azharuddin agusriyanti
TRANSCRIPT
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KARDIOTONIK
KELOMPOK 1 :
DESI SATRANA
AGUSRIYANTI
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Obat kardiovaskular adala obat!obat "a#$ s%&ara la#$su#$
da'at (%(ulika# )u#$si otak *a#tu#$ "a#$ t%r$a#$$uk%adaa# #or(al+
Kardioto#ika adala obat!obat d%#$a# kasiat (%('%rkuat
ko#traktilitas otot!*a#tu#$ ,%)%k i#otro' 'ositi)-+ T%ruta(a
di$u#aka#
'ada $a$al *a#tu#$ ,d%ko('%#sasi- u#tuk (%('%rbaiki )u#$si
'o('a#"a+
K%lo('ok kardioto#ika t%rdiri dari :A+ Glikosida .a#tu#$ , digoksin, metildigoksin, dan
digitoksin-
/+ Do'a(i#%r$ika , dopamin, ibopamin, dan dobutamin-
0+ P%#$a(bat )os)odi%st%ras% ,amrinon da# milrinon-
PENDAHULUAN
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Glikosida *a#tu#$ adala alkaloid "a#$ b%rasal dari
ta#a(a# Digitalis purpurea "a#$ k%(udia# dik%taui
b%risi di$oksi# da# di$itoksi#+
K%dua#"a b%k%r*a s%ba$ai i#otro'ik 'ositi) 'ada $a$al
*a#tu#$+ Di$italis 'ali#$ b%r$u#a u#tuk '%#$obata#takikardi supraventrikel t%ruta(a u#tuk
(%('%rla(bat
d%#"ut v%#trik%l 'ada brilasi atriu(+
S%(ua $likosida *a#tu#$ (%(iliki ru(us st%roida2 s%'%rtior(o# k%la(i# da# a#ak $i#*al2 kol%st%rol2 da# vita(i#
D+
A. Glikosida Jantun
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DIGOKSIN
! M%ka#is(% K%r*aM%ka#is(% k%r*a di$oksi# "aitu d%#$a# (%#$a(bat 'o('a Na
K ATPas% "a#$ (%#$asilka# '%#i#$kata# #atriu( i#tra&%llular
"a#$ (%#"%babka# l%(a#"a '%rtukara# #atriu(3kaliu( da#
(%#i#$katka# kalsiu( i#tra&%llular+ 5al t%rs%but da'at
(%#i#$katka# '%#"i('a#a# kalsiu( i#tras%llular di sar&o'las(i&r%ti&ulu( 'ada otot *a#tu#$2 da# da'at (%#i#$katka# &ada#$a#
kalsiu( u#tuk (%('%rkuat 3(%#i#$katka# ko#traksi otot+
! E)%k sa('i#$
/iasa#"a b%rubu#$a# d%#$a# dosis "a#$ b%rl%bi2 t%r(asuk :
a#or%ksia2 (ual 2 (u#ta2 diar%2 #"%ri abdo(%#2 $a#$$ua#'%#$liata#2 sakit k%'ala2 rasa &a'%k2 (%#$a#tuk 2 bi#$u#$2
d%liriu(2 alusi#asi2 d%'r%si 6 arit(ia2 %art blo&k 6 *ara#$ t%r*adi
ras2 is&k%(ia i#t%sti#al 6 $"#%&o(astia 'ada '%#$$u#aa# *a#$ka
'a#*a#$2 tro(bosito'%#ia+
PENGGOLONGAN O!AT
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Do'a(i#%r$ika adala #%urotra#s(itt%r s%#tral2 "a#$ s%ba$ai'r%&ursor+
Adr%#ali# (%(iliki kasiat )ar(akolo$i '%#ti#$+ Di *ari#$a#
'%ri)%r
T%rda'at dua *%#is r%s%'tor!do'a(i#2 "ak#i r%s%'tor DA1 da#
DA7+
Sti(ulasi r%s%'tor i#i ol% do'a(i#%r$ika (%#$akibatka# %)%k
"a#$ sa(a d%#$a# kasiat do'a(i#+
R%s%'tor DA1 t%ruta(a b%rada di otot 'olos *a#tu#$2 otak2 da#
$i#*al+
Do'a(i#%r$ika DA1 "a#$ (%#sti(ulasi r%s%'tor DA1 adala
do'a(i#2 Dobuta(i#2 da# ibo'a(i#+
R%s%'tor DA7 t%rda'at di sara) da# $a#$lia si('atis2 *u$a dala(
*a#tu#$ da# kulit+ Do'a(i#%r$ika DA7 (%#sti(ulasi r%s%'tor
DA7 da# (%li'uti bro(okri'ti# s%rta &ab%r$oli# ,Dosti#%8-+
!. Dopa"inerika
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Do'a(i# M%ka#is(% K%r*a
M%#sti(ulasi r%s%'tor adr%#%r$ik da# do'a(i#%r$ik6 dosis "a#$ l%bi
r%#da t%ruta(a (%#sti(ulsi do'a(i#%r$ik da# (%#$asilka#
vasodilatasi r%#al da# (%s%#t%rik 6 dosis "a#$ l%bi ti#$$i
(%#sti(ulasi do'a(i#%r$i& da# b%ta1!adr%#%r$ik da# (%#"%babka#
sti(ulasi *a#tu#$ da# vasodilatasi r%#al 6 dosis b%sar (%#sti(ulasir%s%'tor al)a!adr%#%r$ik+
E)%k sa('i#$
S%ri#$ : d%#"ut %kto'ik2 takikardia2 sakit kar%#a a#$i#a2 'al'itasi2
i'ot%#si2vasoko#striksi2 sakit k%'ala2 (ual2 (u#ta2 dis'#%a+ .ara#$ :
bradikardia2 arit(ia v%#trikular ,dosis ti#$$i-2 $a#$r%#%2 i'%rt%#si2a#si%tas2 'ilo%r%ksi2'%#i#$kata# s%ru( $lukosa2 #%krosis *ari#$a#
,kar%#a
%kstravasasi do'a(i#-2'%#i#$kata# t%ka#a# i#traokular2 dilatasi 'u'il2
a9ot%(ia2 'ol"uria+
PENGGOLONGAN O!AT
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Obat!obat dala( $olo#$a# i#i (%ru'aka# '%#$a(bat
%#9i( )os)odi%st%ras% "a#$ s%l%kti) b%k%r*a 'ada *a#tu#$+
5a(bata# %#9i( i#i (%#"%babka# '%#i#$kata# kadar
siklik AMP ,&- dala( s%l (iokard "a#$ aka#
(%#i#$katka# kadar kalsiu( i#tras%l+
P%#$$u#aa# i#trav%#a u#tuk *a#$ka '%#d%k da'at
(%(ba#tu sirkulasi 'ada $a$al *a#tu#$ la#*ut2 t%ta'i
'%#$$u#aa# oral u#tuk *a#$ka 'a#*a#$ s%ri#$kali(%#"%babka# %)%k sa('i#$ "a#$ tidak da'at di tol%ra#si
da# baka# (%#"%babka# '%#i#$kata# (ortalitas+
#. Pen$a"%at&os'odiesterase
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Na"a O%at (an dipasaran
DIGOKSIN
1+
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TERI)A KA*IH
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