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Tiu lun

GVHD: Nguyn Ngc Hnh HVTH: Nguyn Th M Nguyn Phng Quyn Trn Anh V

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NI DUNG1 2 Gii thiu chung v ung th Tm hiu mt s ung th thng gp

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Tng quan v bnh i tho ngiu tr ung th bng tho dc

2

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1.Khi nim v ung thBnh ung th xy ra khi cc t bo phn chia bt thngCc t bo bt thng c th xm nhp vo cc m ln cn, hoc xa hn ca c th, bng cch i vo mu hoc bch huyt. Trn thc t, t ung th bt ngun t ting latinh Cancri, ngha l con cua Ngi xa ngh rng: Cc mch mu phnh to quanh khi u ln trng nh cc chn v cng cua.

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T bo ung th c m t nh sau

4

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2.Chc nng ca gan trong c th To ra nng lng mt cch nhanh chng khi cn thit Sn xut protein mi cho c th Ngn nga s thiu ht nng lng cho c th Bng cch: d tr mt s vitamin, khong cht v ng iu ha s vn chuyn m d tr

Gip ch cho s tiu ha bng cch to ra mt Kim sot vic sn xut v bi tit cholesterol

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Chc nng ca gan trong c th Trung ha v loi b cc cht c Chuyn ha ru Kim sot v duy tr nng thch hp ca nhiu ha cht v nng thuc trong mu Lc mu v thi cc sn phm cn vo trong mt

Duy tr s cn bng ni tit t C vai tr mt c quan to mu thai nhi

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Chc nng ca gan trong c th

Gip c th chng li s nhim trng Bng cch: to ra cc yu t min dch v loi b cc vi khun lu thng trong mu Ti to li m tn thng ca chnh n D tr st

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LOGO Ung th gan l mt loi ung th ng tiu ha thng gp T l pht bnh cao chu v chu Phi, tui trung nin v nam gi

Tm hiu v ung th gan

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LOGO c im lm sn, au vng gan, gan to cng, km theo st, vng da, ri lon tiu ha v xut huyt

Ung th thng chia ra 3 thi k K 1: Khng c triu chng r rt, biu hin sm nht l ri lon tiu ha K 2: Nng hn k 1, nhng cha c Tri chng c trng K 3: C th suy kit, vng da, bng nc, c di cn. Thc t lm sn, ung th gan g 1 v 2 rt kh pht hin Trn 90% c pht hin l giai on 3, v vy bnh ch ko di t 3-4 thng

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Cu to l gan trong c th

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LOGO Ri ro a ti ung th gan: nguyn nhn chnh xc cha bit r, tuy nhin c mt s ri ro c chng minh

Vim gan kinh nin Do cc loi vrut gy ra nh Siu vi B,C

X cng gan Do ru,ha cht c hiV mt s vrut

Ung qu nhiu ru s a ti Cu trc m bo NG N Gan b thay i UNG THGAN ?

Ha cht aflatoxin Mc bnh tiu do mt vi loi nm ng , bnh ng mc sn xut, thng dn mt, ht thuc c trong bp, u, l cc loi ht b mc

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3.Tm hiu v cu to v chc nng ca vChc nng: To sa To hoomon Estrogen To s thm m

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Tm hiu v ung th v Ung th v l cn bnh ph bin ph n

Nguy c b ung th v tng len theo tng tui Hu ht ch em ph n mt ln trong i u c nguy c mc phi ( lnh tnh hay c tnh) Cn bnh ny rt nguy him, nhng nu pht hin sm th hon ton c th iu tr c

Hin nay t l ung th v nc ta tng rt ng k, v t l t vong rt cao do pht hin tr V vy chng ta cn quan tm,v kim tra nh k 13

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Du hiu nhn bit sm v ung th v1. Xut hin cc u y l du hiu ph bin ca ung th v Nu cc u cng v t di chuyn th kh nng ung th v cao hn cc u mm, d di chuyn xung quanh Ngoi l: Cc u ny thng xut hin v bin mt trong mi chu k kinh nguyt. N s bin mt sau khi bn mn kinh bi u nang v c gy ra bi nng estrogen cao.14

LOGO 2. B phn ngc to ln Nu nhn thy ngc b sng, v nng n th c th l ung th v Hin tng ny thng thng xy ra mt bn ngc nn bn rt d pht hin Ngoi l: Mang thai hoc b tch nc do n thc phm qu mn cng khin ngc ca bn nng n hn. Nhng trng hp ny s xy ra c hai bu ngc.

