assessment of quality of life of patients with gastric cancer after surgery:
DESCRIPTION
Assessment of quality of life of patients with gastric cancer after surgery: a systematic review. Ana Rita Marques; Natália Ferreira; Mylene Costa; Paula Joana Moreira; Paula Campelo; Paulo Leandro; Pedro Barbosa; Pedro Mendes [Class 17 – 1st year ]. - PowerPoint PPT PresentationTRANSCRIPT
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Assessment of quality of life of Assessment of quality of life of patients with gastric cancer after patients with gastric cancer after
surgery:surgery:
a systematic review a systematic review
Ana Rita Marques; Natália Ferreira; Mylene Costa; Paula Joana Moreira; Paula Campelo;
Paulo Leandro; Pedro Barbosa; Pedro Mendes [Class 17 – 1st year]
Supervisors: Claúdia Camila e Mário RibeiroFMUP/ Serviço de Bioestatística e Informática Médica
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IntroductionIntroductionMeta-analysis, a final step in a systematic review:
“(…) statistical pooling of data across studies to generate summary estimates of effects .” [1]
“(…) the term “effect” refers to any measure of association between exposure and outcome” [1]
[1] Pai M, McCulloch M, Gordan JD, Pai N, Enanoria W, Kennedy G, Tharyan P, Colford,Jr JM. Systematic reviews and meta-analyses: An illustrated, step-by-step guide The National Medical Journal of India Vol.17 No.2,2004
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Gastric cancer as:
•A malignant cell growth;•Second leading cause of cancer deaths worldwide [2];
Surgery as the major way for treatment [3]:
• Distal gastrectomy without or with pylorus preservation;• Total gastrectomy without or with pouch;• Endoscopic mucosal resection or limited resections • Proximal gastrectomy
[2] Plummer M, Franceschi S, Munoz N Epidemiology of gastric cancer IARC Sci Publ. 2004;(157):311-26.[3] Roukos DH. Related Articles, Links Current advances and changes in treatment strategy may improve survival and quality of life in patients with potentially curable gastric cancer. Ann Surg Oncol. 1999 Jan-Feb;6(1):46-56.
Review.
IntroductionIntroduction
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IntroductionIntroduction
Rate of surviving is increasing
GASTRIC CANCER IN CANCER DEATH RATE (1973-92)
http://plan1998.cancer.gov/PRGRES.htm (National Cancer Institute)
Quality of life (QoL) is then particularly important in health care. Quality of life (QoL) is then particularly important in health care. [4][4]
[4] Kaptein AA, Morita S, Sakamoto J. Quality of life in gastric cancer World J Gastroenterol 2005
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Quality of life (QoL):
“The functional effect of an illness and its consequent therapy upon a patient, as perceived by the patient.” [5]
“The degree to which a person enjoys the important possibilities of his or her life.” [6]
Instruments for studying QoL:
• Questionnaires• Interviews • Physical examination and laboratory tests
[5]Schipper H, Clinch J, Olweny LM. Definitions and conceptual issues. Spilker B Philadelphia: Lippincott-Raven, 1996
[6]Qualitty of life Research Unit, University of Toronto, www.gdrc.org/uem/qol-define.html.
IntroductionIntroduction
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• Assess and summarize QoL in patients submitted to surgery for gastric cancer.
Study QoL in a generic view:
functional limitations;emotional state; gastrointestinal symptoms; social maladjustment; physical performance and
dependence(…)
• Clarifying validity and validation of the instruments used.
AimsAims
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MethodsMethodsInclusion criteria:
•Include a population with gastric cancer that have been submitted to a gastrectomy;•Include post-surgery QoL evaluation.•With abstracts.
