Bibliography

Bibliography

174

Abe, N., Ebina, T., Ishida, N. 1982. Interferon induction by glycyrrhizin and glycyrrhetinic acid

in mice. Microbiol. Immunol. 26, 535-539.

Adenis, A., Carlier, D., Darloy, F., Pion, J.M., Bonneterre, J., Demaille, A., 2005. Cytarabine and

cisplatin as salvage therapy in patients with metastatic colorectal cancer who failed 5-fluorouracil

+ folinic acid regimen. French Northern Oncology Group. Am J Clin Oncol. 18, 158-160.

Adida, C., Crotty, P.L., Mcgrath, J., Berrebi, D., Diebold, J., Altieri, D.C. 1998. Developmentally

regulated expression of the novel cancer anti-apoptosis gene survivin in human and mouse

differentiation. Am. J. Pathol. 152, 43–49.

Adrain, C., Martin, S.J., 2001. The mitochondrial apoptosome: a killer unleashed by the

cytochrome seas. Trends Biochem Sci. 26, 390-7.

Agarwal, R., Wang, Z.Y., Mukhtar, H. 1991. Inhibition of mouse skin tumor- initiating activity of

DMBA by chronic oral feeding of glycyrrhizin in drinking water. Nutr. Cancer 15, 187–193.

Aggarwal, B.B., Gehlot, P., 2009. Inflammation and cancer: how friendly is the relationship for

cancer patients? Curr. Opin. Pharmacol. 9, 351-369.

Ambrosini, G., Adida, C., Altieri, D. 1997. A novel anti-apoptosis gene, survivin, expressed in

cancer and lymphoma. Nat. Med. 3, 917–921.

Ames, B.N., Gold, L.S., 1990. Too many rodent carcinogens: mitogenesis increases mutagenesis.

Science. 249, 970-71.

Andersen, M.H., Becker, J.C. and Straten, P., 2005. Regulators of apoptosis: suitable targets for

immune therapy of cancer. Nat. Rev. Drug Discov. 4, 399-409.

Andoh, A., Deguchi, Y., Inatomi, O., Yagi, Y., Bamba, S., Tsujikawa, T., Fujiyama, Y. 2006.

Immunohistochemical study of chymase-positive mast cells in inflammatory bowel disease.

Oncol. Rep. 16, 103–107.

Arase, Y., Ikeda, K., Murashima, N., Chayama, K., Tsubota, A., Koida, I., Suzuki, Y., Saitoh, S.,

Kobayashi, M., Kumada, H. 1997. The long term efficacy of glycyrrhizin in chronic hepatitis C

patients. Cancer. 79, 1494–1500.

Bibliography

175

Arikawa, A.Y., Gallaher, D.D. 2008. Cruciferous vegetables reduce morphological markers of

colon cancer risk in dimethylhydrazine-treated rats. J. Nutr. 138, 526–532.

Arutiunian, A.V., Prokopenko, V.M., Burmistrov, S.O., Oparina, T.I., Frolova, E.V.,

Zabezhinskiĭ, M.A., Popovich, I.G., Anisimov, V.N., 1997. Free-radical processes in blood

serum, liver and large bowel during 1, 2-dimethylhydrazine-induced carcinogenesis in rats. Vopr.

Onkol. 43, 618–622.

Ashkenazi, A., Dixit, V.M., 1998. Death receptors: signaling and modulation. Science. 281, 1305-

8.

Ashton-Rickardt, P.G., Dunlop, M.G., Nakamura, Y., Morris, R.G., Purdie, C.A., Steel.

C.M., Evans. H.J., Bird, C.C., Wylie, A.H., 1989. High frequency of APC loss in sporadic

colorectal carcinoma due to breaks clustered in 5g21-22.Oncogene. 4, 1169-1174.

Ashwell, J.D., 2006. The many paths to p38 mitogen-activated protein kinase activation in the

immune system. Nat. Rev. Immunol. 6, 532-540.

Atessahin, A., Ceribasi, A.O., Yuce, A., Bulmus, O., Cikim, G., 2007. Role of ellagic acid against

cisplatin-induced nephrotoxicity and oxidative stress in rats. Basic Clin. Pharmacol. Toxicol. 100,

121-126.

Baker, S.J., Fearon, E.R.. Nigro, J.M., Hamilton, S.R.. Preisinger, A.C., Jessup, J.M.,

vanTuinen, P., Ledbetter, D.H., Barker, D.F., Nakamura, Y., White, R., Vogelstein, B.,

1989. Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science.

244, 217-221.

Baker, S.J., Preisinger, A.C., Jessup, J.M., Paraskeva, C., Markowitz, S., Willson, J.K..,

Hamilton, S., Vogelstein, B., 1990. p53 gene mutations occur in combination with 17p

allelic deletions as late events in colorectal tumorigenesis. Cancer Res. 50, 7717-7722.

Balkwill, F. 2004. Cancer and the chemokine network. Nature Rev. Cancer 4, 540–550.

Balkwill, F., Mantovani, A., 2001. Inflammation and cancer: back to Virchow? Lancet. 357, 539-

545.

Bibliography

176

Bandipalliam, P., Garber, J., Syngal, S., Kolodner, R.D., 2004. Clinical presentation correlates

with the type of mismatch repair gene involved in hereditary nonpolyposis colon cancer.

Gastroenterology. 126, 936-67.

Bansal, B.R., Rhoads, J.E., Bansal, S.C., 1978. Effects of diet on colon carcinogenesis and the

immune system in rats treated with 1, 2-dimethylhydrazine, Cancer Res. 38, 3293-3303.

Barbaric, M., Miskovic, K., Bojic, M., Loncar, M.B., Smolcic-Bubalo, A., Debeljak, Z., Medic-

Saric, M., 2011. Chemical composition of the ethanolic propolis extracts and its effect on HeLa

cells. J. Ethnopharmacol. 135, 772-778.

Barth, S.W., Fahndrich, C., Bub, A., Dietrich, H., Watzl, B., Will, F. 2005. Cloudy apple juice

decreases DNA damage, hyperproliferation and aberrant crypt foci development in the distal

colon of DMH-initiated rats. Carcinogenesis 26, 1414–1421.

Bartsch, H., Nair, J., 2002. Potential role of lipid peroxidation derived DNA damage in human

colon carcinogenesis: studies on exocylic base adducts as stable oxidative stress marker, Cancer

Detect. Prev. 26, 308-312.

Bartsch, H., Nair, J., 2006. Chronic inflammation and oxidative stress in the genesis and

perpetuation of cancer: role of lipid peroxidation, DNA damage, and repair. Langenbecks Arch.

Surg. 391, 499-510.

Basu, A., Krishnamurthy, S., 2010. Cellular responses to cisplatin-induced DNA damage. J.

Nucleic Acids. 1-16.

Bearcroft, C.P., Domizio, P., Mourad, F.H., André, E.A., Farthing, M.J., 1999. Cisplatin impairs

fluid and electrolyte absorption in rat small intestine: a role for 5-hydroxytryptamine. Gut. 44,

174-179.

Belanger, J.T., 1998. Perillyl alcohol: applications in oncology. Altern. Med. Rev. 3, 448-457.

Bharti, A.C. Aggarwal, B.B., 2002. Chemopreventive agents induce suppression of nuclear

factor-κB leading to chemosensitization. Ann. NY Acad. Sci. 973, 392-395.

Bhattacharya, G., Boman, B.M., 1995. Phosphorylation of the adenomatous polyposis coli

protein and its possible regulatory effects in cells. Biochem. Biophys. Res. Commun. 208,

103-110.

Bibliography

177

Bienz, M., Clevers, H. 2000. Linking colorectal cancer to Wnt signaling. Cell 103, 311–320.

Bird, P.R., 1995. Role of aberrant crypt foci in understanding the pathogenesis of colon cancer.

Cancer Lett. 93, 55-71.

Bird, R.P.,1987. Observation and quantification of aberrant crypts in murine colon treated with a

colon carcinogen: preliminary findings. Cancer Lett. 37, 147-51.

Blakey, D.H., Duncan, A.M.V., Wargovich, M.J., Goldberg, M.T.. Bruce, W.R., Heddle. J.A.,

1985. Detection of nuclear anomalies in the colonic epithelium of the mouse. Cancer Res.

45, 242-249.

Bodmer, J.L., Holler, N., Reynard, S., Vinciguerra, P., Schneider, P., Juo, P., Blenis, J., Tschopp,

J., 2000. TRAIL receptor-2 signals apoptosis through FADD and caspase-8. Nat. Cell. Biol. 2,

241-3.

Boldin, M.P., Varfolomeev, E.E., Pancer, Z., Mett, I.L., Camonis, J.H., Wallach, D., 1995. A

novel protein that interacts with the death domain of Fas/APO-1 contains a sequence motif

related to the death domain. J. Biol. Chem. 270, 7795-8.

Bonizzi, G. Karin, M., 2004. The two NF-κB activation pathways and their role in innate and

adaptive immunity. Trends Immunol. 25, 280-288.

Boogaard, P.J., Lempers, E.L., Mulder, G.J., Meerman, J.H.N.1991. 4-methylthiobenzoic acid

reduces cisplatin nephrotoxicity in rats without compromising anti-tumor activity. Biochem

Pharmacol. 41, 1997-2003.

Boveri, T., 1902. U¨ ber mehrpoligeMitosen alsMittel zur Analyse des Zellkerns. Verh. D. Phys.

Med. Ges. 35, 67-90.

Bratton, S.B., MacFarlane, M., Cain, K., Cohen, G.M., 2000. Protein complexes activate distinct

caspase cascades in death receptor and stress-induced apoptosis. Exp Cell Res. 256, 27-33.

Brechbuhl, H.M., Kachadourian, R., Min, E., Chan, D., Day, B.J., 2011. Chrysin enhances

doxorubicin-induced cytotoxicity in human lung epithelial cancer cell lines: The role of

glutathione. Toxicol Appl Pharmacol. 258, 1-9.

Bibliography

178

Brooks, C., Wei, Q., Feng, L., Dong, G., Tao, Y., Mei, L., Xie, Z.J., Dong, Z., 2007. Bak

regulates mitochondrial morphology and pathology during apoptosis by interacting with

mitofusins. Proc. Natl. Acad. Sci. USA. 104, 11649-11654.

Bülow, S., Björk, J., Christensen, I.J., 2004. Duodenal adenomatosis in familial adenomatous

polyposis. Gut. 53, 381-86.

Bulavin, D.V., Saito, S., Hollander, M.C., Sakaguchi, K., Anderson, C.W., Appella, E., Fornace,

A.J. Jr., 1999. Phosphorylation of human p53 by p38 kinase coordinates N-terminal

phosphorylation and apoptosis in response to UV radiation. EMBO J. 18, 6845-6854.

Burke, F., Balkwill, F.R., 1996. Cytokines in animal models of cancer. Biotherapy. 8, 229-41.

Burke, Y.D., Ayoubi, A.S., Werner, S.R., McFarland, B.C., Heilman, D.K., Ruggeri, B.A.,

Crowell, P.L., 2002. Effects of the isoprenoids perillyl alcohol and farnesol on apoptosis

biomarkers in pancreatic cancer chemoprevention. Anticancer Res. 22, 3127-3134.

Burstein, M.J., 1993. Dietary factors related to colorectal neoplasms. Surg. Clin. N. Am. 73, 13-

29.

Buskens, C.J., Van Rees, B.P., Sivula, A., Reitsma, J.B., Haglund, C., Bosma, P.J., Offerhaus, G.J.,

Van Lanschot, J.J., Ristimäki, A., 2002. Prognostic significance of elevated cyclooxygenase-2

expression in patients with adenocarcinoma of the esophagus. Gastroenterology. 122, 1800- 7.

Butterworth, B.E., 1990. Consideration of both genotoxic and nongenotoxic mechanisms in

predicting carcinogenic potential. Mutat. Res. 239, 117-32.

Buttke, T.M., Sandstrom, P.A., 1994. Oxidative stress as a mediator of apoptosis. Immunol.

Today. 15, 7-10.

Caderni, G., Femia, A.P., Giannini, A., Favuzza, A., Luceri, C., Salvadori, M., Dolara, P., 2003.

Identification of mucin-depleted foci in the unsectioned colon of azoxymethane-treated rats:

correlation with carcinogenesis. Cancer Res. 63, 2388-92.

Cancer incidence and mortality worldwide: Lyon, International Agency for Research on Cancer,

2011 (IARC CancerBase No.10).

Bibliography

179

Canman, C.E., Chen, C.Y., Lee, M.H., Kastan, M.B., 1994. DNA damage responses: p53

induction, cell cycle perturbations, and apoptosis. Cold Spring Harb. Symp. Quant. Biol. 59,

277-286.

Cardenas, M., Marder, M., Blank, V.C., Roguin, L.P., 2006. Antitumor activity of some natural

flavonoids and synthetic derivatives on various human and murine cancer cell lines. Bioorg. Med.

Chem. 14, 2966-2971.

Carswell, E.A., Old, L.J., Kassel, R.L., Green, S., Fiore, N., Williamson, B., 1975. An endotoxin-

induced serum factor that causes necrosis of tumors. Proc Natl Acad Sci USA. 72, 3666-70.

Carter, B.Z., Milella, M., Altieri, D.C., Andreeff, M. 2001. Cytokine-regulated expression of

survivin in myeloid leukemia. Blood 97, 2784–2790.

Carter, J.W., Lancaster, H.K., Hardman, W.E., Cameron, I.L., 1994. Distribution of

intestine-associated lymphoid tissue, aberrant crypt foci, and tumors in the large bowel of

1.2-dimethylhydrazine-treated mice. Cancer Res. 54, 4304-4307.

Cavalieri, E.L., Rogan, E.G., 2002. A unified mechanism in the initiation of cancer. Ann. N.Y.

Acad. Sci. 959, 341-354.

Chadha, V.D., Vaiphei, K., Dhawan, D.K., 2007. Zinc mediated normalization of

histoarchitecture and antioxidant status offers protection against initiation of experimental

carcinogenesis. Mol. Cell Biochem. 304, 101-108.

Chan, A. T., Ogino, S., Fuchs, C.S. 2007. Aspirin and the risk of colorectal cancer in relation to

the expression of COX-2. N. Engl. J. Med. 356, 2131–2142.

Chang, B., Nishikawa, M., Sato, E., Utsumi, K., Inoue, M., 2002. L-Carnitine inhibits cisplatin-

induced injury of the kidney and small intestine. Arch Biochem Biophys. 405, 55-64.

