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Australian Centre for NanoMedicine

Annual Report 2012

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Australian Centre for NanoMedicine: 2012 Annual Report

CONTENTS

Directors’ Report 3 ACN Mission Statement 6 ACN Vision and Goals 6 ACN’s Management, Advisory Panels, Staff and Researchers in 2012 8 Key ACN Activities 10 Total Projects Commenced in Year 11 Number of DEST “A” and Publications 12 Number of Industry/Government Partner Based Projects 16 Number of Media References/Mentions 17 Number of Australian Conferences Presented 19 Number of International Conferences Presented 21 Number of Community/Practice Presentations 25 Post Doc Years 28 Post Graduate Students 29 PhD Completions 29 NanoMed Conference in Australia 30 Stakeholder Seminar Series (Off Campus) 31 Other External Stakeholder Meetings (On Campus) 32 Clinical/Research Roundtable 33 Other Achievements 34 ACN Financial Report 37

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Australian Centre for NanoMedicine: 2012 Annual Report

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Nanotoxicology/nanosafety

DIRECTORS’ REPORT

In this 2012 Annual Report of the Australian Centre for Nanomedicine (ACN) reflects back over our first full year as an UNSW Research Centre, having been officially launched in July 2011. Through this report, we reflect our pride in the achievements we have enabled both in the lab and through outreach activities. Through these achievements, ACN is now positioned as a leader both in the Australian and international nanomedicine research community. ACNs drive comes from a knowledge that there is global unmet need to cure and prevent diseases for which we currently lack efficient treatments and which cause

suffering and a shortened life expectancy. There is an urgent need to make significant advances in these key areas, and particular for refractory malignancies with poor survival rates. We understand that a paradigm shift is required in terms of current approaches to cancer and other hard to treat disease diagnosis and how we tackle these clinically important problems. Current approaches to diagnosis and treatment routinely involve invasive and damaging techniques, including surgical biopsy for diagnosis, and chemotherapy and radiation for treatment, which causes toxicity to normal tissues and undesirable side effects, due to their lack of specificity. Nanomedicine (the medical application of nanotechnology) has the potential to revolutionise cancer and other disease therapies through the development of nanoelectronic biosensors for the detection and monitoring of the disease, through to biocompatible and biodegradable drug and gene delivery systems. Recent examples of clinically approved cancer nanomedicines include Abraxane (paclitaxel-protein-bound particle) and Doxil (liposomal formulation of doxorubicin), which are exhibiting substantially lower toxicity for patients. It is only possible to achieve nanomedical applications by utilising a cross/multi-disciplinary model incorporating research strengths in medicine, science and engineering. Nanomedicine collaborations require the skills including those of material science, pharmacology, toxicology, pharmaceutical technology, academia, biotech/pharmaceutical industry, health authorities and naturally there is an important role for government. These are the key stakeholder groups that ACN has identified and who we consult with and encourage participation through our annual International NanoMedicine Conference and visiting professor program. Our research and outreach program makes ACN part of a global research/commercialisation chain that has seen in the order of 40+ marketed products come into everyday use. And

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Australian Centre for NanoMedicine: 2012 Annual Report

CANCER rates are predicted to shoot up almost 40 per cent from 2007 levels by 2020.

32,000 extra cases a year in Australia

‘Survival time for all cancer types 40 years ago was just one year, now it is predicted to be nearly six years. This improvement is testament to improvements in surgery, diagnosis, radiotherapy and new drugs.’Claran Devane – Chief Executive of Macmillan Cancer Support

“The healthcare market is poised to see some of the earliest benefits of nanotechnology. Over the decade, it will be one of nanotech’s highest growth sectors. Targeted drug delivery therapies for the treatment of cancer is one of the most commonly cited healthcare benefits of nanotechnologies.” Cientifica Market Report 2012.

Cancer as an example of nanomedicine potential

Australian Centre for NanoMedicine

the benefits of nanomedicine are apparent with organisations including the UK based Macmillan Cancer Support showing “a dramatic increase in the median cancer survival times over the past 40 years. Coupling nanotechnology drug delivery (NDD) methods with improvements in diagnostic, we can expect that much more progress will be made in the next 10 years than in the previous 40”. Through the unique disease focus multi-disciplinary model adopted by ACN, it allows us to continue examining the body at the molecular level, with greater understanding of how the body functions unveiling new possibilities and hopes for patients as well as in terms of preventative medicine. NanoMedicine is already having success in Targeted Drug Delivery, Diagnosis and Imaging, and Regenerative Medicine. ACN continues our strong commitment to these research themes (admittedly to a lesser extent in the regenerative medicine field), with our work having a view to any nanosafety concerns. In 2012 ACNs commitment to hard to treat diseases has increased from our work in four disease areas (view Tables below), to include another two research areas (table to right), pancreatic cancer and blood cancers.

Our research is an outcome of pulling together a team of 40+ researchers who commit around 80 percent of time to disease driven research, while the final 20 percent is dedicated to enabling research. Already ACNs research in these six areas has extended current literature and offered new findings towards finding solutions. We have spread the message on our research findings at numerous domestic and international conferences, plus using the media as a tool to communicate to the broader community.

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Australian Centre for NanoMedicine: 2012 Annual Report

It has meant that behind the scenes, all members of Team ACN have been on a sharp learning curve, with one of the most important aspects to understand the language and research techniques of the other disciplines we interact with. ACNs research plan is on track, and just as important to us is the development of outreach programs to communicate our findings. As researchers our communication plan often means conferences and publications, but we also aim to communicate to wider audiences. In 2012 we hosted the 3rd International NanoMedicine Conference, through which presentations by researchers and clinicians allow “light-bulb” moments to occur. This has become the most significant annual nanomedicine conference in the southern hemisphere. Through ACNs Visiting Professor program we invite high profile nanomedicine experts from around the world to join our team and share their experience. In 2011, we hosted Professor Molly Stevens of Imperial College London who spent four weeks with ACN. 2012 we saw Professor Alan Trounson President of the California Institute for Regenerative Medicine join us. In 2013 Samuel Stupp, Professor of Materials Science, Chemistry, and Medicine; and Director Institute for BioNanotechnology in Medicine, Northwestern University USA; and in 2014 Professor Mark E Davis of the Californian Institute of Technology will be hosted by ACN in this important research/collaboration program. ACNs intention is to dominate the Australian research space in this emerging area, by running the prime Australian conference in this field and by capturing strategic partnerships in the Australian research and clinical environment. In our first two years of operation, we are confident we have taken significant steps in achieving this aim. ACN Directors PROFESSOR MARIA KAVALLARIS || PROFESSOR JUSTIN GOODING || PROFESSOR TOM DAVIS

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Australian Centre for NanoMedicine: 2012 Annual Report

ACN is about converging

nanotechnology and medicine for

the prevention, diagnosis and

curing of disease.

Summary of ACN Objective:

Converge nano research from

engineering and science into

medical research to seek novel

therapies

Create a new academic area of

research and education using a

disease focus

Encourage industry capacity

Translate research into solution

driven medicine

Create domestic and

international alliances to identify

research opportunities

Meet Federal Government Super

Science initiatives

Be an Australian first and a

model for future international

NanoMedicine Centres.

ACN MISSION STATEMENT

Mission Statement: The Australian Centre for NanoMedicine (ACN) combines medicine, science and engineering to deliver therapeutic solutions to research problems in medicine. The ACN will become the hub of all nanomedicine research in Australia.

