ATRIAL FIBRILLATIONMECHANISMS AND NEW DIRECTIONS IN THERAPY

January 24 – 26, 2019Seaport World Trade Center | Boston, MA

A CME Symposium Jointly provided by Postgraduate Institute for Medicine

and Advanced Medical Education

24th Annual International AF SymposiumTM

FINAL SCIENTIFIC PROGRAM AND FACULTY

Register online at: afsymposium.com

COURSE DIRECTORS

Jeremy Ruskin, MD Moussa Mansour, MD David Keane, MD, PhD Pierre Jais, MD Vivek Reddy, MD

It is with great pleasure I invite you to attend the 24th Annual International AF Symposium on January 24-26, 2019 at the Seaport World Trade Center, Boston, Massachusetts. The AF Symposium was initiated in 1995 in response to the growing epidemic of atrial fibrillation. Over the past 24 years, the meeting has become a

major scientific forum at which health care professionals have a unique opportunity to learn about advances in research and therapeutics directly from many of the most eminent investigators in the field.

This intensive, highly focused three-day symposium brings together the world’s leading medical scientists to share in a highly interactive environment the most recent advances in the field of atrial fibrillation. The primary objective of the meeting is to provide attendees with a thorough and practical course on the current state of the art in the field of atrial fibrillation in a scholarly and collegial atmosphere, as well as an opportunity to network with colleagues and faculty between sessions. The meeting employs advanced teaching tools including real-time case presentations as well as an interactive audience response system to share with attendees the most current basic, translational and clinical science in the field.

The past two decades have witnessed dramatic advances in all areas of AF research. These developments have contributed to major progress in the understanding of the pathophysiology of this arrhythmia and to the development of safer and more effective strategies for the management of AF and the prevention of AF-related stroke. The AF Symposium is dedicated to bringing these advances to our attendees each year in an exceptionally organized and exciting scientific program. We are delighted to return to the Seaport World Trade Center for the 2019 meeting. In celebration of our return to Boston we invite you to join us for an evening at the John F. Kennedy Presidential Library, including dinner, networking and full access to the museum.

We hope that you will join us.

Jeremy Ruskin, MD

JFK Presidential Library & MuseumEvening CelebrationThursday Jan 24, 7:00-10:00 PMWe welcome all attendees, industry and faculty to an evening of food, wine, conversation and full access to the museum.

Registration Pick-Up:Wednesday January 23, 12 Noon – 6:30 PM All-day Thursday January 24 Friday, January 25, starting at 6:30 AMExhibit Floor:Opens Thursday January 24, 9:00 AM – 4:30 PM

Scientific Sessions

Thursday January 24, 20196:30 - 7:30 AM Continental Breakfast

Medical Device and New Technology Symposium7:30 - 10:00 AMEmerging New Technologies: Implications for the Future of Medicine and CardiologyChairs: non-cmeAll Talks 15 minutes & 5 minutes Q&A (7:30-9:10 AM)Artificial Intelligence, Machine Learning & Big Data: Convergence and Automated InnovationThe Future of Robotics in Medicine: Research and Clinical ApplicationApplications of Virtual and Augmented Reality in Medical Practice and TrainingCRISPR/Cas9 Technology: From Disease Modeling to Therapeutic InterventionsWhat VCs Want and How to Finance A Medical Device Startup

Spotlight Session: Early Stage & Emerging Technologies in Cardiac Mapping and AblationChairs:All Talks 5 Minutes (9:10-10:00 AM)Presenters:Adagio Medical – Lucas Boersma, MD Acesion Pharma – TBA Acutus – Claudio Tondo, MD, PhD Affera – Vivek Reddy, MD CardioNXT – Subbarao Choudry, MD Cardiva Medical – Amin Al-Ahmad, MD EP Dynamics – Hugh Calkins, MD InCarda Therapeutics – Jeremy Ruskin, MD Kardium – Hans Kottkamp, MD LuxCath – David Hanes, MD

