Binary Binary Ionization Ionization

Technology Technology SystemsSystems

Binary Binary Ionization Ionization

Technology Technology SystemsSystems

This technical data is controlled under the U.S. International Traffic in Arms Regulations (ITAR) and may not be exported to a Foreign Person, either in the U.S. or abroad, without the proper authorization by the U.S. Department of State.

H2O2 Solutions LLC

Binary Ionization Technology Systems

Energized Chemistry - H2O2 Ionization:

Cold Plasma (BIT Plasma)UV Light, heat, ozoneChemical Activation (BIT Chemical)

Basic Chemical Reaction:H2O2 + activator peroxy acids + hydroxyls,

reactive oxygen species (ROS)Redox potential greater than chlorine or

peroxide alone

What it Does:Destroys proteins on contact (via oxidation)

killing biological agents including viruses, molds, bacteria and bacterial spores

Reacts with chemical bonds in chemical agents destroying their activity

BIT Mobile Control Units

BIT Plasma Head

This technical data is controlled under the U.S. International Traffic in Arms Regulations (ITAR) and may not be exported to a Foreign Person, either in the U.S. or abroad, without the proper authorization by the U.S. Department of State.

What is the BIT Plasma System?

What is the BIT Plasma System? Aerosolized solution

containing hydrogen peroxide

Electric arc produced by 17K volt potential

Hydrogen peroxide, nitrogen and oxygen are energized (ionized)

Creates a variety of “free radicals” including:Hydroxyl radicalHydroxyl ionSuperoxide anionSinglet oxygenOther reactive oxygen

species (ROS)

Aerosolized solution containing hydrogen peroxide

Electric arc produced by 17K volt potential

Hydrogen peroxide, nitrogen and oxygen are energized (ionized)

Creates a variety of “free radicals” including:Hydroxyl radicalHydroxyl ionSuperoxide anionSinglet oxygenOther reactive oxygen

species (ROS)

Reactive Oxygen Species (ROS) Destroy Chemical Bonds, Disrupting Proteins, Lipids and Chemicals

GA VX

DPCP

This technical data is controlled under the U.S. International Traffic in Arms Regulations (ITAR) and may not be exported to a Foreign Person, either in the U.S. or abroad, without the proper authorization by the U.S. Department of State.

BIT Plasma System Commercial Product

SteraMist Fogging Unit

Primary use is to decontaminate surfaces in tissue banks, hospitals and pharmaceutical manufacturing facilities

Extensive in-house and 3rd party testing against a wide range of pathogens

Production of commercial units and sales began in September 2008

Use of extendable ‘pods’ allow for flexibility of mist application

This technical data is controlled under the U.S. International Traffic in Arms Regulations (ITAR) and may not be exported to a Foreign Person, either in the U.S. or abroad, without the proper authorization by the U.S. Department of State.

Extensive Testing Against Biologicals

In-house and multiple 3rd party tests

Exposure times 15-90 seconds

Killing up to 9 logs

Effective against mold, spores, viruses and bacteria

BIT Plasma AdvantagesBIT Plasma Advantages

Broad spectrum including bacterial and fungal endospores

ROS kill by lysis of cell walls Rapid cycle time Environmentally friendly-residue

H2O+O2 H2O2 concentration of 7.5% is safe for

personnel No damage to interior materials Electrostatic spray extensive distribution Log kill organisms >6 for all organisms

tested

Broad spectrum including bacterial and fungal endospores

ROS kill by lysis of cell walls Rapid cycle time Environmentally friendly-residue

H2O+O2 H2O2 concentration of 7.5% is safe for

personnel No damage to interior materials Electrostatic spray extensive distribution Log kill organisms >6 for all organisms

tested

How Common Is MRSA?How Common Is MRSA?