Chapple, K.S., Scott, N., Guillou, P.J., Coletta, P.L., Hull, M.A., 2002. Analysis of

cyclooxygenase expression in human colorectal adenomas. Dis. Colon Rectum. 45, 1316-24.

Chaudhary, S.C., Alam, M.S., Siddiqui, M.S., Athar, M., 2009. Chemopreventive effect of

farnesol on DMBA/TPA-induced skin tumorigenesis: Involvement of inflammation, Ras-ERK

pathway and apoptosis. Life Sciences 85, 196-205.

Bibliography

180

Chen, G., Goeddel, D.V., 2002. TNF-R1 signaling: a beautiful pathway. Science. 296, 1634-5.

Cherng, J.M., Tsai, K.D., Yu, Y.W., Lin, J.C. 2011. Molecular mechanisms underlying

chemopreventive activities of glycyrrhizic acid against UVB-radiation-induced carcinogenesis in

SKH-1 hairless mouse epidermis. Radiat. Res. 176, 177-186.

Chirino, Y.I., Hernandez-pando, R., Pedraza-Chaveri, J., 2004. Peroxynitrite decomposition

catalyst ameliorates renal damage and protein nitration in cisplatin-induced nephrotoxicity in rats.

B.M.C. Pharmacol. 4, 20-29.

Cho, H., Yun, C.W., Park, W.K., Kong, J.Y., Kim, K.S., Park, Y., Lee, S., Kim, B.K., 2004.

Modulation of the activity of pro-inflammatory enzymes, COX-2 and iNOS, by chrysin

derivatives. Pharmacol Res. 49, 37-43.

Church, S.L., Grant, J.W., Ridnour, L.A., Oberley, L.W., Swanson, P.E., Meltzer, P.S., Trent,

J.M., 1993. Increased manganese superoxide dismutase expression suppresses the malignant

phenotype of human melanoma cells. Proc Natl Acad Sci USA. 90, 3113-3117.

Clarkson, P.M., Thompson, H.S., 2000. Antioxidants: What role do they play in physical activity

and health? Am. J. Clin. Nutr. 72, 637S-646S.

Clere, N., Faure, S., Martinez, M.C., Andriantsitohaina, R., 2011. Anticancer properties of

flavonoids: roles in various stages of carcinogenesis. Cardiovasc Hematol Agents Med Chem.

9, 62-77.

Cohen, G.M., 1997. Caspases: the executioners of apoptosis. Biochem. J. 326, 1-16.

Coleman, P.S., Chen, L-C., Sepp-Lorenzino, L., 1997. Cholesterol metabolism and tumor cell

proliferation. Subcell. Biochem. 28, 363-426.

Cooke, M.S., Evans, M.D., Dizdaroglu, M., Lunec, J., 2003. Oxidative DNA damage:

mechanisms, mutation and disease. FASEB J. 17, 1195-1214.

Corpet, D.E., Tache, S., 2002. Most Effective Colon Cancer Chemopreventive Agents in Rats:

A Systematic Review of Aberrant Crypt Foci and Tumor Data, Ranked by Potency. Nutr.

Cancer. 43, 1-21.

Correa, P., Haenszel, W., 1978. The epidemiology of large bowel cancer. Adv. Cancer Res. 26,

1-141.

Bibliography

181

Cotgreave, I.A., Gerdes, R.G., 1998. Recent trends in glutathione biochemistryglutathione-

protein interactions: a molecular link between oxidative stress and cell proliferation? Biochem.

Biophys. Res. Commun. 242, 1-9.

Cotgreave, I.A., Mold´eus, P., Orrenius, S., 1988. Host biochemical defen mechanisms against

prooxidants. Annu. Rev. Pharmacol. Toxicol. 28:189-212.

Coussens, L.M., Werb, Z., 2002. Inflammation and cancer. Nature. 420, 860-7.

Creech, J., Jr., Johnson, M., 1974. Angiosarcoma of liver in the manufacture of polyvinyl

chloride. J. Occup. Med. 16, 150-151.

Crick, D.C., Andres, D.A. Waechter, C.J., 1997. Novel salvage pathway utilizing farnesol and

geranylgeraniol for protein isoprenylation. Biochem. Biophys. Res. Commun. 237, 483-487.

Crowell, P.L., 1999. Prevention and therapy of cancer by dietary monoterpenes. J. Nutr. 129,

775S-778S.

Curreli F, Friedman-Kien AE, Flore O.Glycyrrhizic acid alters Kaposi sarcoma– associated

herpesvirus latency, triggering p53-mediated apoptosis in transformed B lymphocytes. J. Clin.

Invest. 115:642–652 (2005).

Davis, E.A., Morris, D.J. 1991. Medicinal uses of licorice through the millennia: The good and

plenty of it. Mol. Cell Endocrinol. 78, 1–6.

Debatin, K.M., 2004. Apoptosis pathways in cancer and cancer therapy. Cancer Immunol.

Immunother. 53, 153-9.

Dehpour, A.R., Zolfaghari, M.E., Samadian, T. 1995. Antiulcer activities of liquorice and its

derivatives in experimental gastric lesion induced by ibuprofen in rats. Int. J. Pharm. 119, 133-

138.

Deschner, E.E., Ruperto, J., Wong, G., Newmark, H.L. 1991. Quercetin and rutin as inhibitors

of azoxymethanol-induced colonic neoplasia. Carcinogenesis (Lond.) 12, 1193-1196.

Dimitriadou, V., Koutsilieris, M. 1997. Mast cell-tumor cell interactions: for or against tumour

growth and metastasis? Anticancer Res. 17, 1541–1549.

Bibliography

182

Dinkova-Kostova, A.T., Talalay, P., 2000. Persuasive evidence that quinone reductase type 1

(DT diaphorase) protects cells against the toxicity of electrophiles and reactive forms of oxygen.

Free Radic. Biol. Med. 29, 231-240.

Doll, R., 1980. General epidemiologic considerations in etiology of colorectal cancer, in: S.

Winawer, D. Schotterfield, P. Sherlock (Eds.), Colorectal Cancer: Prevention, Epidemiology, and

Screening, Raven Press, New York, 1980. pp. 3-12.

Doll, R., Hill, I.D. 1962. Triterpenoid liquorice compound in gastric and duodenal ulcer. Lancet

2, 1166-1167.

Donehower, L.A., Harvey, M., Slagle, B.L., McArthur, M.J., Montgomery, C.A., Butel, J.S.,

Bradley, A. 1992. Mice deficient for p53 are developmentally normal but susceptible to

spontaneous tumours. Nature 356, 215-221.

Dosaka-Akita, H., Katabami, M., Hommura, H., Fujioka, Y., Katoh, H., Kawakami, Y. 1999.

Bcl-2 expression in non-small cell lung cancers: higher frequency of expression in squamous cell

carcinomas with earlier pT status. Oncology 56, 259–264.

Douglas, K.T., 1987. Mechanism of action of glutathione-dependent enzymes. Adv. Enzymol.

Relat. Areas Mol. Biol. 59, 103-67.

Dragan, Y.P., Campbell, H.A., Baker, K., Vaughan, J., Mass, M., Pitot, H.C., 1994. Focal and

non-focal hepatic expression of placental glutathione S-transferase in carcinogen-treated rats.

Carcinogenesis. 15, 2587-2591.

Dreher, D., Junod, A.F., 1996. Role of oxygen free radicals in cancer development. Eur. J.

Cancer. 32 30–38.

Druckrey, H., 1970. Production of colonic carcinomas by 1 ,2-dialkylhydrazines and azoalkanes,

in: Carcinoma of the Colon and Antecedent Epithelium, W. J. Burdette, (Eds,). Sprinpfield,

Charles C Thomas, 1970; pp. 267-279.

Druckrey, H., Preussmann, R., Matzkies, F., Ivankovic, S., 1967. Selektive Erzeugung von

Darmkrebs bei Ratten durch 1,2-DimethyIhydrazin. Naturwissmschaftm. 54, 285-286.

Bibliography

183

Du, C., Fang, M., Li, Y., Li, L., Wang, X., 2000. Smac, a mitochodrial protein that promotes

cytochrome c-dependent caspase activation by eliminating IAP inhibition. Cell. 102, 33-42.

Dubina, M.V., Iatckii, N.A., Popov, D.E., Vasil'ev, S.V., Krutovskikh, V.A. 2002. Connexin 43,

but not connexin 32, is mu-tated at advanced stages of human sporadic colon cancer. Oncogene

21, 4992–4996.

Dubois, R.N., 2003. Leukotriene A4 signaling, inflammation, and cancer. J. Natl. Cancer. Inst.

95, 1028-9.

DuBois, R.N., Radhika, A., Reddy, B.S., Entingh, A.J., 1996. Increased cyclooxygenase-2 levels in

carcinogen-induced rat colonic tumors. Gastroenterology. 110, 1259-62.

Dudeja, P.K., Brasitus, T.A., 1990. 1,2-Dimethylhydrazine-induced alterations in lipid

peroxidation in preneoplastic and neoplastic colonic tissues. Biochim. Biophys. Acta. 1046, 267-

270.

Eastman, A., 1985. Activation of programmed cell death by anticancer agents: cisplatin as a

model system. Cancer Cells. 2, 275-280.

Eberhart, C.E., Coffey, R.J., Radhika, A., Giardiello, F.M., Ferrenbach, S., Dubois, R.N., 1994.

Upregulation of cyclooxygenase-2 gene expression in human colorectal adenomas and

adenocarcinomas. Gastroenterology. 107, 1183-8.

Edwards, P.A., Ericsson, J., 1999. Sterols and isoprenoids: signaling molecules derived from the

cholesterol biosynthetic pathway. Annu. Rev. Biochem. 68, 157-185.

Ekbom, A., Helmick, C., Zack, M., Adami, H.O., 1990. Increased risk of large-bowel cancer in

Crohn's disease with colonic involvement. Lancet. 336, 357-359.

Ekbom, A., Helmick, C., Zack, M., Adami, H.O., 1990. Ulcerative colitis and colorectal cancer: a

population-based study. N Engl J. Med. 323, 1228-1233.

Ekbom, A., McLaughlin, J.K., Nyren, O., 1993. Pancreatitis and the risk of pancreatic cancer. N

Engl J. Med. 329, 1502-1503.

Eliyahu D., Goldfinger N., Pinhasi-Kimhi, 0., shaulsky, G., skurnik, Y., Arai, N., Rotter, V.,

Bibliography

184

Oren, M., 1988. Meth A fibrosarcoma cells express two transforming mutant p53 species.

Oncogene 3, 313-321.

Ercal, N., Gurer-Orhan, H., Aykin-Burns, N., 2001. Toxic metals and oxidative stress part I:

mechanisms involved in metal-induced oxidative damage. Curr. Top. Med. Chem. 1, 529-539.

Evans, M.D., Dizdaroglu, M., Cooke, M.S., 2004. Oxidative DNA damage and disease:

induction, repair and significance. Mutat. Res. 567, 1-61.

Farrow, D.C., Vaughan, T.L., Hansten, P.D., Stanford, J.L., Risch, H.A., Gammon, M.D., Chow

W.H., Dubrow, R., Ahsan, H., Mayne, S.T., Schoenberg, J.B., West, A.B., Rotterdam, H.,

Fraumeni, J.F. Jr., Blot, W.J., 1998. Use of aspirin and other nonsteroidal anti-inflammatory

drugs and risk of esophageal and gastric cancer. Cancer Epidemiol. Biomarkers. Prev. 7, 97-102.

Fearon, E.R., 1993. K-ras gene mutation as a pathogenetic and diagnostic maker in human

cancer. JNCI. 85, 1978-1980.

Fearon, E.R., Cho, K.R., Nigro, J.M., Kern, S.E., Simons, J.W., Ruppert, J.M., Hamilton, S.

R., Preisinger, A.C., Thomas, G., Kinzler, K.W., Vogelstein, B., 1990.

Identification of a chromosome 18q gene that is altered in colorectal cancers. Science. 247,

49-56.

Fearon, E.R., Hamilton, S.R., Vogelstein, B., 1987. Clonal analysis of human colorectal

tumors. Science. 238, 193-197.

Feinberg, A.P., Tycko, B., 2004. The history of cancer epigenetics. Nat. Rev. Cancer. 4, 143-53.

Femia, A.P., Bendinelli, B., Giannini, A., Salvadori, M., Pinzani, P., Dolara, P., Caderni, G., 2005.

Mucin-depleted foci have b-catenin gene mutation, altered expression of its protein, and are

dose- and time dependent in the colon of 1,2-dimethylhydrazine-treated rats. Int. J. Cancer. 116,

9-15.

Femia, A.P., Caderni, G., Bottini, C., Salvadori, M., Dolara, P., Tessitore, L., 2007. Mucin-

depleted foci are modulated by dietary treatments and show deregulation of proliferative activity

in carcinogen-treated rodents. Int. J. Cancer. 120, 2301-5.

Bibliography

185

Femia, A.P., Dolara, P., Caderni, G. 2004. Mucin-depleted foci (MDF) in the colon of rats

treated with azoxymethane (AOM) are useful biomarkers for colon carcinogenesis.

Carcinogenesis 25, 277–281.

Femia, A.P., Dolara, P., Giannini, A., Salvadori, M., Biggeri, A., Caderni, G., 2007. Frequent

mutation of Apc gene in rat colon tumorsand mucin-depleted foci, preneoplastic lesions in

experimental colon carcinogenesis. Cancer Res. 67, 445-9.

Femia, A.P., Dolara, P., Luceri, C., Salvadori, M., Caderni, G., 2009. Mucin-depleted foci show

strong activation of inflammatory markers in 1,2-dimethylhydrazine-induced carcinogenesis and

are promoted by the inflammatory agent sodium dextran sulfate. Int. J. Cancer. 125, 541-7.

Femia, A.P., Giannini, A., Fazi, M., Tarquini, E., Salvadori, M., Roncucci, L., Tonelli, F., Dolara,

P., Caderni, G., 2008. Identification of mucin depleted foci in the human colon. Cancer Prev.

Res. 1, 562-7.

Femia, A.P., Salvianti, F., Luceri ,C., Dolara, P., Salvadori, M., Pinzani, P., Caderni, G., 2011.

Sustained proliferation and resistance to apoptosis after a cytotoxic insult are early alterations in

rat colon carcinogenesis. Int. J. Cancer. doi: 10.1002/ijc.26406.

