basics with the experts -basics of nerve conduction …...-study enough nerves and muscles to...
TRANSCRIPT
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Basics with the Experts -Basics of Nerve Conduction Study and Needle EMG Mohammad Kian Salajegheh, MDChief, Neuromuscular Division and Director, EMG Laboratory Department of Neurology, VA Boston Healthcare SystemBrigham and Women’s Hospital, Harvard Medical School
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Financial DisclosureNothing to disclose
WarningVideotaping or taking pictures of the slides associated with this presentation is prohibited. The information on the slides is copyrighted and cannot be used without permission and author attribution.
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Outline of Session8:00-8:05 am 5 min Introduction
8:05-8:25 am 20 min Nerve Conduction Basics & Approach to Study
8:25-8:55 am 30 min Nerve Conduction Study Methods
8:55-9:25 am 30 min Needle EMG Basics and Specialized Studies
9:25-9:30 am 5 min Discussion, questions, and answers
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• Speaker: M. Kian Salajegheh, MD
• Anatomy and physiology of the PNS• Measurement of combined action potentials• EDX changes in disease states• Approach to the study
Basics of Nerve Conduction and Approach to Study
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• Speaker: Kelly G. Gwathmey, MD
• Review anatomy of nerves and their study technique • Anomalous innervations• Alternative studies
Upper and Lower Extremity Nerve Conduction Studies
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• Speaker: Aaron Izenberg, MD
• Repetitive nerve stimulation• Blink reflex• Needle EMG basics
Specialized Studies and Basics of Needle EMG
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INTRODUCTION
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Nerve Conduction Study & EMG• Electrodiagnostic (EDX) studies are valuable tools for the
assessment of neuromuscular disorders
• Numerous studies and various techniques are used today o Nerve conduction studies (NCSs)o Late responses (F response and H reflex)o Repetitive nerve stimulation (RNS)o Needle electromyography (EMG)o Specialized examination
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• Recording electrodes typeso Ring or clamp electrodes o Bar or disk electrodeso Needle electrodes
• Recording o Active (G1) and reference (G2) electrodes
• CMAP: mostly belly (G1) and tendon (G2) montage• SNAP: usually 3-4 cm apart• Needle usually concentric
EDX technical aspects
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• Groundingo Obtain waveform free of artifact
• Machine settingso Gain (sensitivity)o Sweep speedo Filter settings
• Stimulation (red anode and black cathode)o Orthodromic vs. antidromic (for sensory)o Stimulation duration usually 0.1-0.2 mso Intensity (usually supramaximal stimulation)
EDX technical aspects
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BASICS OF NCS ANDAPPROACH TO STUDY
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• Critical tools for the assessment of patients with neuromuscular disorders
• Mainly extensions of the clinical evaluationo Obtain focused history and examo Form clinical impression with differential Dxo Design study NCS > Needle EMG
o Report exam with clinical impression in mind
Electrodiagnostic Studies
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• Knowledge of peripheral nervous system anatomy key to optimal localization (main role of EDX)
• Knowledge of nerve and muscle physiologyimportant to determine type and timing of lesion
Nerve Anatomy & Physiology
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Peripheral Nervous System
31 pairs:8 cervical12 thoracic5 lumbar5 sacral 1 coccygeal
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Peripheral Nervous System
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• Axonal membrane is electrically active with restingmembrane potential
• Depolarization leads to an action potential propagating in both directions away from sight of depolarization
• We record only what we stimulate and capture – importance of correct stimulation and recording sites
Nerve & Muscle Physiology
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Combined Action Potentials (AP)
Combined motor nerve AP (CMAP)Mixed nerve AP (MNAP)Sensory nerve AP (SNAP)
Negative deflection is upwardsPositive defection is downwards
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Combined AP - Amplitude
• Amplitudeo Usually baseline-peak but also peak-peako Reflective of
• SNAP and MNAP: all nerve fibers stimulated and captured• CMAP: all nerve fibers stimulated and muscle fibers stimulated and
captured
CMAP - in mVSNAP & MNAP - in μV
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Combined AP - Amplitude• Amplitude reduction
o SNAP & MNAP: loss of nerve fiberso CMAP: loss of motor nerve or muscle fibers or neuromuscular
junction (NMJ) block• Lesion location (after Wallerian degeneration)
Motor neuron
Cord Roots
