Atlas of Dermatological Manifestations of Gastrointestinal Disease || Cirrhosis: Dermatological Features

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<ul><li><p>179G.Y. Wu et al. (eds.), Atlas of Dermatological Manifestations of Gastrointestinal Disease,DOI 10.1007/978-1-4614-6191-3_68, Springer Science+Business Media New York 2013</p><p> Clinical characteristics include: Liver disease often presents with cutaneous fi ndings: chronic alcoholism, 43% have cutaneous fi ndings; alco-hol cirrhosis, 72% have spider angioma, palmar erythema, or Dupuytrens contractures [ 1 ] Jaundice: occurs when serum bilirubin &gt;2.53.0 mg/dL; if mild, skin is yellow; if severe, skin is brown [ 1 ] Pruritus of cholestasis: tends to be generalized, worse in hands and feet [ 1 ] Prurigo nodularis: associated especially with cirrhosis due to hepatitis C; fi rm, pruritic hyperkeratotic nodules 1 mm2 cm in diameter; usually on the extremities although no part of the body is exempt, often with xerotic/licheni fi ed skin between nodules and excoriations/crusting on the lesions [ 1, 2 ] Spider angiomas (spider nevi) ( see Fig. 68.1 ): occur in vascular area drained by superior vena cava [ 3 5 ] in 33% of cirrhotics; the more present, the worse the cirrhosis; on examination, they will disappear with pressure [ 1 ] and if large enough, they will pulsate [ 3 ] ; they are closely asso-ciated with esophageal varices [ 3 ] </p><p> Bier spots: hypopigmented, small irregular-shaped patches on the arms and legs; on examination, the lesions will disappear with pressure and with limb elevation [ 1 ] Paper money skin: upper trunk with scattered, needle-thin super fi cial capillaries; common in alcoholic cirrhosis [ 1 ] Palmar erythema: fl orid, crimson color of palms and fi ngertips [ 1 ] (most common on the thenar or hypothenar eminences), characteristically bilateral and symmetrical in 23% of cirrhotics [ 4 ] ( see Fig. 68.2 ) Xanthelasma: can be a feature of cholestatic liver disease; localized cholesterol deposits beneath the skin (especially the eyelids); painless, yellow, soft plaques with well-de fi ned borders that often grow over weeks [ 1 ] Hair and/or nail Loss; clubbing of nails; fl at nails; Terrys nails ( see Fig. 68.3 ), a nail fi nding in which the proximal two thirds of the nail appear white, with preservation of a normal 13 mm band of color at the distal nail bed [ 1, 5 ] Dupuytrens contracture: progressive fi brosis and thick- ening of the tendons in the palmar fascia that over time leads to stiffness in the joints to the point that a patients fi ngers cannot fully extend or fl ex ( see Fig. 68.4 ) [ 1 ] Disseminated super fi cial porokeratosis: multiple pink, tan fl at annular papules and plaques with a slightly elevated keratotic margin (the process is more commonly seen in cirrhotics); of concern because these lesions can progress rarely to squamous cell carcinoma [ 1 ] Dilated super fi cial abdominal veins due to diversion of blood away from the portal venous system is exempli fi ed by the caput medusa ( see Fig. 68.5 ) </p><p> Pathogenesis is based on abnormalities caused by liver dysfunction:</p><p> Pruritus: failure to metabolize toxins and fi lter bile salts; somewhat centrally mediated due to increased central nervous system opioids [ 1 ] </p><p> Cirrhosis: Dermatological Features </p><p> Liam Zakko , Justin Finch , Marti J. Rothe , and Jane M. Grant-Kels </p><p> 68</p><p> L. Zakko (*) Yale Department of Internal Medicine , Yale New Haven Hospital , New Haven , CT , USA </p><p> Yale Primary Care Clinic , 789 Howard Avenue , New Haven , CT 06519-1304 , USA e-mail: </p><p> J. Finch M. J. Rothe J. M. Grant-Kels Department of Dermatology , University of Connecticut Health Center , 21 South Road , Farmington , CT 06030 , USA e-mail: fi;; </p></li><li><p>180 L. Zakko et al.