Femia, A.P., Tarquini, E., Salvadori, M., Ferri, S., Giannini, A., Dolara, P., Caderni, G., 2008. K-

ras mutations and mucin profile in preneoplastic lesions and colon tumors induced in rats by 1,2-

dimethylhydrazine. Int. J. Cancer. 122, 117-23.

Fenoglio, C.M., Pascal, R.R., 1982. Colorectal adenomas and cancer: pathologic

relationships. Cancer. 50, 2601-2608.

Fenoglio-Preiser, C.M., Pascal. R.R., Perzin, K.H., 1990. Tumors of the intestines

(Washington. D.C.: Armed Forces Institute of Pathology).

Ferlay, J., Shin, H.R., Bray, F., Forman, D., Mathers, C., Parkin, D.M., 2010. Estimates of

worldwide burden of cancer in 2008: GLOBOCAN 2008. Int J Cancer. 127, 2893-2917.

Ferrero-Miliani, L., Nielsen, O.H., Andersen, P.S., Girardin, S.E., 2007. Chronic inflammation:

importance of NOD2 and NALP3 in interleukin-1beta generation, Clin. Exp. Immunol. 147,

227-235.

Bibliography

186

Fiala, E.S., 1997. Investigations into the metabolism and mode of action of the colon

carcinogens 1, 2-dimethylhydrazine and azoxymethane. Cancer 40, 2436-2445.

Fields, S., Jang, S.K., 1990. Presence of a potent transcription activating sequence in the

p53 protein. Science. 249, 1046-1049.

Filipe, M.I. 1975. Mucus secretion in rat colonic mucosa during carcinogenesis induced by

dimethylhydrazine. A morphological and histochemical study. Br. J. Cancer 32, 60-77.

Filipe, M.I., Branfoot, A.C. 1974. Abnormal patterns of mucus secretion in apparently normal

mucosa of large intestine with carcinoma. Cancer 34, 282-290.

Finkel, T., Holbrook, N.J., 2000. Oxidants, oxidative stress and the biology of ageing. Nature.

408, 239-247.

Flohe, L. 1989. The selenoprotein glutathione peroxidase, in: Dolphin, D., Avramovic, O.,

Poulson, R., (Eds.), Glutathione: Chemical, Biological and Medical Aspects Part A. John Wiley

and Sons. pp 643-731.

Flohe, L., 1978. Glutatione peroxidase: fact and fiction. Ciba Found. Symp. 65, 95-112.

Flossmann, E., Rothwell, P.M., 2007. Effect of aspirin on long-term risk of colorectal cancer:

consistent evidence from randomised and observational studies. Lancet. 369, 1603-1613.

Fodde, R., Edelmann, W., Rang, K.., Van, Leeuwen, C., Carlson, C., Renault, B., Breukel.

C., Alt, E., Liphin, M., Khan, P.M., 1994. A targeted chain-termination mutation in the

mouse .4P(' gene results in multiple intestinal tumors. Proc. Natl. Acad. Sci. USA. 91, 8969-

8973.

Forman, H.J., Zhang, H., Rinna, A., 2009. Glutathione: Overview of its protective roles,

measurement, and biosynthesis. Mol. Aspects Med. 30, 1-12.

Forrester, K., Almoguera, C., Han, K., Grizzle, W.E., Perucho, M., 1987. Detection of high

incidence of K-ras oncogenes during human colon tumorigenesis. Nature. 32,

298-303.

Fu, Z., Zhen, W., Yuskavage, J., Liu, D., 2011. Epigallocatechin gallate delays the onset of type 1

diabetes in spontaneous non-obese diabetic mice. Br. J. Nutr. 105, 1218-1225.

Bibliography

187

Fujisawa, Y., Sakamoto, M., Matsushita, M. 2000. Glycyrrhizin inhibits the lytic pathway

ofcomplement: possible mechanism of its anti-inflammatory effect on liver. Microbiol. Immunol.

44, 799-804.

Galli, S.J., Nakae, S., Tsai, M. 2005. Mast cells in the development of adaptive immune

responses. Nat. Immunol. 6, 135–142.

Garcia-Lafuente, A., Guillamon, E., Villares, A., Rostagno, M.A., Martinez, J.A., 2009.

Flavonoids as anti-inflammatory agents: implications in cancer and cardiovascular disease.

Inflamm Res. 58, 537-552.

Garodia, P., Ichikawa, H., Malani, N., Sethi, G., Aggarwal, B.B., 2007. From ancient medicine to

modern medicine: Ayurvedic concepts of health and their role in inflammation and cancer. J.

Soc. Integr. Oncol. 5, 25-37.

Ghavami, S., Asoodeh, A., Klonisch, T., Halayko, A.J., Kadkhoda, K., Kroczak, T.J., Gibson,

S.B., Booy, E.P., Naderi-Manesh, H., Los, M., 2008. Brevinin-2R(1) semi-selectively kills cancer

cells by a distinct mechanism, which involves the lysosomal-mitochondrial death pathway. J. Cell

Mol. Med. 12, 1005-22.

Ghavami, S., Hashemi, M., Ande, S.R., Yeganeh, B., Xiao, W., Eshraghi, M., Bus, C.J.,

Kadkhoda, K., Wiechec, E., Halayko, A.J., Los, M. 2009. Apoptosis and cancer: mutations within

caspase genes. J. Med. Genet. 46, 497–510.

Ghavami, S., Kerkhoff, C., Los, M., Hashemi, M., Sorg, C., Karami-Tehrani, F., 2004.

Mechanism of apoptosis induced by S100A8/A9 in colon cancer cell lines: the role of ROS and

the effect of metal ions. J. Leukoc. Biol. 76, 169-75.

Ghosh, S., Karin, M., 2002. Missing pieces in the NF-kB puzzle. Cell. 109, S81-S96.

Ghosh, S., May, M.J., Kopp, E.B., 1998. NF-kappa B and Rel proteins: evolutionarily conserved

mediators of immune responses. Annu. Rev. Immunol. 16, 225-60.

Giardiello, F.M., Offerhaus, G.J., DuBois, R.N., 1995. The role of non-steroidal anti-

inflammatory drugs in colorectal cancer prevention. Eur. J. Cancer. 31A, 1071-6.

Bibliography

188

Gillen, C.D., Walmsley, R.S., Prior, P., Andrews, H.A., Allan, R.N., 1994. Ulcerative colitis and

Crohn's disease: a comparison of the colorectal cancer risk in extensive colitis. Gut. 35, 1590-

1592.

Gilmore, T.D., 1999. The Rel/NF-kappaB signal transduction pathway: introduction. Oncogene.

18, 6842-4.

Goncalves, J.R., Araujo, P., Pinho, M.J., Martel, F., 2011. In vitro studies on the inhibition of

colon cancer by butyrate and polyphenolic compounds. Nutr. Cancer. 63, 282-294.

Goncu, E., Parlak, O., 2008. Some autophagic and apoptotic features of programmed cell death

in the anterior silk glands of the silkworm, Bombyx mori. Autophagy. 4, 1069-1072.

Gonda, T.A., Tu, S., Wang, T.C., 2009. Chronic inflammation, the tumor microenvironment and

carcinogenesis. Cell Cycle. 8, 2005-2013.

Gounaris, E., Erdman, S.E., Restaino, C., Gounari, F., Lee, D.M., Zhang, G., Glickman, J.N.,

Shin, K., Rao, V.P., Poutahidis, T., Weissleder, R., McNagny, K.M., Khazaie, K. 2007. Mast cells

are an essential hematopoietic component for polyp development. Proc. Natl. Acad. Sci. USA.

104, 19977–19982.

Grady, W.M., 2003. Genetic testing for high-risk colon cancer patients. Gastroenterology. 124,

1574-94.

Green, D.R., Kroemer, G., 2009. Cytoplasmic functions of the tumour suppressor p53. Nature.

458, 1127-1130.

Greten, F.R., Eckmann, L., Greten, T.F., Park, J.M., Li, Z.W., Egan, L.J., Kagnoff, M.F., Karin,

M., 2004. IKKβ links inflammation and tumorigenesis in a mouse model of colitisassociated

cancer. Cell. 118, 285-296.

Grossman, H.B., Liebert, M., Lee, I.W., Lee, S.W. 1994. Decreased connexin expression and

intercellular communication in human bladder cancer cells. Cancer Res. 54, 3062–3065.

Guerrero-Beltrán, C.E., Calderón-Oliver, M., Tapia, E., Medina-Campos, O.N., Sánchez-

González, D.J., Martínez-Martínez, C.M., Ortiz-Vega, K.M., Franco, M., Pedraza-Chaverri, J.,

2010. Sulforaphane protects against cisplatin-induced nephrotoxicity. Toxicol Lett. 192, 278-285.

Bibliography

189

Guillouf, C., Rosselli, F., Krishnaraju, K., Moustacchi, E., Hoffman, B., Liebermann, D.A.,

1995. p53 involvement in control of G2 exit of the cell cycle: role in DNA damage-induced

apoptosis. Oncogene. 10, 2263-2270.

Half, E.E., Bresalier, R.S., 2004. Clinical management of hereditary colorectal cancer syndromes.

Curr. Opin. Gastroenterol. 20, 32-42.

Halliwell, B., Gutteridge, J.M.C., 1990. Role of free radicals and catalytic metal ions in human

disease: an overview. Methods in Enzymology. 186, 1-85.

Hansemann, D,. 1890. U¨ ber asymmetrische Zelltheilung in Epithelkrebsen undderen

biologische Bedeutung. Virchows Arch. Pathol. Anat. 119, 299-326.

Hardman, W.E., Cameron, I.L., Heitman, D.W., Contreras, E., 1991. Demonstration of the

need for end point validation of putative biomarkers: failure of aberrant crypt foci to predict

colon cancer incidence. Cancer Res. 51, 6388-6392.

Hardman, W.E., Cameron, L.L., 1994. colonic crypts located over lymphoid nodules of 1.2-

dimethylhydrazine-treated rats are hyperplastic and at high risk of forming

adenocarcinomas. Carcinogenesis. 15, 2353-2356.

Hardwick, J.C., van den Brink, G.R., Offerhaus, G.J., van Deventer, S.J., Peppelenbosch, M.P.,

2001. NF-kB, p38 MAPK and JNK are highly expressed and active in the stroma of human

colonic adenomatous polyps. Oncogene 20, 819–827.

Hashemi, M., Karami Tehrani, F., Ghavami, S., 2004. Cytotoxicity effect of Cladribine on the

MCF-7 human breast cancer cell line. Iranian Biomed. J. 8, 7-12.

Haupt, Y., Maya, R., Kazaz, A., Oren, M., 1997. Mdm2 promotes the rapid degradation of p53.

Nature. 387, 296-299.

Hawks, A., Magee, P.M., 1974. The alkylation of nucleic acids of rat and mouse in vim by the

carcinogen 1,2-dimethylhydrazine. Br. J. Cancer. 30, 440-447.

Hayden, M.S., Ghosh, S., 2004. Signaling to NF-kB. Genes Dev. 18, 2195-2224.

He, L., Mo, H., Hadisusilo, S., Qureshi, A.A., Elson, C.E., 1997. Isoprenoids suppress the

growth of murine B16 melanomas in vitro and in vivo. J. Nutr. 127, 668-674.

Bibliography

190

He, S.H. 2004. Key role of mast cells and their major secretory products in inflammatory bowel

disease. World J. Gastroenterol. 10, 309–318.

Heitman, ] D.W., Grubbs, B.G., Heitman, T.O., Cameron, I.L., 1983. Effects of 1,2-

dimethylhydrazine treatment and feeding regimen on rat colonic epithelial cell proliferation.

Cancer Res. 43, 1153-1162.

Hennings, H., Shores, R., Wenk, M.L., Spangler, E.F., Tarone, R., Yuspa, S.H., 1983. Malignant

conversion of mouse skin tumours is increased by tumor initiators and unaffected by tumour

promoters. Nature. 304, 67-69.

Herlich, P., Bohner, F.D., 2000. Redox regulation of signal transduction in mammalian cells.

Biochem. Pharmacol. 59, 35-41.

Hertog, M.G., Feskens, E.J., Hollman, P.C., Katan, M.B., Kromhout, D. 1993. Dietary

antioxidant flavonoids and risk of coronary heart disease: the Zutphen Elderly Study. Lancet

342, 1007–1011.

Heunks, L.M., Dekhuijzen, P.N., 2000. Respiratory muscle function and free radicals: from cell

to COPD. Thorax. 55, 704-716.

Hibasami, H., Iwase, H., Yoshioka, K., Takahashi, H. 2005. Glycyrrhizin induces apoptosis in

human stomach cancer KATO III and human promyelotic leukemia HL-60 cells. Int. J. Mol.

Med. 16, 233-236.

Hibasami, H., Iwase, H., Yoshioka, K., Takahashi, H. 2006. Glycyrrhetic acid (a metabolic

substance and aglycon of glycyrrhizin) induces apoptosis in human hepatoma, promyelotic

leukemia and stomach cancer cells. Int. J. Mol. Med. 17, 215-219.

Hioki, K., Shivapurkar, N., Oshima, H., Alabaster, O., Oshima, M., Taketo, M.M., 1997.

Suppression of intestinal polyp development by low-fat and high-fiber diet in Apcn716 knockout

mice. Carcinogenesis. 18, 1863-1865.

Hirose M, Takahashi S, Ogawa K, Futakuchi M, Shirai T, Shibutani M, Uneyama C, Toyoda K,

Iwata H. Chemoprevention of heterocyclic amine-induced carcinogenesis by phenolic

compounds in rats. Cancer Lett. 1999 Sep 1;143(2):173-8.

Bibliography

191

Hoensch, H., Richling, E., Kruis, W., Kirch, W., 2010. [Colorectal cancer prevention by

flavonoids]. Med Klin (Munich). 105, 554-559.

Hofseth, L.J., Hussain, S.P., Wogan, G.N., Harris, C.C., 2003. Nitric oxide in cancer and

chemoprevention. Free Radic. Biol. Med. 34, 955-68.

Horn, T.L., Long, L., Cwik, M.J., Morrissey, R.L., Kapetanovic, I.M., McCormick, D.L., 2005.

Modulation of hepatic and renal drug metabolizing enzyme activities in rats by subchronic

administration of farnesol. Chem. Biol. Interact.152, 79-99.

Huang, C., Ma, W.Y., Maxiner, A., Sun, Y., Dong, Z., 1999. p38 kinase mediates UV-induced

phosphorylation of p53 protein at serine 389. J. Biol. Chem. 274, 12229-12235.