Motor Root
Sensory Root
NMJ
Muscle
Sensory End Organ
Lesions proximal to the DRG not measured by the SNAP
DRG
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Combined AP - Latency
• Latency (time)o Peak: Stimulus to first negative peako Onset: Stimulus to initial negative deflection
• Reflective of fastest conducting fibers• Used for calculation of conduction velocity
In milliseconds (ms)
Conduction velocity (m/s) = Distance/Latency
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CV - CMAP vs SNAP
NMJ
Sensory End Organ
A. Stimulate B. Record
SNAP & MNAP: CV=Distance stimulus to recording/onset latency
CMAP: Onset latency includes NMJ and muscle conduction
A. StimulateRecord
NMJ
CMAP: CV=Distance A-B/latency A-B
A. StimulateRecord
B. Stimulate
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Combined AP - Duration
• Durationo Negative peak onset to first baseline crossing (i.e. negative
peak duration) o Marker of synchrony of action potentialso SNAP duration typically 1.5 ms
In milliseconds (ms)
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• Axonal loss (NCS)o Reduction in amplitude
• CMAP 3–5 days• SNAP 6-10 days
o Preserved latency and CV• Mild reduction with loss of fastest conducting fibers (not within
demyelinating range)• Axonal loss (EMG)
o Acute: reduced recruitment patterno Subacute: appearance of membrane irritabilityo Chronic (months): large and long MUAP
EDX Changes in NMD Disorders
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• Demyelination (NCS)o Reduced CV <75% LLN
• ~ 35 m/s UE and 30 m/s LEo Prolonged latency >130% ULNo Preserved amplitude except for
• Conduction block
EDX Changes in NMD Disorders
Stimulate ARecord Stimulate B
BA
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• Temporal dispersion (Increased CMAP duration)EDX Changes in NMD Disorders
Stimulate ARecord Stimulate B
BA
Both conduction block and temporal dispersion are markers of acquireddemyelinationWithin few days from lesion onset may be due to pseudo-conduction block (repeat study ~1 week)
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• Demyelination (EMG) o Should only show reduced recruitment pattern o Most lesions have some axonal damage as well
• Late responseso Important to look for lesions proximal to the usual sites of
stimulation in motor studieso Evaluate the entire length of the nerve
• F waves: motor nerve• H reflex: sensory and motor nerves
EDX Changes in NMD Disorders
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APPROACH TO EDX: CLINICAL LOCALIZATION IN THE PNS
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• Sensory▫ Roots (dorsal)▫ Dorsal sensory ganglion▫ Nerve (sensory fiber)
• Motor▫ Motor neuron (anterior horn)▫ Roots (ventral)▫ Nerve (motor fiber)▫ Neuromuscular junction▫ Muscle
NMD Presentation
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• Sensory▫ Roots (dorsal)▫ Dorsal sensory ganglion▫ Nerve (sensory fiber)
• Motor▫ Motor neuron (anterior horn)▫ Roots (ventral)▫ Nerve (motor fiber)▫ Neuromuscular junction▫ Muscle
NMD Presentation Sensorimotor
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• Radiculopathyo Disco Clinical
• Radicular pain• Weakness in myotome, sensory change in dermatome
• Polyradiculopathyo Diffuse meningeal processo Clinical
• Diffuse pain and motor/sensory change• May involve cranial nerves and cognition
NMD Presentation Sensorimotor
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• Radiculopathy/polyradiculopathy
NMD Presentation Sensorimotor
NCS/EMG:- Normal SNAP (lesion central to DRG)- Possible low CMAP amplitude (depending on level)
- Denervation in muscles sharing myotome (s)- Denervation of parapsinal muscles
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• Mononeuropathieso Initial demyelinating: “Compressive”
• Median at wrist “carpal tunnel syndrome”• Ulnar at elbow “cubital tunnel syndrome” • Peroneal (fibular) neuropathy at fibular head
o Axonal• Traumatic
oClinical• Weakness and sensory change in distribution of a single
nerve
NMD Presentation Sensorimotor
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• Mononeuropathies
NMD Presentation Sensorimotor
NCS/EMG:- Focal demyelination and/or low SNAP and CMAP amplitude in single nerve territory
-Denervation in muscles innervated by the nerve (if axonal)
- Exact localization only possible with demonstration of focal demyelination
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• Multiple mononeuropathieso Demyelinating and/or axonal
• Vasculitis “mononeuritis multiplex”• Infiltration (lymphoma)• Infection (Lyme, leprosy)• Granulomatous (sarcoid)• CIDP variants• Hereditary (HNPP)
oClinical• Weakness and sensory change in distribution of multiple
individual nerves or asymmetric polyneuropathy (due to lesion confluence)
NMD Presentation Sensorimotor
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• Generalized polyneuropathyo Distal symmetric length dependent sensory > motor
• Diabetic• Toxic (alcohol and drugs)
o Non-length dependent sensory < or = motor• Autoimmune (GBS or CIDP)• Hereditary