Jarvis, et al,”National Prevalence of MRSA in Inpatients in Health Care Facilities,2006,” AJIS, vol35#10, 12-07

P > 46.3/1000 inpatients ( 34 infect and 12 colonization /1000 inpatients )

Jarvis, et al,”National Prevalence of MRSA in Inpatients in Health Care Facilities,2006,” AJIS, vol35#10, 12-07

P > 46.3/1000 inpatients ( 34 infect and 12 colonization /1000 inpatients )

The Value of a Clean EnvironmentThe Value of a Clean Environment

Huang et al, “The Risk of Aquiring Antibiotic Resistant Bacteria From Prior Room Occupants,” Arch of Int Med, vol 166#18, 10-06

Drees et al,”Prior Environmental ContaminationIncreases the Risk of Acquisition of Vancomycin-Resistant Enterococci,” Clin Infect Dis, vol 46 #2, 3-08

Otter et al,”Survival of Nosocomial Bacteria and Spores on Surfaces and Inactivation by H2O2 Vapour,”J Clin Microbiol, vol47#2, 2-09

Huang et al, “The Risk of Aquiring Antibiotic Resistant Bacteria From Prior Room Occupants,” Arch of Int Med, vol 166#18, 10-06

Drees et al,”Prior Environmental ContaminationIncreases the Risk of Acquisition of Vancomycin-Resistant Enterococci,” Clin Infect Dis, vol 46 #2, 3-08

Otter et al,”Survival of Nosocomial Bacteria and Spores on Surfaces and Inactivation by H2O2 Vapour,”J Clin Microbiol, vol47#2, 2-09

How Important is the EnvironmentHow Important is the Environment

Harris, Anthony, “Editorial: How important is the environment inj the Emergence of Nosocomial Antibiotic Resistant Bacteria?,” Clin Infect Dis, vol 46#2 3-08

While patient to patient transmission via health care workers is an important mechanism, the role of environmental contamination appears significant

Harris, Anthony, “Editorial: How important is the environment inj the Emergence of Nosocomial Antibiotic Resistant Bacteria?,” Clin Infect Dis, vol 46#2 3-08

While patient to patient transmission via health care workers is an important mechanism, the role of environmental contamination appears significant

Does Disinfection Reduce Risk?Does Disinfection Reduce Risk?

Deterkofer et al,” Does Disinfection of Environmental Surfaces Influence Nosocomial Infection Rates? AIIC vol 32 #2, 4-04

Deterkofer et al,” Does Disinfection of Environmental Surfaces Influence Nosocomial Infection Rates? AIIC vol 32 #2, 4-04

Are Conventional Techniques Adequate?Are Conventional Techniques Adequate?

Carling et al,”Intensive Care Unit Environmental Cleaning: An Evaluation of Sixteen Hospitals Using a Novel Assessment tool,” J of Hosp Infect, vol 68, 1-08

Goodman et al,”Impact of Environmental Cleaning Intervention on the Presence of MRSA and VRE on Surfaces in Intensive Care Unit Rooms,” Infec Control and Hosp Epi, vol29#7, 7-08

Carling et al,”Intensive Care Unit Environmental Cleaning: An Evaluation of Sixteen Hospitals Using a Novel Assessment tool,” J of Hosp Infect, vol 68, 1-08

Goodman et al,”Impact of Environmental Cleaning Intervention on the Presence of MRSA and VRE on Surfaces in Intensive Care Unit Rooms,” Infec Control and Hosp Epi, vol29#7, 7-08

Is Infection Control Cost Effective?Is Infection Control Cost Effective?