10:30 - 11:00 AM Break and Exhibits

10:30 AM - 12:00 PMNovel Mapping and Ablation Technologies for Catheter Ablation of Atrial FibrillationSponsored Session (Non-CME) - Abbott MedicalChairs: Moussa Mansour, MD and Vivek Reddy, MDAll Talks 10 minutes & 5 minutes Q&AA Novel Multielectrode/Omnipolar Mapping Technology to Address the Limitations of Traditional Bipolar Mapping Kumaraswamy Nanthakumar, MDNew Insights into Arrhythmia Mechanisms Using A High Density Multielectrode Mapping Array Jacob Koruth, MD

New Generation Ablation Catheters: Combining Force Sensing with Accurate Catheter Localization Monica Lo, MDHigh Power Short Duration Ablation for AF: Unmet Needs and Potential Solutions Andrea Natale, MDPanel and Audience Discussion Q&A - All Faculty (30 minutes)Chairs: Moussa Mansour, MD and Vivek Reddy, MD

12:00 - 1:15 PM Lunch, Exhibits and Product Theaters

1:15 - 2:45 PMCABANA: New Analyses, Long-Term Follow-Up and Debate - Interpretation and Implications for Clinical PracticeChair: Hugh Calkins, MDDebate and Discussion:CABANA is a Negative Trial (10 minutes) Peter Kowey, MDCABANA is a Positive Trial (10 minutes) Eric Prystowsky, MDWhy CABANA Is A Neutral Trial that Isn’t Neutral; New Analyses; Long-Term Follow-upQuality of Life; and Sinus Rhythm vs Atrial Fibrillation (20 Minutes) Douglas Packer, MDEssential Lessons Learned from AF Ablation Mortality Trials (ATAAC-AF, CASTLE AF, CABANA)(15 Minutes) Nassir Marrouche, MDPanel and Audience Discussion (35 Minutes) - All FacultyChair: Hugh Calkins, MD

2:50 - 3:20 PM Break and Exhibits

3:20 -5:30 PMChallenging Cases in AF Management: Drugs, Anticoagulation, Ablation & LAA ClosurePanel and Audience Discussion (10 minutes per case)Moderators: Eric Prystowsky, MD and David Wilber, MDCase Presenters: Eric Prystowsky, MD, Elad Anter, MD, David Keane, MD, PhD, Francis Marchlinski, MD, Oussama Wazni, MD, Douglas Packer, MD, Jacqueline Saw, MD, David Wilber, MD

5:30 PM Adjourn

7:00 - 10:00 PM - JFK PRESIDENTIAL LIBRARY & MUSEUM - DINNER CELEBRATIONAll Attendees, Industry and Faculty - Dinner, Networking & Optional Guided ToursBuses leave Seaport Hotel for JFK Library at 6:30PM

Friday January 25, 20196:30 - 7:30 AM Continental Breakfast

7:30 - 10:00 AMReal-Time Case Transmissions - New Imaging, Mapping and Ablation Technologies

Friday Scientific Session ContinuedInteractive Panel & Audience Discussions (All Cases 30 Minutes)Chairs: David Keane, MD, PhD, Moussa Mansour, MD and Jeremy Ruskin, MDPanel: Pierre Jais, MD, Dhanunjaya Lakkireddy, MD, Francis Marchlinski, MD, Andrea Natale, MD, and Vivek Reddy, MDPulmonary Vein Isolation with Ultrasound Mapping and Ablation Na Homolce Hospital, Prague, Czech Republic Jan Petru, MD, Moritoshi Funasako, MD and Petr Neuzil, MDTemperature Controlled High Power Short Duration Focal RF Ablation for AF Mount Sinai Medical Center, New York, NY Srinivas Dukkipati, MD, William Whang, MD, MS and Vivek Reddy, MDPulmonary Vein Isolation with a Multi-Electrode Radiofrequency Balloon Catheter Massachusetts General Hospital, Boston, MA Moussa Mansour, MD, Andrea Natale, MD and Kevin Heist, MD, PhDPulmonary Vein Isolation with 3-D Cryoballoon Visualization St. Luke’s Medical Center, Aurora Health Care, Milwaukee, WI Jasbir Sra, MD and Mohamed Hani, MDConvergent Hybrid Ablation for Atrial Fibrillation Emory Heart and Vascular Center Saint Joseph’s Hospital, Atlanta, GA Non-CME Sponsored Case (Atricure Inc.) David Delurgio, MD, Michael Halkos, MD and Kevin Makati, MDAudience and Panel Q&A and Discussion During Cases