</p><p> Prurigo nodularis: postulated that it may be due to increased neuropeptides, electrolyte abnormalities, changes in growth factors, or deposition of immune com-plexes [ 2 ] Spider nevi: associated with increased estrogen and estrogen/androgen ratio, although unclear if due to estro-gen or elevations in growth factors, vascular endothelial growth factor (VEGF)/basic fi broblast growth factor (bFGF) [ 5 ] Palmar erythema: also associated with increased estrogen and estrogen/androgen ratio; due to vasodilation from increased prostacyclins and nitric oxide that accumulate in patients with liver disease [ 1 ] ; may be increased in those with alcoholic cirrhosis due to phytoestrogen con-tent of alcohol, acetaldehyde (an ethanol metabolite), and calcitonin gene-related peptide [ 5 ] </p><p> Xanthelasma: secondary to dyslipidemia; increased trig- lycerides and decreased high-density lipoprotein (HDL) are most common [ 1 ] Dupuytrens contracture: etiology unknown but associ- ated with alcoholic cirrhosis [ 1 ] Porokeratosis: likely due to decreased humoral and cell- mediated responses [ 1 ] </p><p> The pathology of the skin is varied: Spider angioma: small dilated arterioles (0.5 cm in diam- eter) from which small telengiectatic vessels radiate [ 5 ] Terrys nails: distal band with telangiectasia; proximal area with hyperplasia of connective tissue between nail and bone [ 5 ] Porokeratosis: presence of cornoid lamella [ 5 ] Prurigo nodularis: compact hyperkeratosis with focal par- akeratosis and marked acanthosis often of pseudoepith-iliomatous proportions; thickening of papillary dermal collagen often in vertical orientation; hypertrophy and increased proliferation of dermal nerves; lymphocytes, histiocytes, mast cells and occasional eosinophils within the dermis [ 2 ] </p><p> Diagnosis is made on the basis of clinical features, imaging, blood tests, and pathology:</p><p> Fig. 68.1 Spider angiomata. A fl orid case on the chest. Telangiectatic arms extending radially from a central vessel is characteristic </p><p> Fig. 68.2 Palmar erythema. Crimson color of palms, fi ngertips, thenar, and hypothenar eminences </p><p> Fig. 68.3 Terrys nails. Apparent leukonychia (whitish nails) of all fi ngernails, obscuring the lunulae and sparing the distal 23 mm </p></li><li><p>18168 Cirrhosis: Dermatological Features</p><p> Fig. 68.4 Dupuytrens contractures. Progressive fi brosis and thicken-ing of the tendons in the palmar fascia that prevents complete extension or fl exion of the fi ngers </p><p> Fig. 68.5 Distended super fi cial abdominal veins due to diversion of blood from the portal venous system and is exempli fi ed by the caput medusa </p><p> Above fi ndings in adults merit a workup for liver disease including liver function tests, tests for hepatic injury, and hepatic imaging The differential diagnosis includes: Variable depending on the skin fi ndings but includes the differential for cirrhosis as well as a number of rheumato-logic diseases, particularly rheumatoid arthritis and lupus, and high estrogen states such as pregnancy Treatment is largely symptomatic: Pruritus: resin cholestyramine, rifampin, naltrexone, and in severe/refractory cases consider plasmapheresis; responds to liver transplantation [ 1 ] Prurigo nodularis: fi rst line, topical antipruritics (corti- costeroids, pramoxine, menthol), intralesional steroids; second: ultraviolet light treatment, cryotherapy, vitamin D, capsaicin; third: naltrexone, cyclosporine, low-dose thalidomide [ 1, 2 ] </p><p> Dupuytren contractures: surgical fasciectomy [ 1 ] Porokeratosis: clears with improved liver function [ 1 ] </p><p> References </p><p> 1. Hazin R, Abu-Rajab Tamimi TI, Abuzetun JY, Zein NN. Recognizing and treating cutaneous signs of liver disease. Cleveland Clin J Med. 2009;76:599606. </p><p> 2. Lee MR, Shumack S. Prurigo nodularis: a review. Australas J Dermatol. 2005;46:21120. </p><p> 3. Ruocco V, Psilogenis M, Schiavo AL, Wolf R. Dermatologic mani-festations of alcoholic cirrhosis. Clin Dermatol. 1999;17:4638. </p><p> 4. Serrao R, Zirwas M, English JC. Palmar erythema. Am J Clin Dermatol. 2007;8:34756. </p><p> 5. Ghosn SH, Kibbi AG. Cutaneous manifestations of liver diseases. Clin Dermatol. 2008;26:27482. </p><p>68: Cirrhosis: Dermatological FeaturesReferences</p></li></ul>