Du hiu nhn bit sm v ung th v

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Du hiu nhn bit sm ca ung th v3. Vng da ngc thay i Nu vng da trn v hoc nh hoa chuyn sang mu , dy ln hoc c vy th rt c th l du hiu ca bnh ung th v. c bit l khi vng da ny b lu ngy, m khng bin mt. Ngoi l: Vng da ngc c th b d ng do cc ha cht trong qun o, x phng, sa tm Nhng loi d ng ny s bin mt sau mt vi ngy ngng s dng.16

LOGO Du

hiu nhn bit sm v ung th v

4. au v hoc nm v: Nu bn b au ngc hoc nh hoa trong thi gian di, hy kim tra ngay vi bc s chuyn khoa v rt c th bn b ung th v. Ngoi l: U nang v cng c th gy ra au v c bit vi nhng bn gi ang tui ln. Nhng hin tng ny s ko di khng lu.17

Du LOGO hiu nhn bit sm v ung th 5. Mt trong hai u nh hoa b tht vo trong

v

Nh hoa b tht vo trong c th l triu chng ca 1 khi u nm ngay pha sau (do cc t bo ung th ko lp biu b vo pha trong). Trong trng hp c u, nh hoa b tht vo trong s tr nn cng. Ngay c khi dng tay, bnh nhn cng khng th ko nh hoa ny ra c.

6. Xut hin cht lng trn nh hoa Bt c cht lng no xut hin trn u nh hoa (khng phi sa m) u cn kim tra ngay c bit l khi cht lng c mu hoc nu . Nhng cht lng ny c th l triu chng ca bnh ung th v. Cht lng ny c th c kim tra bng knh hin vi pht hin xem c cha cc t bo ung th hay khng. Ngoi l: Trong trng hp bn b nhim trng hoc chn thng cng khin u nh hoa tit dch. Nu cht lng mu sa hoc xanh l cy th khng chc l du hiu ca ung th.18

Du hiu nhn bit sm v ung th v LOGO7. C hch di nch Nhng khi u v c th ko thm hch sng v au di cnh tay. N cng c th l du hiu u tin bo hiu bnh tt. Hy n ngay bnh vin c kim tra. Ngoi l: Khi bn b nhim trng nhng b phn xung quanh khu vc ngc cng c th gy ra nhng cc hch nh di nch. Trng hp ny khng qu nghim trng

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TNG QUAN V BNH I THO NG i tho ng : cn gi l Bnh tiu ng, l bnh ngy cng ph bin trong x hi, gy ra nhiu bin chng nghim trng. Chn on i tho ng khi lng ng (Glucose) trong mu tng cao. i tho ng xy ra khi c th khng sn xut insulin, hoc c th gim p ng vi tc dng ca insulin ( khng vi insulin). Insulin, c sn xut t tuyn tu , mt tuyn nm sau d dy, gip cho cc t bo ca c th s dng ng t mu ca bn.Glucose l mt ngun nng lng cho cc t bo. Glucose c to ra t thc n (tinh bt) v thc ung .

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TNG QUAN V BNH I THO NGKhi b i tho ng , nng ng trong mu tng cao. iu ny c th dn n nhng vn sc khe nghim trng. l l do ti sao h thp lng ng trong mu l cha kha qun l bnh i tho ng. Gi lng ng trong mu n nh s gip gim nguy c b cc bin chng. ng huyt cao c th gy tn hi cho c quan v tng nguy c b bnh tim. C ba type i tho ng chnh :

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TNG QUAN V BNH I THO NGBnh i tho ng type 1: Type i tho ng ny thng nh hng n tr em, nhng cng c th xy ra ngi ln. Trong i tho ng type 1, c th khng th sn xut insulin. L do,h thng min dch ca c th do nhm ln tn cng cc t bo trong tuyn tu lm cho t bo tuyn ty khng cn sn xut c insulin. Khi khng c Insulin, t bo s khng s dng c ng glucose, do Glucose trong mu s tng rt cao. Bnh nhn cn c tim insulin sng.