10:00 - 10:30 AM Break and Exhibits

10:30 AM - 12:00 PMNew Trends in Catheter Ablation for Atrial Fibrillation: Improving Efficacy and EfficiencySponsored Session (Non-CME) - Biosense WebsterChairs: Larry Chinitz, MD and Luigi Di Biase, MD, PhDAll Talks 10 minutes & 10 minutes Q&AIntroduction - Luigi Di Biase, MD, PhD (5 minutes)Improving Procedural Efficiency: Contributions of Ultrasound and Low Fluoroscopy Procedures Paul Zei, MD, PhDA Tailored Approach to AF Ablation: How to Customize Your Ablation Strategy to the Individual Patient Larry Chinitz, MDShortening Procedure Times and Improving Periprocedural Efficiency: How to Treat More Patients Per Day While Enhancing Quality and Patient Experience Jose Osorio, MDPanel and Audience Discussion (25 minutes)Chair: Larry Chinitz, MDPanel: Amin Al-Ahmad, MD, Luigi Di Biase, MD, PhD, Jose Osorio, MD, Jason Zagrodzky, MD and Paul Zei, MD, PhD

12:00 - 1:15 PM Lunch, Exhibits and Product Theaters

1:15 - 3:30 PMNew Technologies for Mapping and Ablation of Atrial FibrillationChairs: David Keane, MD, PhD and Pierre Jais, MDAll Talks 10 Minutes Q&A During Panel DiscussionBenefits of Ultra High-Density Mapping in AF and AT Pierre Jais, MD

Advances in Catheter Technologies for Focal RF Ablation (CFS; Temp Control; Trial Updates) David Wilber, MDCatheter Ablation for AF Aiming for Contiguous Lesions Using a Novel Ablation Tag Index Mattias Duytschaever, MD, PhDNew Directions in Cryoablation for AF Michel Haissaguerre, MDUpdate on Balloon Technologies for AF Ablation Karl-Heinz Kuck, MDPulsed Electrical Field Ablation for PVI: Preclinical and Clinical Experience Vivek Reddy, MDFDA Perspective: How to Balance Safety, Regulatory Requirements and the Need for Innovation to Advance Patient Care in AF Ablation Mark FellmanPanel and Audience Discussion (40 Minutes) – All Faculty Chairs: David Keane, MD, PhD and Pierre Jais, MD

3:30 - 4:00 PM Break and Exhibits

4:00 - 6:30 PMStroke Prevention in AF: Current Issues in Anticoagulation, Ablation and LAA ClosureAnticoagulationChairs: John Camm, MD and Elaine Hylek, MD, MPHAll Talks 10 Minutes Q&A During Panel DiscussionUpdate on Completed Trials in Anticoagulation - Clinical Implications Elaine Hylek, MD, MPHRelationship Between AF Burden and Stroke Risk: What is the Threshold for Anticoagulation? Daniel Singer, MDPill-in-the-Pocket Anticoagulation in Selected Patients with AF: Rationale, Observational Data and Upcoming Clinical Trials Rod Passman, MD, MSCEShould We Discontinue Oral Anticoagulation After Successful Ablation of AF? Atul Verma, MDAdherence to Anticoagulation in Clinical Practice - Current Data John Camm, MDPanel and Audience Discussion (30’) All Faculty

Left Atrial Appendage ClosureChair: Jacqueline Saw, MD and Dhanunjaya Lakkireddy, MDUpdate on New Technologies and Clinical Trial Outcomes for LAA Closure Dhanunjaya Lakkireddy, MDLAA Closure in Patients at High Risk for Bleeding Moussa Mansour, MDLAA Closure Combined with AF Ablation - Indications, Timing and Outcomes Andrea Natale, MDManagement of Complications with LAA Closure Jacqueline Saw, MDFDA Perspective on New Technologies for Left Atrial Appendage Closure: Challenges and Opportunities Andrew Farb, MDPanel and Audience Discussion (30 minutes) All Faculty

