atrial fibrillation in endurance athletes s_ de vries... · atlas diabetes challenge . het nut van...
TRANSCRIPT
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Atrial Fibrillation in
Endurance Athletes
Maart 2015
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• Inleiding
• Nut van bewegen
• AF
• Mogelijke oorzaken van AF
• Conclusie
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Cardiology
and Sport
AtlasDiabetesChallenge2010
Suzanna de Vries, sportscardiologist
www.fotohoogendoorn.nl
www.fotohoogendoorn.nl
www.fotohoogendoorn.nl
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6962m
5895m
4167m
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Before our expeditions: testing,
selection and training
Dutch Heart Expedition
Patients = 1 W/kg
Not fit = 2 W/kg
Fit = 3 W/kg
Well trained = 4 W/kg
Professional = 5 W/kg
Worldclass = 6 W/kg
VO2= HF x SV x 1.3(Hb) x a-vO2
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The expedition:
Acclimatisation
M.Meru, Tanzania
www.fotohoogendoorn.nl
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www.fotohoogendoorn.nl
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www.fotohoogendoorn.nl
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www.fotohoogendoorn.nl
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The expedition: Research at high altitude
www.fotohoogendoorn.nl
www.fotohoogendoorn.nl
www.fotohoogendoorn.nl
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The expedition:
Energy expenditure
4000
6000
8000
10000
12000
14000
16000
18000
20000
T1DM Controls
Steps
Mean steps per day in average W-European country
Recommended steps per day
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Visceral fat
0
100
200
300
400
500
Vis
cera
l ab
do
min
al (
ml)
Before training
After training
*
* P<0.05
Atlas Diabetes Challenge
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Het nut van bewegen
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Obesity Trends* Among U.S. Adults
BRFSS, 1985 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” woman)
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19% 20%–24% ≥25%
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Obesity Trends* Among U.S. Adults
BRFSS, 1995 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” woman)
Source: Behavioral Risk Factor Surveillance System, CDC
No Data <10% 10%–14% 15%–19% 20%–24% ≥25%
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Obesity Trends* Among U.S. Adults
BRFSS, 2005 (*BMI ≥30, or ~ 30 lbs overweight for 5’ 4” person)
No Data <10% 10%–14% 15%–19% 20%–24% 25%–29% ≥30%
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Redenen om niet te bewegen
• I don’t have the time
• I don’t like to sweat
• I’ll look silly
• It hurts
• I don’t know what to
do
• It’s not important
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The inability to achieve at least 85% of age-related maximal heart rate
was associated with a lower event-fress survival compared to those
who reached this heart rate. Lauer MS et al. JACC 1998
Het nut van bewegen
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Het nut van bewegen:
Metabool syndroom
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BMI and age-related mortality
Waaler Acta Med Scand 1984
Relative
risk 2.4
2.2
2.0
1.8
1.6
1.4
1.2
1.0
0.8
2.4
2.2
2.0
1.8
1.6
1.4
1.2
1.0
0.8
21 25 29 33 37 41 21 25 29 33 37 41
BMI (kg/m2) BMI (kg/m2)
women men 50–54
55–59
60–64
Leeftijd
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Risicofactoren
x1,6 x4,5
• DM: RR 2-4
x16
x6 x9
x3
x4
Roken Hypertensie
Cholesterol
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Cardiovasculair risico management
bij het metabool syndroom
• Voldoende lichaamsbeweging
• Niet roken, matig alcohol
• metformine, TZD’s
• Strikte controle van:
– glucose stofwisseling
– bloeddruk
– Vetspectrumafwijkingen
– Gewichtsreductie!
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DEVELOPMENT OF ATHEROSCLEROSIS
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ARTERY COMPARISONS
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Blair River
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Blair River (†29)
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Benefits of Exercise
RR/BMI/glucose/HDLC Pattyn – Sports Med 2013:43
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Endurance
• Phidippides
• Marathon naar Athene
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Haimar Zubeldia (Tour de France: 5th in 2003 and 2007, 6th in 2012, 8th in 2006)
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Haimar Zubeldia (Tour de France: 5th in 2003 and 2007, 6th in 2012, 8th in 2006)
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Risk factors for AFIB
• Age
• Structural heart disease • eg LVH/ atrial dil.
• Hypertension
• Hyperthyroidism
• DM
• Exercise ????
