basic pharmacology hamza
Post on 13-Jul-2015
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General Pharmacological TermsHamza HemalRadiant Pharmaceuticals Ltd. Hamza
Brand NameTrade nameGiven by the Manufacturer companyTo distinguish products from each other.Example:ACOS (Radiant)ZIMAX ( Square)
Generic NameOfficial medical name for the active ingredient of the medicine.Example:AzithromycinEsomeprazoleHamza
APIActive Pharmaceutical IngredientAny component that provides pharmacological activity Hamza
Dosage Form A dosage form is the physical form in which a drug is produced and dispensed.Example: Tablet,Capsule,PFS (Powder for Suspension) InjectionHamza
StrengthAmount of the active ingredient is present in each dosage.Example:500mg Tablet200mg/5ml PFSHamza
Brand NameGeneric NameStrengthDosage FormHamza
COGSCost of Goods soldRaw material + Packaging Material + Utility cost + Per head costTPTrade PriceCOGS + ProfitInvoice PriceTP+ VATMRPMaximum Retail PriceTP+ VAT+ Chemist ProfitHamza
Pharmacodynamicswhat the drug does to the bodyPharmacokineticswhat the body does to the drugHamza
BioavailabilityAmount of drug that present in blood after administration.
INTRAVENOUS Route- Bioavaiability 100%Hamza
Peak Plasma concentration, CmaxThe maximum plasma concentration of the drug achieved in blood after a doseTmaxThe time when the maximum plasma concentration (Cmax) is reached.
Plasma half life/ Elimination Half Life, T1/2Time necessary for the drug to be reduced to half of its plasma concentration
01 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17
Area Under the Curve (AUC)The area under the plot of plasma concentration of drug against time after drug administration.
MECMinimum Effective ConcentrationThe smallest concentration of a drug that will induce the desired pharmacological effectMICMinimum inhibitory concentration MIC is defined as the minimum concentration of antibiotic which will inhibit the growth of the microorganismHamza
First pass effect/ First pass metabolismThe removal of a drug by the liver, before the drug has become available for use, is called the first pass effect.
Tendency of a drug to combine with receptorEfficacyPower or capacity to produce a desired effectPotencyAmount of drug required to produce a particular responseAffinity:Hamza
Therapeutic doseThe dose that may be required to produce a desired effect.Sub Therapeutic doseIndicating a dosage of a drug, less than the amount required for a therapeutic effect. Hamza
BactericidalAntibiotic that kills the bacteriaBacteriostaticAntibiotics that inhibit the growth or reproduction of bacteria