bagian awal proposal krg nip dr.bekti

8/19/2019 Bagian Awal Proposal Krg Nip Dr.bekti

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EFEKTIFITAS HIDROGEL BINAHONG ( Anredera cordifolia (Ten.) Steenis)

TERHADAP EKSPRESI TGF-β1 PADA JARINGAN GRANULASI ULKUS DERAJAT

DUA TIKUS DIABETES

PROPOSAL TUGAS AKHIR

Untuk Memenuh Pe!"#$!$t$nMem%e!&'eh Ge'$! S$!$n$ I'mu Ke%e!$)$t$n

O'eh*

An"+u' L$'' Mun$)$!&h

1,,.,/,1101,,

JURUSAN ILMU KEPERAATAN

FAKULTAS KEDOKTERAN

UNI2ERSITAS BRAIJA3A MALANG

/,10

HALAMAN PERSETUJUAN


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PROPOSAL TUGAS AKHIR

EFEKTIFITAS HIDROGEL BINAHONG ( Anredera cordifolia (Ten.) Steenis)

TERHADAP EKSPRESI TGF-β1 PADA JARINGAN GRANULASI ULKUS DERAJAT

DUA TIKUS DIABETES

Untuk Memenuh Pe!"#$!$t$n

Mem%e!&'eh Ge'$! S$!$n$ Ke%e!$)$t$n

O'eh *

Anisful Lailil Munawaroh

NIM. 105070201131005

Menyetujui untuk diuji :

en!uji I en!uji II

Ns. "ina "ewi #artika L.I$ #.%e&$ M.%e& dr. 'a(h)ad #arwo *ekti$ M.Med.+dNI. 1,-00217 200501 2 002 NI. 1,-101, 200-12 1 001

KATA PENGANTAR


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uji syukur kehadirat Allah #/ atas erkat dan rah)atNya sela)a

&enulisan sehin!!a &enulis da&at )enyelesaikan &ro&osal &enelitian den!an

judul +4+%I4IA# I"'6+L *INA6N 8 Anredera cordifolia (Ten.) Steenis)

+'A"A +%#'+#I 491 A"A A'INAN 'AN;LA#I ;L%;# "+'AA ";A

I%;# "IA*++#”. %etertarikan &enulis akan to&ik ini didasari fakta ahwa

se)akin )enin!katnya ju)lah &enderita diaetes di Indonesia$ dan &enderita

diaetes )ellitus ini )e)iliki risiko dua &uluh se)ilan kali terkena ulkus dan

)enurunnya &roduksi 491 yan! da&at )e)&erla)at &enye)uhan luka.

#ehin!!a dihara&kan da&at )en!uran!i an!ka kejadian a)&utasi akiat luka

diaetes &enulis in!in )en!uji keefektifan alukan luka diaetes den!an hidro!el

inahon!. Melalui tulisan ini$ &enulis )en!u(a&kan teri)a kasih ke&ada :

1. 4akultas %edokteran ;ni


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Munawaroh$ Anisful Lailil. 2013. EFEKTIFITAS HIDROGEL BINAHONG

( Anredera cordifolia (Ten.) Steenis) TERHADAP EKSPRESI TGF-β1 PADA

JARINGAN GRANULASI ULKUS DERAJAT DUA TIKUS DIABETES”

;lkus diaetes sulit untuk di se)uhkan karena adanya keadaan

hi&er!like)ia yan! )enyeakan eks&resi 491 yan! )enurun. *inahon!

)eru&akan tana)an fa


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udulD#a)&ul .................................................................................................... i

ala)an en!esahan ...................................................................................... ii

%ata en!antar ................................................................................................ iii

Astrak ............................................................................................................. i<

"aftar Isi. ...........................................................................................................<

"aftar ael ...................................................................................................... iE

"aftar a)ar. ..................................................................................................E

BAB 1 PENDAHULUAN

1.1 Latar *elakan! ...........................................................................................1

1.2 'u)usan Masalah ......................................................................................7

1.3 ujuan enelitian ......................................................................................7

1.3.1 ujuan ;)u) ...........................................................................................7

1.3.2 ujuan %husus...........................................................................................7

1.= Manfaat enelitian ......................................................................................-

1.=.1 Manfaat eoritis-

1.=.2 Manfaat raktis .........................................................................................,

BAB / TINJAUAN PUSTAKA

2.1 *inahon! ....................................................................................................10

2.1.1 aksono)i *inahon! ................................................................................10

2.1.2 "eskri&si ana)an ..................................................................................10

2.1.3 Manfaat dan %andun!an %i)ia *inahon!.................................................12

2.1.3.1 4la


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2.1.3.2 olifenol ................................................................................................1=

