bacterias acido lacticas y peptidos en cod

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Ž . Aqu aculture 167 1998 103–113 Effects of supplementing the feed to Atlantic cod ž / Gadus morhua fry with lactic acid bacteria and immuno-stimulating peptides during a challenge trial with Vibrio anguil larum Asbjørn Gildberg ) , Helene Mikkelsen  Norwegian Institute of Fisheries and Aquaculture, 9005, Tromsø, Norway Accepted 8 June 1998 Abstract Ž . Atlan tic cod Gadus morhu a fr y we re reared on a commercial fe ed supplement ed wi th Carno bact erium diÕergens, is ol at ed fr om the inte st ines of At lant ic cod and At lant ic sa lmon Ž . Salmo salar alone or in combination with immuno-stimulating peptides. In vitro experiments showed that culture filtrates from the isolates from cod and salmon inhibited the growth of Vibrio anguillarum. Af te r 3 we ek s of feeding, the fish were ch al lenged by ba th exposure to V. Ž 7 . Ž . anguillarum 10 rml, 1 h . Twelve days after infection significant p -0.05 reduced cumul ative mortality was recorded in fish given feed supplemented with lactic acid bacteria isolated from Atlantic salmon and with immuno-stimulating peptides. No synergistic or cumulative effects were achieved by combining lactic acid bacteria and immuno-stimulating peptides. Four weeks after Ž . infec tion the s ame cumulati ve mortality 80–84% was rea ched in al l groups . Both stra ins of lact ic acid bacteria could colonize the internal mucus layer of the cod fry pyloric caeca, and a significant number of the bacteria survived the passage of the whole gastrointestinal tract. q 1998 Elsevier Science B.V. All rights reserved. Keywords: Immu no-stimula ting pepti des; Probi otics; Carn obact eriu m diÕergens; Atl ant ic cod ; Intest ina l colonisation 1. Introduction In recent years efficient vaccines have been developed against many of the major bacterial diseases in aquaculture. Nevertheless, considerable efforts are still being made ) Correspondence author. Tel.: q47-776-29-000; Fax: q47-776-29-100; E-mail: [email protected] 0044-8486r98r$ - see front matter q 1998 Elsevier Science B.V. All rights reserved. Ž . PII: S0044-8486 98 00296-8

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8/6/2019 Bacterias Acido Lacticas y Peptidos en Cod

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