Autoimmune DiseaseRheumatoid Arthritis

AndSystemic Lupus Erythematosus

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What is autoimmune disease?

• Characteristics– Inappropriate response of immune system– Against self components– Tissue destruction– Sometimes fatal

• RA and SLE– Autoantibody– Immune complex

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Rheumatoid Arthritis

• Mechanism – Rheumatoid factors– Binding with IgG (Fc part)– IgM-IgG complexes deposited in the joints– Type III hypersensitive

圖、 IgG 結構

圖、 Type III hypersensitive3

Typelll Hypersensitivity

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Rheumatoid Arthritis

• Symptoms – Joints become red, swollen, painful, and tender

• production of excessive joint fluid

– Joints are usually inflamed in a symmetrical pattern

– Loss of cartilage – Erosion and weakness of the bones

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• Mechanism -Type IIIhypersensitive

SLE

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•Symptoms

-Harms the heart, joints, skin, lungs, blood vessel, liver, kidneys, and nervous system.-Is dubbed ” the great imitators”.-female:male=10:1

SLE

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參考資料• Thomas J. Kindt; Richard A. Goldsby. Immunology . Freeman.• http://www.medicinenet.com/rheumatoid_arthritis/page2.htm• http://en.wikipedia.org/wiki/Type_III_hypersensitivity• http://en.wikipedia.org/wiki/Immunoglobulin_G

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