basics of molecular gerontology – aging theories

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Manifestation of Novel Social Challenges of the European Union in the Teaching Material of Medical Biotechnology Masters Programmes at the University of Pcs and at the University of Debrecen Identification number: TMOP-4.1.2-08/1/A-2009-0011. - PowerPoint PPT Presentation

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Manifestation of Novel Social Challenges of the European Unionin the Teaching Material ofMedical Biotechnology Masters Programmesat the University of Pcs and at the University of DebrecenIdentification number: TMOP-4.1.2-08/1/A-2009-0011Basics of molecular gerontology Aging theoriesKrisztin KvellMolecular and Clinical Basics of Gerontology Lecture 28Manifestation of Novel Social Challenges of the European Unionin the Teaching Material ofMedical Biotechnology Masters Programmesat the University of Pcs and at the University of DebrecenIdentification number: TMOP-4.1.2-08/1/A-2009-0011Average lifespan:Age at which 50% of cohort has died (much controled by environment)Maximum life-span: Essentially the age of the last survivor (much controlled by genetics)What is lifespan?TMOP-4.1.2-08/1/A-2009-0011y = 5.58x0.146r2 = 0.340tmax (yrs)10001001011.E+001.E+021.E+041.E+061.E+081.E+10M (g)Correlation between body mass and lifespan

TMOP-4.1.2-08/1/A-2009-00114Three major branches:Biometric branch:complex, difficult to perform interventionInductive branch:few, simple, universal mechanismsRegeneration and renewal branch:focus on replacement and remodelingApproaches in senescence researchTMOP-4.1.2-08/1/A-2009-0011Adaptive concept:Aging evolved to cleanse the population from old, non-reproductive consumersNon-adaptive concept:Aging is due to greater weight on early survival / reproduction rather than vigor at later agesAugust Weismannsconcepts on agingTMOP-4.1.2-08/1/A-2009-0011Denham HarmanGeorge SacherNathan ShockBernard StrehlerAlex Comfort

John Maynard SmithZhores MedvedevPaola TimirasLoenard HayflickGeorge Martin

Pioneers of aging research includeTMOP-4.1.2-08/1/A-2009-0011The family tree of aging theoriesGeneral formulationsIndividual mechanismsStress-induced premature senescence (SIPS) Damage theoriesEvolutionary theories of living and longevityBeyond molecular biology of agingProgrammed theoriesAging theoriesTMOP-4.1.2-08/1/A-2009-00118Evolutionary theoriesProgrammed theoriesDamage theoriesGeneral formulationsIndividual mechanismsStress induced premature senescence (SIPS)Beyond molecular biology of aging

Major groups of aging theoriesTMOP-4.1.2-08/1/A-2009-0011Major groups of aging theories,in depth IEvolutionary theories ofliving and longevityProgrammed death theoryMutation accumulation theoryThe antagonistic pleiotropy theoryTMOP-4.1.2-08/1/A-2009-0011Major groups of aging theories,in depth IIProgrammed theoriesImmune system compromiseNeurological degenerationHormonal theory of agingThe genetic clock(programmed epigenomic theory)TMOP-4.1.2-08/1/A-2009-0011Major groups of aging theories,in depth IIIGeneral formulationsMisrepair accumulation theoryWaste accumulation theory of agingError catastrophe theoryWear and tear theoryTMOP-4.1.2-08/1/A-2009-0011Major groups of aging theories,in depth IVIndividual mechanismsChronic or excess inflammationMitochondrial damageMethylationGlycationOxidative damage-Free radicalSomatic DNA damage/mutationTMOP-4.1.2-08/1/A-2009-0011Major groups of aging theories,in depth VBeyond molecular biology of agingThermodynamics of agingReliability theoryRate of living theoryTMOP-4.1.2-08/1/A-2009-0011Trade-off between fertility and longevity genesOptimal conditions: invest in growth and reproductionRestrictive conditions: shut off reproduction, invest in somatic maintenance and survival

Theory of antagonistic pleitropyTMOP-4.1.2-08/1/A-2009-0011AsthmaRenal diseaseDiabetesCardiac diseaseArthritisCancerCorrelation ofmorbidity rates and ageMorbidity rateincrease peaksat 60y,deceleratesafter 80y,remains linearafter 110y

0204060801001030500204060% with diseaseAge (years)SinusitisTMOP-4.1.2-08/1/A-2009-001116

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