ACN VISION AND GOALS

Vision and Goals Through a commitment to research, education, knowledge transfer and commercialisation, ACN will be dedicated to the prevention, diagnosis and curing of diseases. ACN will be the focus of nanomedicine research in Australia and will attract leading edge staff and students to UNSW. The goals of ACN go beyond research, also seeking to educate, transfer knowledge and commercialise, through:

Internal UNSW goals:

Establishing a world-class multidisciplinary nanomedicine centre

Bringing the existing research strength in nanomedicine at UNSW under a distinct banner

Providing a significant impetus in nanomedicine research and encourage the UNSW research community to work in this area and then using this as a springboard for ARC, NHMRC and international funding

Establish links with external UNSW stakeholders to conduct research and create opportunities for participation

Improving the quality of undergraduate and postgraduate education/supervision

Providing funding support to attract researchers with interests in nanomedicine to UNSW generating critical mass

Externally communicable goals: 1. Bringing together a multidisciplinary team of internationally

recognised polymer chemists, engineers and other technologists with clinical and medical practitioners to more clearly understand the requirements to deliver improvements in health

2. Showcasing and promoting nanomedicine through forums,

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Australian Centre for NanoMedicine: 2012 Annual Report

publications, conferences and news outlets and seek feedback on new projects 3. Working with Australian decision makers to deliver on national priorities for scientific excellence and

industrial competitiveness 4. Partnering with other academics and commercial ventures to contribute to advances in the field 5. Establishing an annual nanomedicine conference in Sydney as a main conference in the Asia-Pacific

region, and using this to leverage a strong network involving medical institutes and companies

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Australian Centre for NanoMedicine: 2012 Annual Report

ACN’s MANAGEMENT, ADVISORY PANELS, STAFF AND RESEARCHERS IN 2012

ACN has a Management Board with a structure based on the UNSW Centres model. The Board consists of the following people: Management Board Member Meeting

13/03/2012 Meeting

24/07/2012 Meeting

20/11/2012 Prof Graham Davies (Chairman), Dean of Engineering, UNSW

Prof Merlin Crossley, Dean of Science, UNSW

Prof Peter Smith, Dean of Medicine, UNSW*

Prof Tom Davis, School of Chemical Engineering, UNSW

Prof Maria Kavallaris, Head of Program, Tumour Biology and Targeting Program, Children's Cancer Institute Australia

Prof Justin Gooding, School of Chemistry, UNSW

Prof Ian Dawes, School of Biotechnology and Biomolecular Sciences, UNSW

Prof Peter Gunning, School of Medical Sciences, UNSW

Ms Carla Gerbo, Australian Centre for NanoMedicine, UNSW *Professor Peter Smith nominated Prof Peter Gunning as his representative

ACN does not have an Advisory Committee; however ACN has established three advisory panels that assist ACN in its positioning towards the Australian leader in this burgeoning field. Strategic Advisory Panel ACN’s Strategic Advisory Panel provides advice on strategic activities including future directions and opportunities, assisting with the clarification and attainment of our vision, creating strategies, implementing actions and measuring results. Strategic panel members include: Prof Chris Fells Prof Mark Wainwright.

Medical Advisory Panel ACN’s Medical Advisory Panel is made up of leading clinicians that provide independent medical advice on specific research projects being undertaken. Medical Advisory Panel members include: Prof Glenn Marshall (Paediatric Haematologist and Oncologist, Professor of Paediatrics and Director of the

Centre for Children’s Cancer and Blood Disorders, Sydney Children’s Hospital), Prof Jacob George (Professor of Gastroenterology and Hepatic Medicine and Head of Gastroenterology and

Hepatology at Westmead Hospital) A/Prof Craig Lewis (Director, Medical Oncology at The Prince of Wales Hospital).

Industry Advisory Panel ACN's Industry Advisory Panel will assist ACN to adopt leading research and provide advice on translating research to the benefit of health based organisations Dr Jason Harcup, Vice President of R&D and Head of Unilever’s Research Organisation (China) Dr Sridhar Iyengar, Chief Technical Officer and Founder, Agamatrix (USA)

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Australian Centre for NanoMedicine: 2012 Annual Report

Dr Peter French, Chief Executive Officer, Benitec (Australia) ACN Directors:

Prof Tom Davis

Prof Justin Gooding

Prof Maria Kavallaris Management: Carla Gerbo

Project Leaders: Dr Cyrille Boyer Prof Katharina Gaus Dr Joshua McCarroll Dr Michael Whittaker Research Fellows: Dr Helder Marcal Dr Sharon Sagnella Post Docs:

Dr Mariana Beija Dr Ales Benda Dr Hien Duong Dr Rafael Erlich Dr Bin Guan Dr Mathew Jones Dr Stuart Lowe

Dr Astrid Magenau Dr Dylan Owen Dr Jeremie Rossy Dr Stacy Slavin Dr Alex Soeriyadi Dr Thibault Tabarin Dr David Williamson

Postgraduate Students and Researchers:

Swahnnya de Almedia Shree Augustina Johan Sebastian Basuki Carola Benzing Quill Bowden Xin Chen Xiaoyu (Jet) Cheng Kyloon Chuah Rhea Cornely Lars Esser Zoe Fairjones Christopher Fife

Bakul Gupta Cheng (Johnson) Jiang Felicity Kao Alexandre Kross Daniel Li Jinna Liu Xun Lu

Siti Hawa Ngalim Stephen Parker Maryam Parvez Abigail Pollock John Rondolo

Sema Sevimli Ahmed Abu Siniyeh Roya Tavallaie Yui Yamamoto Zhengmin Yang Yong (Jerry) Lu Ying Zhu

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Australian Centre for NanoMedicine: 2012 Annual Report

KEY ACN ACTIVITIES

The table below provides a summary of ACNs performance for the year in relation to its identified non-financial targets devised at the time ACN was established. The two 2012 columns shows both forecast and actual outcomes.

Non-Financial Targets 2011 Forecast 2012

Actual 2012

Forecast 2013

Total Projects commenced in year 4 2 2 2

Number of DEST “A” Publications 10 15 18 20

Number of industry/Government partner based projects

2 2 4 2

Number of media references/mentions 5 10 50 10

Number of Australian conferences presented

3 4 12 5

Number of international conferences presented

3 4 31 5

Number of community/practice presentations

3 3 22 3

Post doc years 3 4 14 5

Post graduate students (actuals) – PhD and Researchers

2 4 31 6

PhD Completions (cumulative) 0 2

Associate Faculty Staff 2 3 4

NanoMed Conference in Australia 1 1 1 1

Stakeholder seminar series (off campus)

2 2 5 2

Other external stakeholder meetings (on campus)

2 2 6 2

Clinician/Research Roundtable 1 1 0 1

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Australian Centre for NanoMedicine: 2012 Annual Report

Non-Financial Targets 2011 Forecast 2012

Actual 2012

Forecast 2013

Total Projects commenced in year 4 2 2 2

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Australian Centre for NanoMedicine: 2012 Annual Report

Non-Financial Targets 2011 Forecast 2012

Actual 2012

Forecast 2013

Number of DEST “A” Publications 10 15 18 20

December 3, 2012 Publication: Australian Society for Biochemistry and Molecular Biology (Volume 43, No. 3, December 2012) Nanotechnology in Therapeutics

Technical Feature Page Guest Editor: Maria Kavallaris

Drug Delivery: A Nanomedicine Approach Sharon Sagnella and Calum Drummond

Nanoparticle Delivery of siRNA as a Novel Therapeutic for Human Disease Joshua McCarroll and Maria Kavallaris

A New Generation of Nanoparticles for Image Enhancement Cyrille Boyer and Thomas Davis

Introducing the Nanopatch: A Skin-based, Needle-free Vaccine Delivery System Simon Corrie, Alexandra Depelsenaire and Mark Kendall

Great Expectations Michelle Haber

November 16, 2012 Publication Chemical Communications (DOI: 10.1039/C2CC37181B ). Intracellular nitric oxide delivery from stable NO-polymeric nanoparticle carriers. Hien T T Duong,

a

Zulkamal M Kamarudin,a Rafael B Erlich,

ab Yang Li,

a Mathew W Jones,

a Maria Kavallaris,

ab

Cyrille Boyer*a

and Thomas P Davis*a

aAustralian Centre for NanoMedicine (ACN), School of Chemical Engineering, The University of

New South Wales, Sydney, NSW 2052, Australia bChildren’s Cancer Institute Australia, Lowy Cancer

Research Centre, The University of New South Wales, Sydney, NSW 2052, Australia.