o Clinical• Diffuse weakness and sensory changes• Look for signs of chronicity (pes cavus and hammertoes)• Family history important (most AD)
NMD Presentation Sensorimotor
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• Generalized polyneuropathy
NMD Presentation Sensorimotor
NCS/EMG:-Study enough nerves and muscles to establish pattern and symmetry- Determine axonal vs demyelinating- If demyelinating determine hereditary vs acquired- Consider proximal stimulation and late responses if suspicion for demyelinating
NCS and EMG are normal in small fiber sensory neuropathy
Cold nerves are slow so pay attention to limb temperature and warm them up
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• Plexopathieso Brachial
• Brachial plexitis “Parsonage-Turner syndrome”• Radiation (may have myokymia)
o Lumbosacral• Radiation• Retroperitoneal process
o Clinical• May start with shoulder or hip pain• Diffuse weakness and sensory changes in single limb
NMD Presentation Sensorimotor
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• Plexopathies
NMD Presentation Sensorimotor
NCS/EMG:-Expanded study of nerve and muscle in involved limb- Consider side to side comparison-Myokymia on exam and EMG suggestive of radiation
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• Sensory▫ Roots (dorsal)▫ Dorsal sensory ganglion▫ Nerve (sensory fibers)
• Motor▫ Motor neuron (anterior horn)▫ Roots (ventral)▫ Nerve (motor fiber)▫ Neuromuscular junction▫ Muscle
NMD Presentation Sensory
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• Ganglionopathyo Sjogren’s syndromeo Drugs (B6 toxicity, thalidomide)o Paraneoplastic (anti-Hu)o Autoimmune
o Clinical• Non-length dependent, focal or generalized• All sensory modalities with severe sensory ataxia
NMD Presentation Sensory
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• Ganglionopathy
NMD Presentation Sensory
NCS/EMG - Non length dependent or asymmetric loss of SNAP amplitude- Normal CMAP and EMG studies
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• Sensory▫ Roots (dorsal)▫ Dorsal sensory ganglion▫ Nerve (sensory fiber)
• Motor▫ Motor neuron (anterior horn)▫ Roots (ventral)▫ Nerve (motor fiber)▫ Neuromuscular junction▫ Muscle
NMD Presentation Motor
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• Motor neuron diseaseo ALS o Spinal muscular atrophy (SMA)o Infections (polio, WNV)
o Clinical• Muscle weakness and atrophy (regional, diffuse)• Bulbar and/or respiratory symptoms• Cramps and fasciculations• Upper motor neuron symptoms and signs in ALS
NMD Presentation Motor
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• Motor neuron disease
NMD Presentation Motor
NCS/EMG - Normal SNAP amplitudes (usually)- Reduced CMAP amplitude (usually asymmetric) with normal latency and CV- Important to consider proximal stimulation and late responses if no upper motor neuron findings
- Denervation changes in muscles sharing myotome(s) and also bulbar/cranial
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• Neuropathy (motor fibers)o Demyelinating (multifocal mononeuropathy; MMN)o Axonal (GBS variant)o Hereditary
o Clinical• Muscle weakness and possible atrophy• Distribution of multiple nerves or generalized
distal>proximal (not myotomal)
NMD Presentation Motor
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• Neuropathy (motor fibers)
NMD Presentation Motor
NCS/EMG Similar to MND except for- Demyelination in MMN - Denervation in distribution of nerves or distal>proximal rather than myotomal
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• Neuromuscular junction disordero Pre-synaptic
• Lambert Eaton (LEMS)• Botulism
o Post-synaptic• Myasthenia gravis
o Clinical• Fluctuating and fatigable muscle weakness• Ocular and bulbar involvement• LEMS and botulism with autonomic symptoms
NMD Presentation Motor
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• Neuromuscular junction disorder
NMD Presentation Motor
NCS/EMG - Slow repetitive nerve stimulation (RNS)- Fast RNS for presynaptic (or check for abnormal post 10-second exercise facilitation)
- Routine NCS and needle EMG to exclude underlying muscle denervation/reinnervation or myopathy
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• Myopathyo Proximal > distal
• Endocrine and Toxic• Polymyositis and dermatomyositis
o Distal > or = proximal• Myotonic dystrophy type 1 and other inherited
myopathies• Inclusion body myositis
o Diffuse• ICU myopathy• Periodic paralysis
NMD Presentation Motor
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2019
• Myopathyo Clinical
• Progressive muscle weakness and atrophy• Some episodic/periodic -/+ triggers• Some with myotonia
NMD Presentation Motor
NCS/EMG - Normal SNAP- Normal CMAP (unless distal myopathy)
- Myopathic units- Membrane irritability and myotonic discharges in some (inflammatory, toxic,…)
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2019
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2019
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