bacterias infection and immune system response
TRANSCRIPT
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BACTERIAS
INFECTION AND
IMMUNE
SYSTEM
RESPONSE
DIANA AGUDELO JARAMILLO
MEDICINE STUDENT
+FOLDING
+FOLDING
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INTRODUCTION
CELLS
Eukaryotic
Nuclear membrane and cytoplasm
organelles.Human cells
Prokaryotes
Doesn’t have a nuclear membrane and the genetic material is
dispersed in the cytoplasm
Bacteria
Pathogenic bacteria to the body.
No pathogenic Bacteria on the body.
+TYPHOID FEVER: A RACE AGAINST TIME
Constantly the body istrying to protect himselfof the pathogenicmicroorganism that canaffect significantly.
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TYPHOID FEVER:
A RACE AGAINST
TIME
Neutrophils and monocytesenclose the bacteria to formabscess. But some of them canescape and continue infecting
+TYPHOID FEVER: A RACE
AGAINST TIME
Although the immune cells
kill a lot of bacteria
Salmonella, there are others
that evade that abscess and
escape, guaranteed his
survival and his replicates in
all the body.
+ TYPHOID FEVER: A
RACE AGAINST TIME
Salmonella
Food or water contaminates
Begins on the intestine and then invades other organs
typhoid fever particularly insidious
CONSTANTLY ANTIBIOTIC RESISTANT
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STUDENT OBSERVATION
It is important to
further scientific
development in
these areas to
achieve eradicate
Salmonella, who
generate resistance
even faster than the
creation of new
antibiotics.
+ Steps leading to necrotizing
fasciitis revealed, opening way to
possible new treatments for
bacterial infections
Group A Streptococcus (GAS) or S.
Pyogenes, is a silent bacteria that colonize
the body without produce any symptoms and
can be mortal in a lot of cases such as toxic
shock syndrome and streptococcal
necrotizing fasciitis (flesh-eating disease)
+ STEPS LEADING TO NECROTIZING
FASCIITIS REVEALED, OPENING WAY TO
POSSIBLE NEW TREATMENTS FOR
BACTERIAL INFECTIONS
Once the bacteria
enter to the cell,
liberates two
streptolysins that
inhibit the synthesis
of proteins in the
cytoplasm.
BACTERI
A
CELL
STREPTOLYSINS
mRNA
+ STEPS LEADING TO NECROTIZING
FASCIITIS REVEALED, OPENING WAY TO
POSSIBLE NEW TREATMENTS FOR
BACTERIAL INFECTIONS
The human cells
increases the
production of the
amino acid
asparagine as a
method of defence
that alters gene
expression of
GASand increases
his virulence. ASPARAGINE
+STEPS LEADING TO
NECROTIZING FASCIITIS
REVEALED, OPENING
WAY TO POSSIBLE NEW
TREATMENTS FOR
BACTERIAL INFECTIONS
Asparaginase degrades
asparagina. Thats why they use
it to reduce the growth of GAS
in human blood and mouse
models of human infection.
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Asparaginase has never before used to treat GAS infections.
Knowing the metabolic changes occurring between the
pathogen and its host´s infection can lead to develop a few of
effective treatment against infection diseases.
STUDENT OBSERVATION
+MEDICAL UTILITY
The doctors, food distributors,
among many other companies,
are straining to maintain the
necessary hygiene for disease
control in clients, workers or
patients.
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MEDICAL UTILITY
As health workers, we should
alert people about this kind of
diseases that are so contagious
and how they can prevent
them.
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Someexamples can betaking care of his own body,washing hands with a verygood disinfectant and notconsuming food which hasexpired date of caducity,also prevent thetransmission, trying to coverthe mouth when sneezing,or not share stuff that canhave contact with fluids orblood of our body.
MEDICAL UTILITY
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With the development of the studies about the virulence of
those bacterias and how can they affect us, we can investigate
more about a lot treatments that can helps to control the early
effects that cause a lot of damage even if we don't feel any
symptom, reducing the annual number of deaths.
MEDICAL UTILITY
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REFERENCES
1. 1. MARTÍNEZ SANCHEZ, LinaMaría; et alt. Biología molecular. 7th ed. Medellín, Col: Universidad PontificiaBolivariana; 2012.
2. BROOKS, GF; CARROLL, KAREN; BUTEL, JANET; MORSE, STEPHEN; MIETZNER, TIMOTHY. Jawetz, Melnick y Adelberg, MicrobiologíaMédica. (2010). 25 Edición. Mc Graw Hill. Mexico, DF. PP: 145,147,159,160.
3. niversität Basel (2014, January 16). Typhoid fever: A race against time. ScienceDaily. Retrieved January 25, 2014, from http://www.sciencedaily.com/releases/2014/01/140116085053.htm.
4. The Hebrew University of Jerusalem. (2014, January 20). "Steps leading to necrotizing fasciitis revealed, opening way to possible new treatments for bacterial infections." Medical News Today. Retrieved fromhttp://www.medicalnewstoday.com/releases/271385
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“As we look higher, we get higher”