November 10, 2012 Publication: Angiogenesis DOI 10.1007/s10456-012-9321-x. Concentration- and schedule-dependent effects of chemotherapy on the angiogenic potential and drug sensitivity of vascular endothelial cells. Eddy Pasquier

1, 2, Maria-Pia Tuset

1, Janine

Street1, Snega Sinnappan

1, 6, Karen L MacKenzie

1, Diane Braguer

3, Nicolas Andre

2, 3, 4 and

Maria Kavallaris1, 5

1Children’s Cancer Institute Australia for Medical Research, Lowy Cancer Research Centre, UNSW,

Australia; 2Metronomics Global Health Initiative, Marseille, France;

3Faculty of Pharmacy, INSERM

UMR 911, Centre de Recherche en Oncologie biologique et Oncopharmacologie, Aix-Marseille University, Marseille, France;

4Hematology and Pediatric Oncology Department, La Timone

University Hospital of Marseille, Marseille, France; 5Australian Centre for Nanomedicine,

University of New South Wales, Kensington, NSW, 2051, Australia; 6

October 19, 2012 Publication: Chemical Communications (DOI 10.1039/c2cc35954e). One-pot synthesis of colloidal silicon quantum dots and surface functionalization via thiol–ene click chemistry. Xiaoyu Cheng,

a Richard Gondosiswanto,

a Simone Ciampi,

a Peter J. Reece

b and

J. Justin Gooding*a

aSchool of Chemistry and Australian Centre for NanoMedicine, University of New South Wales,

Sydney, NSW 2052, Australia. bSchool of Physics, University of New South Wales, Sydney, Australia

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Australian Centre for NanoMedicine: 2012 Annual Report

October 18, 2012 Publication: Langmuir 2012, 28(44), pp 15444–15449 DOI: 10.1021/la303649u. Depth-Resolved Chemical Modification of Porous Silicon by Wavelength-Tuned Irradiation. Bin Guan †, Simone Ciampi †, Erwann Luais †, Michael James §, Peter J Reece ‡, and J Justin Gooding *† †School of Chemistry and the Australian Centre for Nanomedicine and

‡School of Physics,

University of New South Wales, Sydney 2052, Australia §Bragg Institute, Building 87, Australian

Nuclear Science and Technology Organisation (ANSTO), Australia

October 18, 2012 Publication: Molecular Pharmaceutics (DOI: 10.1021/mp300144). Functionalizing Biodegradable Dextran Scaffolds Using Living Radical Polymerization: New Versatile Nanoparticles for the Delivery of Therapeutic Molecules. Hien T. T. Duong

†, Felicity

Hughes†, Sharon Sagnella

†‡, Maria Kavallaris

†‡, Alexander Macmillan

§, Renee Whan

§,

James Hook?, Thomas P Davis

*†, and Cyrille Boyer

*†

†Australian Centre for NanoMedicine

‡Children’s Cancer Institute Australia, Lowy Cancer Research

Centre, §Biomedical Imaging Facility, Mark Wainwright Analytical Centre,

?Nuclear Magnetic

Resonance Facility, Mark Wainwright Analytical Centre, The University of New South Wales, Sydney, NSW 2052, Australia

September 28, 2012 Publication: Journal of Material Chemistry (Issue 2012 22 21382-21386). Polymer–gold nanohybrids with potential use in bimodal MRI/CT: enhancing the relaxometric properties of Gd(III) complexes. Mariana Beija,

a Yang Li,

a Hien T Duong,

a Sophie Laurent,

b

Luce Vander Elst,b Robert N Muller,

bc Andrew B Lowe,*d Thomas P Davis*

a and Cyrille

Boyer*a

aAustralian Centre for NanoMedicine (ACN), School of Chemical Engineering, The University of

New South Wales bNMR and Molecular Imaging Laboratory, Department of General, Organic and

Biomedical Chemistry, University of Mons, 7000 Mons, Belgium cCenter for Microscopy and

Molecular Imaging, Rue Adrienne Bolland 8, 6041 Charleroi, Belgium dCentre for Advanced

Macromolecular Design.

July 30, 2012 Publication: Polymer Chemistry (Issue 8 2012). Synthesis, self-assembly and stimuli responsive properties of cholesterol conjugated polymers . Sema Sevimli,

a Sharon

Sagnella,a Maria Kavallaris,

ac Volga Bulmus

b and Thomas P Davis*

a

aAustralian Centre for Nanomedicine (ACN), The University of New South Wales, Sydney, NSW

2052, Australia. bDepartment of Chemical Engineering, Izmir Institute of Technology, Gulbahce,

I_zmir, 35430, Turkey cChildren’s Cancer Institute Australia (CCIA), Lowy Cancer Research Centre,

The University of New South Wales, Sydney, NSW 2052, Australia

June 22, 2012 Publication: Angewandte Chemie DOI: 10.1002/anie.201202118. Using an Electrical Potential to Reversibly Switch Surfaces between Two States for Dynamically Controlling Cell Adhesion

†. Dr Cheuk Chi Albert Ng

1, Dr Astrid Magenau

2, Siti Hawa

Ngalim2, Dr Simone Ciampi

1, Dr Muthukumar Chockalingham

1, Dr Jason Brian Harper

1,

Prof Dr Katharina Gaus2, Prof Dr John Justin Gooding

1,*

1Dr A Ng, Dr S. Ciampi, Dr M. Chockalingham, Dr J Harper, Prof Dr J Gooding School of Chemistry

and Australian Centre for NanoMedicine, The University of New South Wales Sydney NSW 2052 (Australia)

2Dr A Magenau, S Ngalim, Prof Dr K Gaus Centre for Vascular Research and Australian

Centre for NanoMedicine, The University of New South Wales Sydney NSW 2052 (Australia)

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Australian Centre for NanoMedicine: 2012 Annual Report

June 2012 Book: Maria Kavallaris (Editor) Cytoskeleton and Human Disease, Humana Press. Cytoskeleton and Human Disease Book Summary reviews the key components, mechanisms and clinical implications of cytoskeletal defects in disease. Contributed by leading investigators in their respective fields, the chapters include topics associated with the basics of the cytoskeleton, actin-associated disease states, microtubule-associated disease states and intermediate filament-associated disease states. This authoritative volume is intended for a wide audience of clinicians, researchers and students with an interest in the application of biomedical research to the understanding and management of disease states associated with the cytoskeleton.

May 25, 2012 Publication: Angewandte Chemie: DOI: 10.1002/anie.201202350. The Biochemiresistor: An Ultrasensitive Biosensor for Small Organic Molecules

†. Dr Leo M H Lai

1, Dr Ian Y.

