B-Z Device

Chengde Mao

[-] NODE

RIGHT-HANDEDB-DNA

[-] NODES

[+] NODE

LEFT-HANDEDZ-DNA

[+] NODES

Right-Handed and Left-Handed DNA

B-ZZ-B

A Device Based on the B<-->Z Transition

Mao, C., Sun, W., Shen, Z. & Seeman,N.C. (1999), Nature 397, 144-146.

+ Co(NH 3)6+++- Co(NH 3)6

+++

A Sequence-Dependent Device

Hao Yan

Derivation of PX DNA

Seeman, N.C. (2001) NanoLetters 1, 22-26.

+

+

DS+DS

Resolve

Everywhere

Reciprocal

Exchange

Everywhere

Resolve

Everywhere

Reciprocal

Exchange

Everywhere

P X

Strand

Polarity

Ident ical

Strand

Polarity

Opposite

C D

P X

A B

J X 2

A B

D C

Yan, H., Zhang, X., Shen, Z. & Seeman, N.C. (2002), Nature 415, 62-65..

Switchable Versions of PX and JX2

J X 2

A B

D C

A B

C D

P X

Machine Cycle of the PX-JX2 Device

A B

C D

A B

C D

A B

D C

JX2

A B

D C

PX

I II

IV III

System to Test the PX-JX2 Device

JX2

JX2

JX2

PXPXPX

AFM Evidence for Operationof the PX-JX2 Device

Yan, H., Zhang, X., Shen, Z. & Seeman, N.C. (2002), Nature 415, 62-65.

Inserting a PX-JX2 Device into a 2D Array

Baoquan Ding

Cassette To Be Inserted

B. Ding & N.C. Seeman, Science 314, 1583-1585 (2006).

Array for Insertion

B. Ding & N.C. Seeman, Science 314, 1583-1585 (2006).