asthma - zain cawasji

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    AsthmaZain Cawasji

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    A 26 year old lady with a history of asthma presents to the ER

    with a 3 day history of progressive wheezing and shortness of

    breath after an upper respiratory tract infection. She is takingSalbutamol inhalers and over the counter medication for her cold.

    Her respiratory rate is 28/min, and her pulse is 110/min; she is

    afebrile. Her right nasal turbinate is edematous and erythematous.

    On examination there is bilateral wheezing but no crackles.

    Supplemental Oxygen is given. How would you manage this patient?

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    Objectives

    Definition.

    Pathophysiology.

    Clinical Features.

    Objective measures of severity

    assessment. Management.

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    Asthma

    Asthma is a disease characterised by inflammatory

    hyperactivity of the respiratory tree to various stimuli.,

    resulting in reversible airway obstruction. A combination

    of mucosal inflammation, bronchial muscle constriction,and an excessive secretion of viscous mucus causing

    mucus plugs produce bronchial obstruction. The

    bronchial hyper reactivity occurs in an episodic pattern

    with interspersed normal airway tone. Asthma can occurat any age but is most commonly seen in young people,

    half of whom outgrow their asthma by adulthood.

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    Etiology

    Genetic.

    Environmental factors.

    Occupational exposure.

    Cold air and exercise.

    Diet.

    Emotions.

    Drugs.

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    Allergic

    Immediate Asthma. Airflow limitation begins inminutes, reaches its maximum in 15-20 min and subsides within an

    hour.

    Dual and late phase reactions. Following animmediate reaction, many patients develop a prolonged and

    sustained attack to airflow limitation that responds poorly tobronchodilators. Upto several weeks after exposure, the airways

    are hyperresponsive.

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    Pathophysiology

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    Symptoms

    Intermittent dyspnea

    Wheeze

    Cough

    Sputum

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    History

    Precipitating Factors: Cold air, exercise, emotions, allergens(dust mite, pollen, animal fur), infection, drugs (aspirin, NSAIDs, beta

    blockers).

    Diurnal Variation: In symptoms or peak flow. Exercise: Amount tolerated.

    Disturbed sleep: Nights per week?

    Acid Reflux.

    Other Atopic diseases: Eczema, hay fever, allergy, familyhistory.

    The Home: Pets, carpets, feather pillows, dust.

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    Signs

    Tachypnea.

    Audible wheeze.

    Hyperinflated chest.

    Diminished air entry.

    Hyperresonant percussion note.

    Wheezing on auscultation.

    Severe attack: inability to complete sentences, pulse >110/min,

    RR >25/min, PEF 33-55% of predicted.

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    Investigations

    Peak expiratory flow rate.

    Exercise tests.

    Histamine or methacholine bronchial

    provocation test.

    Corticosteroid trial. Blood and sputum tests.

    Cheast xray.

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    Management

    Aims to: Abolish symptoms.

    Restore best possible lung functions. Reduce the risk of severe attacks.

    Enable normal child growth.

    Reduce absence from work or school.

    By: Patient and family education.

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