Hussain, S.P., Trivers, G.E., Hofseth, L.J., He, P., Shaikh, I., Mechanic, L.E., Doja, S., Jiang, W.,

Subleski, J., Shorts, L., Haines, D., Laubach, V.E., Wiltrout, R.H., Djurickovic, D., Harris, C.C.,

2004. Nitric oxide, a mediator of inflammation, suppresses tumorigenesis. Cancer Res. 64, 6849 -

53.

Hwang, D., Scollard, D., Byrne, J., Levine, E., 1998. Expression of cyclooxygenase-1 and

cyclooxygenase-2 in human breast cancer. J. Natl. Cancer. Inst. 90, 455-60.

Ichii, S., Horii, A., Nakatsuru, S., Furuyama, J., Utsunomiya, J., Nakamura, Y., 1992.

Inactivation of both APC alleles in an early stage of colon adenomas in a patient with

familial adenomatous polyposis (FAP). Hum. Mol. Genet. 1, 387-390.

Ikeda, K., Arase, Y., Kobayashi, M., Saitoh, S., Someya, T., Hosaka, T., Sezaki, H., Akuta, N.,

Suzuki, Y., Suzuki, F., Kumada, H. 2006. A long-term glycyrrhizin injection therapy reduces

hepatocellular carcinogenesis rate in patients with interferon-resistant active chronic hepatitis C:

a cohort study of 1249 patients. Dig. Dis. Sci. 51, 603–609.

Itzkowitz, S.H., Hapraz, N., 2004. Diagnosis and management of dysplasia in patients with

inflammatory bowel disease. Gastroenterology. 126, 1634-48.

Jahangir, T., Khan, T.H., Prasad, L., Sultana, S., 2006. Farnesol prevents Fe-NTA mediated

renal oxidative stress and early tumour promotion markers in rats. Hum. Exp. Toxicol. 25, 235-

242.

Bibliography

192

Janbaz, K.H., Saeed, S.A., Gilani, A.H. 2002. Protective effect of rutin on paracetamol- and

and CCl4-induced hepatotoxicity in rodents. Fitoterapia. 2002 Dec;73(7-8):557-63.

Janne, P.A., Mayer, R.J., 2000. Chemoprevention of colorectal cancer. N. Engl. J. Med. 342,

1960-1968.

Järvinen, H.J., Aarnio, M., Mustonen, H., Aktan-Collan, K., Aaltonen, L.A., Peltomäki, P., et al.

2000. Controlled 15-year trial on screening for colorectal cancer in families with hereditary

nonpolyoposis colorectal cancer. Gastroenterol. 118, 829-834.

Jemal, A., Center, M.M., Ward, E., Thun, M.J., 2009. Cancer occurrence. Methods Mol. Biol.

471, 3-29.

Jemal, A., Siegel, R., Ward, E., Hao, Y., Xu, J., Thun, M.J., 2009. Cancer statistics. CA Cancer J.

Clin., 59, 225-249.

Jen, J., Powell, S.M., 1994. Molecualr Determinants of Dysplasia in colorectal Lesions.

Cancer Res. 54. 5523-5526.

Jen, J., Powell, S.M., Papadopoulos, N., Smith, K.J., Hamilton, S.R., Vogelstein, B., Kinzler,

K.W., 1994. Molecular determinants of dysplasia in colorectal lesions. Cancer Res. 54, 5523-6.

Jin, S., Levine, A.J. 2001. The p53 functional circuit. J. Cell Sci. 114, 4139–4140.

Johnson, J. J., Mukhtar, H. 2007. Curcumin for chemoprevention of colon cancer, Cancer Lett.

255, 170–181.

Joo, J.H., Jetten, A.M., 2010. Molecular mechanisms involved in farnesol-induced apoptosis.

Cancer Lett. 287, 123–135.

Joslyn, G., Carlson, M., Thliveris, A., Albertson, H., Gelbert, L., Samowitz, W., Groden, J.,

Stevens, J., Spiro, L., Robertson, M., Sargeant, L., Krapcho, K.. Wolff, E., Burt, R.,

Hugher, J.P., Warrington, J., McPherson, J., Wasmuth, J., Lepaslier, D., Abderrahim, H.,

Cohen, D., Leppert, M., White, R., 1991. Identification of deletion mutations and three new

genes at the familial polyposis locus. Cell. 66, 601-6 10.

Bibliography

193

Kanczuga-Koda, L., Sulkowski, S., Lenczewski, A. 2006. Increased expression of connexins 26

and 43 in lymph node metastases of breast cancer. J. Clin. Pathol. 59, 429–433.

Karin, M., Cao, Y., Greten, F.R., Li, Z.W., 2002. NF-κB in cancer: from innocent bystander to

major culprit. Nature Rev. Cancer 2, 301-310.

Kawamori, T., Tanaka, T., Hara, A., Yamahara, J., Mori, H. 1995. Modifying effects of naturally

occurring products on the development of colonic aberrant crypt foci induced by azoxymethane

in F344 Rats. Cancer Res. 55, 1277-1282.

Kawamori, T., Tanaka, T., Kojima, T., Suzui, M., Ohnishi, M., Mori, H. 1994. Suppression of

azoxymethane-induced rat colon aberrant crypt foci by dietary protocatechuic acid. Jpn. J.

Cancer Res. 85, 686-691.

Kawanishi, S., Yamamoto, K., 1991. Mechanism of site-specific DNA damage induced by

methylhydrazines in the presence of copper (II) or manganese (III). Biochemistry. 30, 3069-

3075.

Kawanishi, S., Yamamoto, K., 1991. Mechanism of site-specific DNA damage induced by

methylhydrazines in the presence of copper (II) or manganese (III). Biochemistry. 30, 3069-

3075.

Kerr, J.F., Wyllie, A.H., Curie, A.R., 1972. Apoptosis: a basic biological phenomenon with wide

ranging implications in tissue kinetics. Br. J cancer. 26, 237-259.

Kerr, J.F.R., Winterford, C.M., Harmon, C.V., 1994. Apoptosis- its significance in cancer and

cancer therapy. Cancer. 73, 2013-2026.

Keshgegian, A.A., Johnston, E., Cnaan, A. 1998. Bcl-2 oncoprotein positivity and high MIB-1

(Ki-67) proliferative rate are independent predictive markers for recurrence in prostate

carcinoma. Am. J. Clin. Pathol. 110:443–449.

Khan, N., Afaq, F., Mukhtar, H., 2007. Apoptosis by dietary factors: the suicide solution for

delaying cancer growth. Carcinogenesis. 28, 233-239.

Khan, R., Sultana, S., 2011. Farnesol attenuates 1,2-dimethylhydrazine induced oxidative stress,

inflammation and apoptotic responses in the colon of Wistar rats. Chem. Biol. Interact. 192, 193-

200

Bibliography

194

Kikuchi-Yanoshita, R., Konishi, M., Ito, S., Seki, M., Maeda, Y., Iino, H.M., Fukayama,

Koike, M., Mori, T., 1992b. Genetic changes of both p53 alleles associated with the

conversion from colorectal adenoma to early carcinoma in familial adenomatous polyposis

and non-familial adenomatous polyposis patients. Cancer Res. 52. 3965-3971.

Kikuchi-Yanoshita,. R., Konishi, M., Fukunari, H., Tanaka, K., and Miyaki, M., 1992a. Loss

of expression of the DCC gene during progression of colorectal carcinomas in

familial adenomatous polyposis and non-familial adenomatous polyposis patients. Cancer

Res. 52. 3801-3803.

Kim, H.J., Lee, J.H., Kim, S.J., Oh, G.S., Moon, H.D., Park, C., Park, B.H., Lee, H.K., Chung,

S.Y., Park, R., So, H.S., 2010. Roles of NADPH oxidases in cisplatin-induced reactive oxygen

species generation and ototoxicity. J. Neurosci. 30, 3933-3946.

Kim, R., 2005. Recent advances in understanding the cell death pathways activated by anticancer

therapy. Cancer. 103, 1551-60.

Kim, S.H., Hong, K.O., Chung, W.Y., Hwang, J.K., Park, K.K., 2004. Abrogation of cisplatin-

induced hepatotoxicity in mice by xanthorrhizol is related to its effect on the regulation of gene

transcription. Toxicol Appl Pharmacol. 196, 346-55.

Kim, S.H., Hong, K.O., Hwang, J.K., Park, K.K., 2005. Xanthorrhizol has a potential to

attenuate the high dose cisplatin-induced nephrotoxicity in mice. Food Chem Toxicol. 43, 117-

122.

Kim, Y.H., Woo, K.J., Lim, J.H., Kim, S., Lee, T.J., Jung, E.M., Lee, J.M., Park, J.W., Kwon,

T.K., 2005. 8-Hydroxyquinoline inhibits iNOS expression and nitric oxide production by down-

regulating LPS-induced activity of NF-κB and C/EBPh in Raw 264.7 cells. Biochem. Biophys.

Res. Commun.329, 591-7.

Kinzler, K.W., Nilbert, M.C., Su, L.K., Vogelstein, B., Bryan, T.M., Levy, D.B., Smith. K.J.,

Preisinger, A.C., Hedge, P., Finniear, R., Groffen, J., Bogusi, M.S., Altshul, S.F., Miyoshi, Y.,

Miki, Y., Nishisho, I., and Nakamura, Y., 1991. Identification of FAP locus genes from

chromosome 5g21. Science. 253, 661-665.

Kinzler, K.W., Vogelstein, B., 1996. Lessons from hereditary colorectal cancer. Cell. 87, 159-170.

Bibliography

195

Kischkel, F.C., Hellbardt, S., Behrmann, I., Germer, M., Pawlita, M., Krammer, P.H., Peter,

M.E., 1995. Cytotoxicity-dependent APO-1 (Fas/CD95)-associated proteins from a death-

inducing signalling complex (DISC) with the receptor. EMBO J. 14, 5579-88.

Klaunig, J.E., Kamendulis, L.M., 2004. The role of oxidative stress in carcinogenesis. Annu. Rev.

Pharmacol. Toxicol. 44, 239-267.

Koc, A., Duru, M., Ciralik, H., Akcan, R., Sogut, S., 2005. Protective agent, erdosteine, against

cisplatin-induced hepatic oxidant injury in rats. Mol Cell Biochem. 278, 79-84.

Koehne, C.H., Dubois, R.N., 2004. COX-2 inhibition and colorectal cancer. Semin. Oncol.

31,12-21.

Kolaja, K.L., Klaunig, J.E., 1996. Selective Dieldrin Promotion of Hepatic Focal Lesions in Mice.

Carcinogenesis. 17, 1243-50.

Korinek, V., Barker, N., Morin, P.J. 1997. Constitutive transcriptional activation by a beta-

catenin-Tcf complex in APC-/- colon carcinoma. Science 275, 1784–1787.

Korkmaz, A., Kolankaya, D. 2010. Protective effect of rutin on the ischemia/reperfusion

induced damage in rat kidney. J Surg Res. 164, 309-315.

Kovacic, P., Osuna, J.A., Jr., 2000. Mechanisms of anti-cancer agents: emphasis on oxidative

stress and electron transfer. Curr. Pharm. Des. 6, 277-309.

Kris, M., Gralla, R., Clark, R., 1988. Control of chemotherapy induced diarrhoea with a synthetic

enkephalin BW942C: a randomised trial with placebo in patients receiving cisplatin. J. Clin.

Oncol. 6, 663-668.

Krok, K.L., Lichtenstein, G.R., 2004. Colorectal cancer in inflammatory bowel disease. Curr.

Opin. Gastoenterol. 20, 43-48.

Krutovskikh, V.A., Piccoli, C., Yamasaki, H., 2002. Gap junction intercellular communication

propagates cell death in cancerous cells. Oncogene 21, 1989–1999.

Laird, P.W., Jaenisch, R., 1996. The role of DNA methylation in cancer genetic and epigenetics,

Annu. Rev. Genet. 30, 441-464.

Lane, D.P., 1992. Cancer P53, guardian of the genome. Nature. 358, 15-16.

Bibliography

196

Lane, D.P., Lu, X., Hupp, T., Hall, P.A., 1994. The role of the p53 protein in the apoptotic

response. Philos. Trans. R. Soc. Lond. B. Biol. Sci. 345, 277-280.

Lane, N., Kaplan, H., Pascal, R.R., 1971. Minute adenomatous and hyperplastic polyps of

the colon: divergent patterns of epithelial growth with specific associated nesenchymal

changes. Gastroenterology. 60, 537-551.

Langerak, A.D., Dreisbach, L.P., 2001. Chemotherapy Regimens and Cancer Care. Landes

Bioscience; Georgetown, Texas.

Lapidot, T., Walker, M.D., Kanner. J., 2002. Antioxidant and prooxidant effects of phenolics on

pancreatic beta-cells in vitro. J. Agric. Food. Chem. 50, 7220-7225.

Laqueur, G. L., 1965. The induction of intestinal neoplasms in rats with the glycoside cycasin and

its aglycone. Virchows. Arch. [Pathol. Anat.] 340, 151-163.

Laqueur, G.L., Spatz, M., 1975. Oncogenicity of cycasin and methylazoxymethanol. Gann

Monogr. Cancer Res. 17, 189-204.

Latham, P., Lund, E.K., Johnson, I.T., 1999. Dietary n-3 PUFA increases the apoptotic response

to 1, 2- dimethylhydrazine, reduces mitosis and suppresses the induction of carcinogenesis in the

rat colon. Carcinogenesis. 20, 645-650.

LeBrun, D.P., Warnke, R.A., Cleary, M.L. 1993. Expression of bcl-2 in fetal tissues suggests a

role in morphogenesis. Am. J. Pathol. 142, 743–753.

Lebwohl, D., Canetta, R., 1998. Clinical development of platinum complexes in cancer therapy:

an historical perspective and an update. Eur. J. Cancer .34, 1522-1534.

Leithe, E., Sirnes, S., Omori, Y., Rivedal, E. 2006. Downregulation of gap junctions in cancer

cells. Crit. Rev. Oncog. 12, 225–56.

Leonardi, T., Vanamala, J., Taddeo, S.S., Davidson, L.A., Murphy, M.E., Patil, B.S., Wang, N.,

Carroll, R.J., Chapkin, R.S., Lupton, J.R. Turner N.D. 2010. Apigenin and naringenin suppress

colon carcinogenesis through the aberrant crypt stage in azoxymethane-treated rats. Exp. Biol.

