1

Ayyalusamy Ramamoorthy Robert W. Parry Collegiate Professor of Chemistry and Biophysics

University of Michigan 930 North University Avenue

Ann Arbor, Michigan 48109-1055 Phone: (734) 647-6572

Email Address: ramamoor@umich.edu Website: www.umich.edu/~ramslab

Positions: 2008-present Professor, Department of Chemistry & Biophysics, Biomedical Engineering,

Macromolecular Science and Engineering, University of Michigan 2015-2018 Hans Fischer Senior Fellow, Technical University of Munich, Germany 2012-2014 Associate Chair, Biophysics 2000-2016 Co-Director, Biomolecular NMR Facility 2002-2008 Associate Professor, Department of Chemistry & Biophysics, Univ. of Michigan 1996-2002 Assistant Professor, Department of Chemistry & Biophysics, University of Michigan 1996-2002 Assistant Professor, Macromolecular Science & Engineering, Univ. of Michigan 1993-1996 Research Associate, Department of Chemistry & NIH Center, Univ. of Pennsylvania 1992-1993 Scientist, Biometrology Laboratory, JEOL Ltd., Tokyo, Japan 1989-1992 Fellow Scientist, Central Leather Research Institute, India Honors, Awards and Societies:

• Elected Fellow of the Royal Society of Chemistry (2018) • Distinguished Faculty Achievement Award, University of Michigan (2016) • Hans Fischer Senior Fellow, Technical University of Munich, Germany (2015-2018) • Robert W. Parry Collegiate Professor, University of Michigan (2013-present) • Faculty Recognition Award, University of Michigan (2012) • Fellow of the American Association for the Advancement of Science (2009) • CAREER Development Award, National Science Foundation (1999-2004) • Japan Society for the Promotion of Science Fellow (2009) • 2016 Visiting Professor, Bioengineering Institute, Kyoto University, Japan • 2009 Visiting Scientist, Max Planck Institute, Mainz • 2009 Willsmore Fellow, University of Melbourne, Australia • 2009 Visiting Professor, Yokohama National University, Japan • 2008 Visiting Professor, Department of Chemistry, Kyoto University, Japan • 2005 Visiting Professor, Institute for Protein Research, Osaka University, Japan • 1998 Visiting Scientist, National Institutes of Health, Bethesda • Member: AAAS, American Chemical Society, Biophysical Society

Research Interests My research interests include high-resolution structure, dynamics, and function of biomacromolecules and materials using a variety of biophysical techniques including solution- and solid-state NMR spectroscopy and biochemical approaches. Specifically, my current research focus is on biological molecules or systems such as membrane-bound cytochrome-P450s (human and rabbit), cytochrome-P450-reductase, cytochrome-b5, membrane-bound protein-protein complexes, amyloid proteins, polymer/peptide based nanodiscs, and membrane-disruptive peptides that include anticancer peptides and antimicrobial peptides. My research group is also developing NMR and biophysical/biological approaches for investigation of cancer metabolomics and in-cell physiological processes. In addition, my laboratory characterizes nanomaterials (e.g., nanocomposites, nanoparticles, graphene-based materials,

2

fibers, bone materials and dendrimers), polymorphic pharmaceuticals and hydrates using cutting-edge solid-state NMR techniques including ultrafast-MAS methods. Research Cohort: Graduate Students (mentored as Chair):

• Giacomo De Mauro (Since 2017) • Nathaniel Hardin, Chemistry (since 2017) • Nirupama Sumangala Korada, Biophysics (since 2016) • Christian Macdonald, Biophysics (since 2016; jointly with Professor Randy Stockbridge) • Sarah Cox, Chemistry (since 2016-continuing) • Katherine Gentry, Biophysics (2014-continuing) • Joshua Damron Chemistry (2013-Graduated April 2018) • Kian Kamgar-Parsi, Applied Physics (2014-Graduated Jan.2018) • Kyle Korshavn, Chemistry, graduated in Dec. 2016 (jointly with Prof. Mi Hee Lim) • Meng Zhang, Chemistry, graduated in Aug. 2016 • Amit Pithadia, Chemistry, graduated in Dec. 2015 (jointly with Prof. Carol Fierke) • Samuel Kotler, Biophysics, graduated in August 2015 • Rui Huang, Chemistry, graduated in April 2014 • Wencheng Ge, Chemistry, graduated in Dec. 2013 • Stephanie Le Clair, Chemistry graduating in April 2012 • Kevin Hartman, Chemistry, graduated in April 2012 • Kazutoshi Yamamoto, Chemistry, graduated in May 2011. • Ravi Prakash Reddy Nanga, Chemistry, graduated in April 2011. • Pieter Smith, Biophysics, graduated in April 2010. • Katherine Henzler, Department of Chemistry, graduated in July 2003 • Srikanth Kidambi, Department of Chemistry, graduated in Feb. 2003 • Kevin J. Hallock, Department of Chemistry, graduated in Aug. 2002 • Jose S. Santos, Biophysics, graduated in June 2001 • Deanne Taylor, Biophysics, graduated in 2001 • Duane A. Chung, Biophysics, graduated in Oct. 2000 (jointly with Prof. Richard Neubig)

Rotation Students:

• Kristine Parson, Chemistry (2017-Rotation) • Tehetina Waldamachi, Biophysics (2013-Rotation) • Elizabeth Gichana, Biophysics (2013-Rotation) • Zachery Stein, Biophysics Rotation Student, (Winter 2008) • Alexandro Navarro, Biophysics Rotation Student (Fall 2010) • Shirley Lee, PIBS Rotation Student (Fall 2010) • Alana Canfield, Chemistry Rotation Student (Winter 2009) • Marchello Cavitt, Chemistry, Jun. 2007-Aug. 2007 (Masters degree) • Aijdin Kavara, Department of Chemistry (Sep.- April 2004; Research Rotation) • James P. Johnson, Department of Chemistry (Sep. ’04 – July ‘05) • Yuchun Mao, Department of Chemistry (May ‘01- ‘03; Masters degree) • Jia Zhao, Department of Chemistry (Sep.-Dec. 2002; Research Rotation) • Caroline Keenan Pointer, Department of Chemistry (Jan. ‘02- Dec. 2002; Masters Degree) • Kyu Park, Department of Chemistry (Sep.- Dec. 2004; Research Rotation) • Jeffrey Brender, Biophysics Research Division (Sep. ‘00-Feb.2000; Research Rotation)

3

• Orkurn Soyer, Department of Chemistry (Sep. ‘00- Dec. ‘00; Research Rotation) • Erin Wimmers, Department of Chemistry (July ‘00- Aug. ’00; Research Rotation) • Maricel Kann, Department of Chemistry (Jan. ‘97-July ’97; Research Rotation) • Michael T. Dehring, Department of Chemistry (Sep. ‘97- April ’99; Masters Degree)

Undergraduate Students (mentored):

• 3 REU students starting from June, 2019. • 2 Visiting students (for 6 months) from Nankai University (from June) • 1 visiting student from India will start from June 2019. • Brenna Bunch Biochemistry (2019-continuing) • Kevin Nguyen Chemistry (2018-continuing) • Ajay Prasad Chemistry (2018-continuing) • Brian Lam Chemistry (2016-2019) • Zichen Liu Nankai University (2018-continuing) • Salwan Butrus Bioengineering (from Sep. 2017 – 2018) • Genjo Takuya Bioengineering, Kyoto University (2017-2018) • Alex Miller Biochemistry (Sep.-Dec., 2017) • Hosu Kim Honors, Biochemistry (2016-2017) • Fucheng Guo Nankai University (2016-2017) • Oluseun Oladipo Chemistry (from Jan. 2016-April 2017) • Joseph Joel Calvin College (May-Aug, 2016) • Michael McCullough Chemical Sciences (from Jan. 2015-2016) • Ali Farhart Biochemistry & Math-Biology (2015-2016) • Cholavardhan Kondati REU, Biophysics (2015) • Michael Paul Biochemistry (from 2014-2015) • Nirbhay Jain Chemistry, Sep. ’11- 2015 (Honors thesis) • Jeffrey Derrick Chemistry; graduated 2014 • Paige Pearcy Biochemistry, Sep.’11-Apri 2014 (graduated) • Jenn Chen Biochemistry, Sep.’11- Apri 2014 (graduated) • Binyamin Jacobovitz Biochemistry & Biophysics, July ’12-‘13 (graduated) • Tejas Karnati Physics & Biophysics, July ’12-‘13 (graduated) • Morgan Brisse Biochemistry, Sep.’11-‘13 (graduated) • Anna Jones Biochemistry, Sep.’11-‘12 (graduated) • Akira Asano Yokohama National University (1-year visit from Japan) • Melissa Gildenberg Biochemistry, Sep.’10-Aug. 2012 (Honors thesis; graduated) • Austin McHenry Biochemistry, Jan.’10-July 2012 (Honors thesis; graduated) • Chang-soo-You National University of Technology, South Korea (2012) • Mi-Lim Jang National University of Technology, South Korea (2012) • Yoon-woo Nam National University of Technology, South Korea (2012) • Samer Salamekh Biochemistry, Sep.’09-2011; (Honors thesis; graduated) • Regina Wong Biophysics, Sep.’10-Sep. ‘11 • Naimish Bakane Biomedical Engineering (2010-2011) • Dan Youngstrom Biophysics, 2009-2010; (Honors thesis; graduated) • Cameron Bates Engineering, Sep. ’08-April ‘09 • Jeffrey Barry Physics, Math, Biology, Sep. ’07-(Honors thesis; graduated) • Michelle Fritz Physics, Sep. ’07-April ‘09 • Ikenna Nwamba Biochemistry, Nov. ’07-Dec. ‘07 • Amy Kruckemeyer Biochemistry (honors thesis) Jan. ’05-Aug. ‘06

4

• Nicholas Reder Biochemistry (honors thesis) Jan. ’06-May ‘06 • Rahul Neogi Biochemistry (honors thesis) Jan. ’06-May 2007 • Genevieve Lampinen Chemical Engineering, Jan. ’06-Aug. ‘06 • Akihisha Kimura Biochemistry (honors thesis) April ’05-Aug.’06 • Alan Poon Biochemistry (honors thesis) Jan.’03- April 2005 • Ravi patel Biochemistry (honors thesis) Sep. ’03-Dec.’04 • Kwasi Mendoza REU (Oct. 2003-Aug.’04) • Raquel Daboul Chemistry & Biochemistry (Oct. 2003-Dec.’05) • Benjamin Lack Biochemistry (honors thesis) Jan. ’04-Aug. ‘04 • Max Burgman Biochemistry Sep. ’03-April ‘04 • Jeffrey Birn Cellular & Mol. Biol. Jan.’03- July ‘04 • Adam Sorini, Physics May ‘01- Dec.‘02 • Wendy Schumacher, Biochemistry May ‘00-April ‘01 • Kyle Stout, Biophysics May ‘99- Aug.’00 • Jeffrey Brender, Chemistry Jan. ‘99- Aug.’00 • Hongmei Ge Biochemistry July ‘99- Aug.’00 • Matthew G. Agasan Chemistry Jan.’98-Aug.’99 • Alfred Fleming Jr. Chemistry May ‘98-June ‘98 • Shawn Lopis Summer Research Student 1997 • Kevin Cox Chemistry April ‘97 - Dec. ‘98 • Bonita G. Poon Cellular & Mol. Biol. Jan. ‘97 - Jan. ‘98 • Kiyoko Ikeuchi Biochemistry Aug. ‘97 - Jan. ‘98 • Melissa A. Zagors Biochemistry Sep. ‘96 - April ‘97 • Michael T. Dehring Cellular & Mol. Biol. Sep. ‘96-Aug.’97 • Khaled Taleb Agha Cellular & Mol. Biol. Sep. ‘96-Dec. ‘96 • Nicholas T. Boon Biochemistry Sep. ‘96 - Dec. ‘96

Postdoctoral and Visiting Fellows: • Vojc Kockman (2018-continuing) • Bikash Sahoo (2017-continuing) • Mukesh Mahajan (2017-continuing) • Thiruppathi Ravul (2015-continuing) • Jia Bai (2016-2018; Scientist, Novartis, Shanghai, China) • Carlo Barnaba (2017-2018; faculty in Michigan State University) • Tomoya Yamamoto (2017-2018; employed in RIKKEN, Japan) • Venkata Sudheer Kumar (2015-2018) • Diana Rodriguez (jointly with TUM, Munich; supported by Hans Senior Fellowship) • Kyle Korshavn (2017); post-doc at Harvard Medical School • Jian Wang (2016-2017); Director, Biomolecular NMR Center, Shanghai • Elke Prade – (2016-2017); Scientist, Pharmaceutical Co., Germany • Karthik Chandrababu – (2015-2016) (supported by a collaborative project with Army lab) • Rongchun Zhang – (2013-2016); Associate Professor, South China University of Technology • Kamal Mroue – (2011-2016); Professor, Qatar Environment & Energy Research Institute • Kazutoshi Yamamoto – 2011-2015; Scientist at NIH • Professor Dong-Kuk Lee, Seol National University (visiting Professor in the lab) • Professor Anirban Bhunia, Bose Institute (visiting Professor in the lab) • Russell Pandian – March 2014; Scientist, National Lab, Chennai, India

5

• Patrick Walsh – June 2014; Scientist, Arizona • Manoj Kumar Pandey – 2011-2014; Scientist, RIKKEN, Yokohama, Japan • Pratima Misra-2011-2014; Scientist, University of Kentucky • Somashekar Baggenthalli-2011-2014; Scientist, University of Kentucky • Janarthanan Krishnamoorthy – 2011-2013; Scientist, India • Nicole Jahr – 2011-2013; Scientist, Max-Planck Institute, Freiburg, Germany • Neil Mackinnon, Sep. 2009-Jan. 2013; Scientist, Max-Planck Institute, Freiburg, Germany • Jeffrey Brender, June ’06 – 2013; Research Scientist, Univ. Michigan • Subramanian Vivekanandan, June 2009-2013; Research Scientist, Univ. Michigan • Dong-Kuk Lee, Professor, Chemistry, Seoul University, South Korea (Visiting Professor) • Kenjirou Higashi, Professor, Medicinal Chemistry, Chiba University (Visiting Professor) • Michelle Sciacca, Jan. 2011-Dec. 2012, Assistant Professor, University of Catania, Italy • Nataliya Popovych, Jan. 2009-Oct. 2011, Scientist, Genentech, CA • Shivani Ahuja, Feb. 2009-Sep. 2011, Scientist, Genentech, CA • Ronald Soong, Sep. 2008 – Aug. 2010, Assistant Professor, University of Toronto • Anatoly Khitrin, Visiting Professor (from Professor, Kent State University, OH)2011 • Kazuyuki Takeda, Visiting Professor (from Chemistry, Kyoto University, Japan)2009 • Sathan Thennarasu, Visiting Professor (from National Lab, India)2009-2010 • Jiadi Xu, June 2006 – March 2011, Research Assistant Professor, John Hopkins Univ. • Dong-Kuk Lee (Visiting Professor, Dec. ’08 – Feb. ’09) • Ravi Prakash Reddy Nanga, Research Scientist, July ’07- July ’08, • Research Assistant Professor, University of Pennsylvania, Philadelphia. • Ulli H. N. Dürr, Sep. ’05 – June 2007, Scientist, Germany • Prof. Deborah Heyl-Clegg, (on sabbatical leave from the Eastern Michigan Univ., 2007) • Kazutoshi Yamamoto (Research Scientist), (Sep. ’04 – Aug. ‘06) • Sudheendra, Sep. ’05-Aug. ’06, Scientist • Vishnu Dhople, Jan. ’05 – Aug. ’06, Scientist, Cellular Molecular Biology, National Lab • Sergey Dvinskikh, Sep. ’05 - March ’06, Professor, Royal • Vladmir Ermakov, Sep. ’04 – Sep. ’05, Assistant Professor, University of Kazan, Russia • Anmin Tan, Jan. ’04-March ’05, Scientist, Medical School, Univ of Missouri • Tenneru Narasimhaswamy, Visiting Fellow, May ’04-May ’05, • Scientist, Central Leather Research Institute, India • Sathan Thennarasu, Jan. 04-Feb.’05, Scientist, Central Leather Research Institute, India • Ja-Young Moon, Visiting Fellow, March ‘04-Feb.’05, June –Aug. ’05, Professor, South Korea • Dong-Kuk Lee, Research Associate, March ‘97 – Feb.’05, June –Aug. ‘05 • Yufeng Wei, Oct. ‘99- Nov. 2001, Professor at Rockefeller University • Srinivasan C. Shekar, Oct. ‘00-March ’01, Scientist, NHMFL, Tallahasse • Udayar Ilangovan, Oct.’96-Sep.’97, Director, NMR facility, University of Texas

Invited Talks 2019 “Amyloid diseases: from biochemistry to clinical applications" Stockholm (Sweden),

August 14-17. 2019 Shanghai Tech University, China (June 28) 2019 Canadian Science Conference, Québec City, Canada (June 7) 2019 ACS Meeting, Orlando (March) 2019 Chemistry, University of Southern Mississippi (March 8) 2018 International Symposium on Pathomechanisms of Amyloid Diseases, University of

Miami, Florida (Dec. 20-21)

6

2018 Gateway NMR Meeting, University of Pittsburgh (Nov. 2&3) 2018 NIHLB, NIH (Oct.) 2018 Conference on “Protein Misfolding”, Dead Sea, Israel (Sep.) 2018 International Symposium on Inorganic Biochemistry, Univ. of Wroclaw, Poland (Sep.5-9) 2018 National Cancer Institute, Frederick (July 2018) 2018 SMALP Meeting on “Overcoming Bottlenecks of Membrane Biology”, Banff

Conference Centre, Canada (April 11) 2018 “Solid-State NMR of Proteins symposium”, UCSD, San Diego (Feb. 24 & 25) 2018 Lyon University, France (May 2018) 2018 CNRS, Paris, France (May 2018) 2018 Structural Biology Symposium, Univ. of Texas Medical Branch, Galveston (April 28) 2018 Chemistry and Biochemistry, Florida International University, Miami (Feb.1, 2018) 2017 Samsung Symposium on “Biomolecular Structure and Function”, Seoul, Korea (Nov.2-

3) 2017 Nano Center, Kanazawa University, Japan (Oct. 13) 2017 RIKEN-JEOL Project Symposium, Tokyo, Japan (Oct. 12) 2017 "Membrane Proteins: Structure, Function and Drug Development", ACS Meeting,

Washington DC (Aug. 20-24) 2017 International Symposium on Protein Misfolding, University of Catania, Italy

(July 31 – August 3) 2017 100th Canadian Society for Chemistry Conference, Toronto (May 28-June 1) 2017 Chemistry, New York University (Feb. 24) 2017 “Amyloid Diseases: From Patho-Mechanism to Structure” Technical University of

Munich, Germany (Jan. 26-27) 2017 University of Karlsruhe, Germany (Jan. 24) 2017 University of Dortmund, Germany (Jan. 23) 2017 The Schaefer symposium, Washington University, St. Louis (Jan. 6) 2016 Suntory Foundation for Life Sciences, Osaka, Japan (Nov. 4) 2016 Osaka University, Japan (Nov.7) 2016 Kobe University, Japan (Oct. 27) 2016 University of Tokyo, Japan (Oct.) 2016 Medical School, Osaka University, Japan (Oct.) 2016 Department of Molecular Engineering, Kyoto University, Japan (Oct.) 2016 Ulm University, Germany (August) 2016 Max Planck, Gottingen, Germany (August) 2016 CNRS - Universite Bordeaux - Bordeaux INP, France (July) 2016 Invited speaker, Symposium on protein-membrane interactions in amyloid diseases, CECAM,

Lugano, Switzerland (July 11-13) 2016 NMR Workshop on “Protein Structure and Dynamics”, Univ. of Minnesota (June 20-24) 2016 Chianti NMR workshop on “Magnetic Resonance for Cellular Structural Biology”,

Grossato, Italy (June 5-10) 2016 Department of Chemistry, University of Florence, Italy (April) 2016 Institute for Advanced Studies, TUM, Munich, Germany (April) 2016 Chemistry, UCSD (April) 2016 French and German Biophysical Societies on membrane research, Blackforest, Germany

(April 11-14) 2016 Medicinal Chemistry, University of Hawaii (April) 2015 PACIFICHEM ACS meeting, Hawaii (Dec.16) 2015 MOOT NMR meeting, Canada (Oct.) 2015 Biochemistry, Kansas State University (Oct.) 2015 Chemistry, Michigan Technological University (Sep.)