6:30 PM Adjourn

Saturday January 26, 20197:00 - 8:00 AM Coffee and Tea

8:00 - 10:00 AMBeyond PVI: Mechanisms and Targets for AF Ablation (Session I)Chairs: Sanjiv Narayan, MD, PhD and Albert Waldo, MDAll Talks 10 minutes & 5 minutes Q&ARotors and Fibrillation Revisited: New Imaging Technologies to Visualize Cardiac Electromechanical Turbulence Jose Jalife, MDPredicting the Outcome of AF Ablation with Personalized Analysis of the Atrial Fibrotic Substrate: Can We Predict if PVI Will Be Sufficient? Natalia Trayanova, PhDActivation Wavefront Rotation: Which Rotors Are “Real” and Which Truly Contribute to Perpetuation of AF? Ulrich Schotten, MD, PhDComparison of High Resolution Experimental Optical Mapping and Catheter Mapping of AF Patients Hiroshi Nakagawa, MD, PhDStrategies for Ablation of Non-PV Triggers in Patients with Resistant AF Francis Marchlinski, MDA New Single-Procedure Ablation Method for Persistent AF Designed to Minimize Local and Macro-Reentrant Atrial Tachycardias Michel Haissaguerre, MDPanel and Audience Discussion (30 minutes) - All Faculty

10:00 - 11:00 AM Continental Breakfast & Exhibits

11:00 - 11:30 AMBeyond PVI: Mechanisms and Targets for AF Ablation (Session II)All Talks 10 minutes & 5 minutes Q&AChairs: Sanjiv Narayan, MD, PhD and Albert Waldo, MDRole of Vein of Marshall Ablation in Persistent AF Pierre Jais, MDHow Will Genetic Screening Influence Strategies for AF Management Patrick Ellinor, MD, PhD

11:30 AM - 1:00 PMHow to Improve the Safety of AF Ablation ProceduresChairs: Isabel Deisenhofer, MD and Thomas Deneke, MD, PhDAll Talks 10 minutes & 5 minutes Q&AFeasibility of Continuing Ablation for AF after Pericardiocentesis for Cardiac Tamponade Young-Hoon Kim, MD, PhDRelevance and Timing of CT Scans to Diagnose AE Fistula Luigi Di Biase, MD, PhDStrategies for the Prevention of Esophageal Thermal Injury During AF Ablation Isabel Deisenhofer, MDCorrelation of Post-Ablation MRI Esophageal Findings and Endoscopic Evaluation Thomas Deneke, MD, PhDPanel and Audience Discussion (30’) All FacultyChairs: Isabel Deisenhofer, MD and Thomas Deneke, MD, PhD

1:00 - 2:00 PMLate Breaking Clinical Trials and First Report Clinical InvestigationsBest Abstract Award

2:00 PM Adjourn

2:00 PMHRS Program for General Cardiologists & Internists

Amin Al-Ahmad, MD Texas Cardiac Arrhythmia Institute, Austin, TXElad Anter, MD Beth Israel Deaconess Medical Center, Boston, MALucas Boersma, MD St. Antonius Ziekenhuis, Nieuwegein, NetherlandsHugh Calkins, MD Johns Hopkins Hospital, Baltimore, MDA. John Camm, MD St. George’s Medical Center, London, UKLarry Chinitz, MD NYU Langone Medical Center, New York, NYSubbarao Choudry, MD Mount Sinai Medical Center, New York, NYIsabel Deisenhofer, MD German Heart Center, Munich, GermanyDavid Delurgio, MD Emory Heart Center at Saint Joseph’s, Atlanta, GAThomas Deneke, MD, PhD Cardiovascular Center Bad Neustadt, Bad Neustadt, GermanyAndrew ElBardissi, MD Deerfield Management, New York, NYLuigi Di Biase, MD, PhD Montefiore Medical Center, Bronx, NYSrinivas Dukkipati, MD Mount Sinai Medical Center, New York, NY