Med. 235, 710–717.

Leu, J.I., Dumont, P., Hafey, M., Murphy, M.E., George, D.L., 2004. Mitochondrial p53 activates

Bak and causes disruption of a Bak-Mcl1 complex. Nat. Cell. Biol. 6, 443-450.

Bibliography

197

Levy, D.B., Smith, K.J., Beazer-Barclay, Y., Hamiton, S.R., Vogelstein, B., Kinzler, K.W.,

1994. Inactivation of Both APC Alleles in Human and Mouse Tumors. Cancer Res. 54, 5953-

5958.

Li, J., Yuan, J., 2008. Caspases in apoptosis and beyond. Oncogene. 27, 6194-206.

Li, P., Nijhawan, D., Budihardjo, I., Srinivasula, S.M., Ahmad, M., Alnemri, E.S., Wang, X., 1997.

Cytochrome c and dATP-dependent formation of Apaf-1/caspase-9 complex initiates an

apoptotic protease cascade. Cell. 91, 479-89.

Li, Q., Verma, I.M., 2002. NF-kB regulation in the immune system. Nat. Rev. Immunol. 2, 725-

34.

Li, W., Srinivasula, S.M., Chai, J., Li, P., Wu, J.W., Zhang, Z., Alnemri, E.S., Shi, Y., 2002.

Structural insights into the pro- apoptotic function of mitochondrial serine protease

HrtA2/Omi. Nat. Strut. Biol. 9, 436-41.

Li, X., Huang, Q., Ong, C.N., Yang, X.F., Shen, H.M., 2010. Chrysin sensitizes tumor necrosis

factoralpha-induced apoptosis in human tumor cells via suppression of nuclear factor-κB. Cancer

Lett. 293, 109-116.

Lind, D.S., Hochwald, S.N., Malaty, J., Rekkas, S., Hebig, P., Mishra, G., Moldawer, L.L.,

Copeland. 2001. NF-kB is upregulated in colorectal cancer. Surgery. 130, 363–369.

Lipkin M., 1988. Biomarkers of increased susceptibility of gastrointestinal cancer: new

application to studies of cancer prevention in human subjects. Cancer Res. 48, 235-245.

Liu, X., Kim, C.N., Yang, J., Jemmerson, R., Wang, X., 1996. Induction of Apoptotic Program in

Cell-Free Extracts: Requirement for dATP and Cytochrome c. Cell. 86, 147-157.

Llanillo, M. Membrane cholesterol contents influence the protective effects of quercetin

Longo, V., Gervasi, P.G., Lubrano, V., 2011. Cisplatin induced toxicity in rat tissues: The

protective effect of Lisosan G. Food Chem Toxicol. 49, 233-237.

Lopez-Revuelta, A., Sanchez-Gallego, J.I., Hernandez-Hernandez, A., Sanchez-Yague, J.,

Lorenzo, H.K., Susin, S.A., Penninger, J., Kroemer, G., 1999. Apoptosis inducing factor (AIF): a

phylogenetically old, caspase independent effector of cell death. Cell Death Differ. 6, 516-424.

Bibliography

198

Lowe, S. W., Schmitt, E. M., Smith, S.W., Osborne, B.A., and Jacks., T., 1993. p53 is required for

radiation-induced apoptosis in mouse thymocytes. Nature. 362. 847-849.

Lu, Q.L., Abel, P., Foster, C.S., Lalani, E.N. 1996. Bcl-2: role in epithelial differentiation and

oncogenesis. Hum. Pathol. 27, 102–110.

Luebeck, E.G., Hazelton, W.D., 2002. Multistage carcinogenesis and radiation. J. Radiol. Prot.,

22, A43-A49.

Lynch, H.T., de la, Chapelle, A., 2003. Hereditary colorectal cancer. N. Engl. J. Med. 348, 919-

32.

Madara, J.L., Harte, P., Deasy, J., Ross, D., Lahey, S., Steele, G.J., 1983. Evidence for an

adenoma-carcinoma sequence in dimethylhydrazine-induced neoplases of rat intestinal

epithelium. Am. J. Pathol. 110, 230-235.

Mahmoud, A.M. 2011. Influence of rutin on biochemical alterations in hyperammonemia in

Malkin, D., Li, F.P., Strong, L.C., Jr., J.F.F., Nelson, C.E., Kim, D.H., Kassel, J.,

Gryka, M.A., Bischoff. F.Z., Tainsky, M.A., Friend, S.H., 1990. Germ line p53

mutations in a familial syndrome of breast cancer, sarcomas, and other neoplasms. Science . 250.

1233-1238.

Manar, M.H., Brown, M.R., Gauthier, T.W., 2004. Brown LA. Association of glutathione-S-

transferase-P1 (GST-P1) polymorphisms with bronchopulmonary dysplasia. J. Perinatol. 24, 30-

35.

Mandel, S.A., Amit, T., Weinreb, O., Reznichenko, L., Youdim, M.B., 2008. Simultaneous

manipulation of multiple brain targets by green tea catechins: a potential neuroprotective strategy

for Alzheimer and Parkinson diseases. C.N.S. Neurosci. Ther. 14, 352-365.

Mantovani, A., Allavena, P., Sica, A., Balkwill, F., 2008. Cancer-related inflammation. Nature

454, 436-44.

Marcuzzi, A., Pontillo, A., De Leo, L., Tommasini, A., Decorti, G., Not, T., Ventura, A., 2008.

Natural isoprenoids are able to reduce inflammation in a mouse model of mevalonate kinase

deficiency. Pediatr. Res. 64, 177-82.

Bibliography

199

Marklund, S., Marklund, G., 1974. Involvement of the superoxide anion radical in the

autoxidation of pyrogallol and a convenient assay for superoxide dismutase. Eur. J. Biochem. 47,

469-474.

Matsumoto, H., Higa, H.H., 1966. Studies on methylazoxymathanol, the aglycone of cycasin-

Methylation of nucleic acids in vtlro. Eiochm. 98, 20-22c,.

Matsumoto, S., Koshiishi, I., Inoguchi, T., Nawata, H., Utsumi, H., 2003. Confirmation of

superoxide generation via xanthine oxidase in streptozotocin-induced diabetic mice. Free radic.

Res. 37, 767-772.

Maya, R., Balass, M., Kim, S.T., Shkedy, D., Leal, J.F., Shifman, O., Moas, M., Buschmann, T.,

Ronai, Z., Shiloh, Y., Kastan, M.B., Katzir, E., Oren, M., 2001. ATM-dependent

phosphorylation of Mdm2 on serine 395: role in p53 activation by DNA damage. Genes Dev.

15, 1067-1077.

Mclellan, E.A., Bird, R.P., 1988. Aberrant crypts: potential preneoplastic lesions in the

murine colon. Cancer Res. 48, 6187-6192.

Meigs, T.E., Roseman, D.A., Simone, R.D., 1996. Regulation of 3-hydroxy- 3-methylglutaryl-

CoA reductase degradation by the nonsterol mevalonate metabolite farnesol in vivo. J. Biol.

Chem. 71, 7916-7922.

Meigs, T.E., Simoni, R.D., 1997. Farnesol as a regulator of HMGCoA reductase degradation:

characterization and role of farnesyl pyrophosphatase. Arch. Biochem. Biophys. 345, 1-9.

Meister, A., Anderson, M.E., 1983. Glutathione. Annu. Rev. Biochem. 52, 711-60.

Mesnil, M., Crespin, S., Avanzo, J.L., Zaidan-Dagli, M.L. 2005. Defective gap junctional

intercellular communication in the carcinogenic process. Biochim. Biophys. Acta 1719, 125–45.

Meterissian, S.H., Kontogiannea, M., Al-Sowaidi, M. 2001. Bcl-2 is a useful prognostic marker in

Duke’s B colon cancer. Ann. Surg. Oncol. 8, 533–537.

Miller, E.C., 1978. Some current perspectives on chemical carcinogenesis in humans and

experimental animals: presidential address. Cancer Res. 38, 1479-1496.

Miller, J. A., 1964. Comments on chemistry of cycads. Fed. Roc. 23, 1361-1362.

Bibliography

200

Mitchell, R.J., Brewster, D., Campbell, H., Porteous, M.E., Wyllie, A.H., Bird, C.C., Dunlop,

M.G., 2004. Accuracy of reporting of family history of colorectal cancer. Gut. 53, 291-95.

Miyachi, K., Fritzler, M.J., Tan, E.M. 1978. Autoantibody to a nuclear antigen in proliferating

cells. J. Immunol. 121, 2228-2234.

Miyaki, M., Seki, M., Okamoto, M., Yamanaka, A., Maeda, Y., Tanaka, K., Kikuchi, R.,T.,

Iwama-Ikeuchi, T., Tonomura, A., Koike, M., etc. 1990. Genetic changes and

histopathological types in colorectal tumors from patients with familial adenomatous

polyposis. Cancer Res. 50. 7166-7173.

Miyamoto, S., Kohno, H., Suzuki, R., Sugie, S., Murakami, A., Ohigashi, H., Tanaka, T., 2006.

Preventive effects of chrysin on the development of azoxymethane-induced colonic aberrant

crypt foci in rats. Oncol. Rep. 15, 1169-1173.

Miyashita, T., Krajewski, S., Krajewska, M., Wang, H.G., Lin, H.K., Liebermann, D.A.,

Hoffman, B., Reed, J. 1994. Tumor suppressor p53 is a regulator of bcl-2 and bax gene

expression in vitro and in vivo. Oncogene 9, 1799–1805.

Miyoshi, Y., Ando, H., Nagase, H., Nishisho, I., Horii, A., Miki, Y., Mori, T., Utsunomiya.

J., Baba. S., Pererson, G., Hanmilton, S.R.. Kinzler, K.W., Vogelstein, B., Nakamura, Y.,

1992. Germ-line mutations of the APC gene in 53 familial

adenomatous polyposis patients. Proc. Natl. Acad. Sci. USA. 89, 4452-4456.

Mograbi, B., Corcelle, E., Defamie, N., Samson, M., Nebout, M., Segretain, D., Fénichel, P.,

Pointis, G. 2003. Aberrant Connexin 43 endocytosis by the carcinogen lindane involves

activation of the ERK/mitogen-activated protein kinase pathway. Carcinogenesis 24, 1415–1423.

Mohandas, M., Marshall, J.J., Duggin, G.G., Horvath, J.S., Tiller, D.J., 1984. Differential

distribution of glutathione and glutathione related enzymes in rabbit kidney. Biochem

Pharmacol. 33, 1801-1807.

Mollica, L., De Marchis, F., Spitaleri, A., Dallacosta, C., Pennacchini, D., Zamai, M., Agresti, A.,

Trisciuoglio, L., Musco, G., Bianchi, M.E. 2007. Glycyrrhizin binds to high-mobility group box 1

protein and inhibits its cytokine activities. Chem. Biol. 14, 431-441.

Bibliography

201

Mollica, L., De Marchis, F., Spitaleri, A., Dallacosta, C., Pennacchini, D., Zamai, M., Agresti, A.,

Trisciuoglio, L., Musco, G., Bianchi, M.E. 2007. Glycyrrhizin binds to high-mobility group box 1

protein and inhibits its cytokine activities. Chem. Biol. 14, 431-441.

Mori, H., Hata, K., Yamada, Y., Kuno, T., Hara A., 2005. Significance and role of early-lesions in

experimental colorectal carcinogenesis. Chem. Biol. Interact. 155, 1-9.

Morimoto, M., Takagi, Y., Higashi, N. Suzuki, T. 2011. Orally Administered Rutin Inhibits the

Gene Expression of Th2 Cytokines in the Gut and Lung in Aged Mice. J. Vet. Med. Sci. 73,

1257–1263.

Morin, P.J., Sparks, A.B., Korinek, V., 1997. Activation of beta-catenin- Tcf signaling in colon

cancer by mutations in beta-catenin or APC. Science 275, 1787–1790.

Morson, B.C., 1968. Precancerous and early malignant lesions of the large intestine. Brit. J.

Surg. 55, 725-731.

Morson, B.C., 1974. President's address. The polyp-cancer sequence in the large bowel.

Proc. R. Soc. Med. 67, 451-457.

Moslen, M.T., Smith, C.V., 1992. Free radical mechanism of tissue injury. CRC Press, Boca

Raton, FL.

Mukai, F.H., Goldstein, B.D., 1976. Mutagenicity of malonaldehyde, a decomposition product of

peroxidized polyunsaturated fatty acids. Science. 191, 868-869.

Mukhtar, H., Das, M., Khan, W.A., Wang, Z.Y., Bik, D.P., Bickers, D.R., 1988. Exceptional

activity of tannic acid among naturally occurring plant phenols in protecting against 7,12-

dimethylbenz(a)anthracene-, benzo(a)pyrene-, 3-methylcholanthrene-, and N-methyl-N-

nitrosourea-induced skin tumorigenesis in mice.Cancer Res. 48, 2361-2365.

Munemitsu, S., Souza, B., Muller, 0., Albert, I., Rubinfeld, B., Polakis, P., 1995b. The APC

gene product associates with microtubules in vivo and promotes their assembly in vitro.

Cancer Res. 54, 3676-3681.

Munernitsu, S., Albert, I., Souza, B., Rubinfeld, B., Polakis, P., 1995a. Regulation of

intracellular beta-catenin levels by the adenomatous polyposis coli (APC) tumor-suppressor

Bibliography

202

protein. Proc. Natl. Acad. Sci. U S A. 92, 3046-3050.

Muto, T. Bussey, H.J.R., Morson B.C., 1975. The evolution of cancer of the colon and

rectum. Cancer. 36, 2251-2270.

Muto, T., Bussey, H.J.R., Morson, B.C., 1975. The evolution of cancer of the colon and

rectum. Cancer. 36, 2251-2270.

Nakamura, T., Nomura, S., Sakai, T., Nariya, S. 1997. Expression of bcl-2 oncoprotein in

gastrointestinal and uterine carcinomas and their premalignant lesions. Hum. Pathol. 28, 309–

315.

Narula, J., Pandey, P., Arbustini, E., Haider, N., Narula, N., Kolodgie, F.D., Dal Bello, B.,

Semigran, M.J., Bielsa-Masdeu, A., Dec, G.W., Israels, S., Ballester, M., Virmani, R., Saxena, S.,

Kharbanda, S., 1999. Apoptosis in heart failure: release of cytochrome c from mitochondria and

activation of caspase-3 in human cardiomyopathy. Proc. Natl. Acad. Sci. USA. 96, 8144-8149.

