Proteolysis

PhosphorylationIndependence

Wnt/CA2+ Pathway Planar Cell Polarity (PCP) Pathway

Canonical Pathway

PhosphorylationIndependence

+p

+p

+p

G Protein?

Ca2+

-P

+u

+p

CytoskeltalChange

GeneTranscription

DNA

WNT SIGNALING PATHWAY

Nucleus

SMAD4SMAD3Protein52

CBP

PKA

CKIa

Axin

CK2

APC

Rbx1

Prickled

Cell cycle

AlzheimersDisease

FocalAdhesion

Cul1 Skp1

DNA

Ubiquitin MediatedProteolysis

AdherensJunction

Scaffold

FrizzledDally

FRP

ProcCer-1

Wif-1

Dkk

Dvl

GSK-3

IdaxCKIE

PS-1

Axam

-catenin

TCF/LEF

Xsos17

CtBP

Duplin

Groucho NLK

-TrCP

ICAT

RhoA

ROCK2

Rac

JNK

DvlPLC

NFAT

Nkd

FrizzledStbm

Wnt11

Knypek

Frizzled

Wnt55

Uterine PPAR8 cycD fra-1 c-jun

c-mycTGF-SignalingPathway

Daam1

Wnt

p53

PKCCaN

MAPK SignalingPathway

Skp1 Siah-1SIP

PP2AAPC

Aviva Product

Not a Aviva Product

Indirect effect

Another molecule, mostly chemical compound

InhibitionDissociationPhosphorylation+pDephosphorylation-p

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Pathway diagram below is compiled from data from the Kyote Encylopedia of Genes and GenomesKanehisa, M., Goto, S., Furumichi, M., Tanabe, M., and Hirakawa, M.; KEGG for representation and analysis of molecular networks involving diseases and drugs. Nucleic Acids Res. 38, D355-D360 (2010). Kanehisa, M., Goto, S., Hattori, M., Aoki-Kinoshita, K.F., Itoh, M., Kawashima, S., Katayama, T., Araki, M., and Hirakawa, M.; From genomics to chemical genomics: new developments in KEGG. Nucleic Acids Res. 34, D354-357 (2006). Kanehisa, M. and Goto, S.; KEGG: Kyoto Encyclopedia of Genes and Genomes. Nucleic Acids Res. 28, 27-30 (2000).

2011 Aviva Systems Biology

LRP5/6New

GBPNew

Ebi1New

CaMKIINew

TAK1New

PAR-1New