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LOGO TNG QUAN V BNH I THO NG

i tho ng type 2: y l ng i tho ng thng gp nht. Thng thng, vi bnh i tho ng type 2, trong c th vn cn sn xut insulin, nhng cc t bo khng th s dng n. iu ny c gi l khng insulin. Theo thi gian, ng huyt s tng cao trong mu. Bo ph v t vn ng lm tng nguy c pht trin bnh i ng type 2.

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LOGO TNG QUAN V BNH I THO NG i tho ng thai k: Tin i tho ng: Hng triu ngi c y l dng i tho ng xy kh nng b tin-i ra mt s ph n mang thai v tho ng. Tin-i chm dt sau khi sanh. C th tho ng khi ng gy ra cc vn nghim trong huyt trong mu cao cho m v thai nhi trong qu hn mc lng trnh mang thai. ng trong mu bnh thng, nhng khng Ph n b i tho ng thai cao c gi l k c nhiu kh nng pht trin bnh i tho ng. thnh bnh i tho ng type 2 sau ny.

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LOGO CC BiN CHNG CA I THO NG Nu khng c iu tr tt, i tho ng gy ra nhiu bin chng c th lm bnh nhn tn ph, thm ch t vong. Bin chng cp tnh: Do ng huyt tng cao, c th gy hn m nhim cetone hay hn m do tng p lc thm thu. Nu khng c iu tr kp thi c th dn n t vong. H ng huyt l bin chng cp tnh, thng do qu liu thuc ,insulin gy nn. C th do bnh nhn nhn i, king khem qu mc hay do ung nhiu ru. Nu khng c iu tr kp thi c th hn m v thm ch t vong.

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LOGO CC BiN CHNG CA I THO NG Bin chng tim mch: i tho ng lm tng nguy c b nhi mu c tim, t qu, tai bin mch mu no v mch mu ngoi bin a n on chi. Bin chng mt : Bnh l vng mc do i tho ng l nguyn nhn hng u gy m lo, gim th lc. Bin chng thn: l bin chng mn tnh thng gp ca i tho ng, gy bnh thn giai on cui, suy thn. iu tr cn chy thn nhn to hay thm phn phc mc duy tr cuc sng. Bin chng thn kinh: Bin chng thn kinh ngoi bin do i tho ng gy mt cm gic chn, tay hay d cm, t, gy au nhcl nguy c ca nhim trng chn a n on chi.

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Cc nh nghin cu City of Hope Cancer Research v Trung tm iu tr Ung th Duarte, California, pht hin cht ellagitannins trong tri lu c ch mt enzym gip c th tit oestrogen, hcmn gy ra phn ln ung th v. Dc liu nh cht c ch aromatase c dng cho ph n hu mn kinh b ung th v, trong khi hp cht trong tri lu cng c hiu qu tng t. TS Shiuan Chan, mt trong nhng nh nghin cu, ni: Chng ti ngc nhin trc pht hin. 27

DA LOGO

CN NGUYN LIU LM THUC TR UNG TH

Tn khoa hc l Catharanthus Roseus (L.) G. Don Apocynaceae. L loi cy c cao khong 40 60 cm. L hnh trng mc i, mt trn ca l mu xanh m, mt di xanh nht, gn l mu trng ng chy gia chia phin l thnh 2 phn bng nhau. Thn mm t nhiu cnh Hoa c 5 cnh mu pht hng hoc mu trng. Qu c 2 i hi choi ra, thng tp trung phn ngn. Cy c ngun gc Madagasca (chu Phi

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CNG DNG CHA BNH

TY GIUN CHA ST SN DA

LC MU

CY DA CN

TIU NG LI TIU,HUYTP

BNH BCH CU

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CN NGUYN LIU LM THUC TR UNG TH

Hot cht ca da cn l nhng ancaloit c nhn indol c trong tt c cc b phn ca cy, nhiu nht trong r v l.

THNH PHN HA HC SC T FLAVONOID, ANTHROCYANIC

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Nm 1958, Noble v cng s chit c mt alkaloid t l da cn l Vinblastin. Nm 1962,Svoboda v cng s cng tm thm mt alkaloid na l Vincristin. Dng 2 alkaloid ny lm thuc tr ung th di dng mui sunfat

Qu trnh iu ch hai alkaloid ny kh phc tp gi thnh t. Hin nay, tm cch sinh tng hp hoc bn tng hp 2 alkaloid ny gim gi thnh thuc

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VINBLASTIN V VINCRISTINTc dng dc l Nhng cht c ch mnh s phn bo. Cc alkaloid ny lin kt c hiu vi Tubulin, l protein ng vi th thoi phn bo, phong b s to thnh cc vi ng ny v gy ngng phn chia t bo pha gia. nng cao, thuc dit c t bo, cn nng thp lm ngng phn chia t bo. Ngoi ra cao da cn cn c tc dng h huyt p, ngn cn s pht trin ca thai trn ng vt mang thai v khng mt s chng nm gy bnh.

