automated - metasystems...cept provides each mycobacteria scanner with the optimal balance between...

Automated

Mycobacteria

Detection

Fully Networked.

Reduced Costs.

Improved Quality

Management.

Rapid diagnosis of Tuberculosis (TB) is

critical for initiation of treatment and

infection control. Sputum Smear

Microscopy (SSM) of acid fast bacilli is still

the most common TB diagnostic test

globally because of its simplicity and

associated low costs. However, manual

reading of stained slides is time-

consuming the quality of results may be

influenced by factors like user proficiency

or the number of searched Field-Of-Views

(FOV).

Implementation of the Mycobacteria

Scanner* for automated slide scan-

ning and sensitive imaging and detecti-

on of Auramine or Ziehl-Neelsen stai-

ned Mycobacteria can significantly

improve SSM workflows, reduce labor

costs and increase cost-effectiveness.

Improve Workflows

FAST AND EASY

TUBERCULOSIS SPUTUM

SMEAR MICROSCOPY

The Mycobacteria Scanner is a scalable

system adjustable to the individual needs

of your laboratory and able to scan and

analyze from 8 to 800 slides in one batch.

Auramine or Ziehl-Neelsen stained

Mycobacteria are detected and counted

automatically using objective and

reproducible criteria. The system signifi-

cantly increases the flexibility of working

processes within the laboratory because it

scans sputum smear samples unattended

during the day and / or overnight as

needed.

Seamless integration into the existing

laboratory environment facilitates the

exchange of images and data via LIMs

to store them with patient files.

Furthermore, images and results can

be reviewed immediately on the local

workstation or at decentralized review

stations within the laboratory or

hospital network.

Technicians will appreciate the signifi-

cant ergonomic improvement as they

will no longer have to spend countless

hours in front of the microscope and

can review images and data comfort-

ably and quickly onscreen.

Automated slide scanning and image

analysis speeds up SSM, therefore

increasing sample throughput.

Technicians freed from manual slide

screening can use the time saved for

other laboratory activities.

Fully Networked

Reduced Costs

Additionally, standardized and repro-

ducible SSM could be employed in a

low-cost Triage protocol to select

samples which would benefit from

subsequent confirmatory tests such as

Nucleic Acid Amplification Tests

(NAATs).

A u t o m a t e d i m a g i n g w i t h t h e

Mycobacteria Scanner improves your

quality management in multiple ways:

a Laboratories can easily implement

standardized scanning and imaging

procedures.

a Automated object detection, based

on objective and reproducible

criteria is independent from user

proficiency.

a Archiving of images improves

traceability as digitized data are

easy to track and to recall.

Improved

Quality Management

MAGAZINES

The slide frame magazines hold

16 frames with 5 slides each (80

slides in total); one system can

accommodate up to 10

magazines. Magazines are

portable and can be easily taken

to the workbench for convenient

loading.

SLIDE FEEDER

The feeder module picks the slide

frames from the magazines and

delivers them to the barcode

reader, and subsequently to the

microscope stage. The module

runs unattended and can operate

24/7 – including STAT (priority)

sample handling.

CAMERA

Outstanding performance for

clear and crisp color images at

highest speed.

MICROSCOPE

Fully integrated, motorized high-

end microscope equipped with a

high-precision stage.

All microscope functions are

directly driven by the Metafer

software.

The centerpiece of the

Mycobacteria ScannerMetafer software controls the scanning

and imaging hardware and provides a

convenient user interface for all-day

routine use.

The exceptional Metafer classifier con-

cept provides each Mycobacteria

Scanner with the optimal balance

between flexibility and standardiza-

tion. All automated microscope actions

are defined by sets of parameters bun-

dled up in customizable classifiers; they

contain information on hardware- and

software settings, protocols for intelli-

g e n t a n d a d a p t i v e a u t o f o c u s

sequences for the acquisition of high-

quality images of stained micro-

organisms, as well as macros for object

detection of Auramine or Ziehl-Neelsen

stained Mycobacteria.

DETECT

The system automatically

detects labeled bacteria and

calculates their frequency accord-

ing to user-defined settings such

as bacteria per FOV.

The relocation of bacteria under

the microscope for inspection

can easily be done via one

mouse-click.

SCAN

Slides are scanned and

imaged automatically according

to laboratory settings such as

area to be scanned, scanning

pattern and number of Field-Of-

Views.

START

Load stained Tuberculosis

sputum smear slides in the

magazine. Open the Metafer

software and load the pre-

defined settings and standard

operating sequence. Start the

scanning process.

HOW IT WORKS

The Open and

Flexible PlatformAutomated scanning and imaging of

Auramine and Ziehl-Neelsen stained TB

sputum smear sl ides with the

Mycobacteria Scanner is one of the

microbiological applications based on

MetaSystems' Metafer slide scanning

platform.

Further applications are the Gram Scanner* for automated scanning and imaging of Gram stains and Direct Multiplex Imaging (DMI)* for identifica-tion of pathogens directly from patient sample slides.

Due to Metafer´s modular and flexible architecture, it is possible to consoli-date several applications on one workstation. For example, one can combine the Gram Scanner with the Mycobacteria Scanner to process Gram stained slides during the day and TB sputum smear slides overnight.

For more information, see separate

product information or online using:

www.metasystems-international.com

METAFER

[email protected]

www.metasystems-international.com

MetaSystems Hard & Software GmbH (Headquarters)

Robert-Bosch-Str. 6, 68804 Altlussheim, Germany

tel +49 6205 396 10 | fax +49 6205 322 70 | [email protected]

MetaSystems Group, Inc.

70 Bridge Street, Newton, MA 02458, USA


MetaSystems S.r.l.

Via Gallarate 80, 20151 Milano, Italy


MetaSystems India Pvt., Ltd.

No. 1/1, 2nd Floor, 1st Main Rd., 2nd cross, Thimmaiah Garden, R T Nagar, Bangalore Karnataka, 560 032, India

tel +91 9535 7788 01 | [email protected]

MetaSystems Asia Co., Ltd.

Unit 108, 1/F, Bio-Informatics Centre, No. 2 Science Park, West Avenue, Hong Kong Science Park, Shatin, New Territories, Hong Kong

tel +852 2587 8333 | fax +852 2587 8334 | [email protected]

MetaSystems Worldwide

MetaSystems believes that a global company should foster a community of partners

and customers to achieve a climate of collaboration and friendship. Our headquarters

and the subsidiary offices in USA, Italy, India, and Hong Kong with their trained and

motivated staff allow us to work very close to our customers. We know that communi-

cation is crucial to achieve our main goal: to continuously improve our understanding

of demands, requirements, and wishes of lab professionals everywhere in the world.

MetaSystems is very proud having established a worldwide network of competent

sales and servicing partners. Please feel free to contact your local MetaSystems

representative or MetaSystems directly to learn more about the community.

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MetaSystems products are used in many countries worldwide. Depending on the

regulations of the respective country or region, some products may not be used for

clinical diagnostic use.

*In the United States of America (USA) and Canada, the MetaSystems Gram Scanner

and Mycobacteria Scanner are intended for research purposes only.

* In Europe, MetaSystems devices are CE-marked in-vitro diagnostics (IVD) devices.

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