augmentation of alveolar bone and dental implant osseointegration: clinical implications of studies...

Augmentation of Alveolar Bone and Dental Implant Osseointegration: Clinical Implications of Studies with

rhBMP-2

by Ulf M.E. Wikesjö, Rachel G. Sorensen, and John M. Wozney

J Bone Joint Surg AmVolume 83(1 suppl 2):S136-S145

April 1, 2001

©2001 by The Journal of Bone and Joint Surgery, Inc.

Figure 1 For the critical-size supraalveolar periodontal defect model (a), the crowns of the third and fourth mandibular premolar teeth in the dog have been reduced in height to just above the

crown margin.

Ulf M.E. Wikesjö et al. J Bone Joint Surg Am 2001;83:S136-S145


Figure 2 Representative photomicrographs at 8 weeks after surgery from the critical-size supraalveolar periodontal defect model implanted with recombinant human bone morphogenetic

protein-2 (rhBMP-2) in (a) bovine bone mineral matrix (Bio-Oss; Osteohealth);...



Figure 3 Photomicrographs at 16 weeks after surgery from the critical-size supraalveolar peri-implant defect model implanted with (a) recombinant human bone morphogenetic protein-2

(rhBMP-2/ACS); (b) ACS alone; (c) allogeneic, freeze-dried, decalcified bone...



Figure 4 Intrasurgery view of a recombinant human bone morphogenetic protein-2 (rhBMP)-2/decalcified bone matrix (DBM) onlay in the edentulous posterior mandible (a).



Figure 5 Computerized tomography (CT) scan before surgery of the maxillary sinuses in a cynomolgus monkey (a).



Figure 6 Clinical view following surgical exposure and debridement of peri-implant defects (a).



Figure 7 Prosthetically reconstructed dental implants placed into recombinant human bone morphogenetic protein-2 (rhBMP-2)/ACS-induced and into native resident bone in the dog (a).



augmentation of alveolar bone and dental implant osseointegration: clinical implications of studies...

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