Bee Propolis

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<p>OsamuMizukami,MD,PhD,DrPH HealthPromotionClinic,Tokyo</p> <p>Iama doctorofinternalmedicinefromJapan. Ihavemycliniclocatedatthecenterof Tokyo. Ninetypercentofmypatientshaveallsites ofcancer,andmostofthemareadvanced cancerpatients. Myclinicisacomplementaryclinic. Mystandpointisthatchoiceofmeritsfrom conventionalandcomplementarymedicinewould bebeneficialformostpatients. Thepurposeofmyclinicisthatdifficult patientscanhavetheirownhopes.Isupport themasmuchaspossible.</p> <p>Ibecameawareofthelimitationsof conventionalmedicinefromthetimeIwasa medicalstudent.Iwasdisappointedatthe factthatconventionalmedicinecouldntcure advancedcancerpatients. Thisawarenesshasledmetoalongterm studyhowtotreatadvancedcancerpatients, anduseofcomplementarymedicineinmy practice. Ihavetreatedmorethan4,000patientswith advancedcancerinthelast35years,using conventionalandcomplementarymedicine.</p> <p>CancerisaNo.1causeofdeathinmycountry.The numberofJapanesediagnosedwithcancerhasbeen increasing.Thisincreaseisespeciallypronounced amongthesocalledcancersoftheWest suchas colon,pancreas,prostate,breast,andovarycancers. Thistrendhasbeenattributedtoawesternizationof thetypicaldietinJapan.Mycountrywasheavily influencedbytheUnitedStatesafterWorldWarIIand wetoohavedevelopedafondnessforbeefsteakand hamburgers. Japanboaststhelongestlifeexpectancyintheworld, andthisisthoughtduetohealthyJapanesediet. However,Japaneselifeexpectancycouldfallinthe comingyears.</p> <p>40 35 30 25 20 15 10 5 0 ' 75 ' 80 ' 85 ' 90 ' 95 ' 00 ' 05</p> <p>stom ach col on l ung lver i pancreas breast ovary uterus</p> <p> ConventionaltreatmentsinJapanare</p> <p>surgery,chemotherapy,andradiation liketheothercountries. DeathfromcancerinJapanhas increasedannuallyandhas quadrupledinthelast50years. Halfofthepatientsdiefromcancer. Advancedcancerisdifficulttocure usingsolelyconventionaltreatments.</p> <p>Conventionalcancertreatmentsmaynegatively impactpatients qualityoflife. Thesetreatmentsaresometimesdangerous. Postsurgicalmortalityratescanbe1%to3% dependinguponthesiteofthecancerand surgeons abilities. Mortalityratesduringchemotherapycanbe3%to 5%,andpatients qualityoflifeisnegatively affected.Chemotherapycandeterioratebone marrow,kidney,liver,lungandheartfunction. Radiationtherapyisassociatedwithadverse reactions,someofwhichmaybelifethreatening.</p> <p>Theconventionalwisdomisthat considerableprogresshasbeenmadein cancertherapy,butalotofthe availabledatadonotsupportthis characterization.Bytesting,wecan detectearlystagecancerthatis curable,butwecanfindlittle progressinadvancedcancertherapy. Thenextslideillustratesthelackof progressinadvancedbreastcancer survivalratesoverthepastcentury.</p> <p>Newcancertreatmentmethodsareneeded outsideofconventionalmedicine.Thisneed isonereasonwhycomplementarymedicinehas becomesopopularinmanydevelopedcountries. Approximately70%ofJapanesecancerpatients arereportedlyusingsomekindof complementarymedicine,suchasacupuncture orChineseherbalmedicationsincombination withconventionalmedicine.Themajorityof thesepatientsdonottelltheirdoctors abouttheiruse,becausemostJapanese doctorsareskepticalaboutcomplementary medicine.</p> <p> Itwouldbeidealtocureadvanced</p> <p>cancerbyonlynaturalremedy. However,itisverydifficultto cureadvancedcancerbyonly naturalways.Becausethespeedof cancercellproliferationistoo hightostopbythenaturalways. Inmostcases,conventional treatmentisneededtoalleviate thecancercellproliferation.</p> <p>Ifirstlearnedaboutpropolis20years agowhenIwasinUS,andIbecamevery interestedinthisbeeproduct. AfterItookpropoliseveryday,Iam freefromflusyndromewhichoften attackedme. Mythen73yearoldfatherwas diagnosedwithendstagepancreatic cancer16yearsago.Iadvisedhimto takepropolisforcancertreatmentand hetookwaterextractedpropolis.He diedayearlater,butexperiencedno painorseveresymptoms. Ihavesincefeltthatpropoliscould beaneffectivepartofcancer treatment.