Vin Vinca cha alcaloid ton phn ca thn, l lm thuc cha bnh cao huyt p. R Da cn lm nguyn liu chit xut ajmalicin. Vinblastin, vincristin di dng mui sulfat tim cha ung th, c bit l bnh bch cu.

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VINCRISTIN V VINBLASTIN

Vinblastin sulfat: L thuc dng trong liu php phi hp iu tr ung th biu m tinh hon,bnh Hodgkin, ung th nhau, ung th biu m da u, ung th biu m thn, u nguyn bo thn kinh, ung th v, ung th c t cung v ung th dng nm da. N cng c dng cha bnh sarcom lympho, sarcom chy mu Kaposi v sarcom t bo li.

Vincristin sulfat: L mt trong nhng thuc chng ung th c dng rng ri nht, c bit c ch i vi cc bnh ung th mu, thng c dng lm thuyn gim bnh bch cu lympho cp. N c dng trong liu php phi hp thuc,tr bnh Hodgkin, u bch huyt khng - Hodgkin, ung th biu m phi, u Wilm, bch cu ty bo mn (t cp tnh), sarcom Ewing v sarcom c vn.

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MT S BI THUC

1Tng huyt p: 20g thn l da cn kh sao vng v 20g l du, sc ly nc, chia ung t 2 3 ln mi ngy.

2Ung th mu, vim i trng: ly t 15 20g thn l da cn kh sao vng, sc, chia t 2 3 ln ung trong ngy.

3Rong kinh: ly t 20 30g da cn sao vng (ton cy c c hoa v r), sc ly nc, ung lin tc t 3 5 ngy

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NM LIM XANH QUNG NAMNm Lim xanh - Linh Chi: thuc h Nm lim - Ganodermataceae. Nm Lim xanh cn c nhng tn khc nh Tin tho, Nm trng th, Vn nin nhung.

Nm mt nm hoc nhiu nm c th c dng m vi mt vi cung di nh lch v pha bn. Cc tng ng trn. Lp v trn ca m v cung c mu sn bng hoc vng, xm hay en. Bo t hnh trng, c hai lp v (lp ngoi nhn, lp trong sn si) vi mt u t.

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Thnh phn ha hc12-13% H2O 13-14% Ligin 0.14-0.16%% Steroid 1.9-2% Germanium Cht boAcid amin Saponin, protein

54-56% Glulose

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TINH V- TC DNG1V nht, tnh m, tc dng bi b, cng trng

2 3

Cht Germanium gip kh quyt lu thngLng polysacharit cao lm tng s min dch ca c th, lm mnh gan, c lp v dit t bo ung th

4 5 1

Acid Ganodermic chng d ng, chng vim

Cht Lergothioneine, mt cht chng oxy ho ch tm thy trong nm Lim xanh.

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Cng dng tr bnhSuy nhc thn kinh, chng mt, mt ng.

A

Vim kh qun mn tnh, bnh ho lao do nhim bi silic

BC

H nguy c tng trng m trong mu v ung th

Vim gan, huyp p cao, au d dy, chn n

DThp khp, thng phong

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NM LIM XANHTrong nm lim xanh c cc cht kim ch t bo ung th, cc ha cht l: - Letinan: n p s tng trng ca cc ung th - Aromatase inhibitor: n p cht men aromatase, cht ny bin androgen (kch thch t dng) tr thnh estrogen (kch thch t m) Lm h kch thch t m s lm gim nguy c gy ra ung th tin lit tuyn (prostate) v mt vi loi ung th v. - Aromatase inhibitor c rt nhiu trong nm Lim xanh Crimini v Portobello. - Alpha reductase (mt loi men): Cht ny ngn chn s bin th ca testosterone thnh dihydrotestosterone (DHT) mt loi kch thch t khi xng ra bnh ung th tin lit tuyn (prostate).