7

2015 19th Conference of the International Society of Magnetic Resonance (ISMAR) conference, Shangai (Aug.)

2015 Life Sciences Department, Nankai University, China 2015 Polymer Department, Nankai University, China 2015 Chemistry Department, 16 lectures on Molecular Spectroscopy to undergraduate students,

Nankai University, China 2015 Biophysics, Boston University, Boston (March 31) 2015 Chemistry, Brandeis University, Boston (March 30) 2015 American Chemical Society National Meeting, Denver (March 22-26) 2015 Chemical Physics, Weizmann Institute, Rehovot, Israel (Jan.27) 2015 Chemistry, University of Toronto, Missisauga (Jan. 6) 2014 Chemistry, North Carolina State University (Oct.) 2014 4th International Meeting on Antimicrobial Peptides, Graz, Austria (Sep.) 2014 Biochemistry, University of Düsseldorf, Germany (Sep.) 2014 Chemistry, Miami University, Oxford, Ohio (August 5) 2014 Technische Universität München, Freising-Weihenstephen, Germany (May) 2014 Technische Universität München, Garching, Germany (May) 2014 University of Aarhus, Denmark (April) 2014 Tel Aviv University, Israel (April) 2014 Ben Gurion University, Israel (April) 2014 Technion Israeli Institute, Israel (April) 2014 Symposium on “Metal Binding Sites in Amyloids: Complexes and Mechanisms in

Amyloidogenic Diseases”, Athens, Greece (March) 2013 Yokohama National University, Japan (Dec) 2013 JEOL, Tokyo (Dec) 2013 University of Tokyo, Japan (Dec) 2013 Biochemistry & Molecular Biophysics, University of Chicago (Nov) 2013 Metabolomics Summer Workshop, Michigan Regional Comprehensive Metabolomics Research

Core, The University of Michigan, Ann Arbor (June 25&26) 2013 National Magnet Lab, Hefei, China 2013 Wuhan Institute for Science and Technology, Wuhan, China 2013 Symposium on the Application of Solid-State NMR in Advanced Materials, Nankai University,

Tianjin, China 2013 Solid-State NMR Symposium at the

96th Canadian Chemistry Conference and Exhibition, Québec City (May 26-30) 2013 15th Bollum Symposium, University of Minnesota, Minneapolis 2013 American Physical Society, Baltimore (March) 2013 Pharmaceutical Science, Kyoto University (March) 2013 Department of Chemistry, Kyoto University (March) 2013 Institute for Protein Research, Osaka University, Japan (March) 2013 Bioengineering, Nara Institute of Technology, Japan (March) 2012 Biophysics, University of Pennsylvania (Jan.) 2012 NIH Roadmap conference, San Francisco (Nov.) 2012 Chemistry & Physics, Oklahoma University (Sep.) 2012 Chemical Engineering, University of Akron (Sep.) 2012 Chemistry, Laval University, Qubec, Canada (Aug.) 2012 University of Catania, Italy (July) 2012 University of Padova, Chemistry, Italy (July) 2012 University of Viterbo, Chemistry, Italy (July) 2012 Memorial University of Newfoundland, Canada (July) 2012 Student invited speaker, Max-Planck Institute, Liepzig, Germany (March) 2012 Michigan State University (March 2, 2012).

8

2011 NMRS Conference, Bangalore, India (Dec.; declined) 2011 University of Amherst, MA 2011 McGill University, Canada 2011 University of Halifax, Canada 2011 Invited talks from Cambridge University and Oxford University, UK (July 2011; could not make

it) 2011 Lyon University, France 2011 ENC, Asilomar, CA 2011 Biochemistry, University of Calgary, Canada (Feb.) 2011 APS meeting, Dallas (could not make it to deliver an invited talk) 2010 PACIFICHEM, Hawaii, Dec. 2010 Department of Biology, The George Washington University, DC (Sep. 2010) 2010 ACS meeting, Boston (could not make it to deliver an invited talk) 2010 Student invited speaker, Chemical Biophysics Symposium, University of Toronto,

Canada (April) 2010 NMRS Conference, Lucknow, India (Feb.; declined) 2010 MNIMBS, University of Michigan, Ann Arbor (Jan. 11) 2009 2 lectures, School of Chemistry, University of Melbourne, Australia, Dec. 3 and 10 2009 School of Chemistry, University of Western Sydney, Australia, Dec. 7 2009 Key note speaker, Australian Biophysical Society Conference, Ballarat, Nov. 30 2009 Australian Biophysical Society Conference, Melbourne, Australia, Dec. 2009 Key note speaker, Japanese NMR Society Meeting, Fukuoka, Japan, Nov. 10-12 2009 Biotechnology, Tokyo University of Agriculture and Technology, Koganei, Tokyo (Nov.) 2009 RIKKEN, Yokohama, Japan (Nov.) 2009 12 lectures, Yokohama National University, Japan, Nov. 2009 Key note speaker, Japanese Biophysical Society Meeting, Tokushima (Shikoku island), Japan,

Oct. 30-Navo.1 2009 Rocky Mountain Conference, Solid-State NMR Meeting, (Declined the invitation). 2009 Institut fur Physikalische Chemie, Universitat Stuttgart, Germany (Aug. 7). 2009 Leibniz-Institut fur Molekulare Pharmakologie, Berlin (Aug. 12). 2009 University of Frankfurt, Germany (July). 2009 Max-Planck-Institut fuer Polymerforschung, Mainz, Germany, July. 2009 92nd Canadian Chemistry National Conference, May 30-June 3, Hamilton, Canada. 2008 5th Structural Biology & Functional Genomics and 1st Biological Physics International

Conference, Singapore, Dec. 9-11. 2008 Chemistry, Washington University, St. Louis, Nov. 13 2008 South Eastern Magnetic Resonance Conference, Tallahasse, Oct. 17-19. 2008 ICMRBS, San Diego, Aug. 2008 2008 Institute for Protein Research, Osaka University, Japan, July 3 2008 Distinguished lecture series, Kyoto University, Japan, June 20-25 2008 Central Regional ACS Meeting (CERMACS), Columbus, Ohio, June 12 2008 235th ACS National Meeting, New Orleans, April 7 2007 Merck Co., Philadelphia, Dec. 12 2007 Chemistry, University of Michigan, Ann Arbor, Oct. 4 2007 Chemistry, University of Arkansas, Oct. 8 2007 IISc Bangalore, IIT Madras, University of Madras & Madurai Kamaraj University, Aug. 2007 Rocky Mountain Conference in Analytical Chemistry, Breckenridge, Colorado, July 22-26 2007 New York Structural Biology Center, July 12, 2007 2007 ENC (Experimental NMR Conference), Florida, April 22-27, 2007. 2007 The Membrane Structure & Assembly symposium on "Breaking the Barrier with Antimicrobial Peptides", Biophysical Society, March 3, 2007. 2007 Biophysics, Arizona State University, Jan. 17, 2007

9

2006 Structural Biology, University of Florida, Gainesville, Nov. 6. 2006 South Eastern Magnetic Resonance Conference, Gainesville, Nov. 4. 2006 Central Leather Research Institute, Chennai, India, Sep. 4. 2006 General Electric, Co., Bangalore, India, Aug. 22. 2006 Indian Institute of Science, Bangalore, India, Aug. 21. 2006 Rocky Mountain Conference, Denver, CO (declined the invitation) 2006 Conference on Food, veterinary and medical applications of antimicrobial peptides, Nantes, France, 21-23 June 2006 2006 NMR Summer School, Waterloo, Canada, June 9. 2006 Chemistry, Northern University of Illinois, DeKalb (March 20) 2006 Biochemistry and Molecular Genetics, University of Alabama at Birmingham (Feb. 27) 2006 Chemistry, University of Tulane, New Orleans (Feb. 13) 2006 Institut fuer Physikalische Biologie, Heinrich-Heine-Universitaet, Germany (Feb. 6) 2005 “Advances of Solid State NMR on Biological Systems”, PACIFICHEM, Hawaii

(Dec.15-20) 2005 Chemistry, Laval University, Quebec, Canada (Nov. 23) 2005 Chicago NMR Community Symposium, Abbotts Labs, Chicago 2005 Symposium on Membrane Biophysics of Antimicrobial Peptides, University of Michigan, Ann Arbor, Sep. 24-25, 2005. 2005 Suntory Research Institute, Osaka, Japan (Aug. 12) 2005 Hokkaido University, Osaka, Japan (Aug. 9) 2005 Medical School, Kinki University, Osaka, Japan (Aug. 8) 2005 Rocky Mountain Conference, Denver, CO (Aug. 2) 2005 Conference on the Trends in Biological NMR Spectroscopy, Institute for Protein Research, Osaka University, Japan (July 27) 2005 Dept. of Biotechnology, Tokyo Univ. of Agriculture and Technology, Koganei,

Japan (July 22) 2005 Chemistry, Yokohama National University, Yokohama, Japan (July 21) 2005 Chemistry, Tokyo Metropolitan University, Hachioji, Japan (July 20) 2005 RIKEN Research Center, Yokohama, Japan (July 19) 2005 Chemistry, University of Hyogo (Himeji Institute of Technology), Japan (July 14) 2005 Chemistry, Material Science and Engineering, Kobe University, Japan (July 12) 2005 Institute for Protein Research, Osaka University, Japan (July 11) 2005 Chemistry, Hiroshima University (June 29) 2005 Chemistry, University of Akron (April 20) 2005 NMR Community, University of Akron (April 20) 2005 Chemistry & Biochemistry, University of Windsor, Canada (March) 2005 Chemistry, University of British Columbia, Vancouver, Canada (Feb) 2005 Immunology, University of British Columbia, Vancouver, Canada (Feb) 2005 3 lectures in the International Workshop on Recent Trends in Solid State NMR in

Biological Systems, Bangalore, India (Jan. 24-26) 2005 International Conference on Magnetic Resonance in Biological Systems (ICMRBS),

Hyderabad, India (Jan. 16-22) 2004 Chemistry, University of Chicago (Nov. 30) 2004 Chemistry, University of Alberta, Nov. 22 2004 Symposium on “Innovative Technologies in Biological NMR”,

Osaka University, Japan, Nov. 19 2004 Institute for Protein Research, Osaka University, Japan, Nov. 18 2004 Graduate School of Pharmaceutical Sciences, Kyoto University, Japan, Nov. 17 2004 Macromolecular Science, University of Freiburg, Germany, Oct. 13 2004 Chemistry, University of Karlsruhe, Germany, Oct. 13

10

2004 International Congress on the Structure-Function Relationships of Hydrophobic Peptides, Namur, Belgium (October 9-14)

2004 Chemistry, McMaster University, Canada (Sep 30) 2004 NMR Community, McMaster University, Canada (Sep 30) 2004 Physics, University of Guelph, Canada (Sep 28) 2004 45th Rocky Mountain Conference on Analytical Chemistry, Denver (Aug. 2) 2004 Bruker NMR Meeting, Denver (Aug. 1) 2004 Bruker NMR, Bellerica, MA (July) 2004 Biochemistry, University of Minnesota (July) 2004 Chemistry, University of Minnesota (July) 2004 “NMR of Membranes”, 36th Central Regional ACS Meeting, Indiana University Purdue

University, Indianapolis, (June 4) 2004 87th Canadian Chemistry Conference and Exhibition, London, Ontario, Canada (May

29-June 1) 2004 Chemistry, University of Louisville (April) 2004 Chemistry, University of Detroit Mercy (April 6) 2004 Chemistry, University of Delaware (March 29) 2004 PITTCON Conference, Chicago (March 12) 2004 Chemistry, Univ of Illinois, Chicago (March 11) 2004 Chicago NMR Community Symposium, Univ of Illinois, Chicago (March 11) 2004 Chemistry, Western Michigan University (Feb. 9) 2004 Chemistry, Kent State Univ. (Feb. 5) 2004 Chemistry, University of Toledo (Feb. 2) 2004 Chemistry, Eastern Michigan University, Ypsilanti (Jan. 26) 2003 Membrane Biophysics Symposium, Univ of Michigan, Ann Arbor, (Dec. 6, 2003) 2003 Solid-State NMR Symposium, University of Michigan, Ann Arbor, (Dec. 5, 2003) 2002 Central Leather Research Institute, Chennai, India (October 2002) 2002 Chemical Physics, Central Leather Research Institute, Chennai, India (October) 2002 Madurai Kamaraj University (SRNM College, Sattur), India (October 2002) 2002 Indian Institute of technology, Chennai, India (October 2002) 2002 Biophysical Society Meeting, Feb. 2002. 2002 Department of Chemistry, University of Washington, Seattle, Feb. 2001 36th ACS Midwest regional meeting, Lincoln, Nebraska, October 10-13 2001 Department of Radiology, University of Pennsylvania, PA 2001 Chemistry, University of Michigan, Ann Arbor, Sep. 2001 Anesthesiology, University of Michigan, Ann Arbor, Aug. 2001 Chemagnetics/Varian 12th Annual Wokrshop on Solid-state NMR Spectroscopy, Fort

Collins, Aug. 3-4. 2001 Rocky Mountain Conference, Denver, 29th July - 2nd of August 2001 Naval Research Laboratory, Washington, D.C., July 23 2001 AAA-NMR Seminar Series, University of Michigan, June 26 2001 Central/Great Lakes ACS Joint Regional Meeting, Grand Rapids, June 12 2001 Department of Physics, Purdue University, Indianapolis, April 26 2001 Department of Chemistry, University of Minnesota, Feb.2 2000 Department of Chemistry, Georgetown University, Washington D.C., Dec. 2000 Department of Chemistry, Wayne State University, Detroit, Nov. 29 2000 Department of Chemistry, Case-Western Reserve University, Cleveland, Ohio, Nov. 16 2000 Department of Chemistry, University of Illinois-Chicago, Oct.5 2000 Department of Chemistry, Ohio State University, Columbus, Ohio, Oct. 3 2000 Department of Chemistry, Purdue University, West Lafayette, Sep. 27 2000 Department of Chemistry, Miami University, Ohio, Sep. 14 2000 ACS 32nd Central Regional Meeting, Cincinnati, May 19

11

2000 Parke-Davis WL, Ann Arbor, April 20 2000 ACS National Meeting, San Francisco, March 26-30 2000 Department of Chemistry, Michigan State University, March 1999 Department of Chemistry, Iowa State University, Nov. 1999 Parke-Davis WL, Ann Arbor, Dec. 1999 Department of Chemistry, Kent State University, Oct. 1999 Central Leather Research Institute, Madras, Sep. 1999 ACS 31st Central Regional Meeting, Columbus, June 28 1999 Experimental Nuclear Magnetic Resonance Conference, Orlando, March 1999 Flint Ink Company, Ann Arbor, MI, Jan. 1998 ACS Meeting, Baton Rouge, Nov. 1998 XVIIIth International Conference on Magnetic Resonance in Biological Systems,

Tokyo, Japan, August 1998 NIH, Bethesda, July 1998 Ford Company, Dearborn, Detroit 1998 ACS 30th Central Regional Meeting, Cleveland, Ohio, May 27-28 1997 Chicago-area NMR Meeting, Nov. 1997 ACS Central Regional Meeting, Midland, June 1997 Department of Neurology, The University of Michigan, July 1997 Macromolecular Sci. & Engineering, The University of Michigan, July 1997 Department of Biochemistry & Mol. Biology, Wayne State University, Detroit, Feb. 1996 Department of Biochemistry, Parke-Davis, Nov. 1996 Department of Gerontology, The University of Michigan, Dec. 1996 Biomolecular Training Program, The University of Michigan, Dec. 1996 Chemistry & Biophysics, The University of Michigan, Feb. 1996 Chemistry, University of Pennsylvania, Philadelphia, April 1996 NIH Center for Solid-State NMR, University of Pennsylvania, Philadelphia, May 1996 38th Rocky Mountain Conference, Denver, Colorado 1993 Chemistry, Tokyo University, Japan 1993 NMR Young Scientist Meeting, Himamatsu, Japan 1992 Upjohn Pharmaceuticals, Tsukuba, Japan, Sep. 1992 JEOL Ltd., Tokyo, Japan, May Poster Presentations: More than about 1000 posters presented in major conferences including Biophysical Society meeting, ENC (Experimental NMR Conference), Rocky Mountain conference, ACS meetings, and Protein Society Meetings. Symposia or Meetings Organized: 2019 Chair, International Symposium on Pathomechanisms of Amyloid Diseases, University

of Miami, Florida (Dec. 18-20) 2019 Co-Chair, EMBO Workshop on “Tools for Structural Biology of Membrane Proteins”,

EMBL Gamburg, Germany (Oct.7-9) 2019 Co-Chair, “Gateway NMR Meeting”, University of Michigan, Ann Arbor 2018 Co-Chair, “Pathomechanisms of Amyloid Diseases”, Miami, Florida, Dec. 20-21 2017 Co-Chair, International Symposium on Protein Misfolding, University of Catania, Italy

(July 31 – August 3) 2017 Co-Chair, “Amyloid Diseases: From Patho-Mechanism to Structure” Technical

University of Munich, Germany (Jan. 26-27) 2016 Co-Chair, Computational Biophysics Symposium, Univ. of Michigan, Sep. 19. 2016 Chair, Symposium on “Recent Advances in Biological NMR”,

University of Michigan, Ann Arbor (April 16&17)

12

2015 Co-Organizer, PACIFICHEM, ACS meeting, Honolulu, Hawaii (Dec.) 2014 Co-Organizer, “Protein Misfolding and Neurological Diseases”,

Univ. of Michigan (May) 2013 Chair, Atomic View of Biomacromolecules, University of Michigan, Ann Arbor (July 11-13). 2010 Co-Organizer, “Advances in Biological Solid-State NMR”, PACIFICHEM, Hawaii (Dec.). 2005 Organizer, “Advances of Solid State NMR on Biological Systems”, PACIFICHEM, Hawaii

(Dec. 15-20) 2005 Chair, “Membrane Biophysics of Antimicrobial Peptides”, University of Michigan, Ann Arbor,

Sep. 24-25. 2004 Chair, “Solid-State NMR”, 36th Great Lakes Regional ACS meeting, Peoria, Oct. 18. 2004 Chair, “NMR of Membranes”, 36th Central Regional ACS Meeting, Indiana University Purdue

University, Indianapolis, June 4 2004 Chair, “Recent Developments in Solid-State NMR Spectroscopy”, 36th Central Regional ACS

Meeting, Indiana University Purdue University, Indianapolis, June 3, 2004 2003 Chair, “Membrane Biophysics”, University of Michigan, Ann Arbor, Dec. 6 2002 Chair, Solid-State NMR Symposium, ACS Central Regional Meeting, Ypsilanti, June 26-29. 2001 Organized a mini-symposium on “Solid-State NMR Spectroscopy” as part of the Chemistry

603/Biophysics 503 course involving students-only presentations, April 2001 2000 Co-organizer, “Macromolecular Science and Engineering symposium”, held at the University of

Michigan, Ann Arbor (Profs. Robert Zand, Michael Soloman and I co-organized this symposium), Oct. 19.