</p> <p>Sincemyfathersexperience,Ihave beenusingpropolisascomplementary medicineformorethan500patients withadvancedcancer. WhydoIusepropolis? Morethan1200 academicpapersare availableonpropolisfromaroundthe world.Propolisthushasmore scientificsupportcomparedtoother supplements. Theresearchhasshownthatpropolis possessesmanyanticancerproperties.</p> <p>Propolishas 1. Directanticancereffect 2. Immuneenhancingeffect 3. Antioxidanteffect 4. Antiangiogeniceffect 5. Antiinflammatoryeffect 6. Antiviralandantibacterialeffects 7. Tissueregeneratingeffect 8. Chemoprotectiveeffect 9. Radioprotectiveeffect</p> <p>Propolispossessesmanydirectanti canceragents. Caffeicacidphenylester(CAPE) increasestheCD4(+)Tcellsubset,IL 2,IL4andIFN inmice.CAPEalso preventsmetastasistothelungsin breastcancerrats. Propolisinducesapoptosisofhuman melanomacellsinvitro.</p> <p> Almostallcancerpatientshave</p> <p>reducedimmunityforyears. Propolishasamacrophage enhancingeffectinvitro. Propolisactivateslymphocytesand improvesCD4/CD8inmice.</p> <p> Freeradicalsincreaseincancer</p> <p>patients,andthisincrease stimulatescancercellproliferation whichcanresultinrecurrenceand metastasis. CAPEandArtepillinChaveastrong antioxidanteffect. Propolispreventslipidperoxidation. Propolisexhibitsastrongeranti oxidanteffectcomparedtovitaminE inratswithcerebralinfarction.</p> <p> Whenevercancercellsproliferate,</p> <p>angiogenesis(neovascularization) occurstoincreasetheblood supplytothesecancercells. Propolisexhibitsananti angiogeniceffectinvitroandin vivolikeachemicalanticancer agent:Avastin.</p> <p> Canceritselfhasinflammatory</p> <p>propertieswhichleadtoabattle betweencancercellsandimmune cells. Antiinflammatoryagentssuchasthe CoxIIinhibitorareusefulin cancerpreventionandtreatment. Propolisexhibitsantiinflammatory effectbothinvitroandinvivo.</p> <p>ThetypeBandChepatitisvirusescancause hepaticcellcarcinoma. HIVcausesAIDS. Helicobacterpylori isariskfactorfor stomachcancer.HalfoftheJapanesehave pylori infection,andmanyofushave sufferedstomachcancer. Propolishasantiviralandantibacterial propertiesinvitroandinvivo,andthese propertiesareusefulincancertreatment. Propolisshouldhelppreventdeathfrom infectiousdiseases(onethirdofpatients withadvancedcancerwerereportedtodie frominfectiousdiseasessuchaspneumonia duetodeterioratedimmunity)</p> <p> Ifregenerationofcancertissue</p> <p>occursfaster,recoveryfrom cancercouldoccurfaster. Propolisstimulatestissue regenerationinvivo.</p> <p> Manyanimalstudiessuggestthat</p> <p>chemotherapyaccompaniedbythe useofpropolisdecreasesadverse reactions. Propoliscombinedwith chemotherapyhassynergetic effectscomparedtoonly chemotherapyinvitroandinvivo.</p> <p> Manyanimalexperimentsshowthat</p> <p>radiationtherapyaccompaniedby theuseofpropolisdecreases adversereactions. Propoliscombinedwithradiation therapyhassynergeticeffects comparedtoonlyradiationin vitroandinvivo.</p> <p>Ihavetreatedover500patientswith advancedcancerusingpropolis. Thesepatientssufferedavarietyofcancers includinglung,stomach,colon,prostate, breast,ovaryandpancreascancer. Wemustacceptthefactthatcancerpatients willsimultaneouslyundergomultiple therapiesincludingbothconventionaland complementarytherapies. Thustheeffectofpropolisalonecannotbe measuredinsuchcancerpatients.Itisnot ethicalformetohavedoubleblindtests amongadvancedcancerpatients.</p> <p>Mostcancerpatientsundergoconventional treatment,butIrecommendtheuseofpropolisas complementarymedicine. Patientswhotakepropolistendtoexperiencea betterqualityoflife,lesspain,lessfatigue, andimprovedappetite. Thesurvivalperiodofpatientswhotookpropolis tendedtobelonger,sometimesdouble,tripleor 10timeslongerthanexpected. Asmallnumberofpatientshavehadtumorsshrink tosomedegreewithoutconventionaltreatment. Afewpatientshavehadtheircancer(1cmorless indiameter)completelydisappearwithout conventionaltreatment.