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AF in Athletes
Abdulla - Europace 2009;11
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AF and Marathon Running
Molina – Europace 2008;10
Retrospective cohort study
1990-2003 Barcelona Marathon
n=252 marathon runners
n=205 sedientary
Hazard ratio 8.8
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AF in Orienteering
Karjalainen – BMJ 1998-3
Retrospective study
1984-1995
n=300 top ranked veteran orienteers
n=495
RR 5.5
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AF in Cycling (vs Golf)
Baldesberger – EHJ 2008;29
Retrospective study
1955-1975
n=134 swiss professional cyclists
n=62 male golfers
P=0.028
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AF and Cross Country skiing
Andersen – EHJ 2013;188
Retrospective study
Vasaloppet race (90km)
1989-2005
n=52755
RR 1.2
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Afib Athletes and AGE
No higher incidence of Afib in younger athletes
(n=1777/ age 24 +/- 6/ incidence 0.3%).
Pellica – JACC 2005;46
Mozzaffarian
– Circ 2008;118
Decrease in Afib
By exercise
(Age 72 +/- 5.6 yrs)
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Demografics
• Endurance sports
• Increases with training/race load
• Mainly middle aged
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Pathophysiology
• Acute Effects
– Diastolic dysfunction
– Cardiac and inflammatory markers
• Persistent Effects
– Fibrosis -LVH
– Atrial enlargement
– Autonomic nervous system
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Pathofysiology
- Diastolic dysfunction
n=50 recreational marathon runners
Significant change in diastolic function
decrease E wave
increase A wave
increase E/A ratio
White – Clin Science 2005; 108
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Pathophysiology
- HF parameters Significant increase
NT-Pro BNP after marathon
(n=60 Boston marathon 2005)
correlates with LV diastollic
dysfunction
Neilan – Circ 2006;144
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Pathophysiology
– Myocardial markers
Significant increase Troponin after marathon
completion Middelton – JACC 2008;5
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Pathophysiology
– Myocardial markers
Shave – JACC 2010;56
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Pathophysiology
– Myocardial markers
- Physiological mechanisms
- Increase permability
- Cross reaction degraded troponins
Mc Neil - Am J Pathol 1992;140
Feng – Circ 2001;103
- Myocardial cell necrosis ?
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Pathophysiology
- Inflammation
Significant increase in C-reactive protein after
strainious excercise
Kasapis – JACC 2005;45
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Pathophysiology
- Inflammatory markers
Significant increase in inflammatory markers during ultra marathon
Jee – J. of Sports Science 2012;11
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Pathophysiology
- hypertrophy n=43 students of dep. of
athletics/ 6 month intensive
endurance training program.
Jee – Anadol Kardiol 2013;13
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Pathophysiology
- Inflam. Markers Fibrosis
n=45 veteran endurance athletes/ n=45 sedentery subjects
Markers of disruption of collagen inducing fibrosis (CTIP/ PICP)
Lindsday – Br J Sports med 2007;41
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Pathophysiology
- MRI Fibrosis
Breuckmann – Rardiology 2009;251
J Appl physiol 2010;128
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Pathophysiology
- Left atrial dilatation
Veteran marathon runners have a significant increase in LA/RA
dimensions and volumes Wilhelm – Am J Cardiol 2012; 44
Molina - Europace 2008;10
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Pathophysiology
- Autonomic nervous system
Wilhelm – AmJCard 2011;108
Vagus tonus increased with
Liftime training hours
Bradycardie and long PQ
Time are predictors in
Endurance athletes for AF
Grimso – Eur J cardi prev reh 2010-17
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Pathophysiology
- atrial remodeling
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Pathophysiology
Autonomic nervous system
Myocardial injury – Inflammation – fibrosis
Diastolic dysfunction - Atrial remodeling
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Management
• Sport activity reduction
• Pharmacological
• Pulmonary vein or isthmus ablation
• Anticoagulation
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Sport Activity Reduction
Hoogsteen – Europace 2004;6
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Pharmacological
• Class Ic antiarrythmica
• Combination verapamil (1:1 flutter)
• Pill in the pocket
Heidbuchel – Eur J Card Prev Rehab 2006; 13
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Pulmonary vein ablation
Mont – Europace 2009;11
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Anticoagulation
• Exclude individuals from sports with a risk
of trauma
Heidbuchel – Eur J Card Prev Rehab 2006; 13
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Conclusie
• Demografics – middle aged endurance sporters
• Pathofysiology – inflammation – fibrosis – LAD/ LVH
• Treatment – reduction in exercise, class I anti-arrytmica, catheter
ablation
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