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CNG DNG TR UNG TH

H tr tr nhm bnh ung th h tiu ha: ung th ming, ung th li, ung th vm hng, ung th thc qun, ung th d dy, ung th rut, ung th i trng. iu tr nhm bnh ung th h ni tit v cha cc bnh ung th ni tng:c hiu qu tr bnh ung th gan, ung th phi, ung th thn, ung th ty, ung th tuyn gip, ung th no.

iu tr ung th nhm cc bnh ung th h sinh dc: cha tr cc bnh ung th c t cung, ung th v, ung th bung trng, ung th tuyn tin lit, ung th dng vt, ung th tinh hon.

Vin Dc liu Trung ng nghin cu v cng nhn v hiu qu cha tr bnh gan.

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CY DIP H CHU

C tn khoa hc l Phyllanthus Urinaria L, thuc h thu du Euphorbiaceae. Cn c tn l dip h chu ngt, cam kim, kim vn, dip he thi, lo nha chu, trn chu tho... Cy ch cao t 30-60cm, thn nhn, mc thng ng, l mc so le, phin l thon nh di t 5-15mm, rng t 25mm. Cy mc hng nm khu vc nhit i, l loi c mc hoang c th tm thy nhiu ni khp nc ta.

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CNG DNG CHA BNHThanh can lng huyt, li tiu, st trng, gii c Cha cc bnh ngoi da nh l lot, sng n, nga ngy...

NG Y

Tc dng kch thch tit dch mt, tng cng chc nng gan Cha vim bng quang, vng da ph, ri lon tiu ha, au bng kinh thuc gim au, kch thch ngon ming, iu ha kinh nguyt

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DIP H CHU V TY YFlavonoid

Tc dng cha vim gan

AlcaloidPhyllanthine

Hypophyllan -thine

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DIP H CHU V TY Y

Theo bo co ca 2 nh khoa hc Blumberg v Thiogarajan iu tr 37 trng hp vim gan siu vi B vi kt qu 22 trong s 37 ngi t c kt qu m tnh sau 30 ngy dng dip h chu. i vi vim gan siu vi, 50% yu t ly truyn ca virus vim gan B trong mu mt i sau 30 ngy s dng loi cy ny (vi liu 900 mg/ngy). Trong thi gian nghin cu, khng c bt k s tng tc no gia dip h chu vi cc thuc khc. Cng tip theo l nghin cu tin hnh nm 1995, cho thy cy thuc ny c tc dng li tiu, gim huyt p tm thu ngi khng b tiu ng v gim ng k ng huyt bnh nhn tiu ng.

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CY TRINH N HONG CUNG

-Tn khc: Nng l rng, Ti li l rng, Ty nam vn chu lan -Tn khoa hc: Crinum latifolium L., h Thu tin (Amaryllidaceae). -Phn b: Cy c ngun gc t n , sau trng cc nc vng ng Nam nh Thi Lan, Lo, Malaysia,pha Nam Trung Quc v Vit Nam. - B phn dng: L, thn cnh ca cy

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CY TRINH N HONG CUNGM t: L mt loi c, thn hnh nh c hnh ty to, ng knh 10-15cm, b l p nhau thnh mt thn gi di khong 10-15cm, c nhiu l mng ko di t 80100cm, rng 5-8cm, hai bn mp l ln sng Hoa mc thnh tn gm 6-18 hoa, trn mt cn hoa di 30-60cm. Cnh hoa mu trng c im mu tm . Qu gn hnh cu (t gp). Ma hoa qu: thng 8-9. T thn hnh mc rt nhiu c con c th tch ra trng ring d dng.

Thnh phn ha hc c khong 32 alkaloid Cao methanol ca r, thn v cao chit alcaloid ton phn ca cy ny u c tc dng c ch phn bo Mt s alcaloid c tc dng khng u nh: crinafolin, crinafolidin, lycorin, v epoxyambellin tc dng trn t bo T - lymphocyte v cn c tc dng khng khun nh hamayne (bulbispenmin, flavonoid, demethylcrinamin). Ngoi alcaloid cn c cc hp cht bay hi, aldehyd, acid hu c, terpen v glucan A, glucan B.

