© 2011 Medidata Solutions, Inc. – Proprietary and Confidential© 2011 Medidata Solutions, Inc. – Proprietary and Confidential 1Optimizing Clinical Trials: Concept to Conclusion TM © 2011 Medidata Solutions, Inc. – Proprietary and Confidential© 2011 Medidata Solutions, Inc. – Proprietary and Confidential

Optimizing Clinical Trials:

Concept to Conclusion™

Medidata & Amazon Web Services

Glenn Watt | Corporate Information Security & Privacy Officer

June 10 2011

© 2011 Medidata Solutions, Inc. – Proprietary and Confidential© 2011 Medidata Solutions, Inc. – Proprietary and Confidential 2Optimizing Clinical Trials: Concept to Conclusion TM

Company Snapshot

Leading provider of SaaS technology solutions that drive efficiencies across the clinical research process, lowering cost of clinical development

* Phases I-IV, not including pre-clinical expense, labs, or other

• Founded: 1999

• Headquarters: New York City

• Locations: 9 offices across U.S., U.K., Japan and China

• Headcount: 710+

• Customers: 215+ customers include 22 of Top 25 bio-pharmacompanies

• Addressable Bio-pharma clinical Market Size: development trial spend =

$53B*

• Public Co: NASDAQ: MDSO$615M+ market cap (3/11)

• Balance Sheet: $89M cash and marketable securities

© 2011 Medidata Solutions, Inc. – Proprietary and Confidential© 2011 Medidata Solutions, Inc. – Proprietary and Confidential 3Optimizing Clinical Trials: Concept to Conclusion TM

Global Business

Medidata Technology Used in Over 100 Countries

Study design data for over 27,500 protocols

Live data infrastructure for over 2,000 studies, with over

2,000,000 subjects

Financial transactions from over 260,000 site grants and 8,000

CRO contracts

© 2011 Medidata Solutions, Inc. – Proprietary and Confidential© 2011 Medidata Solutions, Inc. – Proprietary and Confidential 4Optimizing Clinical Trials: Concept to Conclusion TM

Medidata spends 16% of revenue on Research & Development

Medidata’s Product Platform

EDC

Early CDMS

Lab Administration

Hybrid Studies

Full Multilingual CDMS

Open API & Developer Central

Enhanced Reporting and Data Handling

Monitor

Designer Gateway

Targeted SDV

AM 2.0

Tech Stack

Designer 3.0

GM 3.0

Contracting

Safety Gateway

1999 2011

© 2011 Medidata Solutions, Inc. – Proprietary and Confidential© 2011 Medidata Solutions, Inc. – Proprietary and Confidential 5Optimizing Clinical Trials: Concept to Conclusion TM

Broad Customer Base

Medical Devices CROs/Service Providers

Institutions Biopharmaceutical

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How Medidata Uses AWS Today

• iMedidata

• Simplified eLearning and user administration

• Launched on AWS in July, 2010

• Balance

• Powerful dynamic allocation and supply planning

• Launched on AWS in July, 2010

• Grants Manager

• Rapid trial forecast and budget development

• Transitioned to AWS in June, 2010

• Coder

• Streamlined enterprise-grade coding

• To be launched on AWS in July, 2011

Medidata leverages Elastic Compute Cloud, Simple Storage Solution, Relational Database service, Elastic Block Store and Elastic Load Balancing

© 2011 Medidata Solutions, Inc. – Proprietary and Confidential© 2011 Medidata Solutions, Inc. – Proprietary and Confidential 7Optimizing Clinical Trials: Concept to Conclusion TM

Selecting the Right Cloud Vendor

AWS Vendor X Vendor Y Vendor Z

Strong Regulatory Compliance

SAS 70 Type II

FISMA

ISO 27000 based Security Policies

Redundant Zones for Business Continuity

Privacy Compliance(Safe Harbor)

Information Security

Interoperability

After more than a year of diligence, AWS was the choice for data security

Source: Medidata Solutions

© 2011 Medidata Solutions, Inc. – Proprietary and Confidential© 2011 Medidata Solutions, Inc. – Proprietary and Confidential 8Optimizing Clinical Trials: Concept to Conclusion TM

Medidata Architecture and Deployment

• Opinionated Deployments

• Architectures deployed in common, best practice way

• Simplifies upgrades

• Ensures strict adherence to SLA, security, backup, and DR policies

• Common Architectures

• Limited, approved set of technologies

• OS, database, monitoring, load balancing, firewalls

• Fully Scripted Deployments

• Using configuration management software

• Timely, easy releases and upgrades

• Better emergency response

© 2011 Medidata Solutions, Inc. – Proprietary and Confidential© 2011 Medidata Solutions, Inc. – Proprietary and Confidential 9Optimizing Clinical Trials: Concept to Conclusion TM

How Medidata Plans to Use AWS

• Increase Medidata transactions on AWS

• Transition existing products to AWS

• Transition existing customers to AWS

• Introduce new products on AWS

• Leverage more AWS solutions across Medidata portfolio

• SimpleDB

• Simple Queue Service

• Simple Notification Service

• Elastic Map Reduce