2019 AF Symposium Faculty

Mattias Duytschaever, MD, PhD AZ St. Jan Hospital, Bruges, BelgiumPatrick Ellinor, MD, PhD Massachusetts General Hospital, Boston, MAAndrew Farb, MD U.S. Food & Drug Administration, Silver Spring, MDMark Fellman U.S. Food & Drug Administration, Silver Spring, MDMoritoshi Funasako, MD Na Homolce Hospital, Prague, Czech RepublicDavid Haines, MD William Beaumont Hospital, Royal Oak, MIMichel Haissaguerre, MD Bordeaux University Hospital, Bordeaux, FranceMichael Halkos, MD Emory University Hospital, Atlanta, GAMohamed Hani, MD St. Luke’s Medical Center, Aurora Health, Milwaukee, WIKevin Heist, MD, PhD Massachusetts General Hospital, Boston, MAElaine Hylek, MD, MPH Boston University Medical Center, Boston, MAPierre Jais, MD Bordeaux University Hospital, Bordeaux, FranceJose Jalife, MD University of Michigan, Ann Arbor, MIDavid Keane, MD, PhD St. Vincent’s University Hospital, Dublin, IrelandYoung-Hoon Kim, MD, PhD Korea University Medical Center, Seoul, KoreaJacob Koruth, MD Mount Sinai Medical Center, New York, NYHans Kottkamp, MD Heart Center Hirslanden, Zurich, SwitzerlandPeter Kowey, MD Lankenau Hospital, Wynnewood, PAKarl-Heinz Kuck, MD St. Georg Hospital, Hamburg, GermanyDhanunjaya Lakkireddy, MD HCA Midwest Health, Kansas City, MOMonica Lo, MD Arkansas Heart Hospital, Little Rock, ARKevin Makati, MD Tampa Cardiac Specialists/St. Joseph’s Hospital, Lutz, FLMoussa Mansour, MD Massachusetts General Hospital, Boston, MAFrancis Marchlinski, MD Hospital of the University of Pennsylvania, Philadelphia, PANassir Marrouche, MD University of Utah Health Centers, Salt Lake City, UTHiroshi Nakagawa, MD, PhD University of Oklahoma Health Science Center, Oklahoma City, OKKumaraswamy Nanthakumar, MD University of Toronto, Toronto, CanadaSanjiv Narayan, MD, PhD Stanford University Medical Center, Stanford, CAAndrea Natale, MD Texas Cardiac Arrhythmia Institute, Austin, TXPetr Neuzil, MD, PhD Na Homolce Hospital, Prague, Czech RepublicJose Osorio, MD Alabama Cardiovascular Group, Birmingham, ALDouglas Packer, MD Mayo Clinic, Rochester, MNRod Passman, MD, MSCE Northwestern Memorial Hospital, Chicago, ILJan Petru, MD Na Homolce Hospital, Prague, Czech RepublicEric Prystowsky, MD St. Vincent Hospital, Indianapolis, INVivek Reddy, MD Mount Sinai Medical Center, New York, NYJeremy Ruskin, MD Massachusetts General Hospital, Boston, MAJacqueline Saw, MD Vancouver General Hospital, Vancouver, BC, CanadaUlrich Schotten, MD, PhD Maastrict University, Maastricht, NetherlandsDaniel Singer, MD Massachusetts General Hospital, Boston, MAJasbir Sra, MD St. Luke’s Medical Center, Aurora Health, Milwaukee, WIClaudio Tondo, MD, PhD University of Milan, Milan, ItalyNatalia Trayanova, PhD John Hopkins Biomedical Engineering Institute, Baltimore, MDAtul Verma, MD St. Michael’s Hospital, University of Toronto, Toronto, CanadaAlbert Waldo, MD University Hospitals of Cleveland, Cleveland, OHOussama Wazni, MD Cleveland Clinic, Cleveland, OHWilliam Whang, MD, MS Mount Sinai Medical Center, New York, NYDavid Wilber, MD Loyola University Medical Center, Chicago, ILJason Zagrodzky, MD Texas Cardiac Arrhythmia Institute, Austin, TXMichael Zalis, MD Massachusetts General Hospital, Boston, MAPaul Zei, MD, PhD Brigham and Women’s Hospital, Boston, MA