Goon2, Kyloon Chuah

1, Dr May Lim

2, Prof Dr Filip Braet

3, Prof Dr Rose Amal

2, Prof Dr J

Justin Gooding1,*

[*] Dr L M H Lai, K. Chuah, Prof Dr J J Gooding School of Chemistry and the Australian Centre for NanoMedicine University of New South Wales, Sydney, NSW 2052 (Australia) Dr I Y Goon, Dr M Lim, Prof Dr R Amal ARC Centre of Excellence for Functional Nanomaterials School of Chemical Engineering University of New South Wales, Sydney, NSW 2052 (Australia) Prof Dr F Braet Australian Centre for Microscopy & Microanalysis and School of Medical Sciences (Discipline of Anatomy and Histology) The Bosch Institute, University of Sydney Sydney, NSW 2006 (Australia)

May 15, 2012 Publication: Polymer Chemistry 2012 Advanced Articles DOI: 10.1039/C2PY20112G. Synthesis, self-assembly and stimuli responsive properties of cholesterol conjugated polymers. Sema Sevimli,

a Sharon Sagnella,

a Maria Kavallaris,

ac Volga Bulmus

b and

Thomas P Davis*a

Children’s Cancer Institute Australia (CCIA), Lowy Cancer Research Centre, The University of New South Wales, Sydney, NSW 2052, Australia, Australian Centre for Nanomedicine (ACN), The University of New South Wales, Sydney, NSW 2052, Department of Chemical Engineering, Izmir Institute of Technology, Gulbahce, I_zmir, 35430, Turkey

May 9, 2012 Publication: Macromolecules May 8 2012 (Vol 45 Issue 9). Macromolecular Ligands for Gadolinium MRI Contrast Agents. Yang Li†, Mariana Beija†, Sophie Laurent‡, Luce vander Elst‡, Robert N Muller‡, Hien T T Duong†, Andrew B Lowe*§, Thomas P Davis*†, and Cyrille Boyer*†§ † Australian Centre for Nanomedicine (ACN), School of Chemical Engineering, The University of

New South Wales, Sydney, NSW 2052, Australia, ‡ NMR and Molecular Imaging Laboratory,

Department of General, Organic and Biomedical Chemistry, University of Mons, 7000 Mons, Belgium,

§Centre for Advanced Macromolecular Design, School of Chemical Engineering, University

of New South Wales, Sydney NSW 2052, Australia

April 2012 Publication: Macromolecular Rapid Communications (Vol 33 Issue 8). Synthesis of Functional Core, Star Polymers via RAFT Polymerization for Drug Delivery Applications Jinna Liu, Hien Duong, Michael R Whittaker, Thomas P Davis

*, Cyrille Boyer

*

Australian Centre for NanoMedicine, School of Chemical Engineering, University of New South Wales, Sydney NSW 2052 Australia

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Australian Centre for NanoMedicine: 2012 Annual Report

February 2012 Publication: The Chemical Record (Vol 12 Issue 1, 2012). The Rise of Self-Assembled Monolayers for Fabricating Electrochemical Biosensors—An Interfacial Perspective.

1 J

Justin Gooding and Nadim Darwish 1 J Justin Gooding and Nadim Darwish, The School of Chemistry and the Australian Centre for

Nanomedicine. The University of New South Wales. Sydney, NSW 2052 (Australia)

February, 2012 Publication: ChemCom (DOI: 10.1039/c2cc30512g) February 2012. Ultrasensitive electrochemical detection of prostate-specific antigen (PSA) using gold-coated magnetic nanoparticles as ‘dispersible electrodes’. Kyloon Chuah,

a Leo M H Lai,

a Ian Y

Goon,b Stephen G Parker,

a Rose Amal

b and J Justin Gooding

aSchool of Chemistry and The Australian Centre for Nanomedicine, University of New South Wales,

Sydney, NSW 2052, Australia. E-mail: bARC Centre of Excellence for Functional Nanomaterials,

School of Chemical Engineering, University of New South Wales, Sydney, NSW 2052, Australia

February 2012 Publication: PLOSOne (February 2012, Volume 7, Issue 2, e30734). Evolution of Resistance to Aurora Kinase B Inhibitors in Leukaemia Cells. Timothy W Failes

1, Gorjana

Mitic1, Heba Abdel-Halim

2, Sela T Po'uha

1, Marjorie Liu

1, David E Hibbs

2, Maria

Kavallaris1,3*

1Children’s Cancer Institute Australia, Lowy Cancer Research Centre, University of New South

Wales, Randwick, Australia, 2Faculty of Pharmacy, University of Sydney, Sydney, Australia,

3Australian Centre for Nanomedicine, University of New South Wales, Sydney, Australia

January, 2012 Publication: Analyst (137, 2012). Development of an electrochemical immunosensor for the detection of HbA1c in serum.

†‡Guozhen Liu,

a Sook Mei Khor,

a Sridhar G Iyengarb

and J Justin Gooding*a

aSchool of Chemistry and The Australian Centre for NanoMedicine, University of New South Wales,

Sydney, NSW, 2052, Australia. bAgaMatrix, Inc., 10 Manor Parkway, Salem, NH, 03079, USA

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Australian Centre for NanoMedicine: 2012 Annual Report

Non-Financial Targets 2011 Forecast 2012

Actual 2012

Forecast 2013

Number of industry/Government partner based projects

2 2 4 2

ACN researchers Dr Michael Whittaker and Dr Cyrille Boyer are working with

ANSTO LifeSciences on the Design of New Smart Polymer structures for dual

PET imaging and drug delivery

ACN researchers Prof Tom Davis, Dr Cyrille Boyer and Dr Hien Duong are

working with Dr Jianhua Wang of the Westmead Millennium Institute on

project Liver Fibrosis.

ACN researchers Prof Maria Kavallaris and Dr Joshua McCarroll have received

funding support from Benitec Biopharma for project Lung Cancer. A

collaborative project is also under way on a NHMRC funded project grant with

Prof Tariq Rana, Sansom-Burham Institute (USA)

ACN Researchers Prof Justin Gooding, Prof Maria Kavallaris and Prof Tom Davis are working with Dr Julio Ribeiro of Inventia Genetic Technologies to examine The development of tuneable materials to allow the three-dimensional printing of cells.

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Australian Centre for NanoMedicine: 2012 Annual Report

Non-Financial Targets 2011 Forecast 2012

Actual 2012

Forecast 2013

Number of media references/mentions 5 10 50 10

11/2012 NanoMedicine hope for childhood cancer UNSW Newsroom

25/09/2012 Young researchers shine at Scopus awards UNSW Engineering Website

24/09/2012 Elsevier and Australasian Research Management Society Announce Winners of the 2012 Scopus Young Researcher of the Year Awards

KWWL.com

21/09/2012 Elsevier and Australasian Research Management Society Announce Winners of the 2012 Scopus Young Researcher of the Year Awards

Finance.yahoo.com

Spring 2012 Small is Big - the next frontier in medicine UNSW UNIKEN Magazine

July 2012 Happy First Birthday Australian Centre for NanoMedicine School of Chemical Engineering Web Page

20/06/2012 UNSW hosts International Nanomedicine Conference UNSW Website

29/06/2012 The next frontier in medicine UNSW Website

30/05/2012 New type of biosensor is fast, super-sensitive UNSW Website

12/06/2012 Dean Lectuer's series 2012 UNSW Medicine website

July 2012 The Silent Assassin DVC(R) publication - Connecting Research Business Industry Government

ACN International NanoMedicine Conference 2012 Media

5/07/2012 Australian Nanomedicine Conference Targets Radical Diseases Voice of America

5/07/2012 Alan Trounson discusses nanomedicine and progress toward stem cell therapies

CIRM

5/07/2012 Alan Trounson discusses nanomedicine and progress toward stem Nanotechnology.org

July 2012 Alan Trounson discusses nanomedicine and progress toward stem cell therapies

Cell News

6/07/2012 Alan Trounson discusses nanomedicine and progress toward stem cell therapies

FriendFeed

4/07/2012 Professor Alan Trounson On The Future Of Nanotechnology In Medicine

The Nanotechnology Times

4/07/2012 Professor Alan Trounson on the future of nanotechnology in medicine

Institute of Nanotechnology

July 2012 Event: 3rd ANNUAL NANOMEDICINE CONFERENCE InterNano

20/06/2012 Sydney to Host Third International Nanomedicine Conference Azone Nano

5/07/2012 Australian Nanomedicine Conference Targets Radical Diseases The Kaahimyang Project

