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Association Between GlycemicControl and Morning Blood

Pressure Surge With VascularEndothelial Dysfunction in

Tye !

Dia"etic PatientsKoichiro Yoda, Masaaki Inaba,

Kae Hamamoto, Maki Yoda,

Akihiro Tsuda,Katsuhito Mori,Shinsuke Yamada, Masanori Emoto,

Hidenori Koyama, and Yasuo Imanishi

Diabetes Care Volume !, March

"#$%

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Patients with DM tend to e#hi"it

accelerated arteriosclerosis and areconse$uently at higher ris% of cardio&asculardisease including stro%e and coronary heartdisease'

(t is ossi"le that inade$uate glycemic

control or the occurrence of insulinresistance acti&ate symathetic acti&ity)which leads to MBPS in DM atients'

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*B+ECT(VE

e&aluate the association ,

insulin resistance + glycemic controlwith Morning Blood Pressure Surge-

association "etween,

MBPSand vascular endothelial

dysfunction) as assessed "yendothelium.deendent /MD and 0MD inT!DM atients'

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1ESEA1C2DES(G0 A0DMET2*DS

34 atients with T!DM-

E#clusion criteria,

renal dysfunction 56eG/17894 m:;min;

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!@ h am"ulatory "lood ressuremonitoring-

Assessed the &ascular function "y,

"rachial arterty ow mediated dilaton5/MD?-

nitroglycerin.mediated dilaton 50MD?'

1ESEA1C2 DES(G0 A0D

MET2*DS

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1ES:TS

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Multi&ariate Association of theClinical Varia"le With MBPS in T!DM

Patients

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Multi&ariate Association of MBPS With/MD) "ut 0ot 0MD in T!DM Patients

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C*0C:S(*0S

:imitations ,

cross .sectional study

insucient to disentangle otentionalrelationshis among oor glycemiccontrol) insulin resistance) and MBPS

5"ecause 2"A

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:imitations,

DM atients enrolled in the study weretreated with &arious drugs) includingantihyertensi&e drugsand statins) theeect of those treatments on MBPScould not "e totally negated

C*0C:S(*0S

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poor glycemic control and insulinresistance are indeendentlyassociated with the occurrence of

MBPSin T!DM atients) which might"e signiFcantly associated withendothelial dysfunction'

C*0C:S(*0S

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TAE 2*ME MESSAGE

Morning Blood Pressure Surge might"e one of the maHor targets forre&enting &ascular damage in T!DMatients'

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T2A0 I*J