basic pharmacology hamza

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General Pharmacological TermsHamza HemalRadiant Pharmaceuticals Ltd. Hamza

Brand NameTrade nameGiven by the Manufacturer companyTo distinguish products from each other.Example:ACOS (Radiant)ZIMAX ( Square)

Generic NameOfficial medical name for the active ingredient of the medicine.Example:AzithromycinEsomeprazoleHamza

APIActive Pharmaceutical IngredientAny component that provides pharmacological activity Hamza

Dosage Form A dosage form is the physical form in which a drug is produced and dispensed.Example: Tablet,Capsule,PFS (Powder for Suspension) InjectionHamza

StrengthAmount of the active ingredient is present in each dosage.Example:500mg Tablet200mg/5ml PFSHamza

Brand NameGeneric NameStrengthDosage FormHamza

COGSCost of Goods soldRaw material + Packaging Material + Utility cost + Per head costTPTrade PriceCOGS + ProfitInvoice PriceTP+ VATMRPMaximum Retail PriceTP+ VAT+ Chemist ProfitHamza

Pharmacodynamicswhat the drug does to the bodyPharmacokineticswhat the body does to the drugHamza

BioavailabilityAmount of drug that present in blood after administration.

INTRAVENOUS Route- Bioavaiability 100%Hamza

Peak Plasma concentration, CmaxThe maximum plasma concentration of the drug achieved in blood after a doseTmaxThe time when the maximum plasma concentration (Cmax) is reached.

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Plasma half life/ Elimination Half Life, T1/2Time necessary for the drug to be reduced to half of its plasma concentration

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Area Under the Curve (AUC)The area under the plot of plasma concentration of drug against time after drug administration.

MECMinimum Effective ConcentrationThe smallest concentration of a drug that will induce the desired pharmacological effectMICMinimum inhibitory concentration MIC is defined as the minimum concentration of antibiotic which will inhibit the growth of the microorganismHamza

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First pass effect/ First pass metabolismThe removal of a drug by the liver, before the drug has become available for use, is called the first pass effect.

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Tendency of a drug to combine with receptorEfficacyPower or capacity to produce a desired effectPotencyAmount of drug required to produce a particular responseAffinity:Hamza

Therapeutic doseThe dose that may be required to produce a desired effect.Sub Therapeutic doseIndicating a dosage of a drug, less than the amount required for a therapeutic effect. Hamza

BactericidalAntibiotic that kills the bacteriaBacteriostaticAntibiotics that inhibit the growth or reproduction of bacteria

HamzaThe End...Hamza