1999 Co-Organizer, “Ultra-High Field NMR Spectroscopy and Structural Biology”, held at the University of Michigan, Ann Arbor. (Prof. Zuiderweg and I co-organized this symposium), May 28.

Committee and Service: University of Michigan 2019 Principal Investigator, “Membrane Protein Structural Biology”, Biosciences

Initiative (in progress) 2018-2019 Faculty search committee, Chemistry 2016-2019 Diversity Committee, Chemistry 2016-2017 Mentoring Committee, Assistant Professors Brent Martin, Randy Stockbridge,

Aaron Frank, Sarah Veatch, Markos Koutmos 2016-2017 Launching Committee, Assistant Professors Randy Stockbridge, Sarah Keane,

Marcos Koutmos 2016-2017 800 MHz NMR Committee 2016-2017 Facilities Committee, Biophysics 2016-2017 Facilities Committee, Chemistry 2015-2016 Chair, Faculty Search Committee, Biophysics (Successfully completed the

search with 2 Assistant Professors hire: Aaron Frank and Sarah Keane were hired as Biophysics-Chemistry as Assistant Professors)

2015 Member, Biophysics Curriculum committee (Devloped undergraduate curriculum to create a new track in Structural Biology (jointly with Prof. Randy Stockbridge)

2015 Mentor of an Assistant Professor 2015 Member, Facilities committee 2014 Chair, Faculty Search Committee, Biophysics (Successful hiring Dr. Randy

Stockbridge as an Assistant Professor – 50:50 Biophysics-MCDB) 2012-present Awards Committee, Chemistry Department 2012-2014 Associate Chair, Biophysics

13

2012-present Member, Biophysics, Graduate Committee 2011-present Member, Biophysics Training Grant Executive Committee 2012-present Member, Chemistry, Graduate Committee 2012-present Member, Biophysics, Instruments Committee 2008-present Advisor, Biophysics Graduate students 2007- present Instrumentation committee, Chemistry 2011 Chair, Biophysics faculty search committee 2011 Member of ad hoc committee for junior faculties in Chemistry 2007- 2010 Member, Graduate student admission committee 2008-2011 Chair, Awards Committee, Biophysics 2008-2009 Faculty search committee, Biophysics 2006-2009 Member, Biophysics curriculum development committee 2008-present Member, NMR Committee, Chemistry & Biophysics 2007-2009 Member, Executive committee, Biophysics 2007-2008 Chair, Faculty search committee, Biophysics 2010-2011 Biophysics Facilities 2007- 2011 Coordinator, Biophysics seminars 2007- 2010 Faculty search committee, Chemistry 2007-2009 Member of Asst. Prof. Jennifer Ogilvie’s promotion committee 2006-2008 Member, Graduate Committee 2004-2007 Biochemistry Advisor, Department of Chemistry 2006-2007 Member, Chemistry instrumentation committee (2006-continuing) 2005-2006 Graduate Chair, Chemistry 2005-2006 Faculty search committee 2005-2008 Chair of Dr. Al-Hashimi’s ad hoc committee (Chemistry & Biophysics) 2005-2006 Chair of Dr. Meiners’s promotion committee (Biophysics) 2004-2010 Member, Biophysics students recruitment committee 2004-2009 Member, PIBS students recruitment committee 2004-2010 Member, Biophysics Program Committee 2004-2005 Chair, Biophysics Equipment Committee 2004-2005 Physical Chemistry Faculty Search committee 2004-2005 Graduate Program Committee, Department of Chemistry 2005-2011 Promotion committee (mentoring junior faculty in Chemistry & Biophysics) 2004-2005 Biochemistry Advisor, Department of Chemistry 2002-July ‘03 Chair, Biophysics Graduate Program 2002-July ‘03 Chair, Biophysics Program Committee 2002-July ‘03 Member, Biophysics Executive committee Member (2001-2002) & Chair (from 2002-July ‘03), PIBS students recruitment committee Member (2001-2002) & Chair (from 2002-July ‘03), Biophysics students recruitment committee 2000-2002 Member of the “NMR committee to purchase NMR spectrometers”, Life Science

Initiatives at the Univ. of Michigan 2000-2002 Coordinator, “Biophysics & Chemical Biology Seminar Series” 1999-2007 Coordinator, “Ann Arbor Area NMR (AAA-NMR) seminar series” 2000-2001 Chair of the special seminar committee (Gomberg lecture series,

Department of Chemistry) 1996-2001 Member of the special seminar committee (Gomberg lecture series,

Department of Chemistry) 1999-2003 Biochemistry Advisor to the undergraduate students 1999-2000 Member of the “Structural Biology committee”,

Michigan Life Science Corridor. 1998-2000 Coordinator, “Biophysics Seminar Series” 1999-2000 Member of the committee to design undergraduate Physical Chemistry courses

14

1996-1998 Member of the “New Equipment Committee”, Department of Chemistry

External Service:

• NIH Director’s Transformative Research Award Study Section (March, 2019) • NIH Fellowship Applications F04B Meeting (March, 2019) • P41ZRG1 BST-T Study Section (Oct. 30, 2018) • F1000 Prime, faculty member (since 2016) • Ad hoc Member, XNDA (Xenobiotic and Nutrient Disposition and Action) NIH Study

Section, Oct., 2016 • Ad hoc Member, Metabolomics study section (2016) • Ad hoc Member, NIH Study Section, F31&F32 applications (2016) • Member, NIH Study Section, S10 Instrumentation proposals (2016) • Member, NSF Panel, MRI proposals (April 2016) • Member of a panel to elect Hans Fischer Fellows, Munich, Germany (2015-2018) • Member, NIH P41 committee (Dec. 2015) • Member, Workshop on Ultra-High Field NMR Instrumentation, NIH (Dec. 2015) • Member, ZRG1 BCMB-D Study section, NIH (Nov. 2015) • Member, XNDA, NIH study section (June 2015) • Member, Reviewer, Canadian Foundation for Innovation (2014) • Ad hoc Member, several NIH study sections (2010, 2011, 2012 & 2013) • Member, Executive Committee, Canadian Foundation for Innovation (2012) • Member, Chemistry, NSF, Oct. 2010 & 2013 • Member, NIH BBM Study Section, Feb. 2009 • Member, NIH Study Section to review Program Projects (2009) • Member, Executive committee of NSERC Funding Agency, Canada • Member, NIH study section (Major research instrument), July 2007 • Member, NSF (Bioengineering) Panel, Jan. 2007. • Member, NIH Study section (ZAI1 DDS-M-M1) (New Drug Discovery for

Tuberculosis), Jan. 2007. • Member, NIH Study section (Biological Chemistry and Macromolecular Biophysics),

March 2006. • Member, NIH Study section (ZRG1 SBIB-L (40)), Jan. 2006. • Ad-hoc member, NIH Study section (Biochemistry and Biophysics of Membranes), June

and Oct., 2005. • Ad-hoc member, NIH Study section (Discovery and Mechanisms of Antimicrobial

Resistance Study Section), 2004. • External Advisory Committee Member, National High Field Magnet Laboratory,

Tallahasse, Florida, 2005-onwards. • Executive Committee Member, National High Field Magnet Laboratory, Tallahasse,

Florida, 2005-onwards.

• Editorial Board of Journal Biological Chemistry • Editorial Board of Plos One • Editorial Board of Scientific Reports (Nature Journal) • Editorial Board of PeerJ • Editorial Board of Journal of Magnetic Resonance (2010-continuing) • Editorial Board of Magnetic Resonance Insights (2008-continuing)

15

• Editorial Board of BBA-Biomembranes journal (2006-continuing) • Editorial Board of “Solid State Nuclear Magnetic Resonance Spectroscopy”

journal (Jan. 2002 onwards) • Advisory Committee of Chemistry and Physics of Lipids • Advisory Committee of Magnetic Resonance in Chemistry • Guest Editor for a special issue on “Lipid Nanodiscs” in Chemistry and Physics of

Lipids (2018-2019). • Guest Editor (with Dr. Ehud Gazit) for a special issue on “Amyloid Proteins” in

Chemical Communication, Royal Society (2017-2018) • Guest Editor for a special issue on “Membrane Assisted Amyloid Aggregation” in

BBA Biomembranes (2017-2018) • Guest Editor for Special Issue: Recent Advances in Connecting Structure,

Dynamics, and Function of Biomolecules by NMR, J. Phys. Chem. B (2016-2017) • Guest Editor for a special issue on “Misfolding of Amyloid Proteins” in PCCP

(Physical Chemistry Chemical Physics, Royal Society (2012). • Guest Editor for a special issue on “NMR Dynamical Studies on Membrane

Proteins” in BBA Biomembranes (2009). • Guest Editor for a special issue on “NMR Structural Studies on Membrane

Proteins” in BBA Biomembranes (2006-2007). • Guest Editor for a special issue on “Antimicrobial Peptides” in BBA

Biomembranes (2005-2006). • Guest Editor for a special issue on “Membrane Biophysics” in Chemistry and

Physics of Lipids (2004-2005). • Guest Editor for a special issue on ‘Solid-State NMR Methods and Applications to

Study Materials’ in Solid-State Nuclear Magnetic Resonance Spectroscopy Journal (2003).

• Guest Editor for a special issue on ‘Solid-State NMR Studies on Biological Solids’ in Magnetic Resonance in Chemistry Journal (2003).

• Edited a book on “NMR Spectroscopy of Biological Solids”, Taylor & Francis (2006).

• Edited a book on “Thermotropic Liquid Crystals – Recent Advances”, Springer (2007).

• Reviewed proposals from NSF, NIH, PRF (ACS), USDA Agriculture Plant Biochemistry, NSERC-Canada, France, UK, India, Italy, Japan, Singapore, Taiwan, and Academy of Sciences of the Czech Republic.

Refereed research papers from Nature, Nature Chemistry, Nature Chemical Biology, Nature Methods, Nature Communications, Science, Science Advances, Cell, eLife, PNAS, Molecular Cell, PLOS one, Biophysics Journal, Biochemistry, BBA Biomembranes, Biomaterials, Langmuir (ACS), Biomacromolecules, Biophys. Biochim. Acta, Journal of Biological Chemistry, Journal of Molecular Biology, FEBS Letters, Protein Science, Chemistry and Physics of Lipids, Journal of Pharmaceutical Chemistry, Journal of the American Chemical Society, Journal of Magnetic Resonance, Inorganic Chemistry, Journal of Physical Chemistry (A,B&C), Journal of Biomolecular NMR, Solid State Nuclear Magnetic Resonance Spectroscopy, Magnetic Resonance in Chemistry, Magnetic Resonance Insights, Protein Science, Journal of Molecular Structure, Macromolecules, Bulletin for Mathematical Biology, Chemical Physics Letters, Journal of Chemical Physics, International Journal of Pharmaceutics, Journal of Neuroscience, The EMBO journal, Science, Chemical Communications, Chemical Science, Angew.Chemie and its sister journals, and many journals published by Royal Society and others. List of Courses Taught (*courses developed and taught by me):

16

• General Chemistry (for undergraduate students) • Physical Chemistry (for undergraduate students) • Thermodynamics and Statistical mechanics (for undergraduate students) • Biophysical Chemistry (for undergraduate students)* • Biophysics of Diseases (for undergraduate students) • Biophysics (for beginning undergraduate students)* • Professional development course (for undergraduate & graduate students)* • Molecular Spectroscopy (a graduate-level course) • Structural Biology I and II (an undergraduate-level course)* • Biological NMR Spectroscopy (a graduate-level course)* • Biophysical Principles and Structural Biology (a graduate-level course) • Principles of NMR Spectroscopy (a graduate-level course)* • Biophysical Techniques (a graduate-level course) • Chemical Biology (a graduate-level course)

List of Publications (Google scholar h index is 76)

327. Sahoo B.R., Genjo T., Watanabe-Nakayama T., Stoddard A., Ando T., Yasuhara K., Fierke C.A., Ramamoorthy A. Cationic polymethacrylate-copolymer acts as an agonist for beta-amyloid and antagonist for amylin fibrillation. Chemical Science DOI: 10.1039/c8sc05771k (2019.

326. Brender JR, Ghosh A, Kotler SA, Krishnamoorthy J, Bera S, Morris V, Sil TB, Garai K, Reif B, Bhunia A, Ramamoorthy A. Probing transient non-native states in amyloid beta fiber elongation by NMR. Chem Commun (Camb). 2019 Mar 27. doi: 10.1039/c9cc01067j.

325. Ravula T, Hardin NZ, Ramamoorthy A. Polymer nanodiscs: Advantages and limitations. Chem Phys Lipids. 2019; 219:45-49.

324. Hardin NZ, Ravula T, Mauro GD, Ramamoorthy A. Hydrophobic Functionalization of Polyacrylic Acid as a Versatile Platform for the Development of Polymer Lipid Nanodisks. Small. 2019 Jan 22:e1804813. doi: 10.1002/smll.201804813.

323. Pandey MK, Damron JT, Ramamoorthy A, Nishiyama Y. Proton-detected 3D 1H anisotropic/14N/1H isotropic chemical shifts correlation NMR under fast magic angle spinning on solid samples without isotopic enrichment. Solid State Nucl Magn Reson. 2019 Feb;97:40-45.

322. Lee YH, Lin Y, Cox SJ, Kinoshita M, Sahoo BR, Ivanova M, Ramamoorthy A. Zinc boosts EGCG's hIAPP amyloid Inhibition both in solution and membrane.

Biochim Biophys Acta Proteins Proteom. 2018 Nov 22. pii: S1570-9639(18)30204-8.

321. Ravula T, Ishikuro D, Kodera, N, Ando, T, Anantharamaiah, G.M., Ramamoorthy A. Real-Time Monitoring of Lipid Exchange via Fusion of Peptide Based Lipid-Nanodiscs,, Chem. Mater., 2018, 30 (10), pp 3204–3207.

320. Sahoo BR, Genjo T, Bekier M, Cox SJ, Stoddard AK, Ivanova M, Yasuhara K, Fierke CA, Wang Y, Ramamoorthy A. Alzheimer's amyloid-beta intermediates generated using polymer-nanodiscs. Chem Commun (Camb). 2018 Nov 13;54(91):12883-12886.

319. Sahoo BR, Genjo T, Cox SJ, Stoddard AK, Anantharamaiah GM, Fierke C, Ramamoorthy A. Nanodisc-Forming Scaffold Protein Promoted Retardation of Amyloid-Beta Aggregation. J. Mol. Biol. 2018 Oct 19;430(21):4230-4244.

318. Ravula T, Hardin N, Bai J, Im S-C, Waskell, Ramamoorthy A. Effect of polymer charge on functional reconstitution of membrane proteins in polymer nanodiscs. Chem Commun (Camb). 2018 Aug 23;54(69):9615-9618.

317. Barnaba C, Ramamoorthy A. Picturing the Membrane-assisted Choreography of Cytochrome P450 with Lipid Nanodiscs. ChemPhysChem. Oct 19;19(20):2603-2613 (2018).

17

316. Barnaba C, Ravula T, Medina-Meza IG, Im SC, Anantharamaiah GM, Waskell L, Ramamoorthy A. Lipid-exchange in nanodiscs discloses membrane boundaries of cytochrome-P450 reductase. Chem Commun (Camb). 2018 Jun 14; 54(49):6336-6339.

315. Damron JT, Ma J, Kurz R, Saalwächter K, Matzger AJ, Ramamoorthy A. The Influence of Chemical Modification on Linker Rotational Dynamics in Metal-Organic Frameworks. Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8678-8681.

314. Gentry KA, Zhang M, Im SC, Waskell L, Ramamoorthy A. Substrate mediated redox partner selectivity of cytochrome P450. Chem Commun (Camb). 2018 May 31;54(45):5780-5783.

313. Rodriguez Camargo DC, Garg D, Buday K, Franko A, Rodriguez Camargo A, Schmidt F, Cox SJ, Suladze S, Haslbeck M, Mideksa YG, Gemmecker G, Aichler M, Mettenleiter G, Schulz M, Walch AK, Hrabě de Angelis M, Feige MJ, Sierra CA, Conrad M, Tripsianes K, Ramamoorthy A, Reif B. hIAPP forms toxic oligomers in plasma. Chem Commun (Camb). 2018 May 24; 54(43):5426-5429.

312. Kotler SA, Ramamoorthy A. Preparation of Stable Amyloid-β Oligomers Without Perturbative Methods. Methods Mol Biol. 2018;1777:331-338.

311. Prade E, Mahajan M, Im SC, Zhang M, Gentry KA, Anantharamaiah GM, Waskell L, Ramamoorthy A. A Minimal Functional Complex of Cytochrome P450 and FBD of Cytochrome P450 Reductase in Nanodiscs. Angew Chem Int Ed Engl. 2018 Jul 9;57(28):8458-8462.

310. Terakawa MS, Lin Y, Kinoshita M, Kanemura S, Itoh D, Sugiki T, Okumura M, Ramamoorthy A, Lee YH. Impact of membrane curvature on amyloid aggregation. Biochim Biophys Acta. 2018 Apr 28. pii: S0005-2736(18)30130-5.

309. Louka A, Matlahov I, Giuntini S, Cerofolini L, Cavallo A, Pillozzi S, Ravera E, Fragai M, Arcangeli A, Ramamoorthy A, Goobes G, Luchinat C. Engineering l-asparaginase for spontaneous formation of calcium phosphate bioinspired microreactors. Phys Chem Chem Phys. 2018 May 9; 20(18):12719-12726.

308. Sciacca MFM, Chillemi R, Sciuto S, Greco V, Messineo C, Kotler SA, Lee DK, Brender JR, Ramamoorthy A, La Rosa C, Milardi D. A blend of two resveratrol derivatives abolishes hIAPP amyloid growth and membrane damage. Biochim Biophys Acta. 2018 Mar 17. pii: S0005-2736(18)30092-0.