July 2012 conference NanoWerk News

2/07/2012 Smart tattoo' may replace finger prick for diabetics Cosmos Magazine

4/07/2012 The future of medicine Cosmos Magazine

6/07/2012 Australian nanomedicine conference targets radical diseases Musloim Village

14/07/2012 Nanomedicine researchers converge in Sydney for annual conference

NSW Trade and Investment

Visiting Professor Media (Prof Alan Trounson - California Institute of Regenerative Medicine)

4/07/2012 Professor Alan Trounson on the future of nanotechnology in medicine

702 ABC Sydney

11/07/2012 Stem Cells: Professor Alan Trounson RadioNational - Life Matters

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Australian Centre for NanoMedicine: 2012 Annual Report

12/07/2012 Human trials for potential HIV stem cell cure Herald Sun

11/07/2012 Human trials for potential HIV stem cell cure News.com.au

12/07/2012 Stem cell cures bring challenges Nine News

12/06/2012 Stem Cell Line Created Without Destroying Embryo The Today Show (Channel 9)

12/06/2012 Trials for Stem-Cell HIV cure The Australian

15/06/2012 Hope stem cells a cure for brain damage through strokes Daily Telegraph

12/06/2012 Stem cell cures bring challenges Bigpond News

12/06/2012 Stell Cell Cures brings challenges Stem Cell Clinic

Other ACN Media

25/11/2012 Nanomedicine breakthrough for childhood cancer University World News

22/11/2012 5 Times More Efficient Against a Childhood Cancer NanoComputer

21/11/2012 Excellent Idea of the Day: Nano Cancer Killers DiscoveryNews

20/11/2012 Nitric oxide-delivering particles could improve neuroblastoma treatment fivefold

FierceDrugDelivery

20/11/2012 Nanomedicine Breakthrough Could Improve Chemotherapy for Childhood Cancer

ScienceDaily

20/11/2012 Nanomedicine breakthrough could improve chemotherapy for childhood cancer

EurekaAlert

21/09/2012 Scopus awards go to young researchers The Australian

21/09/2012 Elsevier and Australasian Research Management Society Announce Winners of the 2012 Scopus Young Researcher of the Year Awards

PRWire

1/06/2012 Speedy, sensitive biosensor created Science Alert

21/06/2012 Biochemiresistor developed in Australia is a super-sensitive sensor Electronics News

4/06/2012 Gold Nanoparticles Detect Traces Of Contaminants In Milk Asian Scientists

1/06/2012 Speedy, sensitive biosensor created The Science Bulletin

HG Smith Memorial Award RACI News

4/06/2012 Biosensor detects nano-contaminates ABC Science

21/01/2012 Nano Particles Detected to Treat Eye Disease Radio National - The Science Show

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Non-Financial Targets 2011 Forecast 2012

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Number of Australian conferences presented

3 4 12 5

November 16 2012

Dr Joshua McCarroll presented at UNSWs Medicinal Chemistry/Drug Discovery Symposium. Title: TBA

November 26-27 2012

Prof Tom Davis presented at Drug Delivery Australia 2012 (Melbourne Australia). Title: TBA

November 30, 2012

Prof Justin Gooding in his role of RSC Australasian Lecturer 2012 presents to the RSC members at Australian National University (Canberra Australia). Title: Nanotechnology and Biosensors: From Detecting Small Molecules and Drugs to Monitoring of the Activity of Whole Cells.

November 14 2012

Prof Justin Gooding in his role of RSC Australasian Lecturer 2012 presents to the RSC members at University of Tasmania (Hobart Australia). Title: Nanotechnology and Biosensors: From Detecting Small Molecules and Drugs to Monitoring of the Activity of Whole Cells.

October 1 2012

Prof Justin Gooding in his role of RSC Australasian Lecturer 2012 presents to the RSC members at Monash University (Melbourne Australia). Title: Nanotechnology and Biosensors: From Detecting Small Molecules and Drugs to Monitoring of the Activity of Whole Cells.

April 18 2012 Professor Justin Gooding presents the Stokes medal presentation and lecture at the 10th International Society of Electrodchemistry (ISE) Spring Meeting, April 16-19, 2012, Perth. Title: Dispersible Electrodes: Gold Coated Magnetic Nanoparticles for Electrochemical Sensing

April 18 2012 ACN PhD student Stephen Parker was a poster prize winner at the International Society of Electrochemistry 10th Spring Meeting in Perth (15- 18 April). Stephen was the winner of the Division 1 Analytical Electrochemistry, Poster prize for a poster entitled Towards Capture and Release of Rare Circulating Tumour Cells (CTCs) Using Electrochemically-Switchable Surfaces.

February 2012 Dr Hien Duong presented an oral presentation at the 33rd Australian Polymer Symposium February 12-15, Hobart Australia. Title: Micelles: NO delivery.

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February 2012 Mr Johan Sebastian Basuki presented an oral presentation at the 33rd Australian Polymer Symposium February 12-15, Hobart Australia. Title: Versatile Multi-functionalization of Magnetic Nanoparticles for Biomedical Applications.

February 2012 Mr Yang (Daniel) Li presented an oral presentation at the 33rd Australian Polymer Symposium February 12-15, Hobart Australia. Title: Multifunctional Star and Hyperbranched polymer for cancer targeted drug delivery and MR imaging.

February 2012 Ms Felicity Hughes presented an oral presentation at the, 33rd Australian Polymer Symposium February 12-15, Hobart Australia Title: New Synthesis of Biodegradable Nanoparticles based on Dextran.

February 2012 Mr Xiaoyu (Jet) Cheng presented a Poster presentation at the 10th Asia-Pacific Microscopy Conference (APMC 10), the 2012 International Conference on Nanoscience and Nanotechnology (ICONN 2012) and the 22nd Australian Conference on Microscopy and Microanalysis (ACMM 22) Perth Australia February 5-9 2012. Title: One-pot synthesis of silicon nanocrystalspassivated with alkanes or alkenes and further functionalization via click chemistry.

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Non-Financial Targets 2011 Forecast 2012

Actual 2012

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Number of international conferences presented

3 4 31 5

November 12-16 2012

Dr Cyrille Boyer presented an Invited address at Zing Conference Polymer Chemistry Conference 2012 Polymers: From Biomedical Applications to Energy (Xcaret Mexico). Title: Engineering Polymeric NanoParticles for Drug Delivery and Energy

November 12-16 2012 Dr Mathew Jones presented an Oral address at Zing Conference Polymer Chemistry Conference 2012 - Polymers: From Biomedical Applications to Energy (Xcaret Mexico). Title: Macromolecular Trivalent Arsenicals for Vicinal Disulfide Bridging.

October 31 - November 3, 2012 Prof Maria Kavallaris presented the plenary address at the Zing Conference Nanotechnology for Medicine and Dentistry in Xcaret Mexico. Title Targeting cytoskeletal proteins involved in drug resistance, tumour formation and metastasis in cancer: Potential of nanoparticle delivery of RNAi

October 8-9 2012

Prof Justin Gooding presented at the International Workshop on the Risk Assessment of Manufactured Nanomaterials (Adelaide Australia). Title: New Sensing Technologies with Potential for Nanotoxicology?

September 24 2012 Prof Justin Gooding in his role of RSC Australasian Lecturer 2012 presented to the RSC Auckland Branch (New Zealand). Title: Biosensors: The Pathway to Portable Analytical Devices Environmental Analysis

September 21 2012 Prof Justin Gooding in his role of RSC Australasian Lecturer 2012 presented to the RSC Waikato Branch (New Zealand). Title: Nanotechnology and Biosensors: From Detecting Small Molecules and Drugs to Monitoring of the Activity of Whole Cells.

September 19-21 2012 Mr Yang (Daniel) Li presented at the 3rd Asia-Pacific Symposium on Nanobionics (Wollongong Australia). Title: Macromolecular Ligands for Gadolinium MRI Contrast Agents: Effect of Polymer Architecture.