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CNG DNGau khp Ho, vim Ph qunU x tuyn tin lit

Mn nht Vim da

U t cung

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MT S BI THUC

1Cha u x t cung +L TNHC 20g. Sc ung ngy mt thang, chia 2-3 ln ung trong ngy. + L TNHC 20g,H kh tho 20g,r C xc 12g,Hong cm 8g, Cam tho dy 6g. Sc ung ngy mt thang, chia 2-3 ln ung trong ngy.

2Cha u x tuyn tin lit + L TNHC 20g. Sc ung ngy mt thang, chia 2-3 ln ung trong ngy. + L TNHC 20g, ht M (Xa tin t) 12g, Cam tho dy 6g. Sc ung ngy mt thang, chia 2-3 ln trong ngy.

3Cha au khp, chn thng t mu: + L TNHC lng va , xo nng, bng p ni au. + C TNHC 20g, dy au xng 20g, Huyt gic 20g, l Ci xay 20g, Cam tho dy 6g. Sc ung ngy mt thang.

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DY THA CANH- TR BNH TIU NG

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DY THA CANHDy tha canh, c tn khoa hc l gymnema sylvestre. Mt loi cy dy leo, thn g, c s dng ti n , Trung Quc hn 2.000 nm nay tr bnh nc tiu ngt nh mt Cn c tn Gurmar, c ngha l k hy dit ng. Dy tha canh c bit n v s dng rng ri ti nhiu nc nh n vi tn Diabeticin, M vi tn Sugarest, Singapore vi tn Glucos care, Nht Bn, Trung Quc, Australia

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HOT CHT CHNH

Tng tit insulin Tng hot lc insulin c ch hp thu glucose rut

Tng hot tnh men hp thu

Gymnemic acid

Gim cholesterol H lipid mu

TR BNH I THO NG

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UNG TH PHI

Khi thuc l mt nguy c quan trng nht v nguyn nhn ch yu nht dn n ung th phi , 80% s trng hp ung th phi Khc : cht raon (kh ga hot tnh), aming, thch tn, crom, ni-ken v nhim khng kh ung th phi t bo nh v khng phi t bo nh

LOGO 70 cht gy ung th gy rng tc, cao rng, ung th da, lot d dy, vy nn, c nhn mt, long xng, bin dng tinh trng... Ph n mang thai thng xuyn ht phi khi thuc s d sinh con nh cn

LOGO Chp phim : chp x-quang vng ngc hoc chp ct lp in ton (CT) Chn on : Xt nghim m , Chc dch mng phi, Ni soi ph qun, M lng ngc.

Triu chng Ho khng khi v ngy cng nng hn. Thng xuyn thy au ngc. Ho ra mu. Kh th, ngt mi, khn ging. Vim phi v vim ph qun ti i ti li. Ph n vng mt v c. Mt cm gic ngon ming hoc gim cn. Mt mi.

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UNG TH D DY

C th pht trin bt c phn no ca d dy, c th lan ra khp d dy v cc c quan khc : thc qun, phi, hch bch huyt v gan

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TRIU CHNG

Kh tiu hoc chng chua Mt ngon ming, c bit l i vi mn tht Triu chng mun au bng hay cm thy kh chu bng trn Bun nn v nn ma Tiu chy hay to bn y bng sau khi n Gim cn Yu v mt mi Xut huyt (nn ra mu ) Kh nut;

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NGUYN NHN

Nhim khun Helicobacter pylori : a s cc loi ung th d dy Cn cc bnh vim : teo mng lt do t min, chuyn sn rut (intestinal metaplasia), nguyn nhn di truyn l cc yu t tng nguy c gy bnh. Ch n ung khng c coi l nguyn nhn gy bnh. H. pylori l yu t nguy c chnh 6580% ca ung th d dy, nhng ch c 2% s ngi b nhim vi khun ny Khong 10% cc ca c lin quan n yu t di truyn.

T l mc bnh chim a s n ng, t l mc n ng/ph n l 3/1. Hoc mn estrogen c th gip bo v ph n khi cn bnh ny

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BNG CI XANH SP L

Bng ci xanh (broccoli)- sp l (cauliflower) thuc h ci. C hai cng thuc loi Brassica oleracea Bng ci xanh c hm lng cao vitamin C, cht x, cha nhiu cht dinh dng ,hm lng glucoraphanin rt ln Cha nhiu hot cht chng ung th mnh, chng hn nh diindolylmethane v selen Cc hot cht trong bng ci xanh sp l gim i rt nhiu nu c un si.