2019 AF Symposium Faculty – Continued

GENERAL INFORMATION

CONFERENCE FEE

The conference fee is $1,195 for physicians and industry and $1,095 for residents, fellows and hospital-based nurses (with a certifying letter from your hospital). The conference fee includes the costs of tuition, syllabus materials, lunch and coffee breaks. All registrations will be confirmed via email. If you do not receive a confirmation please call 508-614-5413.Register online at www.afsymposium.com

CANCELLATION POLICY

Should you cancel your AF2019 registration by 11:59 p.m. EST, Sunday, December 3, 2018, you will be refunded the conference fee less $100. Requests for a cancellation with a refund must be made in writing and sent to Registration via email to reg@amecme.com. The AF Symposium is not responsible for airfare, hotel or other costs incurred by participants in the event of program or registration cancellation. No refunds will be made for cancellations received after the December 3, 2018 deadline.AMA CREDIT DESIGNATION

This activity has been approved for AMA PRA Category 1 Credit(s)™.ACCREDITATION STATEMENT

The Postgraduate Institute for Medicine is accredited by the Accreditation Council for Continuing Medical Education (ACCME) to provide continuing medical education for physicians.

EUROPEAN CONTINUOUS MEDICAL EDUCATION CREDIT

AMA PRA Category 1 Credit(s)™ claimed by physicians attending live events certified and organized in the United States for AMA PRA Category 1 Credit(s)™ can be claimed through the agreement on mutual recognition of credit(s) between UEMS and AMA, considered as being equal to the European Continuous Medical Education Credits (ECMEC©) granted by the UEMS (1) AMA PRA Category 1 Credit™ is equivalent to one (1) hour of European EACCME Credit (ECMEC©.NURSE ACCREDITATION STATEMENT

Postgraduate Institute for Medicine is accredited as a provider for continuing nursing education by the American Nurses Credentialing Center’s Commission on Accreditation.NURSING CREDIT DESIGNATION

This activity is eligible for ANCC credit, see final CE activity announcement for specific details.PHARMACIST CREDIT DESIGNATION

This activity is eligible for ACPE credit, see final CE activity announcement for specific details.FOR MEETING INFORMATION CONTACT

Atrial Fibrillation Symposium Tel: 508-614-5413 Fax: 508-519-0789 Email: info@amecme.com

STATEMENT OF NEED 2019

The planning committee has determined that there is a strong need for this conference based on the clinical and public-health significance of atrial fibrillation as the most common cardiac arrhythmia and a growing global epidemic, as well as rapid advances in the understanding of the mechanisms of and treatment options for this major pubic-health problem. This three-day symposium is designed to meet the following objectives.

1 Provide a current review of new information on the clinical science and pathophysiology of atrial fibrillation and atrial fibrillation-related stroke

2 Provide a detailed presentation of the most recent developments in the diagnosis and treatment of atrial fibrillation

3 Discuss the prevention of AF-related stroke and other sequelae, with an emphasis on current and evolving pharmacological and nonpharmacological therapies and enabling new technologies in the field of cardiac electrophysiology

4 Exchange thoughts and techniques with the treatment team to improve the outcome of patient care and treatment

5 Provide appropriate care and counsel for patients and their families through the education of healthcare professionals

The scientific basis for the clinical experience with new and existing therapies for atrial fibrillation and prevention of atrial fibrillation-related stroke will be explored. In addition to formal lectures, case presentations, case discussions, focused mini-symposia and faculty-audience interactions using an audience response system will be used to highlight the current state of scientific knowledge in areas of major importance to clinicians. The faculty is selected to provide the highest quality teaching and access to the most current scientific information from leading international experts in the field.This symposium has been designed to meet the educational needs of cardiologists, internists, fellows, registered nurses and technicians involved in cases of patients with atrial fibrillation.