September 19-21 2012 Mr Kyloon Chuah presented at 3rd Asia-Pacific Symposium on Nanobionics (Wollongong Australia). Title: Solid-state Nanopore for Single Protein Molecule Detection.

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September 19-21 2012 Dr Mariana Beija presented at 3rd Asia-Pacific Symposium on Nanobionics (Wollongong Australia). Title: Gd(III)-decorated polymer/gold nanohybrids for dual MRI/CT.

September 19-21 2012 Prof Tom Davis presented at the 3rd Asia-Pacific Symposium on Nanobionics (Wollongong Australia). Title: TBA

September 19 2012 Prof Justin Goodingin his role of RSC Australasian Lecturer 2012 presented to the RSC Manawatu Branch (New Zealand). Title: Nanotechnology and Biosensors: From Detecting Small Molecules and Drugs to Monitoring of the Activity of Whole Cells.

September 18 2012 Prof Justin Gooding in his role of RSC Australasian Lecturer 2012 presented to the RSC Wellington Branch (New Zealand). Title: Nanotechnology and Biosensors: From Detecting Small Molecules and Drugs to Monitoring of the Activity of Whole Cells.

September 14 2012 Prof Justin Gooding in his role of RSC Australasian Lecturer 2012 presented to the RSC Otago Branch (New Zealand). Title: Nanotechnology and Biosensors: From Detecting Small Molecules and Drugs to Monitoring of the Activity of Whole Cells.

August 23 2012 Dr Hien Duong presented at the 244th American Chemical Society National Meeting and Exposition - Materials for Health and Medicine (Philadelphia USA). Title: Biodegradable and acid labile dextran-based nanoparticles for doxorubicin delivery.

August 22 2012 Dr Cyrille Boyer presented at the 244th American Chemical Society National Meeting and Exposition - Materials for Health and Medicine (Philadelphia USA). Title: Synthesis of protein decorated, functional core, star polymers via RAFT polymerization for doxorubicin delivery and active targeting.

August 14 2012 ACN PhD candidate Bakul Gupta presented at the SPIE NanoScience and Engineering Conference (August 12-16 San Diego USA). Title: Porous silicon photonic crystals for detection of infections.

July 26 2012 Prof Tom Davis presented an Invited address at NanoBio Seattle. Title: Functionalization of Well-Defined Star Polymers Built from Biodegradable Microgel/Nanogel Cores via Click Chemistry for Drug Delivery and Imaging.

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July 18 2012 Dr Joshua McCarroll presented an Invited ECR Plenary address at the 1st International Conference on BioNano Innovation, Brisbane Australia. Title The Potential of RNA-Interfering Nanoparticles as a Novel Therapeutic for the Treatment of Non-Small Cell Lung Cancer

July 18 2012 Dr Cyrille Boyer presented an Invited ECR Plenary address at the 1st International Conference on BioNano Innovation, Brisbane Australia. Title: Engineering Polymeric NanoParticles for NanoMedicine and Hydrogen Storage

July 18 2012 ACN PhD candidate Yang (Daniel) Li presented an Oral address at the 1st International Conference on BioNano Innovation, Brisbane Australia. Title: Macromolecular Ligands for Gadolinium MRI Contrast Agents: Effect of Polymer Architecture

July 9-11 2012 Dr Mariana Beija presented a Poster at Warwick 2012 Polymers UK conference. Title: Gd(III)-decorated nanoparticles for MRI.

July 11 2012 Dr Cyrille Boyer presented at Warwick 2012 Polymers UK conference. Title: Design of Biodegradable Polymeric Nanoparticles for Delivery of Nitric Oxide. A New Hope for Multi-Drug Resistance in Cancer Treatment.

July 10 2012 Johan Sebastian Basuki presented at Warwick 2012 Polymers UK conference. Title: Versatile Multi-functionalization of Magnetic Nanoparticles for Biomedical Applications

July 9 2012 Professor Tom Davis presented at Warwick 2012 Polymers UK conference. Title: New Synthesis of Biodegradable Nanoparticles based on Dextran.

June 1-5 2012 Dr Sharon Sagnella presented at the 9th World Biomaterials Congress Chengdu, China. Title: Multifunctional Nanocarriers for Targeted Treatment of Neuroblastoma.

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May 28 2012 Professor Tom Davis presented at the 9th International Symposium on Polymer Therapeutics: From Laboratory to Clinical Practice (May 28-30) Valencia Spain. Title: Synthesis and Functionalization of pH-responsive Dextran-g-P(OEG-A) Nanoparticles via RAFT polymerization for Drug and Gene Delivery

April 11 2012 Professor Justin Gooding presents opening plenary address at the 27th Philippine Chemistry Congress 2012 Asia Pacific Conference on Analytical Science 3rd Regional Electrochemistry Meeting of South-East Asia (11-13 April). Title: Nanotechnology and Biosensors: From Detecting Small Molecules and Drugs to the Monitoring of the Activity of Whole Cells.

April 2 2012 Dr Joshua McCarroll presents at the 2012 Annual Meeting of the American Association for Cancer Research (Chicago). Title: Silencing BIII-tubulin by RNA interfering nanoparticles in non-small cell lung cancer.

March 26 2012 Prof Maria Kavallaris presents at the Albert Einstein College of Medicine (NY-USA) in the Department of Molecular Pharmacology Seminar program. Title:on Microtubule proteins in cancer: drug resistance, tumor growth and metastasis

March 6 2012 Congratulations to ACNs PhD student Bakul Gupta who attended the 4th Hope Meeting in Tsukuba Japan. Bakul, who works with Professor Justin Gooding on ACNs Uveitis project, is one of five Australia's selected to attend the meeting which features seven Nobel Laureates in chemistry and physics and over 100 PhD students from the Asia-Pacific region

Dr Cyrille Boyer wins Best Poster at American Chemistry Society Conference. Ttitle: Preparation of hollow polymer nano-capsules exploring gold nanoparticles as sacrificial templates in the Controlled Radical Polymerization.

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Non-Financial Targets 2011 Forecast 2012

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Number of community/practice presentations

3 3 22 3

December 13 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute – Dr Stuart Lowe. Title: Orthogonal Coupling of Quantum Dot-Peptide Conjugates for the Multiplexed Evaluation of Enzyme Activity.

December 13 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute – Dr Rafael Erlich. Title: Mouse models for preclinical testing of nanomedicines in cancer research

December 13 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute – Dr Mathew Jones. Title: Vicinal disulfide bridging polymers

December 13 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute – Dr Sharon Sagnella. Title: Doxorubicin Loaded Nanocarriers for Treatment of Neuroblastoma

December 13 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute – Dr Bin Guan. Title: Fabrication of mesoporous silicon photonic crystal particles: towards single cell sensing

December 13 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute – Mr Stephen Parker. Title: Capture and Releasing Circulating Tumour Cells (CTCs) Using Electrochemically-Switchable Surfaces

December 13 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute – Dr Mariana Beija. Title: Polymer/Gold Nanohybrids with Enhanced Contrast Properties for X-ray Computed Tomography and Magnetic Resonance Imaging

November 19 2012

ACN Post Doc Dr Stuart Lowe presented at the November Team ACN meeting. Title: Orthogonal Coupling of Quantum Dot-Peptide Conjugates for the Multiplexed Evaluation of Enzyme Activity

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October 15 2012 ACN PhD Student Yang (Daniel) Li presented at the October ACN Team Meeting. Title: Macromolecular Ligands for Gadolinium MRI Contrast Agents: Effect of Polymer Architecture

September 17 2012

ACN Post Doc Dr Mariana Beija presented at theSeptember ACN Team Meeting. Title: Gd(III)-decorated polymer/gold nanohybrids for dual MRI/CT .