307. Lee YH, Ramamoorthy A. Semen-derived amyloidogenic peptides-Key players of HIV infection. Protein Sci. 2018 Mar 1. doi: 10.1002/pro.3395.

306. Zhou Y, Damasceno PF, Somashekar BS, Engel M, Tian F, Zhu J, Huang R, Johnson K, McIntyre C, Sun K, Yang M, Green PF, Ramamoorthy A, Glotzer SC, Kotov NA. Unusual multiscale mechanics of biomimetic nanoparticle hydrogels. Nat Commun. 2018 Jan 12;9(1):181.

305. Barnaba C, Bikash Ranjan Sahoo BR, Ravula T, Medina-Meza, IG, Im SC, Anantharamaiah GM, Waskell L, Ramamoorthy A. Cytochrome-P450 Induced Ordering of Microsomal Membranes Modulates Affinity for Drugs, Angew. Chem. Int. Ed Engl. 2018 Mar 19;57(13):3391-3395.

304. Wang J, Yamamoto T, Bai J, Cox SJ, Korshavn KJ, Monette M, Ramamoorthy A. Real-Time Monitoring of the Aggregation of Alzheimer’s Amyloid-β by 1H Magic Angle Spinning NMR Spectroscopy, Chem. Commun. 54(16):2000-2003 (2018).

303. Ravula T, Hardin NZ, Ramadugu S, Cox SJ, Ramamoorthy A. pH resistant monodispersed polymer-lipid nanodiscs. Angew. Chem. Int. Ed Engl. 2017 Dec 12. doi: 10.1002/anie.201712017.

302. Yasuhara K, Arakida J, Ravula T, Ramadugu SK, Sahoo B, Kikuchi JI, Ramamoorthy A. Spontaneous Lipid Nanodiscs Fomation by Amphiphilic Polymethacrylate Copolymers. J. Am. Chem. Soc. 2017 Nov 24. doi: 10.1021/jacs.7b10591.

301. Rodriguez Camargo DC, Korshavn KJ, Jussupow A, Raltchev K, Goricanec D, Fleisch M, Sarkar R, Xue K, Aichler M, Mettenleiter G, Walch AK, Camilloni C, Hagn F, Reif B, Ramamoorthy A. Stabilization and structural analysis of a membrane-associated hIAPP aggregation intermediate. eLife 2017 Nov 17;6. pii: e31226. doi: 10.7554/eLife.31226. News Coverage.

18

300. Ravula T, Barnaba C, Mahajan M, Anantharamaiah G, Im S-C, Waskell, Ramamoorthy A. Membrane Environment Drives Cytochrome P450’s Spin Transition and its Interaction with Cytochrome b5. Chem. Comm. 2017 Nov 28;53(95):12798-12801.

299. Damron JT, Kersten KM, Pandey MK, Nishiyama Y, Matzger AJ, Ramamoorthy A. Role of Anomalous Water Constraints in the Efficacy of Pharmaceuticals Probed by 1H Solid-State NMR. ChemSelect (in press).

298. Beck MW, Derrick JS, Suh JM, Kim M, Korshavn KJ, Kerr RA, Cho WJ, Larsen SD, Ruotolo BT, Ramamoorthy A, Lim MH. Minor Structural Variations of Small Molecules Tune Regulatory Activities toward Pathological Factors in Alzheimer's Disease. ChemMedChem. 2017 Oct 9. doi: 10.1002/cmdc.201700456.

297. Jones MR, Mathieu E, Dyrager C, Faissner S, Vaillancourt Z, Korshavn KJ, Lim MH, Ramamoorthy A, Wee Yong V, Tsutsui S, Stys PK, Storr T. Multi-target-directed phenol-triazole ligands as therapeutic agents for Alzheimer's disease. Chem Sci. 2017 Aug 1;8(8):5636-5643.

296. Ravula T, Hardin NZ, Ramadugu SK, Ramamoorthy A. pH Tunable and Divalent Metal Ion Tolerant Polymer Lipid Nanodiscs. Langmuir. 2017 Oct 10;33(40):10655-10662.

295. Damron JT, Kersten KM, Pandey MK, Mroue KH, Yarava JR, Nishiyama Y, Matzger AJ, Ramamoorthy A. Electrostatic Constraints Assessed by 1H MAS NMR Illuminate Differences in Crystalline Polymorphs. J Phys Chem Lett. 2017 Sep 7;8(17):4253-4257.

294. Gentry KA, Prade E, Barnaba C, Zhang M, Mahajan M, Im SC, Anantharamaiah GM, Nagao S, Waskell L, Ramamoorthy A. Kinetic and Structural Characterization of the Effects of Membrane on the Complex of Cytochrome b 5 and Cytochrome c. Sci Rep. 2017 Aug 10;7(1):7793.

293. Kamgar-Parsi K, Hong L, Naito A, Brooks CL 3rd, Ramamoorthy A. Growth-incompetent monomers of human calcitonin lead to a noncanonical direct relationship between peptide concentration and aggregation lag time. J Biol Chem. 2017 Sep 8;292(36):14963-14976.

292. Ravula T, Ramadugu SK, Di Mauro G, Ramamoorthy A. Bioinspired, Size-Tunable Self-Assembly of Polymer-Lipid Bilayer Nanodiscs. Angew Chem Int Ed Engl. 2017 Sep 11;56(38):11466-11470.(News Coverage on this article)

291. Mukherjee S, Kar RK, Nanga RPR, Mroue KH, Ramamoorthy A, Bhunia A. Accelerated molecular dynamics simulation analysis of MSI-594 in a lipid bilayer. Phys Chem Chem Phys. 2017 Jul 26;19(29):19289-19299.

290. Yamamoto K, Caporini MA, Im SC, Waskell L, Ramamoorthy A. Transmembrane Interactions of Full-length Mammalian Bitopic Cytochrome-P450-Cytochrome-b5 Complex in Lipid Bilayers Revealed by Sensitivity-Enhanced Dynamic Nuclear Polarization Solid-state NMR Spectroscopy. Sci Rep. 2017 Jun 23;7(1):4116.

289. Mroue K. H., Viswan A., Sinha N., Ramamoorthy A. Solid-State NMR Spectroscopy: The Magic Wand to View Bone at Nanoscopic Resolution. Ann. Rep. NMR Spectroscopy (in press).

288. Zhang R., Mroue K. H., Sun P., Ramamoorthy A. High-Resolution Proton NMR Spectroscopy of Polymers and Biological Solids. Modern Magnetic Resonance (2017).

287. Kinoshita M., Kakimoto E., Terakawa M. S., Lin Y., Ikenoue T., So M., Sugiki T., Ramamoorthy A., Goto Y., Lee Y-H. Model membrane size-dependent amyloidogenesis of Alzheimer's amyloid-beta peptides. Phys. Chem. Chem. Phys. 2017 Jun 21;19(24):16257-16266.

286. Naito A, Matsumori N, Ramamoorthy A. Dynamic membrane interactions of antibacterial and antifungal biomolecules, and amyloid peptides, revealed by solid-state NMR spectroscopy. Biochim Biophys Acta. 2017 Jun 6. pii: S0304-4165(17)30190-3.

285. Zhang R, Duong NT, Nishiyama Y, Ramamoorthy A. 3D Double-Quantum/Double-Quantum Exchange Spectroscopy of Protons under 100 kHz Magic Angle Spinning. J Phys Chem B. 2017 Jun 22;121(24):5944-5952.

284. Barnaba C, Gentry K, Sumangala N, Ramamoorthy A. The catalytic function of cytochrome P450 is entwined with its membrane-bound nature. F1000Res. 2017 May 9;6:662. (Invited Review)

19

283. Tian D, Li T, Zhang R, Wu Q, Chen T, Sun P, Ramamoorthy A. Conformations and Intermolecular Interactions in Cellulose/Silk Fibroin Blend Films: A Solid-State NMR Perspective. J Phys Chem B. 2017 Jun 29;121(25):6108-6116.

282. Zhang R, Mroue KH, Ramamoorthy A. Proton-Based Ultrafast Magic Angle Spinning Solid-State NMR Spectroscopy. Acc Chem Res. 2017 Apr 18;50(4):1105-1113.

281. Korshavn KJ, Satriano C, Lin Y, Zhang R, Dulchavsky M, Bhunia A, Ivanova MI, Lee YH, La Rosa C, Lim MH, Ramamoorthy A. Reduced Lipid Bilayer Thickness Regulates the Aggregation and Cytotoxicity of Amyloid-β. J Biol Chem. 2017 Mar 17;292(11):4638-4650.(News Coverage on this publication)

280. Lee HJ, Korshavn KJ, Nam Y, Kang J, Paul TJ, Kerr RA, Youn IS, Ozbil M, Kim KS, Ruotolo BT, Prabhakar R, Ramamoorthy A, Lim MH. Structural and Mechanistic Insights into Development of Chemical Tools to Control Individual and Inter-Related Pathological Features in Alzheimer's Disease. Chemistry. 2017 Feb 21;23(11):2706-2715.

279. Kang J, Lee SJ, Nam JS, Lee HJ, Kang MG, Korshavn KJ, Kim HT, Cho J, Ramamoorthy A, Rhee HW, Kwon TH, Lim MH. An Iridium(III) Complex as a Photoactivatable Tool for Oxidation of Amyloidogenic Peptides with Subsequent Modulation of Peptide Aggregation. Chemistry. 2017 Jan 31;23(7):1645-1653.

278. Datta A, Yadav V, Ghosh A, Choi J, Bhattacharyya D, Kar RK, Ilyas H, Dutta A, An E, Mukhopadhyay J, Lee D, Sanyal K, Ramamoorthy A, Bhunia A. Mode of Action of a Designed Antimicrobial Peptide: High Potency against Cryptococcus neoformans. Biophys J. 2016 Oct 18;111(8):1724-1737.

277. Sciacca MF, Lolicato F, Di Mauro G, Milardi D, D'Urso L, Satriano C, Ramamoorthy A, La Rosa C. The Role of Cholesterol in Driving IAPP-Membrane Interactions. Biophys J. 2016 Jul 12;111(1):140-51.

276. Mroue KH, Xu J, Zhu P, Morris MD, Ramamoorthy A. Selective detection and complete identification of triglycerides in cortical bone by high-resolution (1)H MAS NMR spectroscopy. Phys Chem Chem Phys. 2016 Jul 28;18(28):18687-91.

275. Zhang R, Chen Y, Rodriguez-Hornedo N, Ramamoorthy A. Enhancing NMR Sensitivity of Natural-Abundance Low-γ Nuclei by Ultrafast Magic-Angle-Spinning Solid-State NMR Spectroscopy. Chemphyschem. 2016 Oct 5;17(19):2962-2966.

274. Bera S, Korshavn KJ, Kar RK, Lim MH, Ramamoorthy A, Bhunia A. Biophysical insights into the membrane interaction of the core amyloid-forming Aβ40 fragment K16-K28 and its role in the pathogenesis of Alzheimer's disease. Phys Chem Chem Phys. 2016 Jun 22;18(25):16890-901.

273. Jones MR, Dyrager C, Hoarau M, Korshavn KJ, Lim MH, Ramamoorthy A, Storr T. Multifunctional quinoline-triazole derivatives as potential modulators of amyloid-β peptide aggregation. J Inorg Biochem. 2016 May;158:131-8.

272. Zhang R, Mroue KH, Ramamoorthy A. Hybridizing cross-polarization with NOE or refocused-INEPT enhances the sensitivity of MAS NMR spectroscopy. J Magn Reson. 2016 May;266:59-66.

271. Pandey MK, Yarava JR, Zhang R, Ramamoorthy A, Nishiyama Y. Proton-detected 3D (15)N/(1)H/(1)H isotropic/anisotropic/isotropic chemical shift correlation solid-state NMR at 70 kHz MAS. Solid State Nucl. Magn. Reson. 2016, 76-77:1-6.

270. Fichman G, Guterman T, Damron J, Adler-Abramovich L, Schmidt J, Kesselman E, Shimon LJ, Ramamoorthy A, Talmon Y, Gazit E. Spontaneous structural transition and crystal formation in minimal supramolecular polymer model. Sci Adv. 2016 Feb 12;2(2):e1500827.

269. Zhang M., Huang R., Ackermann R., Im S-C., Waskell, L., Schwendeman A., Ramamoorthy A. Reconstitution of Cytb5-CytP450 Complex in Nanodiscs for Structural Studies by NMR, Angew. Chem. Intl. 2016, 33(14):4497-9. (News Coverage in F1000, Michigan news and other media).

268. Zhang R., Ramamoorthy A. Constant-time 2D and 3D through-bond correlation NMR spectroscopy of solids under 60 KHz MAS. J. Chem. Phys. (2016) 144: 034202.

267. Lee H. J., Kerr, R. A., Korshavn, K. J., Lee J., Kang J., Ramamoorthy A., Ruotolo B. T., Lim M. Effects of Hydroxyl Group Variations on a Flavonoid Backbone Toward Modulation of Metal-

20

Free and Metal-Induced Amyloid-B Aggregation. Inorg. Chem. Front. (2016). 266. Pithadia, A. S., Brender, J. R., Fierke, C. A., Ramamoorthy, A. Inhibition of IAPP Aggregation

and Toxicity by Natural Products and Derivatives. J. Diabetes Res. (2016): 2046327. 265. Pithadia, A. S., Bhunia, A., Sribalan, R., Padmini, V., Fierke, C. A., Ramamoorthy, A. Influence

of a curcumin derivative on hIAPP aggregation in the absence and presence of lipid membranes. Chem. Comm. (2016) 52: 942-5. (News Coverage in F1000)

264. Korshavn, K. J., Bhunia, A., Lim, M. H., Ramamoorthy, A. Amyloid-B Adopts a Conserved, Partially Folded Structure upon Binding to Zwitterionic Lipid Bilayers Prior to Amyloid Formation. Chem. Comm. (2016) 52:882-5. (Journal cover page)

263. Pandey M. K., Zhang R., Hashi K., Ohki S., Nishijima G., Matsumoto S., Noguchi T., Deguchi K., Goto A., Shimizu T., Maeda H., Takahashi M., Yanagisawa Y., Yamazaki T., Iguchi S., Tanaka R., Nemoto T., Miyamoto T., Suematsu H., Saito K., Miki T., Ramamoorthy A., Nishiyama Y. 1020 MHz single-channel proton fast magic angle spinning solid-state NMR spectroscopy. J. Magn. Reson. (2015) 261:1-5.

262. Zhang R., Nishiyama Y., Ramamoorthy A. Proton-detected 3D (1)H/(13)C/(1)H correlation experiment for structural analysis in rigid solids under ultrafast-MAS above 60 kHz. J. Chem. Phys. (2015) 143:164201.

261. Zhang R., Mroue K. H., Ramamoorthy A. Proton chemical shift tensors determined by 3D ultrafast MAS double-quantum NMR spectroscopy. J. Chem. Phys. (2015) 143:144201.

260. Korshavn, K. J., Jang, M., Kwak, Y. J., Kochi, A., Vertuani, S., Manfredini, S., Ramamoorthy, A., Lim, M. H. Reactivity of Metal-Free and Metal-Associated Amyloid-B with Glycosylated

Polyphenols and Their Esterified Derivatives. Sci. Rep. (Nature) 17842 (2015). 259. Derrick, J.S., Kerr, R., Nam, Y., Oh, S. B., Lee, H. J., Earnest, K. G., Suh, N., Peck, K. L.,

Ozbil, M., Korshavn, K. J., Ramamoorthy, A., Prabhakar, R., Merino, E. J., Shearer, J., Ruotolo, B., Lim, M. H. Covalent Link of a Redox-Active, Compact Molecule for the Crosslinking of Amyloidogenic Peptides into Nontoxic, Off-pathway Aggregates. J. Am. Chem. Soc. (2015) 137(46):14785-14797.

258. Zhang R, Ramamoorthy A. Selective excitation enables assignment of proton resonances and 1H-1H distance measurement in ultrafast magic angle spinning solid state NMR spectroscopy. J. Chem. Phys. (2015) 143:034201.

257. Zhang R, Ramamoorthy A. Dynamics-based selective 2D 1H-1H chemical shift correlation spectroscopy under ultrafast MAS conditions. J. Chem. Phys. (2015) 142:204201.

256. Mroue KH, Nishiyama Y, Kumar Pandey M, Gong B, McNerny E, Kohn DH, Morris MD, Ramamoorthy A. Proton-Detected Solid-State NMR Spectroscopy of Bone with Ultrafast Magic Angle Spinning. Sci. Rep. (Nature) (2015) 5:11991.

255. Datta A, Ghosh A, Airoldi C, Sperandeo P, Mroue KH, Jimenez-Barbero J, Kundu P, Ramamoorthy A, Bhunia A. Antimicrobial Peptides: Insights into Membrane Permeabilization, Lipopolysaccharide Fragmentation and Application in Plant Disease Control. Sci. Rep. (Nature) (2015) 5:11951.

254. Kotler SA, Brender JR, Vivekanandan S, Suzuki Y, Yamamoto K, Monette M, Krishnamoorthy J, Walsh P, Cauble M, Holl MM, Marsh EN, Ramamoorthy A. High-resolution NMR characterization of low abundance oligomers of amyloid-beta without purification. Sci. Rep. (Nature) (2015) 5:11811.

253. Zhang R, Pandey MK, Nishiyama Y, Ramamoorthy A. A Novel High-Resolution and Sensitivity-Enhanced Three-Dimensional Solid-State NMR Experiment Under Ultrafast Magic Angle Spinning Conditions. Sci. Rep. (Nature) (2015) 5:11810.

252. Jain N. S., Durr U. H. N., Ramamoorthy A. Bioanalytical methods for metabolomic profiling: Detection of head and neck cancer, including oral cancer. Chinese Chemical Letters. 26, 407-415 (2015).

251. Kamarajan P, Hayami T, Matte B, Liu Y, Danciu T, Ramamoorthy A, Worden F, Kapila S, Kapila Y. Nisin ZP, a Bacteriocin and Food Preservative, Inhibits Head and Neck Cancer Tumorigenesis and Prolongs Survival. PLoS One. 10, e0131008 (2015).

21

250. Zhang M, Huang R, Im SC, Waskell L, Ramamoorthy A. Effects of Membrane Mimetics on Cytochrome P450-Cytochrome b5 Interactions Characterized by NMR Spectroscopy. J. Biol. Chem. 290, 12705-18 (2015).

249. Ghosh A, Pithadia AS, Bhat J, Bera S, Midya A, Fierke CA, Ramamoorthy A, Bhunia A. Self-Assembly of a Nine-Residue Amyloid-Forming Peptide Fragment of SARS Corona Virus E-Protein: Mechanism of Self Aggregation and Amyloid-Inhibition of hIAPP. Biochemistry 54, 2249-61 (2015).

248. Lee DK, Bhunia A, Kotler SA, Ramamoorthy A. Detergent-Type Membrane Fragmentation by MSI-78, MSI-367, MSI-594, and MSI-843 Antimicrobial Peptides and Inhibition by Cholesterol: A Solid-State Nuclear Magnetic Resonance Study. Biochemistry 54, 1897-907 (2015).