</p> <p>Patientsusingpropolisincombinationwith chemotherapyorradiationtendtoexhibit bettertreatmentresultsandlessadverse reactionscomparedtoonlyconventional therapy. Ihavebeenusingethanolextracted,30% (w/v)ofBrazilianpropolisderivedfromthe Baccharisdracunculifoliaplant. Althoughmyusualrecommendeddosefor propolisis10ml3g)ofpropolisaday,I havebeenusing30ml(9g)ormorein patientswithadvancedcancer.</p> <p>Twopatientscomplainedofamildskin rashaftertakingpropolis.These individualswerehypersensitiveto chemicals.Patientswithallergies mustbetreatedwithcare. Afewpatientscomplainedofstomach distressaftertakingpropolis especiallyonanemptystomach. Nootherseriousadversereactionswere reported.</p> <p> Ihaveseenmanyincrediblecancer</p> <p>casesusingpropolisforyears. TodayIwillshowyoumy impressive6cancercases.</p> <p>A46yearoldfemalewithhepatitisC whosubsequentlydevelopedhepaticcell carcinomacametomyhospitalin1998. HerliverCTrevealed3tumorsof1cm indiameter.Irecommended10ml(3g) ofpropolistobetakendaily. Herlivertumorshadcompletely disappearedonCTtwomonthslater,and hertumormarker,feroprotein,was withinthenormalrange.Shehasbeen ingoodhealtheversince.</p> <p>A52yearoldfemalewasdiagnosedwith scirrhoustypestomachcancerbymein 1997.HercancerbelongedtostageIIIand hadanestimated1yearsurvivalrateof only10%. Sheunderwentatotalgastrectomyandthe cancerwasfoundtohavemetastasizedto theperitoneum.Aftertheprocedure,she tookadailydoseof10ml(3g)of propolis. Shehashadnorecurrenceinthe12years sincetheprocedure.</p> <p>A49yearoldmalewasdiagnosedwith stomachcancer(stageIII)in2006.Hewas advisedtoundergosurgery,butdecided againstit.Hetook30ml(9g)ofpropolis for6months.HisstomachXrayshowedno changes. Hethendecidedtoundergosurgery,buta gastroscopyperformedonedaybeforethe procedurerevealednoabnormalities.His biopsyshowednocancercells.Thesurgeons saidthiswasamiracle.Thesurgerywas thuscanceled.Heisveryhealthyat present.</p> <p> A46yearoldmalefracturedhis</p> <p>pelvicboneandwasdiagnosedwith multiplemyeloma(stageIV)in2003. Hisestimated5yearsurvivalrate was25%. Hetook45ml(15g)ofpropolis everydayduringhospitalization.He underwent4cyclesofchemotherapy, butexhibitednoadversereactions includingleucopenia(lowWBC counts).Hehasbeenincomplete remission.</p> <p> A81yearoldmalewithurinary</p> <p>bladdercancerwastoundergoan endoscopicprocedurein2006.He took12capsulesofpropolis(6g)a dayfor1month. Cystoscopywasperformedjustbefore theprocedure.Hiscancertumor completelydisappearedafterfoam likesubstanceexcretionfromhis urethra.Heishealthyatpresent.</p> <p>A57yearoldfemalewasdiagnosedwith ovariancancer.Ovaryanduterusresections wereperformedin1990.Chemotherapy followed,andsheexhibitedhighfever, diarrhea,andleucopenia(lowWBCcounts). Thecancerwasfoundtohavemetastasizedto thececumin2002,andshestartedtotake 6ml(2g)propolis.Sheunderwentasecond procedure.Sheagainunderwentchemotherapy, buthadnoadversereactions.HerCA199has beenreducedandisnowwithinthenormal range.Sheiscurrentlyingoodhealth.</p> <p>Cancerprevention,especiallyprimary prevention,iscriticallyimportantcomparedto secondaryandtertiaryprevention. Itiswellknownthatsimpleuseofvitaminsand mineralscouldntpreventseveralsitesof cancer. Propolisisthoughttobeeffectiveinprimary cancerpreventionbecauseofitspropertiesof directanticancereffect,immuneenhancing effectandantioxidanteffect. Propolismaybeusefulforcancertreatment, sincepropolishasmuchpossibilitytoprevent cancer.</p> <p>Moreclinicalstudiesareneededtodeterminethe efficacyofpropolis. Propolistakenbypatientswithadvancedcancer undergoingchemotherapyorradiationseemsto enhanceeffectivenessandleadtofeweradverse reactions. Propolistakenaloneseemedtoleadtobetter qualityoflife,prolongationoflife,and completeremission. Highdosesofpropolisintherangeof10gormore adaymaybemoreeffectiveinpatientswith advancedcancer. Iamconvincedthatadailydoseofpropolis preventscancerandthatincreaseduseofpropolis byhealthyindividualsishighlyrecommended. Evenadvancedcancerpatientsshouldhavehopeof recoveryusingpropolis,becausewecantlive withouthope.</p>