July 16 2012 ACN PhD Candidate Mr Kyloon Chuah presented at the July ACN team meeting. Title: Towards single molecule detection using nanoparticle-based nanopore biosensor.

June 18 2012 ACN PhD Candidate Mr Stephen Parker presented at the June ACN team meeting: Title: Towards Capture and Release of Circulating Tumour Cells (CTCs) Using Electrochemically-Switchable Surfaces

May 14 2012: Team ACN Presentation: Dr Rafael Erlich. Title: An orthotopic lung cancer model for preclinical testing of nanomedicines.

April 16, 2012 ACN PhD candidate Ying Zhu presented at the April 16th ACN Team meeting. Title: Porous Silicon Mircoarrays for Monitoring Single Cells Activity. View Ying's profile and abstract

March 19, 2012 ACN PhD student (Sam) Sema Sevimli presented at the March ACN team meeting. Title: Cholesterol Conjugated Polymers as Therapeutic Delivery Vehicles: Correlation between Physicochemical and Biological Properties

March 6, 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute - Mr Kyloon Chuah. Title: Gold-coated Magnetic Nanoparticles as Nanoelectrodes.

March 6, 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute - Dr Cyrille Boyer. Title: Design of star polymers for drug delivery and imaging.

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March 6, 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute - Mr Jet Xiaoyu Cheng. Title: Silicon quantum dots: fabrication, surface modifications and biolabeling.

March 6, 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute Dr Hien Duong. Title: Dextran-based biodegradable nanoparticles for Doxorubicin delivery.

March 6, 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute Dr Peter Roth. Title: Thermoresponsive Biocompatible PEG Based (Co) Polymers.

March 6, 2012 Joint meeting with the University of Wollongong Intelligent Polymer Research Institute Mr Christopher Fife. Title: Targeted delivery of stathmin siRNA in neuroblastoma.

February 16, 2012 ACN PhD student Xiaoyu (JET) Cheng presented at the February ACN team meeting. Title: 'Silicon quantum dots: fabrication, surface modifications and biolabeling'.

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Post doc years 3 4 14 5 Post Docs:

Dr Mariana Beija Dr Ales Benda Dr Hien Duong Dr Rafael Erlich Dr Bin Guan Dr Mathew Jones Dr Stuart Lowe

Dr Astrid Magenau Dr Dylan Owen Dr Jeremie Rossy Dr Stacy Slavin Dr Alex Soeriyadi Dr Thibault Tabarin Dr David Williamson

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Non-Financial Targets 2011 Forecast 2012

Actual 2012

Forecast 2013

Post graduate students (actuals) – PhD and Researchers

2 4 31 6

Postgraduate Students and Researchers:

Swahnnya de Almedia Shree Augustina Johan Sebastian Basuki Carola Benzing Quill Bowden Xin Chen Xiaoyu (Jet) Cheng Kyloon Chuah Rhea Cornely Lars Esser Zoe Fairjones Christopher Fife

Bakul Gupta Cheng (Johnson) Jiang Felicity Kao Alexandre Kross Daniel Li Jinna Liu Xun Lu

Siti Hawa Ngalim Stephen Parker Maryam Parvez Abigail Pollock John Rondolo

Sema Sevimli Ahmed Abu Siniyeh Roya Tavallaie Yui Yamamoto Zhengmin Yang Yong (Jerry) Lu Ying Zhu

Non-Financial Targets 2011 Forecast 2012

Actual 2012

Forecast 2013

PhD Completions (cumulative) 0 2 NIL

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NanoMed Conference in Australia 1 1 1 1 ACNs unique structure continues with a program of stakeholder engagement that includes the most significant annual International NanoMedicine conference in the southern hemisphere. Over three days at Coogee Beach, this conference attracts world leaders in the key areas of targeted delivery, sensing, diagnostics, regenerative medicine, imaging and translation of research to practice. Attracting over 200 attendees, this conference provides an opportunity to hear and network with, the very best nanomedicine researchers including medical clinicians and industry representatives. Through this event internationally recognised names including Professor Samuel Stupp (Northwestern University USA); Professor Patrick Stayton (University of Washington USA); Professor Tariq M Rana (Sanford-Burnham USA); Professor Frank Caruso (The University of Melbourne); Professor Gordon Wallace, (University of

Wollongong); Professor Ian Frazer (Translational Research Institute); Professor Calum Drummond, (CSIROs Manufacturing, Materials and Minerals); and Professor Mark Kendall, (Australian Institute for Bioengineering and Nanotechnology) have been highlighted. At the 2012 Conference, plenary speakers included Professor Alan Trounson (Californian Institute of Regenerative Medicine); Professor John Pickup (Kings College London) and Professor Tanja Weil (Ulm University Germany) will join the illustrious

names ACN has attracted to this conference.

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Stakeholder seminar series (off campus)

2 2 5 2

July 9, 2012 ACN in conjunction with Davies Collison Cave hosted an event in Melbourne with guest Professor Alan Trounson, President of the California Institute of Regenerative Medicine (USA). Title: Stem Cells in Biomedicine: Opportunities in Human Therapeutics

May 1, 2012 Professor Tom Davis presented at the University of Sydney hosted Molecular Imaging Symposium Program on Polymeric nanocarriers for diagnostic and delivery applications

May 8, 2012 ACN Director Professor Justin Gooding was the recipient of the 2012 R.SH Stokes medal. This medal is awarded by the Royal Australian Chemical Institute for contributions to electrochemistry carried out mainly in Australasia. In acceptance of the Medal, Justin presented the Stokes lecture at the 10th International Society of Electrodchemistry (ISE) Spring Meeting, April 16-19, 2012, Perth. Title: Dispersible Electrodes: Gold Coated Magnetic Nanoparticles for Electrochemical Sensing

April 18, 2012 Professor Tom Davis presented at the Monash Institute of Pharmaceutical Sciences. Title: The design of polymeric nanoparticles for medical applications on April 18th.

March 22, 2012 ACN Director Prof Maria Kavallaris keynote speaker at the March 22

nd Financial Services

Council Life Insurance Conference. Title The amazing science of Nanomedicine, and the implications for Life Insurance.

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Other external stakeholder meetings (on campus)

2 2 6 2

ACN UNSW Seminar Series with speakers including

• Prof Dave Haddleton, Warwick Uni UK. Title: Bioconjugates and Glycopolymers from Living Radical Polymerisation

• Prof Junpo He, Fudan Uni China. Title: What determines the stability of the RAFT agents? A systematic study on structure-property relationship

• Prof Alan Trounson, President California Institute of Regenerative Medicine USA. Title: Cancer Stem Cells – Attacking the Devil at its Source

• Dr Alexander Zelikin, Aarhus University Denmark. Title: Medicinal polymer chemistry: form polymer design to therapeutic benefit and back

• Dr Annette Kraegeloh, NanoCell Interactions, Leibniz Instiutte for New Materials Germany. Title: Nanoparticles in interaction with cells: insights by microscopic, chemical and biological analyses.

• Prof Ulrich Wiesner, Materials Science and Engineering, Cornell University USA. Title: C dots: Fluorescent silica nanoparticle probes for bioimaging and nanomedicine.

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Non-Financial Targets 2011 Forecast 2012

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Clinician/Research Roundtable 1 1 0 1 NIL

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Other achievements

Congratulations to ACNs A/Prof Shelli McAlpine on her success in funding through the National Health and Medical Research Council (NHMRC). Shelli, in conjunction with the UKs Prof Paul Workman (Deputy Chief Executive of The Institute of Cancer Research (ICR) and Director of the ICR’s Cancer Research UK Cancer Therapeutics Unit) attained $443K to examine Developing novel molecules that target hormone receptors as an alternative cancer therapy

Congratulations to ACNs Dr Sharon Sagnella a recipient of a Balnaves Foundation Young Researcher’s Fund Grant. The Balnaves Foundation Grant Fund was established to support the development of original and innovative ideas in the area of childhood cancer research. The aim is to build track records for young up-and-coming researchers so they can attain peer review funding from national sources such as the National Health & Medical Research Council (NHMRC). Each year young researchers can apply for competitively awarded grants of $100,000. Through this grant Sharon will work on “Neuroblastoma targeted nanocarriers for tumour specific

delivery of therapeutics”.

