Abbrevat ions

Autoant ibodies

Guidelines for diagnostic evaluation of autoimmune diseases

AN

A

ds-D

NA

ss-D

NA

His

tone

Nuc

leos

ome

ENA

RNP

Sm SS-A

SS-B

Scl-7

0

Jo-1

Cent

rom

ere

Ribo

som

al P

PM-S

cl

PCN

A

RF Waa

ler-

Rose

CCP

AN

CA

MPO

PR-3

Lact

ofer

rin

BP1

GS-

AN

A

GB

M

TBM

Card

iolip

in

ß-2

GP1

LA anti-

C1q

AM

A

SMA

LKM

SLA

ASC

A

Endo

thel

ium

Retic

ulin

APC

A

Stria

ted

mus

cle

Card

iac

mus

cle

Coom

bs

Thro

mbo

cyte

TPO

HTG

TSH

rece

ptor

ICA

Adr

enal

(gla

nd)

Ster

oid

cell

Sper

m

EMA

-IgA

EMA

-IgG

tTG

-IgA

tTG

-IgG

Glia

din

IgA

Glia

din

IgG

Pem

phig

us (I

C)

BM

Z

ACh

R

Para

thyr

oid

Systemic autoimmune diseases

Active SLE • • • •Inactive SLE • • •Discoid LE Subacute cutaneous LE

Drug-induced lupus • •Neonatal LE • •MCTD / Sharp syndrome •PSS •CREST syndrome •Raynaud syndrome

PM / DM •PM / Scl overlap •UCTD

RA adult • • •Felty syndrome • • • •JCA

Sjögren syndrome •Polyarthritis nodosa

Primary APS • •Wegener’s granulomatosis • •Vasculitis

Churg-Strauss syndrome

Micropolyangiitis

Arthritis, arthralgia

Myalgia

Hermatological diseases

HUVS •AIHA

Pernicious anemia •ITP

Cryoglobulinemia

Autoimm. thrombosis • • •

Gastrointestinal diseases

Atrophic gastritis

Celiac disease • •Celiac (IgA-deficient) • • •Crohn’s disease

Ulcerative colitis

Liver diseases

CAH •CAH / HBsAg positive CAH / HCV positive

Viral hepatitis

Drug induced hepatitis

PBC •PSC

PBC / PSC overlap syndrome

Renal diseases

Goodpasture syndrome •RPGN

Interstitial nephritis

Lupus nephritis • • • • •Hematuria, proteinuria

Postinfection GN

Cardiovascular diseases

Endocarditis lenta

Pericarditis

Dressler syndrome

Endocrine diseases

IDDM (new diagnosis) •Hashimoto’s thyroiditis •Grave’s disease •Hypoparathyroidism

Hyperthyroidism

Hypothyroidism

Autoimmune PEP I/II

Addison’s disease • •Fertility problems

Habitual abortion

Skin diseases

Pemphigus •Pemphigoid •Alopecia

Vitiligo

Dermatitis herpetiformis •Neurological diseases

Myasthenia gravis •Periferal neuropathy

>90% •50-90% •30-50% •10-30% •<10%

Freq

uenc

y

Dia

gnos

tic M

arke

r

Lege

nd

AChR acetylcholine receptorAIHA autoimmune hemolytic anemiaAMA antimitochondrial antibodiesANA antinuclear antibodiesANCA antineutrophil cytoplasmic antibodiesAPCA gastric parietal cell antibodiesAPS antiphospholipid syndrome ASCA anti-Saccharomyces cerevisiae antibodyBMZ basal membrane zoneBPI bactericidal permeability-increasing proteinß-2 GP1 beta-2 glycoprotein ICAH chronic autoimmune hepatitisCCP cyclic citrullinated peptidesCREST calcinosis, Raynaud phenomenon, oesophagus

dismotility, sclerodactyly, teleargiectasiaC1q complement proteinDIL drug induced lupusDM dermatomyositisds-DNA double stranded DNAEMA endomysium antibodyENA extractable nuclear antibodyGBM glomerular basal membraneGN glomerulonephritisGS-ANA granulocyte-specific ANAHBsAg hepatitis B virus antigenHCV hepatitis C virusHTG human thyroglobulinHUVS hypocomplementemic urticarial vasculitis

syndromeIC intercellularICA islet cell antibodyIDDM insulin dependent diabetes mellitus ITP idiopathic thrombocytopenia

JCA juvenile chronic arthritisJo-1 PM/DM antigenLA lupus anticoagulantLE lupus erythematosusLKM liver-kidney microsomal antibodyMCTD mixed connective tissue diseaseMPO myeloperoxidasePBC primary biliary cirrhosisPCNA proliferating cell nuclearantigen PEP polyendocrinopathyPM polymyositisPR-3 proteinase 3PSC primary sclerotic cholangitisPSS progressive systemic sclerosisRA rheumatoid arthritisRF rheumatoid factorRNP ribonucleoproteinRPGN rapid progressive

glomerulonephritisScl sclerodermaScl-70 scleroderma antigen (70kD)SLA soluble liver antigenSLE systemic lupus erythematosusSm Smith antigenSMA smooth muscle antibodySS-A Sjögren’s syndrome A antigenSS-B Sjögren’s syndrome B antigenss-DNA single-stranded DNATBM tubular basal membraneTPO thyroidperoxidaseTSH thyroid stimulating hormonetTG tissue transglutaminaseUCTD undifferentiated connective

tissue disease

Dia

gn

osi

s

Autoantibody Map

Edited by: Julianna Németh MD and Katalin Miklós PhD, National Medical Centre, Department of Immundiagnostics, Budapest, Hungary

Guidelines for diagnostic evaluation of autoimmune diseases

© HYCOR Biomedical, Inc., 2010P/N A60051 Rev. 7/10

www.hycorbiomedical.com