247. Zhang M, Le Clair SV, Huang R, Ahuja S, Im SC, Waskell L, Ramamoorthy A. Insights into the role of substrates on the interaction between cytochrome b5 and cytochrome P450 2B4 by NMR. Sci. Rep. 5, 8392 (2015).

246. Soblosky L, Ramamoorthy A, Chen Z. Membrane interaction of antimicrobial peptides using E. coli lipid extract as model bacterial cell membranes and SFG spectroscopy. Chem. Phys. Lipids 187, 20-33 (2015).

245. Brender JR, Krishnamoorthy J, Sciacca MF, Vivekanandan S, D'Urso L, Chen J, La Rosa C, Ramamoorthy A. Probing the sources of the apparent irreproducibility of amyloid formation: drastic changes in kinetics and a switch in mechanism due to micellelike oligomer formation at critical concentrations of IAPP. J. Phys. Chem. B 119, 2886-2896 (2015).

244. Huang R, Zhang M, Rwere F, Waskell L, Ramamoorthy A. Kinetic and Structural Characterization of the Interaction between the FMN Binding Domain of Cytochrome P450 Reductase and Cytochrome C. J. Biol. Chem. 290, 4843-4855 (2015).

243. Zhang M, Le Clair SV, Huang R, Ahuja S, Im SC, Waskell L, Ramamoorthy A. Insights into the role of substrates on the Interaction between Cytochrome b5 and Cytochrome P450 2B4 by NMR. Sci. Rep. (Nature) 5, 8392 (2015).

242. Zhang R, Nishiyama N, Sun P, Ramamoorthy A. Phase Cycling Schemes for finite-pulse-RFDR MAS Solid State NMR Experiments. J. Magn. Reson. 252, 55-66 (2015).

241. Yamamoto K, Pearcy P, Lee DK, Yu C, Im SC, Waskell L, Ramamoorthy A. Temperature-Resistant Bicelles for Structural Studies by Solid-State NMR Spectroscopy. Langmuir 31, 1496-1504 (2015).

240. Pandey MK, Malon M, Ramamoorthy A, Nishiyama Y. Composite-180° pulse-based symmetry sequences to recouple proton chemical shift anisotropy tensors under ultrafast MAS solid-state NMR spectroscopy. J. Magn. Reson. 250, 45-54 (2015).

239. Chattah AK, Zhang R, Mroue KH, Pfund LY, Longhi MR, Ramamoorthy A, Garnero C. Investigating Albendazole Desmotropes by Solid-State NMR Spectroscopy. Mol. Pharm. 12, 731-741 (2015).

238. Zhang R, Damron, J, Vosegaard, T, Ramamoorthy A. A Cross-Polarization Based Rotating-Frame Separated -Local-Field NMR Experiment Under Ultrafast MAS Conditions. J. Magn. Reson. 250, 37-44 (2015).

237. Sudheendra US, Dhople V, Datta A, Kar RK, Shelburne CE, Bhunia A, Ramamoorthy A. Membrane disruptive antimicrobial activities of human β-defensin-3 analogs, Eur. J. Med. Chem. 91, 91-99 (2015).

236. Yamamoto K, Caporini MA, Im SC, Waskell L, Ramamoorthy A. Cellular Solid-State NMR Investigation of a Membrane Protein Using Dynamic Nuclear Polarization. BBA Biomembranes 1848, 342-349 (2015).

235. Patel H, Pithadia A, Brender J, Fierke C, Ramamoorthy A. In search of aggregation pathways of IAPP and other amyloidogenic proteins: finding answers through NMR spectroscopy. J. Phys. Chem. Lett. 5:1864-1870 (2014).

234. DeToma AS., Krishnamoorhty J., Nam YW., Lee HJ., Brender JR., Kochi A., Lee DK., Onnis V., Congiu C., Manfredini S., Vertuani S., Balboni G., Ramamoorthy A., Lim MH., Synthetic

22

Flavonoids, Amonoisoflavones: interaction and reactivity with metal-free and metal-associated amyloid-β species. Chem. Sci. 5, 4851-4862 (2014).

233. Mroue KH, Zhang R, Zhu P, McNerny E, Kohn DH, Morris MD, Ramamoorthy A. Acceleration of natural-abundance solid-state MAS NMR measurements on bone by paramagnetic relaxation from gadolinium-DTPA. J. Magn. Reson. 244(2014)90-97.

232. Rui Huang, Kazutoshi Yamamoto, Meng Zhang, Nataliya Popovych, Ivan Hung, Sang-choul Im, Zhehong Gan, Lucy Waskell and Ayyalusamy Ramamoorthy, Probing the Transmembrane Structure and Dynamics of Microsomal Cytochrome P450 Reductase by Solid-state NMR, Biophys. J. 106(2014) 2126-2133; coverage by the journal through a New and Notable article on our publication.

231. Nishiyama Y, Malon M, Ishii Y, Ramamoorthy A. 3D 15N/15N/1H Chemical Shift Correlation Experiment Utilizing an RFDR-based 1H/1H Mixing Period at Ultrafast MAS Frequencies, J. Magn. Reson. 244(2014)1-5; journal cover page.

230. Zhang, R. and Ramamoorthy, A. Performance of RINEPT is Amplified by Dipolar Couplings Under Ultrafast MAS Conditions. J. Magn. Reson. 243(2014)85-92.

229. Yesuvadian R, Krishnamoorthy J, Ramamoorthy A*, Bhunia A*. Potent γ-secretase inhibitors/modulators interact with amyloid-β fibrils but do not inhibit fibrillation: a high-resolution NMR study. Biochem. Biophys. Res. Commun. 447(2014)590-595. (*Corresponding authors)

228. Nishiyama Y, Zhang R, Ramamoorthy A. Finite-pulse radio frequency driven recoupling with phase cycling for 2D 1H/1H correlation at ultrafast MAS frequencies. J. Magn. Reson. 243(2014)25-32.

227. Pandey M, Vivekanandan S, Yamamoto K, Lm S C, Waskell L, Ramamoorthy A. Proton-detected. 2D radio frequency driven recoupling solid-state NMR studies on micelle-associated cytochrome-b5. J. Magn. Reson. 242(2014)169-179.

226. Kotler SA, Walsh P, Brender JR, Ramamoorthy A. Differences between amyloid-beta aggregation in solution and on the membrane: Insights in to elucidation of the mechanistic details of Alzheimer's disease. Chem. Soc. Rev. (2014; in press).

225. Yamamoto K, Paige P, Ramamoorthy A. Bicelles exhibiting magnetically-alignment for a broader range of temperatures - A solid state NMR study. Langmuir 30(2014)1622-1629.

224. Lee S, Zheng X, Krishnamoorthy J, Savelieff MG, Park HM, Brender, JR, Kim, JH, Derrick, JS, Kochi, A, Lee HJ, Kim C, Ramamoorthy, A,* Bowers, MT,* Lim, MH,* Rational Design of a Structural Framework with Potential Use to Develop Chemical Reagents That Target and Modulate Multiple Facets of Alzheimer’s Disease, J. Am. Chem. Soc. 136(2014) 299-319. (*Corresponding authors).

223. Manami T, Kuroda K,* Ramamoorthy A,* Yasuhara K,* Modulation of raft domains in a lipid bilayer by boundary-active curcumin, Chem. Comm. 50(2014)3427-3430.(*Corresponding authors).

222. Higashi K, Yamamoto K, Pandey M, Mroue K, Moribe K, Yamamoto K, Ramamoorthy A. Insights into atomic-level interaction between mefenamic acid and Eudragit EPO in a supersaturated solution by high-resolution magic-angle spinning NMR spectroscopy. Mol. Pharm. 11(2014) 351-357.

221. Savelieff M, Liu Y, Senthamarai R, Korshavn K, Lee H, Ramamoorthy A*, Lim MH*, A small molecule that displays marked reactivity with copper -- versus zinc-amyloid-beta implicated in Alzheimer's disease, Chem. Comm. 50(2014)5301-5303. (*Corresponding authors).

220. Zhao J, Hu R, Sciacca MF, Brender JR, Chen H, Ramamoorthy A, Zheng J. Non-selective ion channel activity of polymorphic human islet amyloid polypeptide (amylin) double channels, Phys. Chem. Chem. Phys. 16(2014) 2368-2377.

219. Yamamoto K, Caporino M, Im SC, Waskell L, Ramamoorthy A. Shortening spin-lattice relaxation using a copper-chelated lipid at low-temperatures -- A magic angle spinning solid-state NMR study on a membrane-bound protein. J. Magn. Reson. 237(2013) 175-181.

218. Pandey M, Vivekanandan S, Ahuja S, Huang R, Im, SC, Waskell L and Ramamoorthy A.

23

Cytochrome-P450-Cytochrome-b5 interaction in a membrane environment changes 15N chemical shift anisotropy tensors. J. Phys. Chem. B, 117(2013) 13851-13860.

217. Vivekanandan S, Ahuja S, Lm SC, Waskell L and Ramamoorthy A. 1H, 13C and 15N resonance assignments for the full-length mammalian cytochrome b5 in a membrane environment. Biomol. NMR Assign. 7(2013).

216. Porcelli F, Ramamoorthy A, Barany G and Veglia G. On the role of NMR spectroscopy for characterization of Antimicrobial peptides. Membrane Proteins: Methods in Molecular Biology. 1063(2013) 159-180.

215. Yamamoto K, Gildenberg M, Ahuja S, Im SC, Pearcy P, Waskell L, Ramamoorthy A. Probing the transmembrane structure and topology of microsomal cytochrome p450 by solid-state NMR on temperature resistant bicelles. Scientific Reports (Nature) 3:2556.

214. Ramamoorthy A. Insights into protein misfolding and amyloidogenesis. Phys. Chem. Chem. Phys. 15(2013) 8867-8867.

213. Ramamoorthy A and Lim MH. Structural characterization and inhibition of toxic amyloid-beta oligomeric intermediates. Biophys J. 105(2013) 287-288.

212. Chatta AK, Mroue KH, Pfund LY, Ramamoorthy A, Longhi MR and Garnero C. Insights into novel supramolecular complexes of two solid forms of norfloxacin and beta-cylcodextrin. J. Pharm. Sci. (2013).

211. McElderry JP, Zhu P, Mroue KH, Xu J, Pavan B, Fang M, Zhao G, McNerny E, Kohn DH, Franceschi RT, Banaszak-Holl MM, Tecklenberg MMJ, Ramamoorthy A and Morris MD. Crystallinity and compositional changes in carbonated apatite. Evidence from 31P solid state NMR, Raman and AFM analysis. J Solid State Chem. (in press)

210. Yamamoto K, Durr UHN, Xu J, Lm SC, Waskell L and Ramamoorthy A. Dynamic interaction between membrane bound full length cytochrome p450 and b5 observed by solid-state NMR spectroscopy. Scientific Reports (Nature) 3:2538.

209. Tripathi P, Somashekar BS, Ponnusamy M, Gursky A, Dailey S, Kunju P, Lee CT, Chinnaiyan AM, Rajendiran TM and Ramamoorthy A. HR-MAS NMR tissue metabolomic signatures cross-validated by mass spectrometry distinguish bladder cancer from benign disease. J Proteome Res. 12(2013) 3519-3528.

208. Ramamoorthy A and Xu J. 2D 1H/1H RFDR and NOESY NMR Experiments on a Membrane-Bound Antimicrobial Peptide Under Magic Angle Spinning. J. Phys. Chem. B. 117(2013) 6693-7000.

207. Ding B, Soblosky L, Nguyen K, Geng J, Yu X, Ramamoorthy A, Chen Z. Physiologically-relevant modes of membrane interactions by the human antimicrobial peptide, LL-37, revealed by SFG experiments. Sci. Rep. 3(2013) 1-8.

206. Lee DK, Brender JR, Sciacca MF, Krishnamoorthy J, Yu C, Ramamoorthy A. Lipid composition dependent membrane fragmentation and pore-forming mechanisms of membrane disruption by pexiganan (MSI-78). Biochemistry. 52(2013) 3254-3263.

205. S. Ahuja, S.-C. Im, S. Vivekanandan, N. Popovych, J. Xu, R. Soong, S. V. Le Clair, R. P. Nanga, K. Yamamoto, A. Bridges, L. Waskell, and A. Ramamoorthy, A model of the membrane-bound cytochrome b5-cytochrome P450 complex from NMR and mutagenesis data. J. Biol. Chem. 288(2013) 22080-22095.

204. Dürr UHN, Soong R, Ramamoorthy A. When the detergent meets bilayer: Birth and coming of age of lipid bicelles. Prog. NMR Spec. 69, 1-22 (2013).

203. J. R. Brender, J. Krishnamoorthy, G. M. L. Messina, A. Deb, S. Vivekanandan, C. La Rosa, J. E. Penner-Hahn, A. Ramamoorthy, Zinc stabilization of prefibrillar oligomers of human islet amyloid polypeptide, Chem. Comm. 49(2013), 3339-3341.

202. J. R. Brender, D. L. Heyl, S. Samisetti, S. A. Kotler, J. M. Osborne, R. R. Pesaru, A. Ramamoorthy, Membrane disordering is not sufficient for membrane permeabilization by islet amyloidogenic polypeptide: studies of IAPP(20–29) fragments, Phys. Chem. Chem. Phys. 15(2013) 8908-8915. Selected for the Journal cover page.

24

201. Suzuki Y, Brender JR, Soper MT, Krishnamoorthy J, Zhou Y, Ruotolo BT, Kotov NA, Ramamoorthy A*, Marsh EN*, Resolution of Oligomeric Species during the Aggregation of Aβ1-40 Using 19F NMR, Biochemistry 52(2013) 1903-1912 (*Corresponding authors).

200. S-J. Hyung, A. S. DeToma, J. R. Brender, S. Lee, S. Vivekanandan, A. Kochi, J-S. Choi, A. Ramamoorthy*, B. T. Ruotolo* and M. H. Lim*, Insights into antiamyloidogenic properties of the green tea extract (−)-epigallocatechin-3-gallate toward metal-associated amyloid-β species. Proc. Natl. Acad. Sci. USA 110(2013)3743-3748 (*Corresponding authors). (News Coverage on this article appeared)

199. M. Pandey and A. Ramamoorthy, Quantum chemical calculation of amide-15N chemical shift anisotropy tensors for a membrane-bound cytochrome b5. J. Phys. Chem. B. 117, 859-867(2013).

198. K. Hartman, J. R. Brender, K. Monde, A. Ono, M. L. Evans, N. Popovych, M. R. Chapman, and A. Ramamoorthy, Bacterial Curli Protein Promotes the Conversion of PAP(248-286) into the Amyloid SEVI: Cross-Seeding of Dissimilar Amyloid Sequences, PeerJ (DOI:10.7717/peerj.5).

197. M. M. F. Sciacca, D. Milardi, G. M. L. Messina, G. Marletta, J. R. Brender, A. Ramamoorthy* and C. La Rosa*, Role of calcium ions in membrane disruption by amyloid fibers and pores, Biophys. J. 104, 173-184 (2013) (*Corresponding authors).

196. Mackinnon N, Somashekar BS, Tripathi P, Ge W, Rajendiran TM, Chinnaiyan AM, Ramamoorthy A. MetaboID: A graphical user interface package for assignment of 1H NMR spectra of bodyfluids and tissues. J. Magn. Reson. 226, 93-99 (2013). (This software package is made freely available to the community)

195. Krishnamoorthy J, Brender JR, Vivekanandan S, Jahr N, Ramamoorthy A. Side chain dynamics reveals transient association of A�(1-40) monomers with amyloid fibers. J. Phys. Chem. B. 116, 13618-23 (2012).

194. Somashekar BS, Amin AG, Tripathi P, Mackinnon N, Rithner CD, Shanley CA, Basaraba R, Henao-Tamayo M, Kato-Maeda M, Ramamoorthy A, Orme IM, Ordway DJ, Chatterijee D. J. Proteome. Res. 11, 4873-4884 (2012).

193. Zhu J, Andres CM, Xu J, Ramamoorthy A, Tsotsis T, Kotov NA. Pseudonegative thermal expansion and state of water in graphene oxide layered assemblies. ACS Nano 6, 8357-8365 (2012).

192. Sciacca MF, Brender JR, Lee DK, Ramamoorthy A. Phosphatidylethanolamine enhances amyloid fiber-dependent membrane fragmentation. Biochemistry 51, 7676-7684 (2012).

191. Mroue KH, MacKinnon N, Xu J, Zhu P, McNerny E, Kohn DH, Morris MD, Ramamoorthy A. High-resolution structural insights into bone: a solid-state NMR relaxation study utilizing paramagnetic doping. J. Phys. Chem. B 116, 11656-11661 (2012).

190. Suzuki Y, Brender JR, Hartman K, Ramamoorthy A, Marsh EN. Alternative pathways of human islet amyloid polypeptide aggregation distinguished by 19F NMR-detected kinetics of monomer consumption. Biochemistry 51, 8154-8162 (2012).

189. Dürr UHN, Gildenberg M, Ramamoorthy A. The magic of bicelles lights up membrane protein structure. Chem. Rev. 112, 6054-6074 (2012). (invited review)

188. McHenry AJ, Sciacca MF, Brender JR, Ramamoorthy A. Does cholesterol suppress the antimicrobial peptide induced disruption of lipid raft containing membranes? Biochim. Biophys. Acta, Biomembr. (2012)

187. Jones MR, Service EL, Thompson JR, Wang MCP, Kimsey IJ, DeToma AS, Ramamoorthy A, Lim MH, Storr T. Dual-function triazole-pyridine derivatives as inhibitors of metal-induced amyloid-beta aggregation. Metallomics 4, 910-920 (2012).

186. Tripathi P, Kamarajan P, Somashekar BS, MacKinnon N, Chinnaiyan AM, Kapila YL, Rajendiran TM, Ramamoorthy A. Delineating Metabolic Signatures of Head and Neck Squamous Cell Carcinoma: Phospholipase A2, a Potential Therapeutc Target. Int. J. Biochem. Cell Biol. 44, 1852-1861 (2012).

185. Sciacca MFM, Kotler SA, Brender JR, Chen J, Lee DK, Ramamoorthy A. Two step mechanism of membrane disruption by Aβ through membrane fragmentation and pore formation. Biophys. J. 103, 702-710 (2012).

25

184. Brender JR, McHenry AJ, Ramamoorthy A. Does cholesterol play a role in the bacterial selectivity of antimicrobial peptides? Front. Immunol. 3, 1-4 (2012).

183. Pandey M, Vivekanandan S, Ahuja S, Kumar P, Waskell L, Im S-C, Ramamoorthy A. Determination of 15N Chemical Shift Anisotropy from a Membrane Bound Protein by NMR Spectroscopy. J. Phys. Chem. B 116, 7181-7189 (2012).

182. MacKinnon N, Ge W, Khan A, Somashekar B, Tripathi P, Siddiqui J, Wei J, Chinnaiyan A, Rajendira T, Ramamoorthy A. Variable Reference Alignment: an improved peak alignment protocol for NMR spectral data with large intersample variation. Anal. Chem. 84, 5372-5379 (2012).