Nathan, C., 2002. Points of control in inflammation. Nature. 420, 846-52.

Navarathna, D.H., Nickerson, K.W., Duhamel, G.E., Jerrels, T.R., Petro, T.M., 2007. Exogenous

farnesol interferes with the normal progression of cytokine expression during candidiasis in a

mouse model. Infect. Immun. 75, 4001-4006.

Nishida, M., Tanabe, S., Maruyama, Y., Mangmool, S., Urayama, K., Nagamatsu, Y., Takagahara,

S., Turner, J.H., Kozasa, T., Kobayashi, H., Sato, Y., Kawanishi, T., Inoue, R., Nagao, T.,

Kurose, H., 2005. Gα12/13- and reactive oxygen species-dependent activation of c-Jun NH2-

terminal kinase and p38 mitogen-activated protein kinase by angiotensin receptor stimulation in

rat neonatal cardiomyocytes. J. Biol. Chem. 280, 18434-18441.

Nishino, H. 1992. Antitumor-promoting activity of glycyrrhetinic acid and its related

compounds. In Cancer Chemoprevention, L Wattenberg, M Lipkin, CW Boone, and GJ Kelloff

(eds). Boca Raton, FL: CRC, 1992, pp 457–467.

Nowell, P., 1976. the clonal evolution of tumor cell populations. Science. 194, 23-28.

Bibliography

203

Nucci, M.R., Robinson, C.R., Longo, P., Campell, P., Hamilton, S.R., 1997. Phenotypic and

genotypic characteristics of aberrant crypt foci in human colorectal mucosa. Hum. Pathol. 28,

1396-1407.

O’Brien, C.A., Pollett, A., Gallinger, S., Dick, J.E., 2007. A human colon cancer cell capable of

initiating tumour growth in immunodeficient mice. Nature. 445, 106-110.

Ong, T.P., Heidor, R., de Conti, A., Dagli, M.L., Moreno, F.S., 2006. Farnesol and geraniol

chemopreventive activities during the initial phases of hepatocarcinogenesis involve similar

actions on cell proliferation and DNA damage, but distinct actions on apoptosis, plasma

cholesterol and HMGCoA reductase. Carcinogenesis. 27, 1194-1203.

Oravec, C.T., Jones, C.A., Huberman, E., 1986. Activation of the colon carcinogen 1, 2-dimethyl

hydrazine in a rat colon cell-mediated mutagenesis assay. Cancer Res. 46, 5068-5071.

Orlowski, R.Z., Baldwin, A.S., Jr., 2002. NFkappaB as a therapeutic target in cancer. Trends Mol.

Med. 8, 385-89.

Ortiz de Montellano, P. R. (ed) (2005) Cytochrome P450: Structure, Mechanism, and

Biochemistry, 3rd Ed., KluwerAcademic/Plenum Publishers, New York, NY

Oshima, M., Oshima, H., Kitagawa, K., Kobayashi, M., Itakura, C., Taketo, M., 1995. Loss

of APC heterozygosity and abnormal tissue building in nascent intestinal polyps in mice

carrying a truncated APC gene. Proc. Natl. Acad. Sci. USA. 92, 4482-4486.

Oyama, K., Fujimura, T., Ninomiya, I., Miyashita, T., Kinami, S., Fushida, S., Ohta, T., Koichi,

M., 2004. A COX-2 inhibitor prevents esophageal inflammation-metaplasia-adenocarcinoma

sequence in rats. Carcinogenesis. 26, 565-70.

Pahl, H.L., 1999. Activators and target genes of Rel/NF-kB transcription factors. Oncogene. 18,

6853-6866.

Parc, Y., Piquard, A., Dozois, R.R., Parc, R., Tiret, E., 2004. Long-term outcome of familial

adenomatous polyposis patients after restorative coloproctectomy. Ann. Surg. 239, 378-82.

Park, J.W., Cundy, K.C., Ames, B.N., 1989. Detection of DNA adducts by HPLC with

electrochemical detection. Carcinogenesis. 11, 1447-1450.

Bibliography

204

Paulsen, J.E., Loberg, E.M., Olstorn, H.B., Knutsen, H., Steffensen, I.L. Alexander, J., 2005. Flat

dysplastic aberrant crypt foci are related to tumorigenesis in the colon of azoxymethane-treated

rat. Cancer Res. 65, 121-129.

Paulsen, J.E., Steffensen, I.L., Loberg, E.M., Husoy, T., Namork, E., Alexander, J., 2001.

Qualitative and quantitative relationship between dysplastic aberrant crypt foci and tumorigenesis

in the Min/+ mouse colon. Cancer Res. 61, 5010-5015.

Pence, B.C., 1991. Dietary selenium and antioxidant status: toxic effects of 1, 2-

dimethylhydrazine in rats. J. Nutr. 121, 138-144.

Perchellet, J.P., Perchellet, E.M., 1989. Antioxidants and multistage carcinogenesis in mouse

skin. Free Radic. Biol. Med. 7, 377-408.

Pereira, M.A., Barnes, L.H., Fassman, V.L., Kelloff, G.V., Steele, V. 1994. Use of azoxymethane-

induced foci of aberrant crypts in rat colon to identify potential cancer chemopreventive agents.

Carcinogenesis 15, 1049–1054.

Pereira, M.A., Khoury, M.D. 1991. Prevention by Chemopreventive agents of azoxymethane-

induced foci of aberrant crypts in rat colon. Cancer Lett. 61, 27-33.

Pichichero, E., Cicconi, R., Mattei, M., Muzi, M.G., Canini, A., 2010. Acacia honey and chrysin

reduce proliferation of melanoma cells through alterations in cell cycle progression. Int J Oncol.

37, 973-981.

Pierini, R., Gee, J.M., Belshaw, N.J., Johnson, I.T., 2008. Flavonoids and intestinal cancers. Br

J Nutr. 99, ES53-59.

Pikarsky, E., Porat, R.M., Stein, I., Abramovitch, R., Amit, S., Kasem, S., Gutkovich-Pyest, E.,

Urieli-Shoval, S., Galun, E., Ben-Neriah, Y., 2004. NF-kB functions as a tumour promoter in

inflammation-associated cancer. Nature. 431, 461-466.

Pitot, H.C., Goldsworthy, T., Moran, S., 1981. The natural history of carcinogenesis: implications

of experimental carcinogenesis in the genesis of human cancer. J. Supramol. Struct. Cel.

Biochem. 17, 133-46.

Pitot, H.C., Sirica, A.E., 1980. The stages of initiation and promotion in hepatic carcinogenesis.

Biochim. Biophys. Acta., 605, 191.

Bibliography

205

Plate, A.Y.A., Gallaher, D.D. 2006. Effects of Indole-3-Carbinol and phenethyl isothiocyanate

on colon carcinogenesis induced by azoxymethane in rats. Carcinogenesis 27, 287–292.

Poirier, M.C., 2004. Chemical-Induced DNA Damage and human cancer risk. Nature. 4, 630-

637.

Poli, G., Leonarduzzi, G., Biasi, F., Chiarpotto, E., 2004. Oxidative stress and cell signalling.

Curr. Med. Chem. 11, 1163-1182.

Pompei, R., Flore, O., Marccialis, M.A., Pani, A., Loddo, B. 1979. Glycyrrhizic acid inhibits virus

growth and inactivates virus particles. Nature 281, 689–690.

Ponder, B.A., Wilkinson, M.M., 1986. Direct examination of the clonality of carcinogen-

induced colonic epithelial dysplasia in chimeric mice. J. Natl. Cancer. Inst. 77, 967-976.

Pott, P., 1775. Chirurgical Observations Relative to the Cataract, in: Hawes, W. Clarke, R.

Collins,(Eds.), The Polypus of the Nose, the Cancer of the Scrotum, the Different Kinds of

Ruptures, and the Mortification of the Toes and Feet. London, UK. pp. 60-68.

Powell, S.M.. Zilz, N., Beazer-Barclay, Y., Bryan, T.M., Hamilton, S.R., Thibodeau. S.N.,

Vogelstein, B., Kinzler, K.W., 1992. APC mutations occur early during colorectal

tumorigenesis. Nature. 359, 235-237.

Pozharisski, K.M., Likhachev, A.J., Klimashevski, V.F., Shaposhnikov, J.D., 1979. Experimental

intestinal cancer research with special reference to human pathology. Cancer Res. 30, 165-237.

Prescott, S.M., Fitzpatrick, F.A., 2000. Cyclooxygenase-2 and carcinogenesis. Biochim. Biophys.

Acta. 1470, M69-78.

Pretlow, T.P., Barrow, B.J., Ashton, W.S., O'Riordan, M.A., Pretlow, T.G., Jurcisek, J.A., Stellato,

T.A., 1991. Aberrant crypts: putative preneoplastic foci in human colonic mucosa. Cancer Res.

51, 1564-7.

Pretlow, T.P., Brasitus, T.A., Fulton, N.C., Cheyer, C., Kaplan, E.L., 1993. K-ras mutation in

putative preneoplastic lesions in human colon. J. Natl. Cancer Inst. 85, 2004-2007.

Pretlow, T.P., Cheter, C. O’Riordan, M.A., 1994. Aberrant crypt foci and colon tumors in F344

rats have similar increases in proliferative activity. Int. J. Cancer. 56, 599-602.

Bibliography

206

Preussmann, R., Druckrey, H., Ivankovic, S., Hodenberg, A.V., 1969. Chemical structure and

carcinogenicity of aliphatic hydrazo, azo, and azoxy compounds and of triazenes, potential in

vivo alkylating agents. Ann. NY. Acad. Sci. 163, 697-716.

Qamar, W., Sultana, S., 2008. Farnesol ameliorates massive inflammation, oxidative stress and

lung injury induced by intratracheal instillation of cigarette smoke extract in rats: An initial step

in lung chemoprevention. Chem. Biol. Interact. 176, 79-87.

Rajamanickam, S., Velmurugan, B., Kaur, M., Singh, R.P., Agarwal, R. 2010. Chemoprevention

of Intestinal Tumorigenesis in APC min/+ Mice by Silibinin. Cancer Res. 70, 2368–2378.

Rajeshkumar, N.V., Kuttan, R., 2003. Modulation of carcinogenic response and antioxidant

enzymes of rats administered with 1,2- dimethylhydrazine by picroliv. Cancer Lett. 191, 137-143.

Raman, M., Earnest, S., Zhang, K., Zhao, Y., Cobb, M.H., 2007. TAO kinases mediate activation

of p38 in response to DNA damage. Embo. J. 26, 2005-2014.

Ranaldi, R., Gioacchini, A.M., Manzin, A., Clementi, M., Paolucci, S., Bearzi, 1., 1995.

Adenoma-carcinoma sequence of colorectum. Prevalence of K-ras gene mutation in

adenomas with increasing degree of dysplasia and aneuploidy. Diagn. Mol. Pathol. 4, 198-

202.

Rao, B.N., Anderson, M.B., Musser, J.H., Gilbert, J.H., Schaefer, M.E., Foxall, C., Brandley, B.K.

1994. Sialyl Lewis X mimics derived from a pharmacophore search are selectin inhibitors with

anti-inflammatory activity. J. Biol. Chem. 269, 19663-1966.

Rao, C.V., 2004. Nitric oxide signaling in colon cancer chemoprevention. Mutat. Res. 555, 107-

19.

Rao, C.V., Desai, D., Simi, B., Kulkarni, N., Amin, S., Reddy, B.S. 1993a Inhibitory effect of

caffeic acid esters on azoxymethane-induced biochemical changes and aberrant crypt foci

formation in rat colon. Cancer Res. 53, 4182-4188.

Rao, C.V., Newmark, H.L., Reddy, B.S., 2002. Chemopreventive effect of farnesol and lanosterol

on colon carcinogenesis. Cancer Detect. Prev. 26, 419-425.

Rao, C.V., Rivenson, A., Simi, B., Reddy, B.S. 1995. Chemoprevention of colon carcinogenesis

by dietary curcumin, a naturally occurring plant phenolic compound. Cancer Res. 55, 259-266.

Bibliography

207

Rao, C.V., Simi, B., Reddy, B.S. 1993b. Inhibition by dietary curcumin of azoxymethane-induced

ornithine decarboxylase, tyrosine protein kinase, arachidonic acid metabolism and aberrant crypt

foci formation in the rat colon. Carcinogenesis (Lond.) 14, 2219-2225.

Rao, C.V., Wang, C., Simi, B., Lubet, R.A., Kelloff, G.J., Steele, V., Reddy, B.S. 1997.

Enhancement of experimental colon cancer by genistein. Cancer Res. 57, 3717–3722.

Ravcroft, L., Wu. H.Y., Lozano, G., 1990. Transcriptional activation by wild-type but not

transforming mutants of the p53 anti-oncogene. Science. 249, 1049-1051.

Ray, G., Husain, S.A. 2002. Oxidants, antioxidants and carcinogenesis. Indian J. Exp. Biol. 40,

1213-1232.

Reddy, B.S., Kawamori, T., Lubet, R.A., Steele, V.E., Kelloff, G.J., Rao, C.V. 1999.

Chemopreventive efficacy of sulindac sulfone against colon cancer depends on time of

administration during carcinogenic process. Cancer Res. 59, 3387-3391.

Reddy, B.S., Narisawa, T., Weisburger, J.H., 1976. Effect of a diet with high levels of protein

and fat on colon carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine. J. Natl. Cancer

Inst. 57, 567-569.

Reddy, B.S., Wang, C.X., Samaha, H., Lubet, R., Steele, V.E., Kelloff, G.J., Rao, C.V. 1997.

Chemoprevention of colon carcinogenesis by dietary perillyl alcohol. Cancer Res. 57, 420-425.

Reddy, B.S., Watanabe, K., Weisburger, J.H. 1977. Effect of high-fat diet on colon

carcinogenesis in F344 rats treated with 1,2-dimethylhydrazine, methylazoxymethanolacetate, or

methylnitrosourea. Cancer Res. 37, 4156–4159.

Rehn, L., 1895. Blasengeschwu¨ lste be: Fuchsin-arbeitern. Arch. Klin. Chir. 50, 588-600.

Reinhardt, H.C., Aslanian, A.S., Lees, J.A., Yaffe, M.B., 2007. p53-deficient cells rely on ATM-

and ATR-mediated checkpoint signaling through the p38MAPK/MK2 pathway for survival after

DNA damage. Cancer Cell.11, 175-189.

