PowerPoint Presentation

RANJU M R16ML14FBIODEGRADABLE CERAMIC-POLYMER COMPOSITES FOR BIOMEDICAL APPLICATION

RANJU M R16ML14FMaterials enggNIT karnataka.

1

2INTRODUCTIONAPPLICATION NEEDEXAMPLESSUMMARY

CONTENTS

3BIOMATERIALS

Non-living materials mainly used for medical purposes. Designed to interact with biological systems.

BIODEGRADABLE MATERIAL

Its mechanical properties does not change during its life time. It gets degrades gradually without leaving trace.

TISSUE ENGINEERING

Maintenance, replacement or regeneration of damaged biological tissues.

INTRODUCTION

APPLICATIONS4

BIOMEDICAL FIELD

scaffolds

5Repeat surgery necessary.Inability to adapt to growth.Stress shielding, corrosion, accumulation of metal in tissues.Thrombogenicity and long term endothelial dysfunction.Chronic inflammatory local reactions.Physical irritations.

PERMANENT IMPLANTATION- PROBLEMSHOW TO OVER COME?

5

6

6BIODEGRADABLE POLYMERSSYNTHETIC POLYMERPLAPGAPCL Synthetic polymer Good mechanical strength To improve biodegradability,biocompatibility & biofunctinality.

BIODEGRADABLE CERAMIC- POLYMER COMPOSITE is used

SOLUTIONNATURAL POLYMERPROTEINSPOLYSACCHARIDES

7BIODEGRADABLE CERAMIC-POLYMER COMPOSITE7 Ceramic-polymer composite : Ceramic fillers incorporated to polymer matrices . Commonly used ceramic polymer composites are ; Silica based composite. Bio glass based composite. Wollastonite based composite. Calcium phosphate ceramics based composite.Michal Dziadek, Ewa Stodolak Biodegradable ceramic-polymer composites for biomedical applications: a review. C71 (2016)

SILICA BASED COMPOSITE Higher biocompatibility. Higher bioresorption rate and porosity. Improves stability, adhesion and mechanical properties.

PLA/SiO2 membrane after 8 week incubation in H2O/37C/PBS

BIOGLASS BASED COMPOSITE9SILICATE BIOACTIVE GLASS SiO2Na2OCaOP2O5 system Bioglass 45S5. Ionic dissolution product stimulate osteoblastic and stem cell growth.

2. BORATE & BOROSILICATE BIOACTIVE GLASSES High reactivity and bioactivity. Lower biocompatibility due to cytotoxicity by borate ions.3. PHOSPHATE GLASSES P2O5-CaO-Na2O system. Chemical similarity to the inorganic phase of human bone. Dissolution product of PBG enhance proliferation of osteoblastic cells.Michal Dziadek, Ewa Stodolak Biodegradable ceramic-polymer composites for biomedical applications: a review. C71 (2016)

10

TISSUE REGENERATION

CONCLUSION Composite material provides greater possibility to control their material and biological properties than the ceramics and the polymer alone.

Mean features for the medical applications can be controlled by using different types of ceramics.

It provides a number of unique and beneficial properties for tissue engineering and regenerative medicine.

REFERENCES121. Michal Dziadek, Ewa Stodolak Biodegradable ceramic-polymer composites for biomedical applications: a review.2. R. Gref, Y.Minamitake,M.T. Peracchia, V. Trubetskoy, V. Torchilin, Langer, Biodegradable long-circulating polymeric nanospheres.3. L.S. Nair, C.T. Laurencin, Biodegradable polymers as biomaterials, progress in polymer ,Science (Oxford) 32 (89) (2007) 7627984. https://www.omicsonline.org

13THANK YOU