Congratulations to ACN Team Members Dr Palli Thordarson and Dr Cyrille Boyer both recipients of ARC Future Fellowships 2012. Palli Thordarson's project is titled: Moving supramolecular assembly of functional systems into water. Smart materials that are pre-programmed to assemble in water have already been shown to have wide applicability from industry to medicine. This project will develop novel display and drug release materials and lead to novel means to control these programmable building blocks thus promoting Australia’s standing in the area of smart materials. Cyrille Boyer's project it titled: Multimodal polymeric nanocarriers designed for the controlled and site specific delivery of nitric oxide. Nitric oxide (NO) plays a key role in the development of different diseases. The chronic deficiency of NO results in severe problems such as cardiovascular diseases, liver fibrosis, diabetes, cancer, Alzheimer’s diseases, etc. This project will describe a new method to deliver specifically nitric oxide using macromolecules.

Dr Cyrille Boyer won the Scopus Young Research Award in the category of Engineering and Technology.

ACN welcomed the following new Team members:

o Dr Stuart Lowe. Stuart joins ACN after completing his PhD in Bioresponsive Nanoparticles at Imperial College London under supervisor Professor Molly Stevens. At ACN Stuart will be working with Prof Justin Gooding working in: Enzyme-responsive systems; Optical properties of nano- and microparticles for imaging and sensing; and Engineering cell-material interfaces.

o A/Prof Shilli McAlpline. Sheli recently moved her research lab from San Diego State University (SDSU) to the University of New South Wales (UNSW). Her team currently consists of 9 people at UNSW (1 honours student, 7 post-grads, and a post-doc). We have just completed our transition from SDSU to UNSW, and now all of our projects are located at UNSW. Shelli has developed a

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fully-fledged research program in organic synthesis, and have initiated biological assays on the compounds we synthesize. She currently has 4 organic synthesis projects and 3 biology projects. Thus, she is looking for both synthetic chemists and biology students to do research in her group. The synthesis ranges from making peptidomimetics using click chemistry to utilising the Hantsch reaction and oxazole forming reactions for the synthesis of complex natural products. Once synthesized, group members run compounds in biological assays ranging from basic cytotoxicity assays using up to cancer cell lines (including colon, pancreatic, breast, and prostate), to mechanistic assays involving apoptosis, pull-down, RNAi, and protein binding assays.

o Dr Palli Thordarson. Palli, who is in UNSW's School of Chemistry, has research interest's in the area of bio-mimetic chemistry and its application in nanotechnology/nanobiotechnology. Palli looks to nature for inspiration when it comes to solving the problems in nanotechnology (eg biosensors or tissue engineering). This is the philosophy of bio-mimetic chemistry, which underpins his work. By applying a combination of organic synthesis, bioconjugate chemistry (chemical modification of biological molecules), cellular biology (for activity assays) and supramolecular chemistry to make our target systems and we use various spectroscopic techniques such as UV, fluorescence and NMR as well as microscopy techniques such as AFM, STM and TEM, to analyse these systems.

o Dr Mathew Jones. Mathew was born in Carmarthen Wales and started his Master’s Degree at the University of Warwick (UK) in 2002, graduating in 2006 with 1st Class Honours with a Maters in Chemistry with Profession Experience. During his undergraduate degree, Mathew spent six months working at Warwick Effect Polymers Ltd developing and optimising strategies for the synthesis of functional polymers by atom transfer radical polymerisation. Mathew undertook his PhD under the supervision of Professor David Haddleton (Warwick) examining Novel Strategies in the Synthesis of Polymer-Protein Conjugates. At ACN Mathew will be working with Prof Tom Davis and Prof Phil Hogg from UNSWs Faculty of Medicine.

o Dr Stacy Slavin. Born in Scotland, Stacy attained a MSci Chemistry from the University of Strathclyde, Glasgow (UK) in 2007 which included a year's industrial placement at Dupont Teijn Films, Wilton (UK). Stacy undertook her PhD at the University of Warwick (UK), under the supervision of Professor David Haddleton. The ChemDoc project investigated the functionalisation of biological surfaces (such as hair) with polymeric species synthesised via living radical polymerisation techniques. At ACN Stacey will be working with Prof Tom Davis and Prof Phil Hogg from UNSWs Faculty of Medicine.

o Dr Alex Soeriyadi. Alex undertook his PhD with Professor Tom Davis and Dr Michael Whittaker in the Centre for Advanced Macromolecular Design at UNSW. Alex's project examined Establishing in-depth understanding of molecular degradation process in acrylic based polymer coil-coating for domestic roofing applications.

Small is Big - the next frontier in medicine. UNSW UNIKEN magazine showcases ACN and NanoMedicine through an article by Stephen Pincock showcasing how nanotechnology has the power to change the way science solves our biggest health problems.

In a relationship between the University of New South Wales (UNSW) and the Australian Nuclear Science and Technology Organisation (ANSTO), Ivan

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Greguric has been appointed as a Conjoint Professor of ACN. Ivan's responsibilities lie primarily in coordinating chemistry research activities in RRI. He is a project leader for the CRC biomedical imaging focusing on the development of 18F labelled radiotracers. Ivan's core expertise lies in radiolabelling small molecules, peptides, proteins and antibodies with radioactive PET and SPECT isotopes.

Congratulations to ACN Project Leader's Dr Joshua McCarroll and Dr Cyrille Boyer who were recently promoted. Both Joshua and Cyrille have been appointed as senior lecturers.

ACNs 2012 Visiting Professor, Professor Alan Trounson spoke at UNSW Dean's Lecturer Series 2012 (Medicine). The theme of the event is Stem Cells in Medicine - Opportunities and Challenges. Hosted by George Negus, Alan Trounson is joined by Dr Bernadette Tobin, Director of the Plunkett Centre for Ethics at St Vincen't Hospital. At this event, the 945 seat UNSW Clancy Auditorium was at capacity, and the event was simulcasted by ABC radio.

Polymer Science – The Next Generation, A special issue in Macromolecular Rapid Communications, guest-edited by Jean-Francois Lutz (Strasbourg, France), Shiyong Liu (Hefei, China) and Brent Sumerlin (Dallas, USA) is highlighting the outstanding research of 21 young polymer scientists from around the world. And who is included in this list of outstanding researchers, none other than ACN's Dr Cyrile Boyer. Congratulations Cyrille.

Tom Davis appointed to NHMRCs Career Development Fellowship (CDF) Industry Panel.

Dr Jason Harcup, Vice President of R&D and Head of Unilever’s Research Organisation China, joined the ACN Industry Advisory Panel. ACN has established three advisory panels: Strategic Advisory Panel, Medical Advisory Panel and Industry Advisory Panel to provide a range of advice and strategic direction. The role of the Industry Advisory Panel will assist ACN to adopt leading research and provide advice on translating research to the benefit of health based organisations.

ACNs Professor Justin Gooding was awarded the 2012 Royal Society of Chemistry Australasian Lectureship. The award is given in recognition of the exceptional research of the recipient and will see Justin visiting up to 32 universities in Australia and New Zealand to present his group’s work. Justin is the Society's 52nd recipient of the Award.

RACI H.G. Smith Memorial Medal 2011 - Congratulations to Scientia Professor Justin Gooding for being awarded the Royal Australian Chemistry Institute' (RACI) H.G. Smith Memorial Medal for making the most significant contribution to an area of chemistry in Australia over the last ten years.

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ACN Financial Report