2.1.3.3 #a&onin..................................................................................................1=

2.1.3.= riter&enoid ...........................................................................................15

2.1.3.5 Asa) ;rsolat .........................................................................................1

2.1.3. Antosianin .............................................................................................1

2.1.3.7 Asa) Askorat 8ita)in >@ .................................................................... 17

2.1.3.- Alkaloid ..................................................................................................17

2.1.= enelitian yan! ernah "ilakukan Men!!unakan *inahon! ....................1-

2.2 ;lkus "iaetes ...........................................................................................22

2.2.1 "efinisi ;lkus "iaetes.............................................................................22

2.2.2 %lasifikasi ;lkus "iaetes ........................................................................23

2.2.3 atofisiolo!i ;lkus "iaetes......................................................................2=

2.2.= Transforming Growth actor !eta-" 8491@ .........................................2

2.2.=.1 #truktur dan #intesis .............................................................................2

2.2.=.2 Akti


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2.=.1 %arakteristik ikus alur /istar ................................................................=2

2.=.2 Lin!kun!an .............................................................................................=3

2.=.3 %etentuan e)erian Makan dan Minu)..................................................=3

2.=.= e)&at idur atau !edding ......................................................................==

2.5 uun!an antara idro!el *inahon! den!an Luka diaetes ......................==

2. I)&likasi %e&erawatan ................................................................................50

BAB 0 KERANGKA KONSEP DAN HIPOTESIS

3.1 %eran!ka %onse&.........................................................................................51

3.2 i&otesis enelitian......................................................................................52

BAB 4 METODE PENELITIAN

=.1 'an(an!an enelitian..................................................................................53

=.2 #a)&el enelitian ......................................................................................53

=.2.1 %riteria #a)&el enelitian .........................................................................53

=.2.2 *esar #a)&el ...........................................................................................5=

=.3 ariael enelitian ......................................................................................55

=.3.1 ariael *eas..........................................................................................55

=.3.2 ariael %ontrol ......................................................................................... 55

=.3.3 ariael er!antun! ..................................................................................55

=.= Lokasi dan /aktu enelitian........................................................................5

=.5 *ahan dan Alat enelitian ...........................................................................5

=.5.1 e)uatan +kstrak *inahon! ..................................................................5

=.5.2 e)uatan idro!el *inahon! ...........................................................57


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=.5.3 e)uatan ;lkus "iaetes ...................................................................... 57

=.5.= erawatan Luka........................................................................................5-

=.5.5 e)eliharaan ikus ..................................................................................5,

=.5. +)edin! dan e)uatan arin!an Luka ................................................5,

=.5.7 ewarnaan I))unohistoki)ia ................................................................0

=. "efinisi 6&erasional ..................................................................................0

=.7 roses enelitian ......................................................................................=

=.7.1 e)uatan +kstrak *inahon! ..................................................................=

=.7.2 e)uatan idro!el *inahon! ................................................................5

=.7.3 e)uatan ;lkus "iaetes ......................................................................

=.7.= e)a!ian %elo)&ok ikus .....................................................................7

=.7.5 erawatan Luka........................................................................................7

=.7. rosedur e)eliharaan ikus ...................................................................,

=.7.7 +ksisi arin!an Luka dan e)uatan re&arat arin!an..........................71

=.7.- en!ukuran Aku)ulasi +ks&resi 491 den!an I)unohistoki)ia .........72

=.- Alur %erja enelitian ....................................................................................7=

=., Analisis "ata ................................................................................................75

"aftar ustaka .........................................................................................7

LAMPIRAN

DAFTAR TABEL

ael 2.1 enelitian yan! ernah "ilakukan Men!!unakan *inahon! .............1-

ale 2.2 4ase enye)uhan Luka ..................................................................33


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ael 2.3 %arakteristik ikus alur /istar .........................................................=2

DAFTAR GAMBAR

a)ar 2.1 "aun *inahon! Anredera (ordifolia8en.@ #teenis .........................12

a)ar 2.2 #intesis dan Akti


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a)ar 2.3 8A@ TG-$ canonical signaling pathway $ 8*@ TG-$ non-canonical

signaling pathway .........................................................................2-

a)ar 2.= ikus alur /istar 8%attus novergicus@ .........................................=2

a)ar 3.1 %eran!ka %onse&...........................................................................51

a)ar =.1 Model Luka +ksisi &ada ikus alur /istar ..................................7

a)ar =.2 %andan! ikus di Laoratoriu) 4ar)akolo!i 4%;* ......................55

a)ar =.3 Alur %erja enelitian ...................................................................... 1

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