Rex, D.K., Smith, J.J., Ulbright, T.M., Lehman, G.A., 1992. Distal colonic hyperplastic polyps do

not predict proximal adenomas in asymptomatic average-risk subjects. Gastroenterology. 102,

317-319.

Bibliography

208

Rezai-Zadeh, K., Shytle, D., Sun, N., Mori, T., Hou, H., Jeanniton, D., Ehrhart, J., Townsend,

K., Zeng, J., Morgan, D., Hardy, J., Town, T., Tan, J., 2005. Green tea epigallocatechin-3-gallate

(EGCG) modulates amyloid precursor protein cleavage and reduces cerebral amyloidosis in

alzheimer transgenic mice. J. Neurosci. 25, 8807-8814.

Riley, T., Sontag, E., Chen, P., Levine, A. 2008. Transcriptional control of human p53- regulated

genes. Nat. Rev. Mol. Cell Biol. 9, 402–412.

Ristimaki, A., Honkanen, N., Jankala, H., Sipponen, P., Harkonen, M., 1997. Expression of

cyclooxygenase 2 in human gastric cancer. Cancer Res. 57, 1276-80.

Robbe, C., Capon, C., Coddeville, B., Michalski, J.C., 2004. Structural diversity and specific

distribution of O-glycans in normal human mucins along the intestinal tract. Biochem J. 384,

307-316.

Rogers, A.E., Nauss, K.M., 1985. Rodent models for carcinoma of the colon. Dig. Dis. Sci. 30,

87S-102S.

Rogers, K.J., Pegg, A.E., 1977. Formation of O6-methyl guanine by alkylation of rat liver colon

and kidney DNA following administration of 1, 2-dimethyhydrazine. Cancer Res. 37, 4082-4087.

Romier, B., Van De Walle, J., During, A., Larondelle, Y., Schneider, Y.J., 2008. Modulation of

signaling NF-jB activation pathway by polyphenols in human intestinal Caco-2 cells. Brit. J.

Nutr.100, 542-551.

Roncucci, L., Stamp, D., Medline, A., Cullen, J.B., Bruce, W.R., 1991. Identification and

quantification of aberrant crypt foci and microadenomas in the human colon. Hum Pathol. 22,

287-94.

Saad, S.Y., Najjar, T.A., Alashari, M., 2004. Role of nonselective adenosine receptor blockade

and phosphodiesterase inhibition in cisplatin-induced nephrogonadal toxicity in rats. Clin Exp

Pharmacol Physiol. 31, 862-867.

Saez, J.C., Berthoud, V.M., Branes, M.C., Martinez, A.D., Beyer, E.C. 2003. Plasma membrane

channels formed by connexins: their regulation and functions. Physiol. Rev. 83, 1359–1400.

Sakahira, H., Enari, M., Nagata, S., 1998. Cleavage of CAD inhibitor in CAD activation and

DNA degradation during apoptosis. Nature. 391, 96-99.

Bibliography

209

Sakai, E., Morioka, T., Yamada, E., Ohkubo, H., Higurashi, T., Hosono, K., Endo, H.,

Takahashi, H., Takamatsu, R., Cui, C., Shiozawa, M., Akaike, M., Samura, H., Nishimaki, T.,

Nakajima, A., Yoshimi, N., 2011. Identification of preneoplastic lesions as mucin-depleted foci

in patients with sporadic colorectal cancer. Cancer Sci. 103, 144-9.

Sandforth, F., Heimpel, S., Balzer, T., Gutschmidt, S., Riecken, E.O. 1988. Characterization of

stereomicroscopically identified preneoplastic lesions during dimethylhydrazine-induced colonic

carcinogenesis. Eur. J. Clin. Invest. 18, 655-662.

Sato, T., Yoshinaga, K., Okabe, S., Okawa, T., Enomoto, M., Takizawa, T., Sugihara, K., 2003.

Cyclooxygenase-2 expression in colorectal adenomas. Dis. Colon Rectum. 46, 786-92.

Schafer, F.Q., Buettner, G.R., 2001. Redox environment of the cell as viewed through the redox

state of the glutathione disulfide/ glutathione couple. Free Rad. Biol. Med. 30, 1191-212.

Schatzkin, A., Gail, M. 2002. The promise and peril of surrogate end points in cancer research.

Nat. Rev. Cancer 2, 19–27.

Schobaum, G.R., Chance, B., 1976. Catalase, in: The enzymes. (Ed. Boyer PD). 2nd Edn. (Vol

13), New York Academy. Pp 363-408.

Scholzen, T., Gerdes, J. 2000. "The Ki-67 protein: from the known and the unknown". J. Cell.

Physiol. 182, 311–322.

Schuler, M., Bossy-Wetzel, E., Goldstein, J.C., Fitzgerald, P., Green, D.R. 2000. p53 induces

apoptosis by caspase activation through mitochondrial cytochrome c release. J. Biol. Chem. 275,

7337-42.

Schulte-Hermann, R., Grasl-Kraupp. B., Bursch, W., 1994. Tumor development and apoptosis.

Int. Arch. Allergy Immunol. 105, 363-367.

Sen, R., Baltimore, D., 1986. Inducibility of kappa immunoglobulin enhancer- binding protein

Nf-kappa B by a posttranslational mechanism. Cell. 47, 921-8.

Sengottuvelan, M., Viswanathan, P., Nalini, N., 2006. Chemopreventive effect of trans-

resveratrol - a phytoalexin against colonic aberrant crypt foci and cell proliferation in 1,2-

dimethylhydrazine induced colon carcinogenesis. Carcinogenesis. 27, 1038-1046.

Bibliography

210

Seven, A., Civelek, S., Inci, E., Korkut, N., Burcak, G. 1999. Evaluation of oxidative stress

parameters in blood of patients with laryngeal carcinoma. Clin. Biochem. 32:369-373.

Shank, R.C., Magee, P.N., 1967. Similarities between the biochemical actions of cycasin and

dimethylnitrosaminc. Biochm. 105, 521-527.

Sharma, S., Sultana, S., 2004. Modulatory effect of soy isoflavones on biochemical alterations

mediated by TPA in mouse skin model. Food Chem. Toxicol. 42,1669-1675.

Shaw, P., Tardy, S., Benito, E., Obrador, A., Costa, J., 1991. Occurrence of Ki-ras and p53

mutations in primary colorectal tumors. Oncogene. 6, 2121-2128.

She, Q.B., Bode, A.M., Ma, W.Y., Chen, N.Y., Dong, Z., 2001. Resveratrol induced activation of

p53 and apoptosis is mediated by extracellular-signal-regulated protein kinases and p38 kinase.

Cancer Res. 61, 1604-1610.

She, Q.B., Chen, N., Dong, Z., 2000. ERKs and p38 kinase phosphorylate p53 protein at serine

15 in response to UV radiation. J. Biol. Chem. 275, 20444-20449.

Sherman, S.E., Gibson, D., Wang, A.H.J., Lippard, S.J., 1985. X-ray structure of the major

adduct of the anticancer drug cisplatin with DNA: cis-[Pt (NH3)2 {d(pGpG)}]. Science. 230,

412-417.

Shiota, G., Harada, K., Ishida, M., Tomie, Y., Okubo, M., Katayama, S., Ito, H., Kawasaki, H.

1999. Inhibition of hepatocellular carcinoma by glycyrrhizin in diethylnitrosamine-treated mice.

Carcinogenesis 20, 59-63.

Shirasawa, S., Furuse, M., Yokoyama, N., Sasazuki, T., 1993. Altered growth of human

colon cancer cell lines disrupted at activated Ki-ras. Science. 260, 85-88.

Sieber, O.M., Lipton, L., Crabtree, M., Heinimann, K., Fidalgo, P., Phillips, R.K., Bisgaard, M.L.,

Orntoft, T.F., Aaltonen, L.A., Hodgson, S.V., Thomas, H.J., Tomlinson, I.P. 2003. Multiple

colorectal adenomas, classic adenomatous polyposis, and germ-line mutations in MYH. N. Engl.

J. Med. 348, 791-99.

Sies, H. 1988. Oxidative stress: quinone redox cycling. ISI Atlas Sci. Biochem. 1, 109.

Singh, J., Kulkarni, N.. Kelloff, G., Reddy, B.S., 1994. Modulation of azoxymethane-induced

mutational activation of ras protooncogenes by chemopreventive agents in colon

carcinogenesis. Carcinogenesis. 15, 1317-1323.

Bibliography

211

Sinicrope, F.A., Hart, J., Michelassi, F., Lee, J.J. 1995. Prognostic value of bcl-2 oncoprotein

expression in stage II colon carcinoma. Clin. Cancer Res. 1, 1103– 1110.

Sirnes, S., Bruun, J., Kolberg, M., Kjenseth, A., Lind, G.E., Svindland, A., Brech, A., Nesbakken,

A., Lothe, R.A., Leithe, E., Rivedal, E. 2011. Connexin43 acts as a colorectal cancer tumor

suppressor and predicts disease outcome. Int J Cancer. 2011 Aug 22. [Epub ahead of print]

Siu, I-M., Pretlow, T.G., Amini, S.B., Pretlow, T.P., 1997. Identification of dysplasia in human

colonic aberrant crypt foci. Am. J. Pathol. 150, 1805-13.

Slater, A.F., Nobel, C.S., Orrenius, S., 1995. The role of intracellular oxidants in apoptosis.

Biochim. Biophys. Acta. 1271, 59-62.

Solomon, E., Voss, R., Hall, V., Bodmer, W.F., Jass, J.R., Jeffreys, A.J., Lucibello, F.C..

Patel. L., Rider, S.H., 1987. Chromosome 5 allele loss in human colorectal carcinomas.

Nature. 328, 616-619.

Soucek, L., Lawlor, E.R., Soto, D., Shchors, K., Swigart, L.B., Evan, G.I. 2007. Mast cells are

required for angiogenesis and macroscopic expansion of Myc-induced pancreatic islet tumors.

Nature Med. 13, 1211–1218.

Specian, R.D., Oliver, M.G., 1991. Functional biology of intestinal goblet cells. Am. J. Physiol.

260, C183-C193.

Steele, V.E., Hawk, E.T., Viner, J.L., Lubert, R.A., 2003. Mechanisms and applications of non-

steroidal anti-inflammatory drugs in the chemoprevention of cancer. Mutat. Res. 523-524, 137-

44.

Steinmetz, K.A., Potter, J.D., 1991.Vegetables, fruit and cancer. I. Epidemiology. Cancer Causes

Control. 2, 325-357.

Steward, B.W., Kleihues, P., 2003. in: Colorectal Cancer., eds. World Cancer Report. Lyon:

IARC Press, pp.198–202.

Stone, K., Bermudez, E., Pryor, W.A., 1994. Aqueous extracts of cigarette tar containing the tar

free radical cause DNA nicks in mammalian cells. Environ. Health Perspect. 102, 173-178.

Bibliography

212

Stopera, S.A., Bird, R.P., 1992. Expression of ras oncogene mRNA and protein in aberrant crypt

foci. Carcinogenesis. 13, 1863-1868.

Stopera, S.A., Davie, J.R., Bird, R.P., 1992. Colonie aberrant crypt foci are associated with

increased expression of c-fos: the possible role of modified c-fos expression in preneoplastic

lesions in colon cancer. Carcinogenesis. 13, 573-578.

Stopera, S.A., Murphy, L.C., Bird, R.P., 1992. Evidence for a ras gene mutation in

azoxymethane-induced colonie aberrant crypts in Sprague-Dawley rats: earliest recognizable

precursor lesions of experimental colon cancer. Carcinogenesis. 13, 2081-2085.

Stryker, S.J., Wolff, B.G., Culp, C.E., Libbe, S.D., Ilstrup, D.M., MacCarty, R.L., 1987. Natural

History of untreated colonic polyps. Gastroenterology. 93, 1009-1013.

Su, L.K., Kinzler, K.W., Vogelstein, B., Preisinger, A.C., Moser, A.R., Luongo, C., Gould,

D.A., Dove, W.F., 1992. A germline mutation of the murine homolog of the :1PC gene

causes multiple intestinal neoplasia. Science. 256, 668-670.

Sun, Y., 1990. Free radicals, antioxidant enzymes and carcinogenesis. Free Radic. Biol. Med. 8,

583–599.

Suzuki, H., Ohta, Y., Takino, T., Fujisawa, K., Hirayama, C. 1983. Effects of glycyrrhizin on

biochemical tests in patients with chronic hepatitis- double blind trail. Asian Med. J. 26, 423-438.

1983.

Tafee, B.G., Kensler, T.W., 1989. Free radicals and signal transduction in tumor promotion,

Genes and signal transduction, in: Multistage carcinogenesis, (Eds.), Colburn, H.N., Marcel

Dekker, New York. Pp 391.

Takahashi, M., Minamoto, T., Yamashita, N., Yazawa, K., Sugimura, T., Esumi, H. Reduction in

formation and growth of 1, 2-dimethylhydrazine-induced aberrant crypt foci in rat colon by

docosahexanoic acid. Cancer Res. 53, 2786-2789.

Takami, M., Preston, S.L., Berhman, H.R., 2000. Eicosatetraynoic and eicosatriynoic acids,

lipooxygenase inhibitors, block meiosis via antioxidantaction. Am. J. Physiol. Cell. Physiol. 278,

C646-650.

Bibliography

213

Takasaki, Y., Deng, J.S., Tan, E.M. 1981. A nuclear antigen associated with cell proliferation and

blast transformation: Its distribution in synchronized cells. J. Exp. Med. 154, 1899-1909

Tamm, I., Wang,Y., Sausville, E., Scudiero, D.A., Vigna, N., Oltersdorf, T., Reed, J.C. 1998. IAP-

family protein survivin inhibits caspase activity and apoptosis induced by Fas (CD95), Bax,

caspases and anticancer drugs. Cancer Res. 58, 5315–5320.

Tanahashi, T., Mune, T., Morita, H., Tanahashi, H., Isomura, Y., Suwa, T., Daido, H., Gomez-

Sanchez, C.E., Yasuda, K. 2002. Glycyrrhizic acid suppresses type 2 11 β-hydroxysteroid

dehydrogenase expression in vivo. J. Ster. Biochem. Mol. Biol. 80, 441-447.