181. Khitrin A, Xu J, Ramamoorthy A. Coherent averaging in the frequency domain. J. Chem. Phys. 136, 214504 (2012).

180. MacKinnon N, Khan AP, Chinnaiyan AM, Rajendiran TM, and Ramamoorthy A., Androgen Receptor Activation Results in Metabolite Signatures of an Aggressive Prostate Cancer Phenotype: An NMR-based Metabonomics Study, Metabolomics 8, 1026-1036 (2012).

179. N. Popovych, J. R. Brender, R. Soong, S. Vivekanandan, K. Hartman, V. Basrur, P. Macdonald, and A. Ramamoorthy, Site Specific Interaction of the Polyphenol EGCG with the SEVI Amyloid Precursor Peptide PAP(248-286), J. Phys. Chem. B 116, 3650-3658 (2012).

178. J. R. Brender, S. Salamekh, and A. Ramamoorthy, Membrane-disruption and early events in the aggregation of the diabetes related peptide IAPP from a molecular perspective, Acc. Chem. Res. 116, 3650-3658 (2012) (invited review).

177. R. Huang, S. Vivekanandan, J. R. Brender, Yuki, A. Naito, and A. Ramamoorthy, NMR Characterization of Monomer and Oligomer Conformations of Human Calcitonin and its interaction with EGCG, J. Mol. Biol 416, 108-120 (2012).

176. A. S. Detoma, S. Salamekh, A. Ramamoorthy*, and M. H. Lim*, Misfolded proteins in Alzheimer's disease and type II diabetes, Chem. Soc. Rev. 41, 608-621 (2012) (invited review; *Corresponding authors).

175. Moon JY, Kang Do, Cho YK, Kong KH, Lee DK, Ramamoorthy A. Characterization of factors favoring the recombinant expression and purification of LL-37 from Escherichia coli. J. Korean Soc. Appl. Biol. Chem. 54, 871-880 (2011).

174. Tomonaga Y, Hidaka T, Kawamura I, Nishio T, Ohsawa K, Okitsu T, Wada A, Sudo Y, Kamo N, Ramamoorthy A, Naito A. An Active Photoreceptor Intermediate Revealed by In Situ Photoirradiated Solid-State NMR Spectroscopy. Biophys. J. 101, L50-L52 (2011).

173. K. Yamamoto, S. Vivekanandan, and A. Ramamoorthy, Fast NMR Data Acquisition From Bicelles Containing a Membrane-Associated Peptide at Natural-Abundance. J. Phys. Chem. B. 115, 12448-12455 (2011).

172. S. Somashekar, P. Kamarajan, T. Danciu, Y. Kapila, A. Chinnaiyan, T. Rajendiran, and A. Ramamoorthy, Magic Angle Spinning NMR Based Metabolic Profiling of Head and Neck Squamous Cell Carcinoma Tissues. J. Proteomic Res. 10, 5232-5241(2011).

169. J. Braymer, J-S. Choi, A. DeToma, C. Wang, K. Nam, J. Kampf, A. Ramamoorthy, and M. H. Lim, Development of Bifunctional Stillbene Derivatives for Targeting and Modulating Metal-Amyloid-beta species. Inorg. Chem. 50, 10724-10734 (2011).

168. A. Khitrin, J. Xu, and A. Ramamoorthy, Cross-Correlations Between Low-gamma Nuclei in Solids Via a Common Dipolar Bath, J. Magn. Reson. 212, 95-101 (2011).

167. R. P. R. Nanga, J. R. Brender, V. Subramanian, and A. Ramamoorthy, Structure and Membrane Orientation of IAPP in its Natively Amidated Form at Physiological pH in a Membrane Environment, Biochim. Biophys. Acta 10, 2337-2342 (2011).

166. J. D. Xu, P. Z. Zhu, M. D. Morris, and A. Ramamoorthy, Solid-State NMR Spectroscopy Provides Atomic-Level Insights Into the Dehydration of Cartilage, J. Phys. Chem. B. 115, 9948-9954 (2011).

165. S. Vivekanandan, J. R. Brender, S. Y. Lee, A. Ramamoorthy, A Partially Folded Structure of Amyloid-Beta(1-40) in an Aqueous Environment. Biochem. Biophys. Res. Commun. 411, 312-316 (2011).

26

164. S. Salamekh, J. R. Brender, S-J. Hyung, R. P. R. Nanga, S. Vivekanandan, and A. Ramamoorthy, Two Site Mechanism for the Inhibition of IAPP Amyloidogenesis by Zinc, J. Mol. Biol. 410, 294-306 (2011). (News Coverage on this article appeared)

163. P. Yang, A. Ramamoorthy, and Z. Chen, Membrane Orientation of MSI-78 Measured by Sum Frequency Generation Vibrational Spectroscopy. Langmuir 27, 7760-7767 (2011).

162. K. M. Lutker, R. Quiñones, J. Xu, A. Ramamoorthy and A. J. Matzger, Polymorphs and hydrates of acyclovir, J. Pharm. Chem. 100, 949-963 (2011).

161. S. Yoo, M. Yang, J. R. Brender, S. Vivekanandan, K. Sun, N. E. Joo, S. H. Jeong, A. Ramamoorthy, and N. A. Kotov, Inhibition of Amyloid Peptide Fibrillation by Inorganic Nanoparticles : Functional Similarities with Proteins, Angew. Chem. Int. Ed. 50, 1 – 7 (2011). (News Coverage on this article appeared; appeared in the journal cover page)

160. J. Xu, P. E. S. Smith, R. Soong, and A. Ramamoorthy A Proton Spin Diffusion Based Solid-State NMR Approach for Structural Studies on Aligned Samples, J. Phys. Chem. B, 115, 4863–4871 (2011).

159. Brender JR, Lee EL, Hartman K, Wong PT, Ramamoorthy A, Steel DG, Gafni A. Biphasic effects of insulin on islet amyloid polypeptide membrane disruption. Biophys. J. 100, 685-692 (2011).

158. Brender JR, Nanga RP, Popovych N, Soong R, Macdonald PM, Ramamoorthy A. The amyloidogenic SEVI precursor, PAP248-286, is highly unfolded in solution despite an underlying helical tendency. BBA Biomembranes 1808, 1161-1169 (2011).

157. Zimmerman LB, Worley BV, Palermo EF, Brender JR, Lee KD, Kuroda K, Ramamoorthy A, Meyerhoff ME. Absorbance-Based Assay for Membrane Disruption by Antimicrobial Peptides and Synthetic Copolymers Using Pyrroloquinoline Quinone-Loaded Liposomes. Anal. Biochem. 411, 194-199 (2011).

156. Palermo E, Lee D-K, Ramamoorthy A, Kuroda K. The Role of Cationic Group Structure in Membrane Binding and Disruption by Amphiphilic Copolymers. J. Phys. Chem. B. 115, 366-375 (2011).

155. J. S. Choi, J. J. Braymer, R. P. R. Nanga, A. Ramamoorthy, and M. H. Lim, Design of Small Molecules that Target Metal-A�-Species and Regulate Metal-Induced A� Aggregation and Neurotoxicity, Proc. Natl. Acad. Sci. USA 107, 21990-21995 (2010). (News Coverage on this article appeared)

154. P. N. Domadia, A. Bhunia, A. Ramamoorthy, and S. Bhattacharjya, Structure, Interactions and Anti-bacterial Activities of MSI-594 Derived Mutant Peptide MSI-594F5A in Lipopolysaccharide Micelles: Role of the Helical Hairpin Conformation in Outer membrane Permeabilization, J. Am. Chem. Soc. 132, 18417-18428 (2010).

153. Thennarasu S, Huang R, Lee D-K, Yang P, Maloy L, Chen Z, Ramamoorthy A. Limiting an Antimicrobial Peptide to the Lipid-Water Interface Enhances Its Bacterial Membrane Selectivity: A Case Study of MSI-367. Biochemistry. 49, 10595-10605 (2010).

152. K. T. Nguyen, R. Soong, S.C. Im, L. Waskell, A. Ramamoorthy, and Z. Chen, Anchored Membrane Protein by Sum Frequency Generation Spectroscopy, J. Am. Chem. Soc. 132 (2010) 15112-15115.

151. J. Xu, P. Zhu, Z. Gan, N. Sahar, M. Tecklenburg, M. D. Morris, D. H. Kohn, and A. Ramamoorthy, Natural-Abundance 43Ca Solid-State NMR Spectroscopy of Bone. J. Am. Chem. Soc. 132, 11504-11509 (2010).

150. J. R. Brender, K. Hartman, R. P. R. Nanga, N. Popovych, R. de la Salud Bea, S. Vivekanandan, E. N. G. Marsh, and A. Ramamoorthy, Role of Zinc in Human Islet Amyloid Polypeptide Aggregation, J. Am. Chem. Soc. 132, 8973-8983 (2010). (News Coverage on this article appeared)

149. J. Xu, R. Soong, S. C. Im, L. Waskell, and A. Ramamoorthy. INEPT-Based Separated-Local-Field NMR Spectroscopy: A Unique Approach to Elucidate Side-Chain Dynamics of Membrane-Associated Proteins. J. Am. Chem. Soc. 132, 9944-9947 (2010).

27

148. P. E. S. Smith, J. R. Brender, U. H. N. Durr, J. Xu, D. G. Mullen, M. M. B. Holl, and A. Ramamoorthy, Solid-State NMR Reveals the Hydrophobic-Core Location of Poly(amidoamine) Dendrimers in Biomembranes, J. Am. Chem. Soc. 132, 8087-8097 (2010).

147. K. Yamamoto, J. Xu, K. K. Kawulka, J. C. Vederas, and A. Ramamoorthy, Use of a copper-chelated-lipid speeds up NMR measurements from membrane proteins, J. Am. Chem. Soc. 132, 6929-6931 (2010).

146. R. Soong, P. E. S. Smith, J. Xu, K. Yamamoto, S. C. Im, L. Waskell, and A. Ramamoorthy, Proton-evolved local-field solid-state NMR studies of cytochrome b5 embedded in bicelles – Revealing both structural and dynamical information, J. Am. Chem. Soc. 132, 5779-5788 (2010).

145. H. Saito, I. Ando, and A. Ramamoorthy, Chemical Shift Tensor - the Heart of NMR : Insights into Biological Aspects of Proteins, Prog. NMR Spectrosc. 57, 181-228 (2010).

144. R. F. Epand, L. Maloy, A. Ramamoorthy, and R. M. Epand, Probing the “charge cluster mechanism” in amphipathic helical cationic antimicrobial peptides, Biochemistry 49, 4076-4084 (2010).

143. A. Bhunia, A. Ramamoorthy, and S. Bhattacharjya, NMR Structure of Pardaxin, a Pore-Forming Antimicrobial Peptide, in Lipopolysaccharide Micelles: Mechanism of Outer membrane Permeabilization, J. Biol. Chem., 285, 3883-3895 (2010).

142. R. F. Epand, L. Maloy, A. Ramamoorthy, and R. M. Epand, Amphipathic helical cationic antimicrobial peptides promote rapid formation of crystalline states in the presence of phosphatidylglycerol: Lipid clustering in purely anionic membranes, Biophys. J. 98, 2564-2673 (2010).

141. S. Thennarasu, A. Tan, R. Penumatchu, C. E. Shelburne, D. L. Heyl, and A. Ramamoorthy, Antimicrobial and Membrane Disrupting Activities of a Peptide Derived from the Human Cathelicidin Antimicrobial Peptide LL37, Biophys. J. 98, 248-257 (2010).

140. T. Io, T. Fukami, K. Yamamoto, T. Suzuki, J. D. Xu, K. Tomono, and A. Ramamoorthy, Mol. Pharm., 7, 299-305 (2010).

139. A. Ramamoorthy, D. K. Lee, T. Narasimhaswamy, and R. P. Nanga, Cholesterol reduces pardaxin’s dynamics – a barrel-stave mechanism of membrane disruption investigated by solid-state NMR, BBA Biomembranes 1798, 223-227 (2010).

138. R. P. R. Nanga, J. R. Brender, S. Vivekanandan, N. Popovych, and A. Ramamoorthy, NMR Structure in a Membrane Environment Reveals Putative Amyloidogenic Regions of the SEVI Precursor Peptide PAP248-286, J. Am. Chem. Soc., 131, 17972-17979 (2009). (News Coverage on this article appeared)

137. P. Z. Zhu, J. D. Xu, N. Sahar, M. D. Morris, D. H. Kohn, and A. Ramamoorthy, Time-Resolved Dehydration-induced Structural Changes in an Intact Bovine Cortical Bone Revealed by Solid-State NMR Spectroscopy, J. Am. Chem. Soc., 131, 17064-5 (2009). (News Coverage on this article appeared)

136. S. S. Hindo, A. M. Mancino, J. J. Braymer, Y. H. Liu, S. Vivekanandan, A. Ramamoorthy, and M. H. Lim, Small Molecule Modulators of Copper-Induced Abeta Aggregation, J. Am. Chem. Soc., 131, 16663-5 (2009). (News Coverage on this article appeared)

135. R. P. R. Nanga, J. R. Brender, J. D. Xu, K. Hartman, S. Vivekanandan, and A. Ramamoorthy, Three-Dimensional Structure and Orientation of Rat Islet Amyloid Polypeptide Protein in a Membrane Environment by Solution NMR Spectroscopy, J. Am. Chem. Soc., 131, 8252-8261 (2009).

134. R. Soong, J. R. Brender, P. M. Macdonald, and A. Ramamoorthy, Association of Highly Compact Type II Diabetes Related Islet Amyloid Polypeptide Intermediate Species at Physiological Temperature Revealed by Diffusion NMR Spectroscopy, J. Am. Chem. Soc., 131, 7079-7085 (2009).

133. P. E. S. Smith, J. R. Brender, and A. Ramamoorthy, Induction of Negative Curvature as a Mechanism of Cell Toxicity by Amyloidogenic Peptides: The Case of Islet Amyloid Polypeptide, J. Am. Chem. Soc., 131, 4470-4478 (2009).

28

132. J. Barry, M. Fritz, J. R. Brender, P. E. S. Smith, D. K. Lee, and A. Ramamoorthy, Determining the Effects of Lipophilic Drugs on Membrane Structure by Solid-State NMR Spectroscopy: The Case of the Antioxidant Curcumin, J. Am. Chem. Soc., 131, 4490-4498 (2009). (News Coverage on this article appeared)

131. J. R. Brender, K. Hartman, L. M. Gottler, M. E. Cavitt, D. W. Youngstrom, and A. Ramamoorthy, Helical Conformation of the SEVI Precursor Peptide PAP(248-286), a Dramatic Enhancer of HIV Infectivity, Promotes Lipid Aggregation and Fusion, Biophys. J., 97, 2474-2483 (2009).

130. T. Fukami, T. Ishii, T. Io, N. Suzuki, T. Suzuki, K. Yamamoto, J. D. Xu, A. Ramamoorthy, and K. Tomono, Nanoparticle Processing in the Solid State Dramatically Increases the Cell Membrane Permeation of a Cholesterol-Lowering Drug, Probucol, Mol. Pharm., 6, 1029-1035 (2009).

129. S. Bhattacharjya and A. Ramamoorthy, Multifunctional host defense peptides: functional and mechanistic insights from NMR structures of potent antimicrobial peptides, FEBS J., 276, 6465-6473 (2009).

128. K. Yamamoto, R. Soong, and A. Ramamoorthy, Comprehensive Analysis of Lipid Dynamics Variation with Lipid Composition and Hydration of Bicelles Using Nuclear Magnetic Resonance (NMR) Spectroscopy, Langmuir 25, 7010-7018 (2009).

127. A. Bhunia, A. Ramamoorthy, and S. Bhattacharjya, Helical Hairpin Structure of a Potent Antimicrobial Peptide MSI-594 in Lipopolysaccharide Micelles by NMR Spectroscopy, Chemistry – A Eur. J. 15, 2036-2040 (2009).

126. E. N. G. Marsh and A. Ramamoorthy, Fluorine-a new element in the design of membrane-active peptides, Mol. Biosys., 5, 1143-1147 (2009).

125. A. Ramamoorthy, Beyond NMR Spectra of antimicrobial peptides: Dynamical images at atomic resolution and functional insights, Solid State NMR Spectrosc., 35, 201-207 (2009).

124. S. K. Kandasamy, D. K. Lee, R. P. R. Nanga, J. Xu, J. S. Santos, R. G. Larson, and A. Ramamoorthy, Solid-state NMR and Molecular Dynamics Simulations Reveal the Oligomeric Ion-Channels of TM2-GABAA Stabilized by Intermolecular Hydrogen Bonding, BBA Biomembranes 1788, 686-695 (2009).

123. M. Fukuchi, A. Ramamoorthy, and K. Takegoshi, Efficient Cross-Polarization Using a Composite 0° Pulse for NMR Studies on Static Solids, J. Man. Reson., 196, 105-109 (2009).

122. L. Gottler and A. Ramamoorthy, Structure, Membrane Orientation, Mechanism, and Function of Pexiganan – A Highly Potent Antimicrobial Peptide Designed from Magainin, BBA Biomembranes 1788, 1680-1686 (2009).

121. R. P. R. Nanga, J. R. Brender, J. Xu, G. Veglia, and A. Ramamoorthy, Structures of at and Human Islet Amyloid Polypeptide (IAPP)1-19 in Micelles by NMR Spectroscopy, Biochemistry 47, 12689-12697 (2008).

120. J. R. Brender, K. Hartman, K. R. Reid, R. T. Kennedy, and A. Ramamoorthy, A Single Mutation in the Non-Amyloidogenic Region of IAPP (Amylin) Greatly Reduces Toxicity, Biochemistry 47, 12680-12688 (2008).

119. D. K. Lee, B. S. Kwon, and A. Ramamoorthy, Freezing Point Depression in Water in Phospholipid Membranes - A Solid-State NMR Study, Langmuir 24, 13598-13604 (2008).

118. J. Xu, U. H. N. Dürr, S-C.Im, Z. Gan, L. Waskell, and A. Ramamoorthy, Bicelle-Enabled Structural Studies on a Membran-Associated Cytochrome b5 by Solid-State MAS NMR Spectroscopy, Angew. Chem., 47, 7864-7867 (2008).

117. F. Porcelli, R. Verardi, L. Shi, K. A. Henzler-Wildman, A. Ramamoorthy, and G. Veglia, NMR Structure of the Cathelicidin-Derived Human Antimicrobial Peptide LL-37 in Dodecylphosphocholine Micelles, Biochemistry 47, 5565-5572 (2008).

116. S. V. Dvinskikh, K. Yamamoto, D. Scanu, R. Deschenaux, and A. Ramamoorthy, High-Resolution Characterization of Liquid-Crystalline [60]Fullerenes using Solid-State NMR Spectroscopy, J. Phys. Chem. B, 112, 12347-12353 (2008).

29

115. L. M. Gottler, R. de la S. Bea, C. E. Shelburne, A. Ramamoorthy, and E. N. G. Marsh, Using Fluorous Amino Acids to Probe the Effects of Changing Hydrophobicity on the Physical and Biological Properties of the �-Hairpin Antimicrobial Peptide Protegrin-1, Biochemistry 47, 9243-9250 (2008).