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LOGO Hai hot cht quan trng cha lu hunh c tm thy l Sulforaphane v Indol-3- Carbinol Tc dng khng xy ha, phng chng ung th d dy, ung th ng rut, ung th tuyn tin lit... Cc hot cht c tc dng phng chng v tiu dit vi khun Helicobacteria pylory (H.P) : nguyn nhn ch yu gy vim lot d dy, t trng. Tc dng tiu dit vi khun H.P rt cao cho d cc vi khun nm trong hay ngoi t bo nim mc d dy v ngay c khi chng khng li mt s khng sinh thng thng.

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Glucoraphanin

sulforaphane

3,3 '-Diindolylmethane(DIM)

indole-3-carbinol (I3C)

3,3 '-Diindolylmethane(DIM)rt tt cho hot ng h thng LOGO phn ng min dch Indole-3-carbinol (I3C), lm tng sa cha DNA trong cc t bo ngn chn s tng trng ca t bo ung th Hot cht sulforaphane to thnh t glucoraphanin l mt hot cht chng ung th ch yu, tr i tho ng, v khng sinh

LOGO QUY

TRNH CHUYN HA CA DIM

Thy phn ca glucobrassicin bi enzym myrosinase pH trung tnh to isothiocyanate indole,hot cht ny khng n nh hnh thnh indole-3-carbinol v ion thiocyanate.

LOGO Sau khi tiu th, enzyme myrosinase tch I3C t glucobrassicin Trong mi trng ca d dy, cc ion indolinium phn ng vi I3C (ion indolinium khc ) hnh thnh cc oligomers : Diindolylmethane (DIM) v cht tam phn Cyclic (Ctr) , ion indolinium lin kt vi gc thiols t do trn protein v glutathione (Tripeptide)

LOGO CHNG UNG TH V IU HA MIN DCH TNH

CA DIM

LOGO QUY TRNH CHUYN HA CA SULFORAPHANE

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CC CHC NNG CA SULFORAPHANE

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Cc Nh khoa hc Vit Nam to ra c mt s ch phm tiu biu nh : Sulcuvina c khong 20% Sulforaphane Sulfovina c khong 10% sulforaphane Sulfocream c 0,5% Sulforaphane.

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TNG HP SULFORAPHANE

Tong Jian DING, Ling ZHOU, Xiao Ping CAO

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Fung-Lung Chung, Lombardi Comprehensive Cancer Center

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CY THNG

Cy thng c tn khoa hc l Taxus wallichiana thuc h Thanh Tng - l loi cy bi hay cy thn g nh nhiu cnh, phn b ti cc hm ni cc huyn c Trng, n Dng, Lc Dng (tnh Lm ng) v TP. Lt, cao t 1.3001.700m

Ung th Gan.Ung th Phi.Ung th d dy. Ung th V. H tr hiu qu cho Bnh nhn tiu ng o thi Cholesterol trong Gan, mu nhanh chng. Hiu qu loi tr c c t cho ngi ung ru bia .Tc dng hiu qu trong S gan, bng to H tr hiu qu trong iu tr Vim xoang mn tnh, Tai bin.

LOGO Trong v, l,r cy thng , cha cht paclitaxel vi hm lng khong 0,045-0,13%, c tc dng cht c ch phn bo mt s loi t bo ung th. Thng thng 1kg l thng chit xut c 20 mg paclitaxel

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LOGOMy li tm

H si

Tng ng My li tm

Lm kh, gim p sut Lm tan ra

b

Feng Xu, Wenyi Tao Long Cheng, Lijia Guo,

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TNG HP

Parayil Kumaran Ajikumar, et al. Precursor Overproduction in Escherichia coli

LOGO Kt qu ghi nhn nhm dng Taxol c hiu qu tt hn ng k v thi gian km khng cho ung th pht trin (trn 3,5 thng) v thi gian ko di s sng (trn 11 thng) Tuy cha c nghin cu k nhng do c ch tc dng ca n, paclitaxel phi c coi l cht gy ung th v c i vi gen. Cc th nghim in vivo v in vitro cho thy paclitaxel c tc dng gy t bin gen trn t bo ng vt c v