Perencevich et al, “Raising Standards While Watching the Bottom Line: Making a Business Case for Infection Control,” Infect Control and Hosp Epi, vol 28#10, 10-07

Perencevich et al, “Raising Standards While Watching the Bottom Line: Making a Business Case for Infection Control,” Infect Control and Hosp Epi, vol 28#10, 10-07

Is H2O2 Decontamination Effective, Safe,

and Practical? (Steris )

Is H2O2 Decontamination Effective, Safe,

and Practical? (Steris )

Boyce,John M.,”New Approaches to Decontamination of Rooms,” Infec Control and After Patients Are Discharged Hosp Epi, vol30#5 6-09

Boyce,John M.,”New Approaches to Decontamination of Rooms,” Infec Control and After Patients Are Discharged Hosp Epi, vol30#5 6-09

BIT Plasma H2O2 vs Steris-VHPBIT Plasma H2O2 vs Steris-VHP

Charged Aerosol In or outside No special Tx Surface activity No prep Active

immediately OK with HVAC Redox =2.8

(fl=3.0)

Charged Aerosol In or outside No special Tx Surface activity No prep Active

immediately OK with HVAC Redox =2.8

(fl=3.0)

Need optimal -dry-conditions

Inside No surface

activity Hours to prep Needs 30’

exposure Corrodes HVAC

duct Redox H2O2 =1.8

Need optimal -dry-conditions

Inside No surface

activity Hours to prep Needs 30’

exposure Corrodes HVAC

duct Redox H2O2 =1.8

BIT Plasma vs Steris VHPBIT Plasma vs Steris VHP

Spread enhanced by charged particles

Std bio indicator Rapidly H2O +O2 Safe with metals H2O2 conc 7% is

non toxic ( except eye)

Fabric/cellulose OK

Spread enhanced by charged particles

Std bio indicator Rapidly H2O +O2 Safe with metals H2O2 conc 7% is

non toxic ( except eye)

Fabric/cellulose OK

Limited penetration b/o moisture effect

Special SS indicator

Slow decomp ,Hard to monitor

Oxidizes metals H2O2 conc 50%-

toxic to lungs skin eye

Fabric-cellulose separate decontam

Limited penetration b/o moisture effect

Special SS indicator

Slow decomp ,Hard to monitor

Oxidizes metals H2O2 conc 50%-

toxic to lungs skin eye

Fabric-cellulose separate decontam

VerificationVerification

3M Clean Trace ATP System

Biological Indicators: Geobacillus stearothemophilus (incubated at 55-60 degrees C, in Trypticase Soy Broth)

3M Clean Trace ATP System

Biological Indicators: Geobacillus stearothemophilus (incubated at 55-60 degrees C, in Trypticase Soy Broth)

H2O2 SolutionsH2O2 Solutions

Sterilization Services

BIT SteraMist Sales

Sterilization Services

BIT SteraMist Sales

Objective - ServicesObjective - Services

To drastically reduce the index and related costs of hospital-acquired infections by efficiently sterilizing the areas where dangerous pathogens are normally found.

To drastically reduce the index and related costs of hospital-acquired infections by efficiently sterilizing the areas where dangerous pathogens are normally found.

AdvantagesAdvantages

Reduction of operational costs (room turn-around times).

Reduction of functional costs (changes in Medicare).

Reduction in exposure to litigious events.

More active protection of patients, staff, and visitors.

Reduction of operational costs (room turn-around times).

Reduction of functional costs (changes in Medicare).

Reduction in exposure to litigious events.

More active protection of patients, staff, and visitors.

H2O2 ServicesH2O2 Services

Proven technology - highly effective, quick to deploy and utilize, no toxic or harmful by-products.

Inclusive of all equipment and materials.

Knowledgeable, flexible staff.

Committed, long term relationship.

Turn-key operation.

24/7 “on-call” availability.

Proven technology - highly effective, quick to deploy and utilize, no toxic or harmful by-products.

Inclusive of all equipment and materials.

Knowledgeable, flexible staff.

Committed, long term relationship.

Turn-key operation.

24/7 “on-call” availability.

Turn-Key OperationTurn-Key Operation

Site survey.Functional qualification of each area.Tailored to customer’s schedule.Process repeatability and quality control.Documented process and results.Record keeping.24/7 “on-call” availability

Site survey.Functional qualification of each area.Tailored to customer’s schedule.Process repeatability and quality control.Documented process and results.Record keeping.24/7 “on-call” availability