticsappliedtocellularandmolecularbiology,andgenomics.• Clinicalinformatics-Informaticsappliedinhealthcareorindividualhealthsettings.Itis
relatedto,suchasnursinginformatics,dentalinformatics,pathologyinformatics.
• Imaginginformatics-Informaticsappliedtoimaging,systemsinhealthcaresettings(storage,retrieval,analysis).
• Consumerhealthinformatics-Informaticsappliestoconsumerandpatientaccess.
• Researchinformatics-Informaticstosupportbiomedicalandhealthresearch,withafocustosupporttranslationofknowledgebenchtobedside.
• Publichealthinformatics-Informaticsappliedtopublichealthsuchashealthsurveillance,reporting,andhealthpromotion.
• Healthinformationmanagement-Arelatedfieldappliedtothemanagementofmedicalrecordsandaccess.
• E-Health–Termsfromthe1990sontheapplicationofelectronicmethodstohealthcare• Telehealth–Studyofthedistributionofhealth-relatedservicesandinformationvia
electronic• ClinicalComputing–EarlytermusedbypioneerssuchasDr.WarnerSlackandDr.Howard
Bleichin1970s
OverviewofBioinformaticsYuriQuintana,Ph.D.
ContactYuriQuintana,Ph.D.Director,GlobalHealthInformaticsBethIsraelDeaconessMedicalCenterHarvardMedicalSchoolEmail:[email protected]:www.yuriquintana.comTwitter:www.twitter.com/yuriquintana
An Academic Division of the Dept of Medicineat Harvard Medical Faculty Physicians at BIDMC, Inc.
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