114. A. Ramamoorthy, D. K. Lee, J. S. Santos, K. A. Henzler-Wildman, Nitrogen-14 Solid-State NMR Spectroscopy of Aligned Phospholipid Bilayers to Probe Peptide-Lipid Interaction and Oligomerization of Membrane Associated Peptides, J. Am. Chem. Soc., 130, 6424-6429 (2008).

113. J. R. Brender, E. L. Lee, M. A. Cavitt, A. Gafni, D. G. Steel, and A. Ramamoorthy, Amyloid Fiber Formation and Membrane Disruption are Separate Processes Localized in Two Distinct Regions of the Amylin Peptide, J. Am. Chem. Soc., 130, 6424-6429 (2008).

112. L. M. Gottler, H. Y. Lee, C. E. Shelburne, A. Ramamoorthy, and E. N. G. Marsh, Using Fluorous Amino Acids to Modulate the Biological Activity of an Antimicrobial Peptide, ChemBioChem 9, 370-373 (2008).

111. D. W. Hoskin and A. Ramamoorthy, Studies on Anticancer Activities of Antimicrobial Peptides, BBA Biomembranes 1778, 357-375 (2008).

110. J. Xu, J. Struppe and A. Ramamoorthy, Two-dimensional homonuclear chemical shift correlation established by the cross-relaxation driven spin diffusion in solids, J. Chem. Phys., 128, 052308 (2008).

109. U. H. N. Dürr, L. Waskell, and A. Ramamoorthy, The cytochrome P450 and b5 and their reductases – Promising targets for structural studies by advanced solid-state NMR spectroscopy, BBA Biomembranes 1768, 3235-3259 (2007).

108. U. H. N. Dürr, K. Yamamoto, S.-C. Im, L. Waskell,and A. Ramamoorthy, Solid-state NMR reveals structural and dynamical properties of a membrane-anchored electron-carrier protein, cytochrome-b5, J. Am. Chem. Soc., 129, 6670 (2007). (News Coverage on this article appeared)

107. J. R. Brender, U. H. N. Dürr, D. Heyl, M. B. Budarapu, A. Ramamoorthy, Membrane fragmentation by human islet amyloid polypeptide detected by solid-state NMR spectroscopy of membrane nanotubes, BBA Biomembranes 1768, 2026-2029 (2007).

106. P. Podsiadlo, A. K. Kausik, E. M. Arruda, A. M. Waas, B. S. Shim, J. D. Xu, H. Nandivada, B. G. Punplin, J. Lahann, A. Ramamoorthy, and N. A. Kotov, Ultrasound and stiff layered polymer nanocomposites, Science 318, 80-83 (2007).

105. S. Dvinskikh, U. H. N. Dürr, K. Yamamoto, and A. Ramamoorthy, High-Resolution 2D NMR Spectroscopy of Bicelles to Measure the Membrane Interaction of Ligands, J. Am. Chem. Soc., 129, 794-802 (2007).

104. C. Shelburne, F. An, V. Dhople, A. Ramamoorthy, D. Lopatin, and M. Lantz, The spectrum of anti-microbial activity of the bacteriocin Subtilosin A, J. Antimicrobial Chemotherapy, 59, 297-300 (2007).

103. A. Ramamoorthy, S. K. Kandasamy, D. K. Lee, S. Kidambi, and R. G. Larson, Structure, Topology and Tilt of Cell-Signaling Peptides Containing Nuclear Localization Sequences in Membrane Bilayers Determined by Solid-State NMR and Molecular Dynamics Simulation Studies, Biochemistry, 46, 965-975 (2007).

102. S. Dvinskikh, K. Yamamoto, U. H. N. Dürr, and A. Ramamoorthy, Sensitivity and Resolution Enhancement in Solid-State NMR Spectroscopy of Bicelles, J. Magn. Reson., 184, 240-247 (2007).

101. S. Dvinskikh, K. Yamamoto, and A. Ramamoorthy, Heteronuclear isotropic mixing separated local field NMR spectroscopy, J. Chem. Phys., 125, 034507 (2006).

100. S. Dvinskikh, U. H. N. Dürr, K. Yamamoto, and A. Ramamoorthy, A High Resolution Solid State NMR Approach for the Structural Studies of Bicelles, J. Am. Chem. Soc., 128, 6326 (2006).

99. T. Fujiwara and A. Ramamoorthy, How far can the sensitivity of NMR be increased? Ann. Rep. NMR Spectrosc., 58, 155-175 (2006).

30

98. V. Dhople, A. Krukemeyer, and A. Ramamoorthy, The human beta-defensin-3, an antibacterial peptide with multiple biological functions, BBA-Biomembranes, 1758, 1499-1512 (2006).

97. A. Ramamoorthy, S. Thennarasu, A. Tan, K. Gottipati, S. Sreekumar, D. L. Heyl, F. Y. P. An, and C. E. Shelburne, Deletion of all cysteines in Tachyplesin I abolishes hemolytic activity and retains antimicrobial activity and LPS selective binding, Biochemistry, 45, 6529-6540 (2006).

96. A. Ramamoorthy, S. Thennarasu, D. K. Lee, A. Tan, and Lee Maloy, Solid-State NMR Investigation of the Membrane-Disrupting Mechanism of Antimicrobial Peptides MSI-78 and MSI-594 Derived From Magainin 2 and Melittin, Biophys. J., 91, 206-216 (2006).

95. U. H. N. Dürr, U. S. Sudheendra, and A. Ramamoorthy, LL-37, the only human member of the cathelicidin family of antimicrobial peptides, BBA-Biomembranes, 1758, 1408-1425 (2006). (News Coverage on this article appeared)

94. F. Porcelli, B. Buck-Koehntop, S. Thennarasu, A. Ramamoorthy and G. Veglia, Structures of the dimeric and monomeric variants of magainin antimicrobial peptides (MSI-78 and MSI-594) in micelles and bilayers by NMR spectroscopy, Biochemistry, 45, 5793-5799 (2006).

93. J. Y. Moon, K. A. Henzler-Wildman, and A. Ramamoorthy, Expression and purification of a recombinant LL-37 from Escherichia coli, BBA-Biomembranes, 1758, 1351-1358 (2006).

92. R.F. Epand, A. Ramamoorthy and R.M. Epand. 2005. Membrane lipid composition and the interaction with Pardaxin: the role of cholesterol, Protein Peptide Letters, 13, 1-5 (2006).

91. K. Yamamoto, S. Dvinskikh, and A. Ramamoorthy, Measurement of Heteronuclear Dipolar Couplings Using a Rotating Frame Solid-State NMR Experiment, Chem. Phys. Lett., 419, 533-536 (2006).

90. A. Ramamoorthy, S. Thennarasu, A. Tan, D. K. Lee, C. Clayberger and A. M. Krensky, Cell selectivity correlates with membrane interactions: a case study on the antimicrobial peptide G15 derived from granulysin, BBA-Biomembranes, 1758, 154-163 (2006).

89. S. Dvinskikh, K. Yamamoto, and A. Ramamoorthy, Separated local field NMR spectroscopy by windowless isotropic mixing, Chem. Phys. Lett., 419, 168-173 (2006).

88. J. P. S. Powers, A. Tan, A. Ramamoorthy, and R. E. W. Hancock, Solution Structure and Interaction of the Antimicrobial Polyphemusins with Lipid Membranes, Biochemistry 44, 15504-15513 (2005).

87. A. Mecke, D. K. Lee, A. Ramamoorthy, B. G. Orr and M. M. B. Holl, Membrane thinning due to antimicrobial peptide binding: An atomic force microscopy study of MSI-78 in lipid bilayers, Biophys. J., 89, 4043-4050 (2005).

86. S. Thennarasu, D. K. Lee, A. Poon, K. E. Kawulka, J. C. Vederas, and A. Ramamoorthy, Membrane permeabilization, orientation, and antimicrobial mechanism of subtilosin A, Chem. Phys. Lipids, 137, 38-51 (2005).

85. T. Narasimhaswamy, M. Monette, D. K. Lee, and A. Ramamoorthy, Solid-state NMR characterization and determination of the orientational order of a nematogen, J. Phys. Chem. B, 109, 19696-19703 (2005).

84. T. Narasimhaswamy, D. K. Lee, N. Somanathan, and A. Ramamoorthy, Solid-State NMR Characterization of a Novel Thiophene-Based Three Phenyl Ring Mesogen, Chem. Mater., 17, 4567-4569 (2005).

83. A. Mecke, D. K. Lee, A. Ramamoorthy, G. Orr, and M. M. Banazak Holl, Synthetic and natural polycationic polymer nanoparticles interact selectively with fluid phase domains of DMPC lipid bilayers, Langmuir 21, 8588-8590 (2005).

82. T. Narasimhaswamy, D. K. Lee, K. Yamamoto, N. Somanathan, and A. Ramamoorthy, A 2D Solid-State NMR Experiment to Resolve Overlapping Aromatic Resonances of Thiophene Based Nematogens, J. Am. Chem. Soc., 127, 6958-6959 (2005).

81. K. Yamamoto, V. L. Ermakov, D. K. Lee, and A. Ramamoorthy, PITANSEMA-MAS, a Solid-State NMR Method to Measure Heteronuclear Dipolar Couplings Under MAS, Chem. Phys. Lett., 408, 118-122 (2005).

80. K. Yamamoto, D. K. Lee, and A. Ramamoorthy, Broadband-PISEMA Solid-State NMR Spectroscopy, Chem. Phys. Lett., 407, 289-293 (2005).

31

79. S. Thennarasu, D. K. Lee, A. Tan, U. P. Kari, and A. Ramamoorthy, Antimicrobial Activity and Membrane Selective Interactions of a Synthetic Lipopeptide MSI-843, Biochim. Biophys. Acta, 1711, 49-58 (2005).

78. T. Narasimhaswamy, N. Somanathan, D. K. Lee and A. Ramamoorthy, Synthesis and 13C CPMAS NMR characterization of Novel Thiophene-based Nematogens, Chem. Mater., 17, 2013-2018 (2005).

77. F. Porcelli, B. Buck, D. K. Lee, K. J. Hallock, A. Ramamoorthy, and G. Veglia, Structure and Orientation of Pardaxin Determined by NMR Experiments in Model Membranes, J. Biol. Chem., 279, 46815-46823 (2004).

76. C. D. Pointer-Keenan, D. K. Lee, K. J. Hallock, A. Tan, R. Zand, and A. Ramamoorthy, Investigation of the Interaction of Myelin Basic Protein with Phospholipid Bilayers using Solid-State NMR Spectroscopy, Chem. Phys. Lipids, 132, 47-54 (2004).

75. A. Mecke, S. Uppuluri, T. M. Sassanella, D. K. Lee, A. Ramamoorthy, J. R. Baker Jr., B. G. Orr, and M. M. Banaszak Holl, Direct Observation of Lipid Bilayer Disruption by Poly(amidoamine) dendrimers, Chem. Phys. Lipids, 132, 3-14 (2004).

74. D. K. Lee, T. Narasimhaswamy, and A. Ramamoorthy, PITANSEMA, A Low-Power PISEMA Solid-State NMR Experiment, Chem. Phys. Lett., 399, 359-362 (2004).

73. A. Poon, J. Birn, and A. Ramamoorthy, Variation of Amide-15N Chemical Shift Tensors in Proteins, J. Phys. Chem. B, 108, 16577 (2004).

72. J. Birn, A. Poon, Y. Mao, and A. Ramamoorthy, Ab Initio Study of 13C Chemical Shift Anisotropy Tensors in Peptides, J. Am. Chem. Soc., 126, 8529-8534 (2004).

71. K. A. Henzler-Wildman, G. V. Martinez, M. F. Brown, and A. Ramamoorthy, Perturbation of the Hydrophobic Core of Lipid Bilayers by the Human Antimicrobial Peptide LL-37, Biochemistry 43, 8459-8469 (2004).

70. D. K. Lee, K. A. H. Wildman, and A. Ramamoorthy, Solid-state NMR spectroscopy of aligned lipid Bilayers at low temperatures, J. Am. Chem. Soc. 126, 2318 (2004).

69. K. A. H. Wildman, A. Ramamoorthy, T. Wakamiya, T. Yoshikawa, M. Crisma, C. Toniolo, and F. Formaggio, A study of a Ca,b-didehydroalanine homo-oligopeptide series in the solid-state by 13C cross-polarization magic angle spinning NMR, J. Peptide Sci., 10, 336 (2004).

68. A. Ramamoorthy, Y. Wei, and D. K. Lee, PISEMA Solid-State NMR Spectroscopy, Ann. Rep. NMR Spectrosc., 52, 1-52 (2004).

67. J. S. Santos, D. K. Lee, and A. Ramamoorthy, Effects of Antidepressants on the Conformation of Phospholipid Headgroups Studied by Solid-State NMR, Magn. Reson. Chem., 42, 105-114 (2004).

66. K. A. H. Wildman, D. K. Lee, and A. Ramamoorthy, Mechanism of lipid bilayer disruption by the human antimicrobial peptide, LL-37, Biochemistry 42, 6545 (2003).

65. K. J. Hallock, D. K. Lee, and A. Ramamoorthy, MSI-78, an analogue of the magainin antimicrobial peptides, disrupts lipid bilayer structure via positive curvature strain, Biophys. J., 84, 3052 (2003).

64. A. Mascioni, F. Porcelli, U. Ilangovan, A. Ramamoorthy, and G. Veglia, Conformational Preferences of the Amylin Nucleation Site in SDS Micelles: an NMR study, Biopolymers 69, 29 (2003).

63. K. A. H. Wildman, E. E. Wilson, D. K. Lee, and A. Ramamoorthy, Determination of the conformation and stability of simple homopolypeptides using solid-state NMR, Solid State Nucl. Magn. Reson., 24, 94 (2003).

62. S. Kidambi, R. W. Schurko, I. Hung, and A. Ramamoorthy, Nuclear magnetic resonance studies of metals in solid state non-metallic materials, Mater. Sci. Tech., 19, 1191-1196 (2003).

61. S. Kidambi, D. K. Lee, A. Ramamoorthy, Interaction of Cd and Zn with biologically important ligands characterized using solid-state NMR and ab initio calculations, Inorg. Chem., 42, 3142 (2003).

60. S. Kidambi and A. Ramamoorthy, Characterization of metal centers in bioinorganic complexes using ab initio calculations of Cd-113 chemical shifts, Inorg. Chem., 42, 2200 (2003).

32

59. K. J. Hallock, Dong-Kuk Lee, John Omnaas, H. I. Mosberg, and A. Ramamoorthy, Membrane composition determines pardaxin’s mechanism of lipid bilayer disruption, Biophys. J., 83, 1004-1013 (2002).

58. K. J. Hallock, K. A. Henzler Wildman, D. K. Lee, and A. Ramamoorthy, Sublimable Solids can be Used to Mechanically Align Lipid Bilayers for Solid-State NMR Studies, Biophys. J., 82, 2499 (2002).

57. K. A. Henzler Wildman, D. K. Lee, and A. Ramamoorthy, Determination of Effect of a-helix and b-sheet Stability in the Solid-State: A Solid-State NMR Investigation of Poly(L-Alanine), Biopolymers, 64, 246-254 (2002).

56. J. S. Santos, D. K. Lee, K. J. Hallock, and A. Ramamoorthy, Cholesterol and Antidepressant Drug Interactions With Phospholipids – A Solid-State NMR Study. Recent Research Developments in Physical Chemistry, Transworld Research Network 6, 179-211 (2002).

55. S. C. Shekar, D. K. Lee, and A. Ramamoorthy, Chemical shift anisotropy and offset effects in cross polarization solid-state NMR spectroscopy, J. Magn. Reson., 157, 223-234 (2002).

54. Y. Wei, D. K. Lee, A. E. McDermott, and A. Ramamoorthy, A 2D MAS solid-state NMR method to recover the amplified heteronuclear dipolar and chemical shift anisotropic interactions, J. Magn. Reson., 158, 23-35 (2002).

53. S. C. Shekar, A. Ramamoorthy, and R. J. Wittebort, Determination of the chemical shielding orientation from two or one of the three conventional rotations of a single crystal, J. Magn. Reson., 155, 257-262 (2002)

52. Y. F. Wei, D. K. Lee, K. J. Hallock, and A. Ramamoorthy, One-dimensional 1H-detected solid-state NMR experiment to determine amide-1H chemical shifts in peptides, Chem. Phys. Lett., 351, 42-46 (2002).

51. D. M. Taylor and A. Ramamoorthy, Coherence transfer through homonuclear dipolar coupling in an unoriented two spin-1/2 solid-state system, J. Mol. Struct., 602-603, 115-124 (2002).

50. S. Kidambi and A. Ramamoorthy, Quantum chemical calculations of cadmium chemical shifts in inorganic complexes, J. Phys. Chem. A106, 10363 (2002).

49. Y. Wei, D. K. Lee, and A. Ramamoorthy, Solid-State 13C chemical shift anisotropy tensors of polypeptides, J. Am. Chem. Soc., 123, 6118-6126 (2001).

48. Y. Wei, D. K. Lee, and A. Ramamoorthy, A two-dimensional magic angle decoupling and magic angle turning solid-state NMR method – An application to study chemical shift tensors from peptides that are non-selectively labeled with 15N isotope, J. Phys. Chem., B104, 4752-4762 (2001).

47. S. C. Shekar, D. K. Lee, A. Ramamoorthy, An experimental strategy to dramatically reduce the RF power used in cross polarization solid-state NMR spectroscopy, J. Am. Chem. Soc., 123, 7467-7468 (2001).

46. Y. F. Wei and A. Ramamoorthy, 2D 15N-15N isotropic chemical shift correlation established by 1H-1H dipolar coherence transfer in biological solids, Chem. Phys. Lett., 342, 312-316 (2001).

45. J. R. Brender, D. M. Taylor, and A. Ramamoorthy, Orientation of Amide-Nitrogen-15 Chemical Shift Tensors in Peptides: A Quantum Chemical Study, J. Am. Chem. Soc., 123, 914-922 (2001).

44. S. C. Shekar and A. Ramamoorthy, The unitary evolution operator for cross-polarization schemes in NMR, Chem. Phys. Lett., 342, 127-134 (2001).

43. K. J. Hallock, D. K. Lee and A. Ramamoorthy, The effects of Librations on the 13C Chemical Shift and 2H Electric Field Gradient Tensors in b-Calcium Formate, J. Chem. Phys., 113, 11187 (2000).

42. Y. F. Wei, D. K. Lee, and A. Ramamoorthy, One-dimensional dipolar-shift spectroscopy under magic angle spinning to determine the chemical-shift anisotropy tensors, Chem. Phys. Lett., 324, 20 (2000).

41. K. L. Stout, K. J. Hallock, J. W. Kampf and A. Ramamoorthy, N-Acetyl-L-phenylalanine, Acta Cryst. C56, e100 (2000).

40. D. M. Taylor and A. Ramamoorthy, Analysis of Dipolar-Coupling Mediated Coherence Transfer in a Homonuclear Two Spin 1/2 Solid-State System, J. Magn. Reson. 141, 18 (1999).