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TI

Trong c ti c cha 0,1-0,36% tinh du, trong hn 90% cha cc hp cht sulfur. Thnh phn ch yu ca ti l cht alicin c mi c trng ti. Nhng trong ti ti khng c alicin ngay, m c cht aliin Cht ny chu tc ng ca enzyme alinasa v khi gi dp mi cho alicin. Ngoi ra c ti cn cha nhiu vitamin v cht khong..., c bit l selen

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LOGO Trong mi trng kim (pH = 8) phn ng trit nht. Trong mi trng acid (pH = 5) phn ng chm 50 ln. Ti ti nguyn tp v ti lm chn khng c mi : khng sinh c cc hp cht sulfur khng c tc dng dc l Ti nu chn sn xut sulfide diallyl (DAS), diallyl disulfide (DADS), diallyl trisulfide (Dats) Ti bm nh trong du hoc ct, p, v li cho mt vi gi hoc vi ngy nhit phng bin i nhng hp cht hng v ngn ngi thnh cc sn phm n nh hn, chng hn nh ajoene, methyl ajoene, v dithiins. Khi ti qu tui, alliin v allicin c chuyn i S-allyl cysteine, S-allyl mercaptocystine,

LOGO Alliin v Allinase c hm lng tng ng nhau. Mi th trong mt ngn ring bit. Khi gi nt c ti, gia alliin v allinase sn sinh ra tc th Allicin (cht gy mi ti ti khi bm thi) Allicin: khng bn, khi tip xc vi khng kh s c chuyn ha : diallyl disulfide, vinydithiin, afoene

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CC PHN NG T ALLICIN

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Ajoene : chng huyt khi mnh nh aspirin. N c ch s hnh thnh cc tiu cu bng cch lin kt vi th th fibrinogen (cht to t huyt), do lm cho n khng th lin kt vi cc fibrinogen khc.

Selen l : mt cht chng oxy ha rt mnh Trong giai on u, qua qu trnh oxy ha chuyn thc n thnh nng lng sn sinh ra cc gc t do ,gy thng tn cc t bo khin n pht trin bt thng. Mt s hp cht sulfur trong ti c th v hiu ha cc gc t do ,tn cng khi u trc khi n c th nhen nhm giai on th hai , nhng t bo ung th s pht trin nhanh nu cc h thng min dch ban u b ph v. Cc hot cht trong ti s c tc dng ngn khng cho cc t bo ung th pht trin, tiu dit s pht trin ca nhng mch mu mi nui sng khi u

Phng php sn xut ca nhng vin thuc ti s dng chng ct hi nc, v iu ny c th ph v mt s hp cht c li. V vy, nu bn mun cc li ch sc khe ca ti, bn thc s nn n ti

LOGO CHC

NNG CC THNH PHN CA TI

Tc dng phng chng cc bnh tim mch - Ti lm gim triglycerid v cholesterol trong mu tng t clofibrat. - Ti lm tng hm lng cholesterol tt (HDL) v gim hm lng cholesterol xu (LDL) do lm gim cc ri lon chuyn ha m trong mu, chng x cng ng mch vnh, ng mch no, ng mch ngoi vi. - Ti c th lm h huyt p tm thu t 20 -30mmHg v h huyt p tm trng t 10 - 20mmHg. - Ti chng sinh huyt khi tng ng vi aspirin nhng khng c tc dng ph c hi nh aspirin. Tc dng khng sinh Khng khun, Khng virus, Dit k sinh trng v nguyn sinh ng vt :L khng sinh mnh m. N s git cht vi khun e. coli, lin cu khun (penicillin) Tc dng vi ri lon tiu ho, ri lon c quan: Tc dng gii c kim loi nng Tc dng chng nhim c cht phng x Tc dng gii c nicotin mn tnh Tc dng bo v gan, c ch s tng trng ca t bo ung th da, ung th trc trng, thc qun, mi hng, gan Tc dng chng cc bnh ng h hp

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TI LIU THAM KHO

1.http://www.diindolylmethane.org 2.http://en.wikipedia.org/wiki/Sulforaphane

LOGO CHNG UNG TH V IU HA MIN DCH TNH

CA DIMChng li s hnh thnh mch mu mi(t mch mu tn ti) c ch sinh trng ca t bo

Lm cht cc t bo c l trnhChng vim

Chng virut, vi Ngn nga cc hiu ng ca androgen khun , ung th di cc hiu ng sinh hc trn cc m nhy cm