Tanaka, T., Makita, H., Kawabata, K., Mori, H., Kakumoto, M. 1997. Chemoprevention of

azoxymethane-induced rat colon carcinogenesis by the naturally occurring flavonoids, diosmin

and hesperidin. Carcinogenesis (Lond.) 18, 957-965.

Tatemichi, M., Sawa, T., Gilibert, I., Tazawa, H., Katoh, T., Ohshima, H., 2005. Increased risk of

internal type of gastric adenocarcinoma in Japanese women associated with long forms of

CCTTT pentanucleotide repeat in the inducible nitric oxide synthase promoter. Cancer Lett. 217,

197-202.

Tatman, D., Mo, H., 2002. Volatile isoprenoid constituents of fruits, vegetables and herbs

cumulatively suppress the proliferation of murine B16 melanoma and human HL-60 leukemia

cells. Cancer Lett. 175, 129-139.

Tenesa, A., Dunlop, M.G., 2009. New insights into the aetiology of colorectal cancer from

genome-wide association studies. Nat. Rev. Genet. 10, 353-358.

Tenesa, A., Dunlop, M.G., 2009. New insights into the aetiology of colorectal cancer from

genome-wide association studies. Nat. Rev. Genet. 10, 353–358.

Terzić, J., Grivennikov, S., Karin, E., Karin, M., 2010. Inflammation and colon cancer,

Gastroenterology. 138, 2101-2114.

Theoharides, T.C., Conti, P. 2004. Mast cells: the Jekyll and Hyde of tumor growth. Trends

Immunol. 25, 235–241.

Thigpen, T., Vance, R., Puneky, L., Khansur, T., 1994. Chemotherapy in advanced ovarian

carcinoma: Current standards of care based on randomized trials. Gynecol. Oncol. 55, S97-107.

Bibliography

214

Thiis-Evensen, E., Hoff, G.S., Sauar, J., Majak, B.M., Vatn, M.H., 1999. Flexible sigmoidoscopy

or colonoscopy as a screening modality for colorectal adenomas in older age groups? Findings in

a cohort of the normal population aged 63-72 years. Gut. 45, 834-839.

Thirugnanam, S., Xu, L., Ramaswamy, K., Gnanasekar, M. 2008. Glycyrrhizin induces apoptosis

in prostate cancer cell lines DU-145 and LNCaP. Oncol. Rep. 20, 1387-1392.

Thornton, T.M., Rincon, M., 2009. Non-classical p38 map kinase functions: cell cycle

checkpoints and survival. Int. J. Biol. Sci. 5, 44-51.

Thorup, I., Meyer, O., Kristiansen, E. 1994. Influence of a dietary fiber on development of

dimethylhydrazine-induced aberrant crypt foci and colon tumor incidence in Wistar rats. Nutr.

Cancer 21: 177-182.

Thurnherr, N., Deschner, E.E., Stonehill, E.H., Lipkin, M., 1973. Induction of adenocarcinomas

of the colon iq mice by weekly injections of 1,2-dimethylhydrazine. Cancer Res. 33, 940-945,

1973.

Trorup, I., Meyer, 0., Kristiansen, E., 1994. Influence of a dietary fiber on development of

dimethylhydrazine-induced aberrant crypt foci and colon tumor incidence in Wistar rats.

Nutr. Cancer. 21, 177-182.

Tsao, A.S., Kim, E.S., Hong, W.K.., 2004. Chemoprevention of Cancer. CA Cancer J. Clin. 54,

150-180.

Tsujii, M., Kawano, S., Dubois, R.N., 1997. Cyclooxygenase-2 expression in human colon cancer

cells increases metastatic potential. Proc Natl Acad Sci U S A. 94, 3336-40.

Tudek, W.R.., Bird, R.P., Bruce, W.R., 1989. Foci of aberrant crypts in the colon of mice

and rats exposed to carcinogens associated with foods. Cancer Res. 49, 1236-

1240.

Vajdic, C.M., McDonald, S.P., McCredie, M.R., van Leeuwen, M.T., Stewart, J.H., Law, M., Van

Kaick, G., Wesch, H., Lu¨ hrs, H., Liebermann, D., 1986. Radiation-induced primary liver

tumors in ‘‘thorotrast patients’’. Rec. Results Cancer Res. 100, 16-22.

Valko, M., Leibfritz, D., Moncol, J., Cronin, M.T., Mazur, M., Telser, J., 2007. Free radicals and

antioxidants in normal physiological functions and human disease. Int. J. Biochem. Cell Biol. 39,

Bibliography

215

44-84.

Van Basten, J.P., Schrafford-Koops, H., Sleijfer, D.T., Pras, E., van Driel, M.F., Hoekstra, H.J.,

1997. Current concept about testicular cancer. Eur. J. Surg. Oncol. 23, 354-360.

Van Loo, G., Saelens, X., VanGroup, M., MacFarlane, M., Martin, S.J., Vandenabeele, P., 2002.

The role of mitochondrial factors in apoptosis: a Russian roulette with more than one bullet. Cell

Death Differ. 9, 1031-42.

van Rossum, T.G., Vulto, A.G., Hop, W.C., Brouwer, J.T., Niesters, H.G., Schalm, S.W. 1999.

Intravenous glycyrrhizin for the treatment of chronic hepatitis C: a double-blind, randomized,

placebo-controlled phase I/II trial. J. Gastroenterol. Hepatol. 14:1093–1099.

Vasen, H.F., Watson, P., Mecklin, J.P., Lynch, H.T., 1999. New clinical criteria for hereditary

nonpolyposis colorectal cancer (HNPCC, Lynch syndrome) proposed by the international

collaborative group on HNPCC. Gastroenterology. 116, 1453-56.

Venesio, T., Molatore, S., Cattaneo, F., Arrigoni, A., Risio, M., Ranzani, G.N., 2004. High

frequency of MYH gene mutations in a subset of patients with familial adenomatous polyposis.

Gastroenterology. 126, 1681-85.

Vessey, D.A. 1993. The cutaneous antioxidant system. Clin. Dermatol. 8, 81-103.

Vijayalakshmi, B., Sesikeran, B., Udaykumar, P., Kalyanasundaram, S., Raghunath, M., 2006.

Chronic low vitamin intake potentiates cisplatin-induced intestinal epithelial cell apoptosis in

WNIN rats. World. J. Gastroenterol. 12, 1078-1085.

Vivona, A.A., Shpitz, B., Mediine, A., Bruce, W.R., Hay, K., Ward, M.A., Stern, H.S., Gallinger,

S., 1993. K-ras mutations in aberrant crypt foci, adenomas and adenocarcinomas during

azoxymethane-induced colon carcinogenesis. Carcinogenesis. 14, 1777-1781.

Vogelstein, B., Fearon, E.R., Hamilton, S.R., Kern, S.E., Preisinger, A.C., Leppert, M.,

Nakamura, Y., White, R., Smits, A.M., Bos, J.L., 1988. Genetic alterations during colorectal-

tumor development. N. Engl. J. Med. 319, 525-532.

Vogelstein, B., Fearon, E.R., Kern, S.E., Hamilton, S.R., Preisinger, A.C., Nakamura. Y..

White, R., 1989. Allelotype of colorectal carcinomas. Science. 244, 207-211.

Bibliography

216

Vogelstein, B., Kinzler, K.W., 1993. The multistep nature of cancer. Trends Genet. 9,138-

141.

VonKruedener, S., Schempp, H., Elstner, E.F., 1995. Gas chromatographic differentiation

between myeleperoxidase activity and Fenton-type oxidants. Free Radic. Biol. Med. 19, 141-146.

Wadler, S., Benson, A.B., 3rd, Engelking, C., Catalano, R., Field, M., Kornblau, S.M., Mitchell,

E., Rubin, J., Trotta, P., Vokes, E., 1998. Recommended guidelines for the treatment of

chemotherapy induced diarrhea. J. Clin. Oncol. 16, 3169-3178.

Wajant, H., Pfizenmaier, K., Scheurich, P., 2003. Tumor necrosis factor signalling. Cell Death

Differ. 10, 45-65.

Wang, G., Reed, E., Li, Q.Q., 2004. Molecular basis of cellular response to cisplatin

chemotherapy in non-small cell lung cancer. Oncol. Rep. 12, 955-965.

Wang, W., Van Alstyne, P.C., Irons, K.A., Chen, S., Stewart, J.W., Birt, D.F., 2004. Individual

and interactive effects of apigenin analogs on G2/M cell-cycle arrest in human colon carcinoma

cell lines. Nutr. Cancer. 48, 106-114.

Wang, X., Morris, M.E., 2007. Effects of the flavonoid chrysin on nitrofurantoin

pharmacokinetics in rats: potential involvement of ABCG2. Drug Metab. Dispos. 35, 268-274.

Ward, J.M., Yamamoto, R.S., Benjamin, T., Brown, C.A., Weisburger, J.H., 1974. Experimentally

induced cancer of the colon in rats apd mice. 3. Am. Vet Med. Assoc. 164, 729-732.

Wargovich, M. J., Jimenez, A., McKee, K., Steele, V. E., Velasco, M., Woods, J., Price, R., Gray,

K., Kelloff, G. J. 2000.Efficacy of potential chemopreventive agents on rat colon aberrant crypt

formation and progression. Carcinogenesis (Lond.) 21, 1149–1155.

Wargovich, M.J., Medline, A., a Bruce, W.R., 1983. Early histopathologic events to

evolution of colon cancer in C57BL/6 and CFI mice treated with 1.2-dimethylhydrazine. J.

Natl. Cancer Inst. 71, 125-131.

Watari, N., Torizawa, K., Kanai, M., Mabuchi, Y., Suzuki, Y. 1976. Ultrastructural studies on the

protective effect of glycyrrhizin for liver injury induced by a carcinogen (3’-Me-DAB) (the

second report). J. Clin. Electron Microsc. 9, 394–395.

Bibliography

217

Wattenberg, L.W., 1996. Chemoprevention of cancer. Prev. Med. 25, 44-45.

Wattenberg, L.W., Lam, L.K.T., Fladmose, A.V., 1979. Inhibition of chemical carcinogen

induced neoplasia by coumarins and α-angelicalactone, Cancer Res. 39, 1651-1654.

Wedemeyer, J., Galli, S.J. 2005. Decreased susceptibility of mast cell-deficient Kit(W)/Kit(W-v)

mice to the development of 1, 2-dimethylhydrazine-induced intestinal tumors. Lab Invest. 85,

388–96.

Wei, H.C., Frenkel, K.. 1993. Relationship of oxidative events and DNA oxidation in

SENECAR mice to in vivo promoting activity of phorbol ester-type tumor promoters.

Carcinogenesis. 14, 1195-1201.

Weisburger, J.H., 1973. Chemical carcinogenesis in the gastrointestinal tract, in: Proceedings of

the Seventh National Cancer Conference. Philadelphia, J. B. Lippincott, 1973, pp.465-473.

Weisburger, J.H., Reddy, B.S., Wynder, E.L., 1977. Colon cancer: its epidemiology and

experimental production. Cancer 40, 2414-2420.

Wen, J., You, K.R., Lee, S.Y., Song, C.H., Kim, D.G., 2002. Oxidative stress-mediated apoptosis:

the anticancer effect of the sesquiterpene lactone parthenolide. J. Biol. Chem. 277, 38954-38964.

Wilcox, G.M., Beck, J.R., 1987. Early invasive cancer in adenomatous colonic polyps (”Malignant

polyps”). Evaluation of the therapeutic options by decision analysis. Gastroenterology. 92, 1159-

1168.

Williams, C.S., Mann, M., DuBois, R.N., 1999. The role of cyclooxygenases in inflammation,

cancer, and development. Oncogene. 18, 7908-16.

Williams, C.S., Smalley, W., DuBois, R.N., 1997. Aspirin use and potential mechanisms for

colorectal cancer prevention. J. Clin. Invest. 100, 1325-9.

Williams, G.M., Weisburger, J.H., 1983. Carcinogen risk assessment. Science. 221, 6

Winawer, S.J., Zauber, A.G., Ho, M.N., O’Brien, M.J., Gottlieb, L.S., Sternberg, S.S., et al. 1993.

Prevention of colorectal cancer by colonoscopic polypectomy. N Engl. J. Med. 329, 1977-1981.

Bibliography

218

Wiseman, D.A., Werner, S.R., Crowell, P.L., 2007. Cell cycle arrest by the isoprenoids perillyl

alcohol, geraniol, and farnesol is mediated by p21 (Cip1) and p27(Kip1) in human pancreatic

adenocarcinoma cells. J. Pharmacol. Exp. Ther. 320, 1163-1170.

Wu, W.S., 2006. The signalling mechanism of ROS in tumor progression. Cancer Metastasis Rev.

25, 695-705.

Wyllie, A.H., Kerr, J.F., Curie, A.R., 1980. Cell death: the significance of apoptosis. Int. Rev.

Cytol. 68, 251-306.

Yasukawa, K., Takido, M., Takeuchi, M., Nakagawa, S. 1988. Inhibitory effect of glycyrrhizin and

caffeine on two-stage carcinogenesis in mice. Yakugaku Zasshi 108, 794–796.

Yau, T.M., 1979. Mutagenicity and cytotoxicity of malonaldehyde in mammalian cells. Mech.

Ageing Dev. 11, 137-144.

Zhang, M.Z., Xu, J., Yao, B., Yin, H., Cai, Q., Shrubsole, M.J., Chen, X., Kon,.V., Zheng, W.,

Pozzi, A., Harris, R.C. 2009. Inhibition of 11β–hydroxysteroid dehydrogenase type II selectively

blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans. J.

Clin. Invest. 119, 876–885.

Zhang, Y.W., Nakayama, K., Morita, I. 2003. A novel route for connexin 43 to inhibit cell

proliferation: negative regulation of S-phase kinase-associated protein (Skp 2). Cancer Res. 63,

1623–1630.

Zhao, J., Nan, P., Zhong, Y., 2004. Chemical composition of the essential oils of Clausena

lansium from Hainan Island, China. Z. Naturforsch. C. 59,153-6.

Zhivotovsky, B., Orrenius, S., 2006. Carcinogenesis and apoptosis: paradigms and paradoxes.

Carcinogenesis. 27, 1939-1945.

Zicca, A., Cafaggi, S., Mariggio, M.A., Vannozzi, M.O., Ottone, M., Bocchini, V., Caviglioli, G.,

Viale, M., 2004. Reduction of cisplatin hepatotoxicity by procainamide hydrochloride in rats. Eur

J Pharmacol. 442, 265-272.