Exclusion criteria:
Title:
•Refer to radiotherapy / chemotherapy exclusively
Abstract:
•If there is only one case in study
•Not refer to a post-operative instrument
•Not approach QoL in a generic view
•If patients with gastric cancer were part of a large group of patients with various other types of cancer
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MethodsMethods
Full article:
Not have access to article Not describe the patients studied Questionnaire is not validated Not refer QoL assessment
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MethodsMethodsArticles searchArticles search
- Pubmed- Pubmed
MESH (Medical Subject Headings) terms:
. Quality of life
. Gastrectomy
. Stomach neoplasm
Limits of the research:
Language: EnglishHumansPublication Date: from 1950 to September 2005Only items with abstracts
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Methods : Methods : Query's Query's DefinitionDefinitionPubmed
("Quality of Life" [MeSH] OR quality of life) AND ("Stomach Neoplasms" [MeSH] OR stomach neoplasms OR gastric cancer OR stomach carcinoma) NOT intestinal cancer AND ("Gastrectomy" [MeSH] OR gastrectomy OR gastric surgery) NOT chemotherapy NOT radiotherapy
173 articles
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MethodsMethods- Scopus- Scopus
Limits of the research:Limits of the research:
- year: until 2005; - year: until 2005; - areas: "health" e "life sciences"; - areas: "health" e "life sciences"; - document type: "review" e "article"- document type: "review" e "article"
Query´s definition:Query´s definition:
TITLE-ABS-KEY("Quality of life") AND TITLE-ABS-KEY(("stomach TITLE-ABS-KEY("Quality of life") AND TITLE-ABS-KEY(("stomach neoplasms") OR ("gastric cancer") OR ("stomach carcinoma")) neoplasms") OR ("gastric cancer") OR ("stomach carcinoma")) AND AND NOT (intestinal cancer) AND TITLE-ABS-KEY(("gastrectomy") OR NOT (intestinal cancer) AND TITLE-ABS-KEY(("gastrectomy") OR ("gastric surgery")) AND NOT (chemotherapy) AND NOT ("gastric surgery")) AND NOT (chemotherapy) AND NOT (radiotherapy)(radiotherapy)
189 articles189 articles
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Articles reachedArticles reached173 + 189 = 362173 + 189 = 362
362 - 102 (common) = 260362 - 102 (common) = 260
Scopus189
Pubmed173 102
71 87
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Methods : Flow Methods : Flow chartchart
76
Start
Pubmed search
Scopus search
Read titles and abstracts
NoYes
Apply exclusion
criteria
Include articles not found at Pubmed
search
260 articlesreached
Excluded by 2 revisors
78 Articles included
Article excluded
Read full article
Apply exclusion
criteria
Excluded by 2 revisors
Article included
Article excluded
NoYes
End
10
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Methods - Methods - Extracted dataExtracted data Extracted data:
- Authors- Title- Magazine- Institution- Characteristics of patients- Number of patients studied- Other important data- Questionnaires- Types of surgery- Assessement of QoL- Stage of disease
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ResultsResults• Included articles (after reading titles and abstracts – exclusion criteria)
Included at previous analysis
n = 57 (pubmed) + 19 (scopus)= 76 art.
• Quality of articles:
Consider a valid article if: - describe the patients studied;
- refer the stage of disease;
- refer the instrument used;
- questionnaire is valid;
10 articles respect these parameters
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02468
101214161820
Localy d
evel
oped
EORTC Q
LQ-C-3
0
DCDS-JSGS
Visic
k sc
ore
Karnofs
ky P
erform
. Sc.
Spitzer
Index
Body sym
ptom
sca
le
CPRS
Gas
troent.
QoL in
dex
MACL
SIP
SSIAM
Frequency of questionnaires
ResultsResults•Description of questionnaires
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ResultsResults
- different characteristics of patients in each articledifferent characteristics of patients in each article
- different stages of disease
- - different techniques
- different times of measurement
- different instruments used
• Validity of the instruments used
• Possible heterogeneityPossible heterogeneity::
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GGantt Chart antt Chart Task not achieved:Task not achieved:
• Extract final quantified QoLExtract final quantified QoL• AnalysisAnalysis
Due to:Due to:• Some results are only shown in graphicsSome results are only shown in graphics• A great variety of surgical technicsA great variety of surgical technics
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Further Results Further Results
Expected results for 3rd apresentation:
Analysis Conclusion of Manuscript writing Website conclusion and presentation
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Webpage Webpage PlanPlan
Home Page
Abstract
Introduction
Materials and Methods
Results
Discussion
References
Full Article (pdf)
Appendix
Acknowledgments
Presentations
Graphics & Tables
Tasks’ Distribution
Searches in Pubmed&Scopus
1st Presentation
2nd Presentation
3rd Presentation
Authors
Reference database
Articles Valid. Question.
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