33

39. D. K. Lee, J. S. Santos and A. Ramamoorthy, Application of One-Dimensional Dipolar-Shift Solid-State NMR Spectroscopy to Study the Backbone Conformation of Membrane-Associated Peptides in Phospholipid Bilayers, J. Phys. Chem. B103, 8383 (1999).

38. D. K. Lee, J. S. Santos and A. Ramamoorthy, Nitrogen-15 Chemical Shift Anisotropy and 1H-15N Dipolar Coupling Tensors Associated with the Phenylalanine Residue in the Solid-State, Chem. Phys. Lett. 309, 209 (1999).

37. A. Ramamoorthy, C. H. Wu and S. J. Opella, Experimental aspects of multidimensional solid-state NMR correlation spectroscopy, J. Magn. Reson. 140, 131 (1999).

36. D. K. Lee and A. Ramamoorthy, Determination of the Solid-State Conformations of Polyalanine Using Magic-Angle Spinning NMR Spectroscopy, J. Phys. Chem. B103, 271 (1999).

35. K. J. Hallock, D. K. Lee and A. Ramamoorthy, Carbon-13 Chemical Shifts and 1H-13C Dipolar couplings in Metal Sandwich Solids Using One-Dimensional Solid-State NMR Spectroscopy, Chem. Phys. Lett., 302, 175 (1999).

34. D. K. Lee, R. J. Wittebort and A. Ramamoorthy, Characterization of 15N Chemical Shift and 1H-15N Dipolar Coupling Interactions in a Peptide Bond of Uniaxially Oriented and Polycrystalline Samples by One-Dimensional Dipolar - Chemical Shift Solid-State NMR Spectroscopy, J. Am. Chem. Soc., 120, 8868 (1998).

33. D. K. Lee and A. Ramamoorthy, A Simple One-Dimensional Solid-State NMR Method to Characterize the Nuclear Spin Interaction Tensors Associated with the Peptide Bond, J. Magn. Reson., 133, 204 (1998).

32. U. Ilangovan and A. Ramamoorthy, Conformational Studies of Human Islet Amyloid Peptide Using Molecular Dynamics and Simulated Annealing Methods, Biopolymers, 45, 9 (1998).

31. D. K. Lee and A. Ramamoorthy, Off-Resonance Proton-Decoupling in Overtone NMR Spectroscopy of Solids, Chem. Phys. Lett. 286, 403 (1998).

30. A. Ramamoorthy, Phase-Alternated Composite Pulses for Zero-Field NMR Spectroscopy of Spin 1 System, Mol. Phys. 93, 757 (1998).

29. D. K. Lee and A. Ramamoorthy, Cross-Polarization in 14N Overtone NMR Spectroscopy of Solids, Chem. Phys. Lett., 286, 398 (1998).

28. M. Ravikumar and A. Ramamoorthy, Exact Evaluation of the Line-Narrowing Effect of the Lee-Goldburg Pulse Sequence in Solid-State NMR Spectroscopy, Chem. Phys. Lett., 286, 199 (1998).

27. D. K. Lee and A. Ramamoorthy, A Composite Pulse Sequence for the Broadband Excitation in Overtone 14N NMR Spectroscopy, Chem. Phys. Lett., 280, 501 (1997).

26. A. Ramamoorthy, Analysis of the Performance of a Phase Alternated Multiple Pulse Sequence in Spin I=7/2 Zero-Field NQR Spectroscopy, Mol. Phys. 92, 1035 (1997).

25. F. M. Marassi, A. Ramamoorthy, and S. J. Opella, Solid-State NMR spectroscopy of Uniformly 15N-Labeled Protein Oriented in Lipid Bilayers, Proc. Natl. Acad. Sci. USA 94, 8551 (1997).

24. A. Ramamoorthy, C. H. Wu, and S. J. Opella, Magnitudes and Orientations of the Principal Elements of the 1H Chemical Shift, 1H-15N Dipolar, and 15N Chemical Shift Interaction Tensors in 15Ne1-Tryptophan and 15Np-Histidine Side Chains Determined by Three-Dimensional Solid-state NMR Spectroscopy, J. Am. Chem. Soc. 119, 10479 (1997).

23. A. Ramamoorthy, L.M. Gierasch, and S. J. Opella, Resolved Two-Dimensional Anisotropic-Chemical-Shift/Heteronuclear Dipolar Coupling Powder-Pattern Spectra by Three-Dimensional Solid-State NMR Spectroscopy, J. Magn. Reson., B110, 102 (1996).

22. A. Ramamoorthy, L.M. Gierasch, and S. J. Opella, Three-Dimensional Solid-State NMR Correlation Experiment with 1H Homonuclear Spin-Exchange, J. Magn. Reson., B111, 81 (1996).

21. A. Ramamoorthy, F. Marassi, and S. J. Opella, Applications of Multidimensional Solid-State NMR Spectroscopy to Membrane Proteins, in "Proceedings of the Int. School of Biological Magnetic Resonance, 2nd course, Dynamics and the Problem of Recognition in Biological Macromolecules" (O. Jardetsky and J. Lefeure, eds.), Chapter 17, p:238, Plenum, NY (1996).

34

20. A. Ramamoorthy, C. H. Wu and S. J. Opella, Three-Dimensional Solid-State NMR Experiment That Correlates the Chemical Shift and Dipolar Coupling Frequencies of Two Heteronuclei, J. Magn. Reson., B107, 88 (1995).

19. A. Ramamoorthy, L. M. Gierasch, and S. J. Opella, Four-Dimensional Solid-State NMR Experiment That Correlates the Chemical-Shift and Dipolar-Coupling Frequencies of Two Heteronuclei with the Exchange of Dilute-Spin Magnetization, J. Magn. Reson., B109, 112 (1995).

18. A. Ramamoorthy, F. Marassi, M. Zasloff, and S. J. Opella, Three-Dimensional Solid-State NMR Spectroscopy of a Peptide Oriented in Membrane Bilayers, J. Biol. NMR, 6, 329 (1995).

17. R. Jelinek, A. Ramamoorthy, and S. J. Opella, High-Resolution Three-Dimensional Solid-State NMR Spectroscopy of a Uniformly 15N-Labeled Protein, J. Am. Chem. Soc., 117, 12348 (1995).

16. A. Ramamoorthy and S. J. Opella, Two-dimensional chemical shift / heteronuclear dipolar coupling spectra obtained with polarization inversion spin exchange at the magic angle and magic-angle sample spinning (PISEMAMAS), Solid state NMR Spectrosc., 4, 387 (1995).

15. C. H. Wu, A. Ramamoorthy, L. Gierasch, and S. J. Opella, Simultaneous Characterization of the Amide 1H Chemical Shift, 1H-15N Dipolar, and 15N Chemical Shift Interaction Tensors in a Peptide Bond by Three-Dimensional Solid-State NMR Spectroscopy, J. Am. Chem. Soc., 117, 6148-6149 (1995).

14. C. H. Wu, A. Ramamoorthy and S. J. Opella, High Resolution Heteronuclear Dipolar Solid-state NMR spectroscopy, J. Magn. Reson., A109, 270 (1994).

13. A. Ramamoorthy, T. Fujiwara, and K. Nagayama, An RF Pulse Sequence Optimized for Homonuclear J Cross-Polarization under Magic-Angle-Spinning, J. Magn. Reson., A104, 366 (1993).

12. A. Ramamoorthy, T. Fujiwara, and K. Nagayama, An RF Pulse Sequence Optimized for Homonuclear J Cross-Polarization under Magic-Angle-Spinning, J. Magn. Reson., A104, 366 (1993).

11. T. Fujiwara, A. Ramamoorthy, K. Nagayama, K. Hioka, and T. Fujito, Dipolar HOHAHA under MAS Conditions for Solid-state NMR, Chem. Phys. Lett., 212, 81 (1993).

10. T. Fujiwara, A. Ramamoorthy, and K. Nagayama, Dipolar recoupling techniques under MAS, JEOL Newsletters (1993) and also presented in the ‘NMR Meeting’ Japan.

9. A. Ramamoorthy and N. Chandrakumar, Comparison of the Coherence-Transfer efficiencies of Laboratory- and Rotating- Frame Experiments, J. Magn. Reson., 100, 60 (1992).

8. N. Chandrakumar and A. Ramamoorthy, Homonuclear deuterium correlation spectroscopy in the rotating frame, J. Am. Chem. Soc., 114, 1123 (1992).

7. A. Ramamoorthy, N. Chandrakumar, A. K. Dubey and P. T. Narasimhan, Analysis of the performance of NQR composite pulses, J. Magn. Reson. A102, 274 (1993).

6. A. Ramamoorthy, Double Quantum Nuclear Quadrupole Resonance Spectroscopy of spin I=7/2 nuclei in zero magnetic field, Mol. Phys. 72, 1425 (1991).

5. A. Ramamoorthy and P. T. Narasimhan, Phase-alternated composite pi/2 pulses for solid state quadrupole echo NMR spectroscopy, Pramana- J. Phys. 36, 399 (1991).

4. A. Ramamoorthy and P. T. Narasimhan, Broadband excitation sequences for NQR spectroscopy, Mol. Phys. 73, 207 (1991).

3. A. Ramamoorthy and P. T. Narasimhan, Numerical Design of Composite Pulses for the Powder Nuclear Quadrupole Resonance Spectroscopy, Z. Naturforsch. 45(a), 581 (1990).

2. A. K. Dubey, A. Ramamoorthy and P. Raghunathan, Application of Zero-time Resolution Technique to non-axially symmetric systems in spin-3/2 pure Nuclear Quadrupole Resonance Spectroscopy, Chem. Phys. Lett. 168, 401 (1990).

1. A. Ramamoorthy and P. T. Narasimhan, Design of Composite Pulses for Nuclear Quadrupole Resonance Spectroscopy, J. Mol. Struct. 192, 333 (1989).

Book Chapters

35

4. R. Soong, J. Xu, and A. Ramamoorthy, Bicelles – A much needed magic wand to study membrane proteins by NMR spectroscopy, ‘Nuclear Magnetic Resonance Spectroscopy of Liquid Crystals’, World Scientific Publishing Co. Pte. Ltd. (Ed. Ronald Y. Dong) London, (2010).

3. A. Naito and A. Ramamoorthy, Atomistic-Resolution Structural Studies of Liquid Crystalline Materials Using Solid-State NMR Techniques, ‘Thermotropic Liquid Crystals – Recent Advances’, Springer (Ed. A. Ramamoorthy) (2007).

2. A. Ramamoorthy and K. Yamamoto, A family of PISEMA experiments for structural studies of biological solids, Handbook of Modern Magnetic Resonance, Springer (Ed. Graham Webb) (2006).

1. K. Saalwachter and A. Ramamoorthy, Sensitivity enhancement by inverse detection in solids, NMR Spectroscopy of Biological Solids, Taylor & Francis (Ed. A. Ramamoorthy) (2006).

Funding Support Current 1) NIH (RO1) (Role: PI) 2008-2019 “Structural Studies on Membrane-Associated Cytochrome b5 and P450 using NMR” 2) NIH (RO1) (Role: PI) 2016-2021 “Membrane Interaction and Disruption by Alzheimer’s Amyloid-beta Peptide”

PAR-18-596 (Ramamoorthy) 9/1/18 - 8/31/23 (0.8 summer) 3) University of Southern Mississippi (Direct)

NIH (RO1; Co-PI) $86,944 annual direct costs “Role of Lipid-derived Oligomer Strains in AD Phenotypes”

3) Funding from the Protein Folding Disease Center, University of Michigan 4) Senior Hans Fischer fellow, Technical University of Munich, Germany:

Funding support for a post-doctoral fellow, travel, and research supplies.

Pending PAR-18-596 (PI: Ramamoorthy) 9/1/18 - 8/31/23 (2.0 summer) NIH $499,816 annual direct costs “Biophysical and Cellular Investigation of Tissue-Derived Amyloid Aggregates of Alzheimer’s Disease” PAS-17-028 (PI: Ivanova; Co-PI: Ramamoorthy) 9/1/18 - 8/31/23 (0.8 academic; 0.3 summer) NIH $584,663 annual direct costs “Implications of Alpha-Synuclein Fibrillation and Structural Polymorphisms in Neurodegeneration” RFA-AG-18-023 (Ramamoorthy is one of the 3 PIs) 9/1/18 - 8/31/23 (2.0 summer) The University of Miami Florida (Direct) NIH (Prime) $150,257 annual direct costs “Investigation of Amyloid-beta Deposits and Neuroinflammation in the Brain of Older Virally-suppressed HIV-infected Individuals with Neurocognitive Deficits”

Completed Funding Support 1. NSF (CAREER Development Award) P.I.: A. Ramamoorthy Title: “Multi-Nuclear, Multi-Dimensional Solid-State NMR Methods for the Structure Determination of Membrane-Associated Proteins” Dates/Costs of entire project March ‘99 to Feb. 04 $482,453 (total costs) 2. NSF ("Research Experiences for Undergraduates") P.I.: A. Ramamoorthy Title: “Multi-Nuclear, Multi-Dimensional Solid-State NMR Methods for the Structure Determination of Membrane-Associated Proteins”

36

Dates/Costs of entire project March ‘00 to April ‘01 $5,000 (total costs) 3. NSF ("Research Experiences for Undergraduates") P.I.: A. Ramamoorthy Title: “Multi-Nuclear, Multi-Dimensional Solid-State NMR Methods for the Structure Determination of Membrane-Associated Proteins” Dates/Costs of entire project March ‘01 to April ‘02 $5,000 (total costs) 4. NSF (REU; CAREER Development Award) P.I.: A. Ramamoorthy Title: “Multi-Nuclear, Multi-Dimensional Solid-State NMR Methods for the Structure Determination of Membrane-Associated Proteins” Dates/Costs of entire project March ‘03 to Feb. 04 $10,000 (total costs) 5. NSF (REU) P.I.: A. Ramamoorthy

“Development and applications of sold state NMR methods for the structure determination of Membrane Associated Peptides” 03/2004-02/2005 $5,000

6. Petroleum Research Fund - Type G P.I.: A. Ramamoorthy Title: “Structure and Dynamics of Pardaxin - a Channel-Forming Neurotoxic Peptide” Dates/Costs of entire project 09/1/’98-08/31/’00 $20,000 (total costs) 7. R21, NIH P.I.: Richard Neubig Role: Co-PI (A. Ramamoorthy) Title: “Structure Determination of a Functional Fragment of a G Protein Coupled Receptor Dates/Costs of entire project 04/1/’99-04/30/’01 $140,000 (total costs) 8. Office of the Vice President for Research, P.I.: A. Ramamoorthy The University of Michigan Distinguished Faculty Seminar: “Biophysics/Chemical Biology Seminar Series” Dates/Costs of entire project 05/1/’99-06/30/’00 $7,500 (total costs) 9. Office of the Vice President for Research, P.I.: A. Ramamoorthy The University of Michigan

Title: “Structure, Dynamics and Function of a Human Antimicrobial Peptide Using Solid-State NMR Spectroscopy” Dates/Costs of entire project 12/01/’00-08/31/’01 $15,000 (total costs)

10. NIH P.I.: E. Zuiderweg Role: Co-PI (A. Ramamoorthy) Title: “High Field NMR Spectrometer” Dates/Costs of entire project 04/1/’98-03/31/’99 $400,000 (total costs) 11. NSF P.I.: E. Zuiderweg Role: Co-PI (A. Ramamoorthy) Title: “High Field NMR Spectrometer” Dates/Costs of entire project 04/1/’98-03/31/’99 $400,000 (total costs) 12. Keck Foundation P.I.: E. Zuiderweg Role: Co-PI (A. Ramamoorthy) Title: “High Field NMR Spectrometer” Dates/Costs of entire project 04/1/’98-03/31/’99 $500,000 (total costs) 13. Michigan Life Science Corridor Role: Co-PI (A. Ramamoorthy)

Title: ““Infrastructure Supporting the Michigan Life Science Corridor: Michigan Center for Structural Biology” $8,000,000

Funds have been obtained to purchase 900 MHz (Solid+Solution), 800 MHz (Solid-state NMR for U.M), 600 MHz (solution) and 700 MHz (solution) NMR spectrometers. Dates/Costs of entire project 04/1/’00-03/31/’02 $8,000,000 (total costs)

14. PRF (ACS) P.I.: A. Ramamoorthy Title: “Solid State NMR Symposium” $3,600.00

Dates/Costs of entire project 06/1/’02-05/31/’03

15. University of Michigan & Industries P.I.: A. Ramamoorthy

37

Title: “Solid State NMR Symposium” $10,000.00

Dates/Costs of entire project 06/1/’02-05/31/’03

16. University of Michigan & Industries P.I.: A. Ramamoorthy Title: “Membrane Biophysics Symposium” $15,000.00

Dates/Costs of entire project 09/1/’03-08/30/’04

17. NSF P.I.: D. Lubman Role: Co-PI (A. Ramamoorthy) Title: “Mass Spectrometer” Dates/Costs of entire project $500,000 (total costs) 18. NSF (Role:Co-PI) P.I.: D. Lubman Title: “MALDI Spectrometer” Dates/Costs of entire project $500,000 (total costs) 19. Eli Lilly Company P.I.: A. Ramamoorthy

“Structural Studies of peptides for oral protein delivery” $10,000 20. NIH (Role: PI)

“Structure and Function of Antimicrobial Peptides” 03/2004-02/2009 ($1,321,386 (total Costs)

21. American Heart Association (Role: PI) 07/01/07-06/30/09 Combating Atherosclerosis with Fluorinated Antimicrobial Peptides $132,000 22. NIH, Center of Nanotechnology Excellence Co-PI/participant: A. Ramamoorthy

P.I.: James R. Baker, JR Dates: 9/29/05 - 9/28/10 23. NIH Shared Instrumentation Award $500,000

Purchase of a 500 MHz Solid-State NMR Spectrometer Role: PI

24. NSF Chemistry Research Instrumentation (CRIF-MU) $499,700 Upgrade of a 600 MHz NMR Spectrometer Role: Co-PI

25. Merck Co. (Role: PI) 09/2008-01/2009 “NMR Characterization of Nanomedicine” $29,000 26. NIH (R21) (Role: PI) 12/01/2008-03/31/11

“Membrane Interaction and Membrane Mediated Aggregation of Amylin” 27. NIH (RO1) (Role: Co-PI; Chen-PI) 07/01/08-06/30/12

“SFG Investigation of Peptides” 28. NIH (RO1) (Role: Co-PI; Mark Banaszak Holl - PI) 8/15/2010 to 5/31/2014

“The Roll of Cell Membrane Disruption in Non-Viral Vector Oligonucleotide Delivery” 29. NIH (RO1) (Role: PI) 12/01/2010-01/31/16

“Rapid and efficient production of functional Cytochrome P450 enzymatic complex for structural studies by NMR”

30. NIH (RO1) (Role: Co-PI; Michael Morris - PI) 09/01/2011-08/31/2015 “Bone mechanics by solids-state NMR”

31. Funding support from South Korea for Collaborative Research with Prof. Mi Hee Lim (UNIST, Korea) 32. NIH (RO1) (Role: Co-PI; Michael Morris - PI) 8/1/2010 to 04/30/2016

“Chemical Structure Effects on Bone Response to Mechanical Load”